Drug discovery, design and development: Sources of drugs: biological, marine, minerals and plant tissue culture, physio-chemical aspects (optical, geometric and bioisosterism) of drug molecules and biological action

1. INNOVATIONS IN
DRUG DISCOVERY:
EXPLORING DIVERSE
SOURCES AND
PHYSIO-CHEMICAL
ASPECTS
BY:
Amit Deshwal
Shivam Khanna

2. Welcome to the presentation on
Innovations in Drug Discovery. This
presentation will explore the diverse
sources and physio-chemical aspects
influencing drug discovery.
INTRODUCTION

3. TRADITIONAL DRUG DISCOVERY
Historically, drug discovery relied on
natural sources such as plants and animals.
This approach often involved trial and error
methods to identify potential compounds.

4. MODERN APPROACHES
Advancements in technology have enabled
the exploration of diverse sources including
microorganisms, marine organisms, and
computational models. These approaches
have revolutionized drug discovery.

5. Understanding the physio-chemical
properties of compounds is crucial for
drug discovery. Factors such as
solubility, stability, and target
interactions play a vital role in the
development of e ective drugs.
PHYSIO-CHEMICAL ASPECTS

6. HIGH-THROUGHPUT SCREENING
High-throughput screening allows for the
rapid testing of a large number of
compounds. This approach has
significantly accelerated the identification
of potential drug candidates.

7. FRAGMENT-BASED DRUG DESIGN
Fragment-based drug design involves the
assembly of small molecular fragments to
create a larger, bioactive compound. This
approach has gained prominence in
modern drug discovery.

8. Natural products continue to serve as a
valuable source of inspiration for drug
discovery. The diverse chemical
structures found in nature provide a rich
foundation for drug development.
NATURAL PRODUCTS AS INSPIRATION

9. TARGETED DRUG DELIVERY
Innovations in drug discovery have led
to the development of targeted delivery
systems. These systems aim to deliver
drugs to specific cellular targets,
enhancing e cacy and reducing side
e ects.

10. The field of drug discovery continues to
evolve with emerging trends such as AI-
driven drug design, CRISPR-based
screening, and 3D bioprinting. These
trends hold promise for future
advancements.
EMERGING TRENDS

11. CHALLENGES AND OPPORTUNITIES
Despite the progress, drug discovery faces
challenges such as cost, regulatory hurdles,
and drug resistance. However, these
challenges present opportunities for
collaborative innovation and novel
solutions.

12. FUTURE PROSPECTS
The future of drug discovery is poised
for groundbreaking advancements
driven by interdisciplinary collaboration,
data-driven approaches, and precision
medicine. The potential for
transformative impact is immense.

13. CONCLUSION
In conclusion, the exploration of diverse sources and physio-
chemical aspects has propelled innovations in drug discovery. The
future holds promise for novel therapies and improved patient
outcomes.

14. Thanks!