This slide was presented in Tokyo.R #22.It describes about design of experiment with R. DoE.base package is useful for software testing because it makes easier for us to make orthogonal array.
This slide was presented in Tokyo.R #22.It describes about design of experiment with R. DoE.base package is useful for software testing because it makes easier for us to make orthogonal array.
A Serious Game for Eliciting Tacit Strategies for Dynamic Table Assignment in...haji mizu
The document describes a serious game developed to elicit strategies for dynamically assigning tables in a restaurant. The game simulates customers arriving and waiting to be seated. Players earn points by seating groups and lose points if groups leave due to long waits. Experiments showed experienced players outscored inexperienced ones. Analyzing game data revealed different strategies - prioritizing small groups or sequencing changes - which were grouped into clusters showing tradeoffs between performance and customer satisfaction. The serious game approach effectively elicited tacit strategies for the dynamic table assignment problem.
1. Process analytical technology (PAT) aims to shift pharmaceutical development and manufacturing from testing quality through sampling to building quality into products using continuous monitoring and control strategies.
2. PAT involves establishing quantitative relationships between raw materials, process parameters, and product quality attributes to decrease variability, contamination, and costs while improving quality.
3. The goals of PAT include encouraging innovation through a risk-based regulatory framework that facilitates new manufacturing technologies and ensures consistent application of regulations.
Paul Brodbeck has 30 years of experience in process control engineering and chemical engineering. He advocates for a top-down approach to developing complex and maintainable PAT systems by starting with simple building blocks and adding complexity over time through a learn-by-doing method. This includes implementing basic PID control loops first and then expanding to more advanced multivariate and multi-variable process control strategies using online analyzers and modeling techniques in MATLAB.
This document provides an overview of Quality by Design (QbD), including its background and definition. It discusses the FDA's initiative on QbD and why the QbD approach is used. Key quality guidance documents such as ICH Q8, Q8(R1), Q9, and Q10 are summarized. The document compares the current and QbD approaches to pharmaceutical development and provides an example of a QbD approach. It also describes several tools used in QbD like design space, design of experiments, quality risk management, and process analytical technology.
Process Analytical Technology
• Hardness monitoring
• Moisture distribution mapping
• Powder drying process monitoring and end point determination
• Capsule content examination
• Particle size monitoring
• Detection of foreign objects in powders
The role of process analytical technology (pat) in green chemistry and green ...dominev
This document discusses the use of process analytical technology (PAT) tools in green chemistry and engineering. It presents case studies on using Fourier transform infrared spectroscopy (FTIR) and reaction calorimetry to monitor and develop continuous bioprocesses and chemical reactions. Specifically, it examines how FTIR was used to monitor a biotransformation reaction and develop a continuous multi-step synthesis. It also explores how reaction calorimetry helped classify reaction kinetics and screen conditions to optimize reactions. The document emphasizes how PAT tools can advance green chemistry principles by enabling real-time process monitoring, improving reaction understanding, and facilitating continuous process development and scale-up.
DOE Applications in Process Chemistry Presentationsaweissman
The document discusses how design of experiments (DOE) can help optimize chemical reactions and processes in a more efficient manner than traditional trial-and-error approaches. It provides examples of how pharmaceutical companies have used DOE to reduce costs and improve yields for key reaction steps. DOE allows researchers to systematically vary multiple reaction factors at once to understand their effects and interactions, requiring fewer total experiments than one-factor-at-a-time testing.
21.2 - Part 2 Reactions of Carboxylic Acid Derivatives - Wade 7thNattawut Huayyai
This chapter discusses nucleophilic acyl substitution reactions of carboxylic acid derivatives. It describes the addition-elimination mechanism and how more reactive derivatives can be converted to less reactive ones. Specific reactions covered include converting acid chlorides to anhydrides, esters, or amides. It also discusses hydrolysis, reduction, reactions of esters, amides, and nitriles, and how these transformations are important in organic synthesis and biochemical processes.
ColPMan: A Serious Game for Practicing Collaborative Production Managementhaji mizu
ColPMan is a serious game developed to train collaborative production management skills. It simulates the operations of a multi-site manufacturing company facing uncertainties. Students play the roles of managers at different sites coordinating production and delivery. Evaluations found the game improved students' understanding of key principles and facilitated communication compared to lectures alone. Future work will simplify the roles' workloads.
A Prototype Prediction Market Game for Enhancing Knowledge Sharing among Sale...haji mizu
This document proposes using a prediction market game with a comment system to enhance knowledge sharing among salespeople. It describes preliminary experiments comparing prediction market sessions with and without the comment system. The sessions with comments had significantly more transactions, suggesting comments activated more frequent information and knowledge sharing. Further experiments are needed to better evaluate the game and identify improvements, such as capturing comment relationships. The goal is to develop a serious gaming approach that motivates truthful information sharing to foster collaboration.
A Prediction Market Game for Route Selection under Uncertaintyhaji mizu
This document describes a prediction market game for route selection under uncertainty. It formulates the route selection problem when the lengths of road arcs are random variables. It then designs a prediction market framework using route and arc securities on a logarithmic market scoring rule to crowdsource information. An experiment applies the game to a sample road network and finds market prices correlate well with theoretical probabilities. The document concludes the gaming approach shows promise in solving routing problems with uncertain information.
A comparison between choice experiments and prediction markets for collecting...haji mizu
- The document compares choice experiments and prediction markets for collecting preference data in conjoint analysis. Choice experiments involve presenting customers with subsets of product concepts and asking them to choose one, while prediction markets gamify the process by having customers trade securities predicting market shares.
- Both approaches were used on a sample conjoint analysis problem involving attributes of a mahjong parlor. The results showed a high correlation between the estimated market shares and partial utilities derived from each approach.
- This indicates prediction markets can substitute for choice experiments by effectively collecting preference data for conjoint analysis. However, more case studies are needed to generalize this conclusion.