This document summarizes Pharos, a knowledge management center and database for biomedical research targets developed by the National Center for Advancing Translational Sciences (NCATS). Key points: - Pharos contains over 20,000 biomedical targets, drugs, diseases, and related publications to facilitate exploration and hypothesis generation. - It provides search, visualization, and filtering capabilities to browse entity relationships and summaries. Target knowledge vectors also enable new methods like recommendations and clustering. - The goals are to characterize understudied targets, identify small molecules/biologics, explore research landscapes, and support data mining. Pharos is intended for biologists, clinical researchers, and informatics scientists. - Future work