CDE Marketplace: Moleculomics
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Presentation from Moleculomics at the Centre for Defence Enterprise Marketplace held on 5 February 2015. For more info see: https://www.gov.uk/government/news/mod-brings-businesses-together-for-innovative-defence-ideas
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This document discusses molecular docking, which is a technique used in bioinformatics and drug design to predict how biological molecules, like proteins and ligands, bind to each other. It begins by defining bioinformatics and explaining why molecular docking is important for applications like drug design and signal transduction. The document then discusses key concepts in molecular docking like rigid and flexible docking, different docking software tools, and challenges associated with molecular docking.
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The document summarizes docking studies performed on ten synthesized quinazoline compounds against the androgen receptor. Two compounds, 1e and 1g, were found to have the most favorable binding energies of -8.45 kcal/mol and -8.21 kcal/mol, respectively. Both compounds docked at the methionine pockets of the receptor. The study suggests compounds 1e and 1g may have potent anti-cancer activity against prostate cancer by binding well to the androgen receptor.
Good Model Organism for Anti Aging Testing
Drug testing is taking more attention than ever before in a fast growing market for longevity compounds. In order to succeed in a competitive market and develop a pipeline method for quick drug development, we need to understand and choose the most suitable model organism for aging studies. The following content is intended to provide information on how to choose the best model for anti-aging drug testing.
Beller BHTP 7 17 09
The void between preclinical testing and clinical trials of drugs reveals a crucial roadblock to efficient drug discovery. This plan defines an apporach to bioengineer structurally representative human tissues in vitro using the power of outstanding international academic collaborations.
collaboration
Proteomics, definatio , general concept, signficance
INTRODUCTION
GENERAL CONCEPT
WHY PROTEIOMIC NECESERY?
WHAT PROTEOMIC CAN ANSWER?
PRTEOMICS- ANALYSIS AND IDENTIFICATION OF PROTEIN
TWO-DIMENSIONAL SDS-PAGE
MASS SPECTROMETERS
SIGNIFICANCE OF STUDY AN ITS IMPORTANCE
APPLICATIONS
CHALLENGES
CONCLUSIONS
REFERENCES
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NanoAgents: Molecular Docking Using Multi-Agent Technology
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Computer aided drug design - a new drug discovery tool
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Finding Optimal Compound Dosage for Anti-Aging Drugs
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Significance of computational tools in drug discovery
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The Defence and Security Accelerator is an innovation network established in 2016 to find and exploit innovations that support UK defence and security. It provides multiple entry points for innovators, including open calls and themed competitions. It offers a simple application process, funding for successful proposals, and support to help bring ideas to UK defence and security customers. Recent themed competitions have focused on areas like autonomous resupply, human-information relationships, battery power alternatives, and aviation security.
Improving crowd resilience themed competition slides
The document summarizes an innovation network event hosted by the Defence and Security Accelerator to launch a competition called "Improving Crowd Resilience". The event provided an overview of the competition which seeks innovative solutions that can use crowds to detect explosive and weapon threats in public spaces. Specifically, it challenges participants to develop technologies or methods that can 1) detect crowds' conscious and subconscious reactions to threats, 2) train the public to spot threats, or 3) enable crowds to report potential threats. Representatives from the Accelerator and Home Office discussed the goals and scope of the competition, emphasized their interest in multi-layered approaches, and took questions from attendees.
Accelerator First Innovation Fund network event Session 1
The document discusses challenges with rapidly integrating new sensors for military use. It describes how sensors currently have different data formats and standards, making integration difficult. It proposes developing common preprocessing and postprocessing functions, as well as an open architecture algorithm repository, to allow automated integration and fusion of data from various sensors. This would help overcome issues around scalability and real-time performance when exploiting sensor data for military operations.
CDE themed comp -syn-bio part 2
This document discusses potential applications of synthetic biology for developing novel transparent materials and adhesives/interlayer materials. It notes that new materials could help address issues like moisture degradation, delamination, and reducing costs. The document outlines challenges with current materials and desirable properties for new solutions. It provides details on a competition seeking proposals for using synthetic biology to create novel transparent materials or adhesives/interlayers, noting what is and isn't desired in submissions. Overall the document scopes opportunities for synthetic biology to enhance transparent materials for defense applications.
CDE themed comp - synbio part 1
The document discusses utilizing synthetic biology to develop novel transparent materials for defence applications such as transparent armor. It describes two challenges for a competition: 1) producing and characterizing novel transparent materials, and 2) developing adhesives and interlayer materials compatible with transparent armor. Currently, transparent armor has poor ballistic performance compared to opaque armor and is expensive due to specialized materials and processing required. Synthetic biology may be able to create new transparent composite materials inspired by biology with enhanced properties for armor applications.
Beyond battery power: future autonomy
The document discusses the limitations of battery power for small autonomous robots and soldiers. While smaller robots are safer and more practical for defense applications, current battery technology only allows for an hour or two of operation, which is not enough. Batteries are also limited in their energy density and unlikely to improve much in the next 10-20 years. The document proposes potential alternative power solutions that could be explored, such as photovoltaic energy capture from flames, novel engine/generator combinations, or single-use power sources that last a day or two before recycling. It concludes that long-endurance power sources for smaller robots present an opportunity for defense applications if technical challenges can be addressed.
CDE themed challenge - Beyond battery power: the technical challenge and futu...
CDE themed challenge - Beyond battery power: the technical challenge and futu...Defence and Security Accelerator
Beyond battery power CDE themed challenge, part 3. Outline of the technical challenge and future aspirations.Beyond battery power - CDE themed competition part 2
The document discusses the limitations of battery power for small autonomous robots and soldiers. While small robots are attractive for defense applications like reconnaissance and patrolling, battery technology cannot provide enough energy density for more than an hour or two of operation. Fuel cells and generators are not feasible options at small scales either. However, the document suggests some potential solutions being explored, such as photovoltaic energy capture from flames, novel engine/generator combinations, or single-use power sources that could operate for a day before recycling. The goal is to develop alternative power sources that would enable the widespread use of smaller autonomous robots in defense applications.
Beyond battery power - CDE themed competition part 1
An introduction to the themed competition and an overview of how it would be applied in a military setting. Presentation first shown on 1 December 2016.
Beyond battery power - how the competition will work
Outline of how the Beyond Battery Power themed competition will operate. Includes key dates and links.
Introduction to the Centre for Defence Enterprise and introducing the Defence...
Introduction to the Centre for Defence Enterprise and introducing the Defence...Defence and Security Accelerator
Introduction to innovation and network event hosted by the Centre for Defence Enterprise. This presentation outlines CDE's role and signposts the future direction of the project.CDE Competition on FASS - technology challenge 1
Overview of the Technology Challenge for the Future Aviation Security Solutions CDE competition - announced on 17 Nov 2016.
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Finding, funding and exploiting innovation for the benefit of UK Defence and ...
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DASA Jim Pennycook - challenge and opportunity - DSEI 2017
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