In the quest to accelerate the clinical trial process, we involve patients as partners; We obtain patient insights that are used to: Fine tune aspects of the clinical protocol for compliance and adherence Train sites on how to effectively communicate with patients about the clinical trial to increase recruitment rates Prepare sites to manage patient expectations about clinical trial participation to increase retention rates We conduct dynamically facilitated Study Seminars that prepare sites for the patient encounter We have measurable results: Study sites that participate in patient-centric Study Seminars will perform at a higher rate for patient recruitment and retention

1. Patient-Centric Site Training to Enhance Clinical Trial
Performance
Liz Moench
Managing Partner, PatientDTC
© Copyright 2017: Liz Moench │Patient DTC LLC

2. Introduction
• 30 years ago, Liz Moench launched the first direct to
consumer (DTC) ad campaign; bringing prescription
medicines direct to consumers (patients).
• Now in a paradigm shift, Liz Moench and PatientDTC
are bringing consumers (patients) direct to clinical
trials with measurable success
© Copyright 2017: Liz Moench │Patient DTC LLC

3. So Where Do We Begin in Terms of Patient Centricity?
PLAN & DESIGN SITE READINESS IMPLEMENTATION
RESCUE
PLANS
• Protocol Amendments
• Re-negotiate Site Budgets
• Re-Motivate Sites
• Add more sites
Study Momentum
Design
Protocol
Identify
Sites
Select
Sites
Protocol
Approval
Site
Training
Develop
Recruit.
Strategies
Approve
Recruit.
Strategies
Identify &
Recruit
Pts.
Enroll
Patients
Pt.
Database
Search
SITE SETUP RECRUITMENT
PATIENT DRIVENSITE DRIVENSPONSOR DRIVEN
© Copyright 2017: Liz Moench │Patient DTC LLC

4. We Avoid ‘Rescue’ by Bringing Patients into Clinical Trial Planning
PLAN & DESIGN SITE READINESS IMPLEMENTATION
RESCUE
PLANS
• Protocol Amendments
• Re-negotiate Site Budgets
• Re-Motivate Sites
• Add more sites
Study Momentum
Design
Protocol
Identify
Sites
Select
Sites
Protocol
Approval
Site
Training
Develop
Recruit.
Strategies
Approve
Recruit.
Strategies
Identify &
Recruit
Pts.
Enroll
Patients
Pt.
Database
Search
SITE SETUP RECRUITMENT
PATIENT DRIVENSITE DRIVENSPONSOR DRIVEN
Patient
Input
Site
Input
Feasibility
Patient
Centered
Seminar
© Copyright 2017: Liz Moench │Patient DTC LLC

5. Patient-Centric Site Planning and Training Drives Clinical Trial Performance
• In the quest to accelerate the clinical trial process, we involve patients as partners;
• We obtain patient insights that are used to:
– Fine tune aspects of the clinical protocol for compliance and adherence
– Train sites on how to effectively communicate with patients about the clinical trial to increase
recruitment rates
– Prepare sites to manage patient expectations about clinical trial participation to increase
retention rates
• We conduct dynamically facilitated Study Seminars that prepare sites for the
patient encounter
• We have measurable results: Study sites that participate in patient-centric Study
Seminars will perform at a higher rate for patient recruitment and retention
© Copyright 2017: Liz Moench │Patient DTC LLC

6. Patient-Centric Site Planning and Training Drives Clinical Trial Performance
modify
An opportunity to refine:
• Site selection criteria
• Patient recruitment
materials
• Protocol clarity
• Patient-centric Study
Seminars
Ask &
Listen
Patients as Partners:
Social Listening
Surveys
Focus Groups
prepare
Patient-Centric
Study Seminars
involving PIs and
CRCs increases
patient
engagement in
clinical trials
retain
Sites that are trained
on patient centric
principals elicit patient
feedback throughout
the study resulting in
higher recruitment and
retention rates
value
Measured in performance:
Sites who participate in
Study Seminars outperform
3:1 in patient recruitment
and retention
COLLECT
ANALYZE
TRAIN
FEEDBACK
MEASURE
© Copyright 2017: Liz Moench │Patient DTC LLC

7. Liz Moench
Managing Partner, PatientDTC
Email: LizMoench@PatientDTC.com
US Tel: +1 610 659 5093
© Copyright 2017: Liz Moench │Patient DTC LLC