Positive Expiratory Pressure (PEP) therapy, developed in the 1980s, involves using devices that provide either low or high pressure (10-20cm H2O or 50-120cm H2O) to facilitate airway clearance and improve lung function in patients with conditions like cystic fibrosis and COPD. PEP operates through mechanisms such as oscillation and positive pressure to mobilize secretions and prevent postoperative atelectasis. Various devices, including flutter, r-c cornet, and acapella, are utilized to deliver PEP therapy tailored to individual patient needs.