Molecular biology work

1. Estefany Vargas Ladino
Medicine student
3er semester
*

2. Central
Dogma of
genetic
By: Estefany
Vargas Ladino
Molecular
biology
upb
Medical utility
Both news items mentioned above
have great medical applications. The
first one with the discovery of new
viruses could be an advantage for us
as it would allow us to find treatment
against different viruses even before
they even affect humans. The second,
its medical utility is clear, since to
know with greater sertase the
cancerigenic mechanisms can be
sought cures with a greater
effectiveness since it would know with
sertesa that it is bad to be able to
repair it
BIBLIOGRAPHY
-Martinez Sanchez, Lina Maria.
Biología Molecular. 7 ed. Medellín:
UPB. Fac.Medicina
-University of Oxford. (2017,
August 4). Unknown virus
discovered in 'throwaway'
DNA. ScienceDaily. Retrieved
August 7, 2017 from
www.sciencedaily.com/releases/
2017/08/170804100414.htm
-University of Seville. (2017, June
30). New elements responsible
for instability in
chromosomes. ScienceDaily.
Retrieved August 5, 2017 from
www.sciencedaily.com/releases/
2017/06/170630105026.htm

3. Introduction
The central dogma of biology is the
route by which information from the
DNA located in the nucleus can reach
the cytoplasm, for the protein synthesis,
which takes place in the cytoplasm.
For this purpose the RNA molecule is
used as an intermediary, this molecule
differs from DNA by its composition of a
single chain, its ribose sugar instead of
deoxyribose and instead of thymine it
uses uracil.
The steps to carry out this process are:
Replication, transcription and
transduction, of which the first 2 are
made in the nucleus and the third in the
cytoplasm
Unknown virus
discovered in
'throwaway' DNA
Researchers at Oxford University
developed an algorithm based on the
technologies of DNA sequences and
databases, which could be used for the
indetermination of new viruses. The
discovery was made accidentally in fish,
which showed how the DNA of the virus
is incorporated into the fish.
Personal opinion
This could be the beginning of a
great revolution that would benefit
to many fields science, is a project
that if it continues evolving could
save many lives with its correct
implementation
New elements
responsible for
instability in
chromosomes
Researchers at the University of Seville
and the Andalusian Center for Molecular
Biology and Regenerative Medicine say
that chromatin is an important issue in
the instability of the human genome,
which is the major risk factor in tumor
development. Explain that mutations in
the transcription and transport of RNA
cause DNA damage which in turn causes
changes in the chromatin
Personal opinion
The cancer is one of the diseases that
with high prevalence and incidence
rates so I think it is opportune to be
able to understand the different
mechanism of how they happen and with
these bases to be able to look for
therapeutic options to improve the
quality of life of patients who suffer
from it and also to find ways To be able
to avoid it

4. *
In the introduction we speak of central dogma of the
genetic information since in both news it is necessary
to understand it in order to know what the news is
being based, since in the first one we have to know
the way in which DNA is replicated in order to
understand how the DNA of these new viruses is
joining that of the fish, and replication is part of the
dogma; And in the second news it is clear that there
is talk of transportation and transcription of RNA that
are also part of the dogma.

5. *

6. *
*For the creation of the algorithm the scientists
used Next-Generation Sequencing that are
platforms that perform sequencing of millions
of small fragments of DNA in parallel

7. *
*The discovery was initially made by accident
manner as they were initially using the
database for the search for an herpes virus in
the primates but found evidence of new virus
induction

8. *
*Taking advantage of the new discovery they
began to do the same but intentionally and
with this found a new lineage of viruses, which
were found dispersed in 15 species of fish,
among which are the Atlantic salmon and
rainbow trout.

9. *
For me it is a project that must continue to work but has
a lot of potential, something that should be extrapolated
from fish to humans, because this could prevent possible
epidemics caused by unknown viruses or even find
viruses that may be benefits for to the humans

10. *

11. *
*The goal for these investigators was to
determine where, when, and why mutations
occur in DNA and how they lead to a risk factor
for cancer, and on that path found a new
element involved in all of this: chromatin

12. *
*In the articles to be used as reference it is said
that the interaction of DNA and RNA occurs by
chance or by diseases where the structure of
the chromatin is altered by causing DNA
damage.
*The damage involves the transport and
transcription of RNA, which also causes DNA
damage, which is expressed as chromatin
damage and in these cases the central dogma
of genetics can not be carried out

13. *
*It is sought that with the advance of the
investigation in the future can be made anti-
tumor drugs based on the found. It was
demonstrated that chromatin has a very
relevant role when it comes to DNA mutation
controlled by RNA

14. *
It is good that for a disease that is so often seen
there is a light of hope about a new possibility of
treatment based on the discoveries made by this
group of people. It is good that we continue to
deepen this research to be able to give more
alternatives of treatment for the different types of
cancer

15. *

16. The main medical utility that this new way of
locating the virus is the doors that it opens for
study and to understand if they are harmless or if
it does not cause damage in its host but at the
moment of its transmission causes pathologies
*

17. The possibility of creating a new way of
treating cancer, probably in a less aggressive
form than there is currently is of great medical
utility and also allows people who for certain
conditions could not access the traditional
ways to treat cancer with this Advance can do
it
*

18. The prevention of the transmission of viruses
thanks to their early detection in certain
species and the possibility of knowing that they
cause before someone is affected is of great
medical benefit because it benefits the whole
community and institutions avoiding
unexpected pandemics
*

19. *Martinez Sanchez, Lina Maria. Biología
Molecular. 7 ed. Medellín: UPB. Fac.Medicina
*University of Oxford. (2017, August 4).
Unknown virus discovered in 'throwaway'
DNA. ScienceDaily. Retrieved August 7, 2017
from
www.sciencedaily.com/releases/2017/08/
170804100414.htm
*University of Seville. (2017, June 30). New
elements responsible for instability in
chromosomes. ScienceDaily. Retrieved
August 5, 2017 from
www.sciencedaily.com/releases/2017/06/
170630105026.htm
*

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development for the conservation of the last tropical forests that exist in
the "Rio Claro del Norte" basin in the central Andean region of Colombia.