Presentation at ISAKOS, 2019
We performed a total of 142 pectoralis major repairs over a ten year period, of which 19 required allograft reconstruction. Of these 19 patients, 11 were available for response. All 11 patients were male with a mean age of 38.3 years (21 to 48 years). The mean time between injury and surgery was 12.2 months (4 to 30 months). Ten patients (91%) were unable to perform their previous level of work pre-operatively, with all patients returning to pre-injury occupation levels post-operatively.
The main complaint prior to surgery was pain on pushing and moving the affected arm across the body, which improved in nine patients (82%), with no improvement reported in two patients. Strength improved significantly post-operatively, with only three patients reporting no improvement (paired t-test p=0.01). Six patients reported an improvement in cosmesis (50%).
Modified Mason-Allen Technique For Rotator Cuff Repairluantran92
This is the technical note and research review for the Modified Mason-Allen technique that I conducted during the fellowship time at Seoul Nation University Bundang Hospital, South Korea.
Presentation on the Anterolateral Ligament (ALL) with information on diagnosis with ultrasound and treatment using an ultrasound guided, percutaneous, reconstruction and an internal brace
Modified Mason-Allen Technique For Rotator Cuff Repairluantran92
This is the technical note and research review for the Modified Mason-Allen technique that I conducted during the fellowship time at Seoul Nation University Bundang Hospital, South Korea.
Presentation on the Anterolateral Ligament (ALL) with information on diagnosis with ultrasound and treatment using an ultrasound guided, percutaneous, reconstruction and an internal brace
Biomechanical Properties of the AnteroLateral Ligament (ALL) of the Knee comp...KHALIFA ELMAJRI
Improvising is an established corner in orthopaedic surgery .But if we start handling healthy body tissues surgically we are actually disturbing nature. The lateral knee region is known by its complex functional anatomy. Injury to the integrity of biceps tendons components in this region or direct injury to the FCL could happen during surgery in this region. As the injuries of FCL augment ALRI of the knee it is worth to study the effect of passing the graft deep to the LCL in lateral extra-articular reconstructions , an injury could arise from fixing distal FCL to its tunnel which prevent FCL normal gliding within this tunnel.
To restore function of a structure in the lateral knee using another structure one should have sound comparable knowledge’s about exact nature of structures to be handled, their clinical anatomy and their material and structural properties is a must before their investment, this to minimise the risk of introducing imbalance to a sensitive ligamentous balance or alter the proprioceptive function or affect the stability of the lateral meniscus .That’s why the more work on the anterolateral knee would be invested, in addition to management of acute knee injury , in the study of graft placement isometry in ACL reconstruction , as well as isometry of lateral extra-articular reconstructions to control (ALRI) with ITT, when indicated .
Total Knee Arthroplasty | Knee Replacement | South Windsor, Rocky Hill, Glast...James Mazzara
https://hartfordsportsorthopedics.com/
In this presentation, Dr. Mazzara discusses total knee arthroplasty. His presentation highlights:
The anatomy of the knee
Normal articular cartilage
Causes and symptoms of osteoarthritis
Diagnosis of osteoarthritis
Non-surgical treatment for osteoarthritis
Candidates for total knee arthroplasty
Surgical approach to knee replacement
Potential complications of knee arthroplasty
Computer-assisted total knee replacement
Post-operative protocol
To learn more about total knee arthroplasty, please visit: https://hartfordsportsorthopedics.com/computer-guided-total-knee-replacement-south-windsor-rocky-hill-glastonbury-ct/
Biologic Knee Replacement (BKR) is our approach to treating knee injuries, from trauma to arthritis, and is designed to help people delay, or even avoid, artificial knee replacement. BKR is a scientifically-proven collection of our out-patient surgical techniques and procedures and consists of any combination of meniscus transplantation, articular cartilage paste grafting, ligament replacement as explained in further detail below. Being "bone on bone" does not always mean that the joint needs to be artificially replaced, often the "bone on bone" is isolated to a portion of the knee joint and this can be repaired using Biologic Knee Replacement.
Isokitenic 2015: Clinical Practice Guidelines for Muscle Injury FC Barcelona...MuscleTech Network
Presentation at: 'Football Medicine Strategies for Player Care', XXIV International Conference on Sports Rehabilitation and Traumatology, 11th- 12th April, 2015- London
https://hartfordsportsorthopedics.com/
In this presentation by Dr. Mazzara, he discusses work-related injuries to the shoulder and knee. This presentation highlights:
Why workers' compensation matters
Justice v. science
Age-related cartilage changes in the knee
Meniscus injuries
Knee arthroscopy
Total knee replacement
Shoulder anatomy
Rotator cuff injuries
Rotator cuff repair
Biceps tendon injuries
Shoulder replacement
Reverse shoulder replacement
To learn more, please visit: https://hartfordsportsorthopedics.com/shoulder-overview-south-windsor-rocky-hill-glastonbury-ct/ and https://hartfordsportsorthopedics.com/knee-anatomy-acl-injury-south-windsor-rocky-hill-glastonbury-ct/.
Biomechanical Properties of the AnteroLateral Ligament (ALL) of the Knee comp...KHALIFA ELMAJRI
Improvising is an established corner in orthopaedic surgery .But if we start handling healthy body tissues surgically we are actually disturbing nature. The lateral knee region is known by its complex functional anatomy. Injury to the integrity of biceps tendons components in this region or direct injury to the FCL could happen during surgery in this region. As the injuries of FCL augment ALRI of the knee it is worth to study the effect of passing the graft deep to the LCL in lateral extra-articular reconstructions , an injury could arise from fixing distal FCL to its tunnel which prevent FCL normal gliding within this tunnel.
To restore function of a structure in the lateral knee using another structure one should have sound comparable knowledge’s about exact nature of structures to be handled, their clinical anatomy and their material and structural properties is a must before their investment, this to minimise the risk of introducing imbalance to a sensitive ligamentous balance or alter the proprioceptive function or affect the stability of the lateral meniscus .That’s why the more work on the anterolateral knee would be invested, in addition to management of acute knee injury , in the study of graft placement isometry in ACL reconstruction , as well as isometry of lateral extra-articular reconstructions to control (ALRI) with ITT, when indicated .
Total Knee Arthroplasty | Knee Replacement | South Windsor, Rocky Hill, Glast...James Mazzara
https://hartfordsportsorthopedics.com/
In this presentation, Dr. Mazzara discusses total knee arthroplasty. His presentation highlights:
The anatomy of the knee
Normal articular cartilage
Causes and symptoms of osteoarthritis
Diagnosis of osteoarthritis
Non-surgical treatment for osteoarthritis
Candidates for total knee arthroplasty
Surgical approach to knee replacement
Potential complications of knee arthroplasty
Computer-assisted total knee replacement
Post-operative protocol
To learn more about total knee arthroplasty, please visit: https://hartfordsportsorthopedics.com/computer-guided-total-knee-replacement-south-windsor-rocky-hill-glastonbury-ct/
Biologic Knee Replacement (BKR) is our approach to treating knee injuries, from trauma to arthritis, and is designed to help people delay, or even avoid, artificial knee replacement. BKR is a scientifically-proven collection of our out-patient surgical techniques and procedures and consists of any combination of meniscus transplantation, articular cartilage paste grafting, ligament replacement as explained in further detail below. Being "bone on bone" does not always mean that the joint needs to be artificially replaced, often the "bone on bone" is isolated to a portion of the knee joint and this can be repaired using Biologic Knee Replacement.
Isokitenic 2015: Clinical Practice Guidelines for Muscle Injury FC Barcelona...MuscleTech Network
Presentation at: 'Football Medicine Strategies for Player Care', XXIV International Conference on Sports Rehabilitation and Traumatology, 11th- 12th April, 2015- London
https://hartfordsportsorthopedics.com/
In this presentation by Dr. Mazzara, he discusses work-related injuries to the shoulder and knee. This presentation highlights:
Why workers' compensation matters
Justice v. science
Age-related cartilage changes in the knee
Meniscus injuries
Knee arthroscopy
Total knee replacement
Shoulder anatomy
Rotator cuff injuries
Rotator cuff repair
Biceps tendon injuries
Shoulder replacement
Reverse shoulder replacement
To learn more, please visit: https://hartfordsportsorthopedics.com/shoulder-overview-south-windsor-rocky-hill-glastonbury-ct/ and https://hartfordsportsorthopedics.com/knee-anatomy-acl-injury-south-windsor-rocky-hill-glastonbury-ct/.
The Stone Clinic is a sports medicine clinic in San Francisco, California, offering orthopaedic surgery and medical care, physical therapy and rehabilitation, and radiology imaging services. The Stone Clinic was founded by Kevin R. Stone, M.D., an orthopaedic surgeon, combining himself with a team of nurses, physical therapists, imaging specialists, and patient coordinators, in 1988 to focus on caring for injured athletes and people experiencing arthritis pain.
The Stone Clinic is founded on the goal of rehabilitating all patients to an operating level higher than before they were injured. The Stone Clinic specializes in sports medicine and injury treatment of knee, shoulder, and ankle joints. Stone has lectured and is recognized internationally as an authority on cartilage and meniscal growth, replacement, and repair. Stone and the Stone Clinic are known for the development of the paste grafting surgical technique in 1991, combined with meniscus replacement, which are biologic joint replacement procedures for the regeneration of the knee joint. Surgical procedures were subjected to rigorous outcomes analysis with the results reported in peer reviewed journals. The surgical techniques have been taught to surgeons in the US and worldwide, through lectures and videos.
Nursing students, medical students, residents, fellows, and other physicians from various institutions around the world, rotate through The Stone Clinic and mentor with Stone. The Stone Clinic hosts the annual Meniscus Transplantation Study Group Meeting as well as the annual Professional Women Athlete's Career Conference.
Total hip arthroplasty has been an important surgical operation in orthopaedics in the 20th century. After many trails, major advancement in Total Hip Arthroplasty was made by Sir John Charnley in 1962, who introduced low friction arthroplasty. This consists of a polyethylene cup and 22.2 mm head, both components being fixed with methacrylate cement. In the following years there were many changes to this basic principle (model) of total hip arthroplasty. Patient education has become an important factor in improvement of function following total hip replacement.
Rotator Cuff Update 2022 for Medbelle Len Funk.pptxLennard Funk
the common questions patients will ask once they have had a scan and a tear has been reported, particularly if they have had no injury of trauma, they ask what caused my tear. If I have a tear what can you do to fix it, it’s got to be fixed. How can I get better if it is not fixed. I have already had physiotherapy and that didn’t fix it so how will more physiotherapy. Some patients who are not keen on surgery, do I really need to have an operation. I have not had an injury.
there are multiple options thrown into the mix here which we need to consider for an individual patient.
The below illustration shows a very rough decision making tool that I would use in determining surgical or treatment options for particular patients.
A younger patient who has both pain and weakness with a massive cuff tear, if it is partially repairable a biological augment would be suitable.
If their predominant weakness is external rotation i.e. a positive Hornblower sign but good elevation, a lat dorsi tendon transfer.
For an older patient who has a predominant weakness but no significant pain, deltoid rehabilitation programme is indicated.
If they do have pain, a suprascapular nerve procedure such as an ablation would be beneficial.
For those that have significant pain and weakness with failed non-operative options, a reverse shoulder replacement would be the best option.
The balloon as we said, has a very limited place and this is for the older patient with slight loss of function and pain with higher demands.
For those that have more significant pain and elevation weakness, a superior capsular reconstruction would be my preferred option.
Should We Repair Rotator Cuff Tears OPN 2017.pdfLennard Funk
Lennard Funk & Puneet Monga
Prepared for Orthopaedic Product News, 2017
Rotator cuff disease is very common. There is as much enthusiastic discussion and debate on its management as there was 80 years ago when Codman (1937) first described the pathology and surgical management. There is great variation amongst surgeons as to the management of rotator cuff tears biased by experience and their understanding of the literature, skills levels and regional variations. There has been a lot of research done on the pathology, non-operative and operative treatments over the last two decades. Also, over the last decade there have been massive strides in the development of new surgical techniques and technologies. However, despite these advances there is as much discussion and debate!
Superior Capsular Reconstruction Outcomes Wrightington 2020Lennard Funk
Hariharan Mohan, Jagwant Singh, Michael Walton, Lennard Funk, Puneet Monga
Cautious optimism following SCR may be offered to this challenging subset of patients with symptomatic irreparable rotator cuff tears. It is likely that the relatively low re-operation rates can be further improved by considering the negative prognostic factors in defining indications for surgery. Further studies with longer term followup are recommended.
Isolated scapula pain is uncommon, but very difficult to diagnose and manage. In this presentation I run through the known causes and an approach to the diagnosis, in order to guide best treatment.
The Incidence of Traumatic Posterior and Combined Labral Tears in Patients Un...Lennard Funk
Presentation at ISAKOS, 2019
There were 442 primary arthroscopic labral repair procedures performed over the three-year period. The total cohort had a mean age of 25.91±9.09 years (range, 14-67 years) and consisted of 89.6% males. There was no significant difference in mean age or gender between the isolated anterior, posterior or combined groups (p=0.383 and p=0.541, respectively).
• Of the 442 patients who underwent a shoulder labral repair, isolated anterior labral pathology occurred in 52.9% (n=234), with posterior and combined labral tears accounting for 16.3% (n=72) and 30.8%, respectively (n=136) (Table 3).
• Patients were stratified as either sporting or non-sporting; 74.9% of patients were categorised as sporting (n=331) and had a mean age of 24.91±5.69 years, which was significantly lower than the mean age of 35.40±11.94 years in the non-sporting population (p<0.001). In the non-sporting population 68.5% (n=76) of patients had isolated anterior labral tears with 12.6% (n=14) posterior and 18.9% (n=21) combined. In the sporting population isolated anterior labral tears accounted for 47.7% (n=158), posterior 17.5% (n=58) and combined labral tears 34.7% (n=115). The sporting population had a significantly greater proportion of posterior and combined labral tears with the non-sporting population a significantly greater proportion of anterior labral tears (p=0.013).
• Rugby players had the greatest incidence of shoulder instability within the sporting cohort accounting for 231 cases. Of the 231 cases, 47.2% were isolated anterior labral tears, 12.6% isolated posterior and 40.3% combined lesions.
Posterior and combined shoulder labral tears are more prevalent than previously reported in the civilian population. The rates are higher in young, sporting populations and especially in contact sports such as rugby.
Hydrodistention is a treatment for frozen shoulder (FS) that is gaining popularity again. However, no large, long-term outcome data has been published yet. Our aims were to evaluate hydrodistension for the treatment of primary frozen shoulder (FS) in a large cohort of patients with long follow-up period.
We present a case series of eighty-nine patients (36 males and 53 females) with a mean age of 52 years (33-73). Eleven (12.4%) had disease associations. We excluded post-operative secondary stiff shoulders. The mean volume injected was 33.7ml (16-66). 36/89 (40%) had capsular rupture. Six (6.7%) had adverse effects. The mean follow-up was 104.5 weeks (8-238).
Mean improvement in forward flexion was 165.4, abduction 111.6, external rotation was hand above head with elbow back (and internal rotation in extension to T12. Mean improvement in quickDASH score was 17.1 (p<0.001) and Constant Score was 70.0 (p<0.001). Mean improvement in VAS was 7.3 (p<0.001). No patients had night pain (p<0.001). Eighty-eight (99%) returned to their previous occupation. Seventy-six (85%) returned to their previous level of sport. Gender, previous intra-articular steroid injection, volume of the injectate, type of steroid used, capsular rupture and underlying aetiology had no impact on outcome.
Clinical predictors hydrodilatation in idiopathic fs 2017Lennard Funk
Clinical predictors of poor outcomes for hydrodilatation include female gender, high pain scores, short length of symptoms, previous contralateral FS, inability to reach the waist in internal rotation and external rotation less than one degree. This information is useful in the treatment decision making process for idiopathic FS.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
1. Surgical Reconstruction of Unrepairable Pectoralis Major Rupture Using Tendo-
Achilles Allograft
M A Imam, S Javed, P Monga, L Funk
Wrightington Hospital, UK
ISAKOS, Cancun 2019
Correspondence: Mr Mohamed Imam MD PHD FRCS (Tr and Orth); Email: Mohamed.imam@aol.com
Background:
Rupture of the pectoralis major remains an infrequent injury but recently
has been reported more commonly. A number of surgical repair techniques
have been described for direct repair. However, on occasion, the pectoralis
major muscle is so retracted that a tension-free direct repair is not possible.
Aim:
We describe a technique for allograft reconstruction of the pectoralis major,
with our preliminary outcomes, where it is found or anticipated that a direct
repair is not possible.
Methods:
The main indication for surgery is pain and functional loss that
adversely affects a manual worker to perform their job or competitive
sporting activity. We describe a technique for allograft reconstruction
of the pectoralis major where a direct repair is not possible.
Figure 1. Three anchors placed in a step wise longitudinal
pattern lateral to biceps to allow a footprint repair
Results:
We performed a total of 142 pectoralis major repairs over a ten year period,
of which 19 required allograft reconstruction. Of these 19 patients, 11 were
available for response. All 11 patients were male with a mean age of 38.3
years (21 to 48 years). The mean time between injury and surgery was 12.2
months (4 to 30 months). Ten patients (91%) were unable to perform their
previous level of work pre-operatively, with all patients returning to pre-injury
occupation levels post-operatively.
The main complaint prior to surgery was pain on pushing and moving the
affected arm across the body, which improved in nine patients (82%), with
no improvement reported in two patients. Strength improved significantly
post-operatively, with only three patients reporting no improvement (paired
t-test p=0.01). Six patients reported an improvement in cosmesis (50%).
Conclusions:
This technique involves the use of cadaveric tendo-achilles allograft to reconstruct the pectoralis major
tendon attachment to the humerus with good early to mid-term results.
References:
•Bak K, Cameron EA, Henderson IJ. Rupture of the pectoralis major: a meta-analysis of 112 cases. Knee Surg Sports Tramatol Arthrosc 2000; 8(2):113-119.
•Pochini A, Ejnisman B, Andreoli CV, Monteiro GC, Silva AC, Cohen M, Albertoni WM. Pectoralis major muscle rupture in athletes: a prospective study. Am J Sports Med 2010; 38(1):92-98.
•Kakwaki RG, Matthews JJ, Mohtadi N. Rupture of the pectoralis major muscle: surgical treatment in athletes. International orthopaedics, 2007; 31(2):159-163
•Petilon J, Carr DR, Sekiya JK, Unger DV. Pectoralis major muscle injuries: evaluation and management. J Am Acad Orthop Surg 2005; 13(1):59-68.
•Butt U, Mehta S, Funk L, Monga P. Pectoralis major ruptures: a review of current management. J Shoulder Elbow Surg 2015; 24(4):655-62
•Butt U. Pectoralis Major. In: Monga P, Funk L. (eds.) Diagnostic Clusters in Shoulder Conditions. Cham, Switzerland: Springer; 2017. p. 165-170
•Shah NH, Talwalker S, Badge R, Funk L. Pectoralis major rupture in athletes: footprint technique and results. Techniques in Shoulder & Elbow Surgery 2010; 11(1):4-7.
•Sikka RS, Neault M, Guanche CA. Reconstruction of the pectoralis major tendon with fascia lata allograft. Orthopedics 2005; 28:1199
•Zacchilli MA, Fowler JT, Owens BD. Allograft reconstruction of chronic pectoralis major tendon ruptures. J Surg Orthop Adv 2013; 22(1):95-102
•Schepsis AA, Grafe MW, Jones HP, Lemos MJ. Rupture of the pectoralis major muscle: outcome after repair of acute and chronic injuries. Am J Sports Med 2000; 28(1):9-15.
•Aarimaa V, Rantanen J, Heikkila J, Helttula I, Orava S. Rupture of the pectoralis major muscle. Am J Sports Med 2004; 32(5):1256-1262.
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Figure 2: Proximal end of allograft tendon secured to pectoralis
major muscle followed by trimming of tendon distally. Suture
anchors are also shown
Figure 3: Final appearance. Schematic illustration of the final
reconstruction