This document summarizes a presentation about the Patient-Centered Outcomes Research Institute (PCORI). PCORI is funding patient-centered comparative effectiveness research. The presentation highlights two award winning projects, discusses some projects that were not funded, and outlines PCORI's funding priorities and challenges. PCORI wants to advance research that engages stakeholders, reflects patient variability, and focuses on important health outcomes without using cost-effectiveness as a funding criterion. Opportunities for PCORI include supporting real-world evidence generation and incorporating diverse stakeholder perspectives, but challenges include stakeholder burnout and operating in the current fiscal environment.