phMRI, fMRI and Drug Development
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Pharmaceutical fMRI (phMRI) combines fMRI with drug delivery to assist in drug discovery and development by making pre-clinical and clinical trials more effective. It uses powerful magnets and complex analysis of subtle blood flow changes to detect brain activity represented by color-coded images. The document discusses applying fMRI to studies of central nervous system disorders by designing studies, executing scans, analyzing and reporting data, and providing consulting services.
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Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
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Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
LOOPS in orthodontics t loop bull loop vertical loop mushroom loop stop loop
LOOPS in orthodontics t loop bull loop vertical loop mushroom loop stop loop
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
phMRI, fMRI and Drug Development
- 2. <<Pharmaceutical fMRI, phMRI>> combining fMRI with drug delivery, this non-invasive tool assists in drug discovery and development making your pre- clinical and clinical trials more effective.
- 3. What is functional MRI? “fMRI is the holy grail of brain imaging…fMRI machines use powerful magnets and complex mathematical analysis to detect subtle changes in blood flow to specific parts of the brain, ultimately representing brain activity in color-coded images that look something like Doppler weather reports. You'll need an expert to interpret these images, unless you're harboring a grad degree in neuroscience”. Steven Berlin Johnson (Discover Magazine)
- 4. Synthesis of Drug Intervention in CNS disorder Studies Using fMRI Fundamental Principles: Taking known psychological facts about syndromes, DSM IV etc. Using scientific facts about brain anatomy and function Indentifying potential ROIs based on previous related research Event related Design Comparison group to determine what “normal” activation is Several scan sessions, including preliminary structural MRI Use of psychological testing outside of the scanner to compare results of treatment on written vs. functional testing.
- 5. Applying fMRI Making fMRI Work For You STUDY PLANNING STUDY EXECUTION ANALYSIS AND REPORTING CONSULTING
- 6. Study Planning Paradigm Design Pilot Study Working with Experts Optimization of Sequences Physics Neuropsychology Administration Customer Service
- 7. Study Execution Subject Recruitment CRO Subject Management and Training Subject Reimbursement IRB fMRI Scanning at the Applied fMRI Institute’s Siemen 3T tim Trio
- 8. Analysis & Reporting On Site Data Analysis System Data Analysis Specialist Standard Reports Customized Reports AFNI and Brain Voyager
- 9. Consulting Never done fMRI before? That’s OK! Team of Experts Design Your Study We Make fMRI Work for You!
- 10. Conclusion fMRI can aid in drug development on many levels The Applied fMRI Institute is here to help
Editor's Notes
- http://www.model.in.tum.de/um/courses/neuro/WS0405/vl10b.pdf