Bernadette Madrid, University of the Philippines, Director of the Child Protection Unit, Philippines - Parenting support in the context of violence prevention, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lorraine Sherr, Professor, University College London– Parenting support in the context of HIV, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ruti Levtov, Program Officer Promundo-US and Co-Coordinator of the MenCare Campaign, Men and Caregiving, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Emebet Mulugeta (Ph.D.), Associate Professor at Addis Ababa University, Ethiopia, and Director at Nia Center for Children and Family Development, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Pat Dolan, Professor and Carmel Devaney, Lecturer and Researcher UNESCO Child and Family Research Centre, School of Political Science and Sociology, Research and Innovation Centre, NUI Galway – Family support for families at risk, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Florence Martin, Senior Coordinator at Better Care Network during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Ninoslava Pecnik, Professor, Department of Social Work, Faculty of Law, University of Zagreb - Drivers of parenting support, policy and provision in Croatia, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
This webcast was developed by the Office of
Adolescent Health (OAH) in May 2013 as a technical assistance product for use with OAH grant programs and presents global strategies for adolescent pregnancy prevention.
Jenny Pearce, Professor of Young People and Public Policy at the University of Bedfordshire, UK, and John Coleman, Senior Research Fellow in the Department of Education at Oxford University, Parenting teenage victims and perpetrators of violence: lessons rom research on prevention and support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lorraine Sherr, Professor, University College London– Parenting support in the context of HIV, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ruti Levtov, Program Officer Promundo-US and Co-Coordinator of the MenCare Campaign, Men and Caregiving, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Emebet Mulugeta (Ph.D.), Associate Professor at Addis Ababa University, Ethiopia, and Director at Nia Center for Children and Family Development, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Pat Dolan, Professor and Carmel Devaney, Lecturer and Researcher UNESCO Child and Family Research Centre, School of Political Science and Sociology, Research and Innovation Centre, NUI Galway – Family support for families at risk, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Florence Martin, Senior Coordinator at Better Care Network during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Ninoslava Pecnik, Professor, Department of Social Work, Faculty of Law, University of Zagreb - Drivers of parenting support, policy and provision in Croatia, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
This webcast was developed by the Office of
Adolescent Health (OAH) in May 2013 as a technical assistance product for use with OAH grant programs and presents global strategies for adolescent pregnancy prevention.
Jenny Pearce, Professor of Young People and Public Policy at the University of Bedfordshire, UK, and John Coleman, Senior Research Fellow in the Department of Education at Oxford University, Parenting teenage victims and perpetrators of violence: lessons rom research on prevention and support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Elana Gaia, Social Policy Specialist, UNICEF CEE/CIS and Denise Stuckenbruck, Child Protection Specialist, UNICEF ESARO – Family support and social protection, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jasmina Byrne and Alice Margaria OoR - Overview analysis of UNICEF supported policy and provision in middle and lower income countries at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Child-health practitioners in Iowa must find better ways to address family, neighborhood and economic factors that shape children' health and well being, according to CFPC executive director Charles Bruner and Debra Waldron, director and chief medical officer of the Child Health Specialty Clinics at the University of Iowa. They presented at the Iowa Governor's Conference on Public Health in Ames on April 5.
Addressing child health disparities: We made the case, we need a movement!renataschiavo
This presentations reviews recent studies and experiences on child health disparities, and provides insights and recommendations to advance child health equity. It was presented at the 2015 Health Equity Capacity Institute of the CDC Division of Community Health, Office of Health Equity.
Poverty, Sexual Practices and Vulnerability of Female Sex Workers to HIV/AIDS...John Bako
The prevalence of HIV among Female who sell sex in Nigeria has witnessed a sharp decline between 2007 to 2014.
The decline was recorded both amidst BBFSWs (30.2% in 2007 to 19.4% in 2014) and NBFSWs (37.4% in 2007 to 8.6 in 2014)
This decline can be attributed to National programmatic response towards achieving universal access to HIV/AIDS preventions in Nigeria.
The Youth-Nex Conference on Physical Health and Well-Being for Youth, Oct 10 & 11, 2013, University of Virginia
"Developing Sustainable Family-Centered Obesity Interventions: What Can
We Learn from Developmental Psychology and Implementation Science?"
- Kirsten Davison, Ph.D.
Davison is an Associate Professor of Nutrition at the Harvard School of Public Health. She completed her PhD at the Pennsylvania State University in Child and Family Development.
Panel 3 — Nutrition and Healthy Eating. As we understand more about what defines good nutrition for youth, we are also increasingly understanding the importance of instilling healthy eating habits for youth in the context of family, school, and sport. This varied panel covers major topics within this under-considered but important area of youth development.
Emebet Mulugeta – Associate Professor, Institute of Gender Studies and Psychology, Addis Ababa – Gender Assigned Roles and Parenting – Ethiopia Case Study, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Rosana Morgado, Professor, Federal University of Rio de Janeiro Brazil – Violence prevention: how to ensure parenting support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Elana Gaia, Social Policy Specialist, UNICEF CEE/CIS and Denise Stuckenbruck, Child Protection Specialist, UNICEF ESARO – Family support and social protection, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jasmina Byrne and Alice Margaria OoR - Overview analysis of UNICEF supported policy and provision in middle and lower income countries at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Child-health practitioners in Iowa must find better ways to address family, neighborhood and economic factors that shape children' health and well being, according to CFPC executive director Charles Bruner and Debra Waldron, director and chief medical officer of the Child Health Specialty Clinics at the University of Iowa. They presented at the Iowa Governor's Conference on Public Health in Ames on April 5.
Addressing child health disparities: We made the case, we need a movement!renataschiavo
This presentations reviews recent studies and experiences on child health disparities, and provides insights and recommendations to advance child health equity. It was presented at the 2015 Health Equity Capacity Institute of the CDC Division of Community Health, Office of Health Equity.
Poverty, Sexual Practices and Vulnerability of Female Sex Workers to HIV/AIDS...John Bako
The prevalence of HIV among Female who sell sex in Nigeria has witnessed a sharp decline between 2007 to 2014.
The decline was recorded both amidst BBFSWs (30.2% in 2007 to 19.4% in 2014) and NBFSWs (37.4% in 2007 to 8.6 in 2014)
This decline can be attributed to National programmatic response towards achieving universal access to HIV/AIDS preventions in Nigeria.
The Youth-Nex Conference on Physical Health and Well-Being for Youth, Oct 10 & 11, 2013, University of Virginia
"Developing Sustainable Family-Centered Obesity Interventions: What Can
We Learn from Developmental Psychology and Implementation Science?"
- Kirsten Davison, Ph.D.
Davison is an Associate Professor of Nutrition at the Harvard School of Public Health. She completed her PhD at the Pennsylvania State University in Child and Family Development.
Panel 3 — Nutrition and Healthy Eating. As we understand more about what defines good nutrition for youth, we are also increasingly understanding the importance of instilling healthy eating habits for youth in the context of family, school, and sport. This varied panel covers major topics within this under-considered but important area of youth development.
Emebet Mulugeta – Associate Professor, Institute of Gender Studies and Psychology, Addis Ababa – Gender Assigned Roles and Parenting – Ethiopia Case Study, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Rosana Morgado, Professor, Federal University of Rio de Janeiro Brazil – Violence prevention: how to ensure parenting support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Florence Martin, Senior Coordinator, Better Care Network – Family support for prevention of family separation, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Maureen Samms-Vaughan, Professor, Department of Obstetrics, Gynecology and Child Health, Faculty of Medical Sciences, The University of the West Indies - The Development and Implementation of a National Parent Support Policy in Jamaica, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Mary Daly, Professor, Department of Social Policy and Intervention, University of Oxford - Presentation of the preliminary findings “Family and Parenting Support: Analytical Framework and Key Orientations in Policy and Provision” at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lena Karlsson, Director, Child Protection Initiative, Save the Children Stockholm, Family and Parenting Support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
young children of human & animals all are equally vulnerable to insults very easily a sliight mistake can take away a precious diamond. Be care full this is sharing for that missing link.
Children tend to think of the last decades of life—when they think of such things at all—as a time of physical limitations rather than a time of active, vibrant and full participation in life. Yet as average longevity increases worldwide and medical progress enables longer healthy lives, a shift in that view is in order.
With this as background, The Economist Intelligence Unit, sponsored by Merck, undertook a study of five nations—representing both wealthy and middle-income countries—to determine the degree to which good health practices are being taught in schools and fostered in the home and in the community.
Where relevant, the research also considers whether health education is being provided in the context of the long-term benefits—that is, with the aim of achieving longer healthy life years. The five countries surveyed are Germany, South Africa, India, Brazil and Saudi Arabia.
Latinos and the Life Cycle
Dr. Judith C. Rodriguez, RD, UNF
Mr. Daniel Santibanez, MPH Candidate, UNF
April 22, 2005 - UNF Hispanic Health Issues Seminars
This is part 3 of an 8 part series of seminars on Hispanic Health Issues brought to you by the University of North Florida’s Dept. of Public Health, College of Health, a grant from AETNA, and the cooperation of Duval County Health Department.
Risk Factors for Child Maltreatment Types of Maltr.docxmalbert5
Risk Factors for Child
Maltreatment
Types of Maltreatment
Physical abuse – nonaccidental injury
inflicted by a caregiver
Sexual abuse – the use of a child for the
sexual gratification of an adult
Psychological maltreatment
◦ Includes emotional abuse and emotional neglect
Neglect – act of omission
◦ Physical neglect
◦ Medical neglect
◦ Educational neglect
Types of Factors
Potentiating: increase risk for maltreatment
Compensatory: buffers, decreases risk
------------------------------------------------------
Transient – temporary
◦ Temporary unemployment, loss of a loved one
Enduring – ongoing; chronic
◦ Chronic unemployment; untreated mental health
issues
------------------------------------------------------
Applied to each level of analysis
http://faculty.weber.edu/tlday/1500/systems.jpg
Levels of Analysis of Each Instance of
Maltreatment
Macrosystemic: broad cultural values and beliefs
in the larger society
Exosystemic: social structures that form the
immediate context in which families and
individuals function (e.g., neighborhood, school)
Microsystemic: environmental setting that
contains the developing person (e.g., family,
classroom)
Ontogenetic: factors within the child
Macrosystemic Issues
Acceptability of violence
◦ Levels of violent crime, presence of weapons
◦ Levels of violence in media
◦ Acceptance of corporal punishment
Sexualization of children
Individualism
◦ Focus on nuclear family both fully responsible for and
controlling of children
◦ Geographical isolation of families with children
Values/definitions of work
Exosystemic Issue:
Poverty
Poverty as a stressor: inadequate resources,
feelings of disempowerment (becomes a
microsystemic issue)
Poverty places individuals in less safe
environments, requiring more parental effort to
protect
Poverty places individuals in resource scarce
environments
Increasingly poor urban areas are places to which
people are not committed - less sense of
community
Microsystemic Issues
History of abuse in parents
Mental illness in parents
Substance abuse in parents
Domestic violence
Problematic parenting practices
Lack of social support
Mental Health Issues in Parents
Mental illness impacts childrearing
Mental health issues increase risk of
substance abuse, especially in women
Personality disorders are thought to be
most common mental health problem
◦ Core component of an individual’s way of
perceiving the world
◦ Often go unrecognized as mental illness
among child welfare workers
History of Child Abuse in Parents
Child abuse in parents may result in
mental health issues (depression, PTSD)
Attachment impairment
Lack of modeling of appropriate parenting
behaviors
Substance Abuse
Direct physical effects on fetus
◦ Critical issue: should prenatal maternal
substa.
There is growing global recognition that violence against women and violence against children, and in particular intimate partner violence against women and violence against children by parents or caregivers, intersect in different ways. As global evidence of and interest in these intersections continue to grow, strategies are needed to enhance collaborations across these fields and thus ensure the best outcomes for both women and children. In response, the Sexual Violence Research Initiative (SVRI), the UNICEF Innocenti – Global Office of Research and Foresight, and the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction hosted by WHO’s Department of Sexual and Reproductive Health, partnered to coordinate a global participatory process to identify research priorities that relate to the intersections between violence against children and violence against women.
While priorities are important, the way in which these priorities are determined is also crucial, especially for ownership, contextualization and use. Inclusive, participatory research-setting, such as used in this work, serves to promote a diversity of voices – especially from low- and middle-income countries which have historically lacked representation – and minimize the risk of bias when establishing research priorities.
This report describes the process used to determine the priorities for research on the intersections between violence against children and violence against women, and the top 10 research questions identified.
A partnership with the UNFPA-UNICEF Global Programme to End Child Marriage, UNFPA-UNICEF Joint Programme on the Elimination of Female Genital Mutilation and the UNICEF Office of Research - Innocenti, the STAR Initiative (Strategic Technical Assistance for Research) to end harmful practices aims to strengthen evidence generation and learning. The initiative has three areas of focus: evidence generation, evidence synthesis and research dissemination and uptake.
African countries are facing the world’s worst teacher shortage. To shore up the deficit and achieve universal primary education by 2030, 6.1 million primary school teachers need to be hired in Africa alone.
As COVID-19 exacerbates pressures placed on education budgets, it is crucial that the deployment of quality teachers in Africa is driven by a quest for equity, effectiveness, and efficiency, since no child should be deprived of learning opportunities because of the school they attend or their area of residence.
UNICEF Innocenti is seeking to expand the evidence base on teacher deployment in Africa in order to identify how the deployment of qualified teachers can be optimized to improve equity in learning outcomes. While the equity of primary school teacher deployment is the intended focus of this research, pre-primary teacher deployment will also be analyzed.
African countries are facing the world’s worst teacher shortage. To shore up the deficit and achieve universal primary education by 2030, 6.1 million primary school teachers need to be hired in Africa alone.
As COVID-19 exacerbates pressures placed on education budgets, it is crucial that the allocation of quality teachers in Africa is driven by a quest for equity, effectiveness, and efficiency, since no child should be deprived of learning opportunities because of the school they attend or their area of residence.
UNICEF Innocenti is seeking to expand the evidence base on teacher allocation in Africa in order to identify how the allocation of qualified teachers can be optimized to improve equity in learning outcomes. While the equity of primary school teacher allocation is the intended focus of this research, pre-primary teacher allocation will also be analyzed.
Evidence suggests that developing specific core capacities from childhood can support performance in school, work, and life.
These nine “core capacities” are cornerstones of life skills. We often overlook these capacities as innate basic skills, so they are underutilized in efforts to promote child well-being and development.
But by nurturing, expanding, and modelling these capacities, children can better understand and interact with the world around them, and realise their unique potential.
Visit our research report launched 9 December 2021: unicef-irc.org/what-makes-me
On 19 October 2021, over 500 researchers, practitioners, policymakers and activists from around the world gathered to take stock of what we know about the intersections between
violence against children and violence against women, identify existing knowledge gaps and discuss opportunities to increase coordination across efforts to prevent and respond to both
forms of violence.
This summary presents key takeaways from the event organized by UNICEF Innocenti, in collaboration with the Global Partnership to End Violence, the World Health Organization,
the Sexual Violence Research Initiative and the UK FCDO.
The Office of Research – Innocenti is UNICEF’s dedicated research centre. Our core mandate is to undertake cutting-edge, policy-relevant research that equips the organization and the wider global community to deliver results for children. This project brief summarizes our research on the Data Must Speak project.
Effective solutions to end violence against children will require researchers, practitioners, and leaders to come together to take stock of what we know, bridge gaps across the field, and influence change through the use and generation of VAC evidence.
This webinar aimed to share evidence and foster discussion on intersections between violence against women and violence against children, highlighting opportunities for greater collaboration, to build knowledge, and to translate it into policy and programmes.
Opening remarks: Alessandra Guedes, Gender and Development Research Manager, UNICEF Innocenti
Presenting evidence:
- Clara Alemann, Director of Programs, Promundo, The Hague
- Manuela Colombini, Assistant Professor in Health Systems and Policy and Gender-based Violence, and Loraine Bacchus, Associate Professor of Social Science, LSHTM
- Chandré Gould, Senior Research Fellow, and Matodzi Amisi, Senior Research Consultant, Institute for Security Studies, South Africa
- Isabelle Pearson, Research Fellow for the Gender Violence & Health Centre at LSHTM and Heidi Stöckl, Professor of Public Health Evaluation, Ludwig-Maximilians-Universität München
Panel discussion:
- Paul Bukuluki, Associate Professor of Social Work and Medical Anthropology, Makerere University, Uganda
- Lina Digolo, Senior Associate, The Prevention Collaborative, Kenya
- Lori Heise, Professor of Gender, Violence and Health at the Johns Hopkins Bloomberg School of Public Health, United States
- Santi Kusumaningrum, Co-founder and Director, PUSKAPA - Center on Child Protection and Wellbeing at Universitas Indonesia
- Tarisai Mchuchu-MacMillan, Executive Director, MOSAIC, South Africa
Closing remarks: Emily Esplen, Head of Ending Violence Team, FCDO, United Kingdom
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on digital learning.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our work on research uptake and impact.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on violence against children and women.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on gender-responsive age-sensitive social protection.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on child labour.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Global Kids Online project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on disrupting harm.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Time to Teach project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Let Us Learn project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on children, migration, and displacement.
More from UNICEF Office of Research - Innocenti (20)
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Parenting support in the context of violence prevention
1. Family & Parenting Support in the
Context of Violence Prevention
Bernadette J. Madrid, MD
University of the Philippines Manila
and
Child Protection Network Foundation
2. 5 year-old Jackson
admitted for
generalized
weakness and
possible child
neglect
3. Critical Periods & Brain Plasticity
• A critical period is a
time during an
organism’s life span
when it is more
sensitive to
environmental
influences or
stimulation than at
other times during
its life.
4. ACEs HAVE MANY IMPACTS THROUGHOUT THE LIFESPAN
Critical &
Sensitive
Dev’tal period
ADVERSE CHILDHOOD
EXPERIENCE
MORE CATEGORIES –
GREATER IMPACT
Physical Abuse, Sexual Abuse,
Neglect Witnessing Domestic
Violence, Depression/Mental
Illness in Home
Incarcerated Family Member
Substance Abuse in Home
Loss of a Parent
GENETICS
Including gender –
Remember that
experience triggers
gene expression
(Epigentics)
CHRONIC DISEASE PSYCHIATRIC
ADAPTATION
Hard-Wired
Into Biology
Brain
Development
Electrical,
Chemical, Cellular
Mass
DISORDER
IMPAIRED
COGNITION
WORK/
SCHOOL
Attendance
Behavior,
Performance
OBESITY
ALCOHOL,
TOBACCO,
DRUGS
RISKY SEX
Carson & Porter, 2011
POVERTY CRIME
INTERGENERATIONAL
TRANSMISSION,
DISPARITY
5. Adverse Childhood Experiences and
Health-Risk Behaviors Among
Adults in a Developing Country Setting
Laurie S. Ramiro, PhD, Bernadette J. Madrid, MD,
David R. Brown, PhD
Child Abuse & Neglect 2010; 34: 842-855
6. Categories of adverse
childhood
experiences, Number
Percentage
(n=1068)
0 26.8
1 24.7
2 18.8
3 13.8
4 or more 9.2
75% had at least one ACE
Ramiro L, Madrid B, Brown D
Child Abuse & Neglect 2010; 34: 842-855
7. Results of the Metro Manila
ACE Study
Those who were sexually abused are:
• 12 times more likely to engage in early sex;
• 9 times more likely to have early pregnancy;
• 5 times more likely to commit suicide.
Ramiro L, Madrid B, Brown D
Child Abuse & Neglect 2010; 34: 842-855
8. Results of the Metro Manila
ACE Study
Individuals who felt that they were not loved
during childhood are:
• Twice as likely to smoke, use illicit drugs,
have early sex and multiple sex partners
• 5 times more likely to commit suicide.
Ramiro L, Madrid B, Brown D
Child Abuse & Neglect 2010; 34: 842-855
9. Strong graded response between number of
ACEs & poor health
• Bronchitis/
emphysema
• Asthma
• Ischemic Heart Disease
• Hypertension
• Tuberculosis
• Skin problems
• UTI
• Liver problems
• GI problems- ulcers,
constipation, indigestion
• Depression
Ramiro L, Madrid B, Brown D.
Child Abuse & Neglect 2010; 34:842-855
10. Diseases Number of deaths Percentage
1. Diseases of the heart 100,908 21.0
2. Cerebro-vascular Many disease chronic diseases 56,670 in adults
11.8
3. Malignant neoplasm 47,732 9.9
4. Pneumonia are determined decades 42,642 earlier,
8.9
5. Tuberculosis by experiences in childhood
25,470 5.3
6. COPD 22,755 4.7
7. Diabetes 22,345 4.6
8. Nephritis, Nephrotic Syndrome 13,799 2.9
9. Assault 12,227 2.5
10. Certain conditions arising from perinatal
11,514 2.4
period
Philippine National Statistics Office, 2009
11.
12. Maternal and Child Health are
Intertwined
• The status of the mother such as stress, anxiety
and depression has been shown to be associated
with an increased risk of developing a wide
variety of disorders in the offspring e.g. LBW,
learning & memory
• Maternal over-and under-nutrition has been
associated with the onset of metabolic syndrome
as well as autism and developmental delays.
13. Maternal and Child Health are
Intertwined
• Maternal iron and iodine deficiency affects the
child’s cognitive development and later
behavioral problems.
• Iron deficiency affects learning & memory, motor
development, language development, behavior
problems including anxiety & depression
• Best time to correct the iron and iodine
deficiencies is during adolescence before the
pregnancy.
14. Age/sex/
Physiologic State Number Prevalence (%)
Philippines 22412
6 mos - < 1 yr 205
1-5 y 2279
6-12 y, M 2039
F 1830
13-19 y, M 1778
F 1488
Pregnant 1516
Lactating 891
19.5
55.7
20.9
20.4
19.2
10.4
18.2
42.5
31.4
Anemia prevalence by age, sex, and physiologic state: FNRI, 2008
15. Perinatal risk factors for infant
maltreatment
• Mother smoked during pregnancy
• Families with 3 or more siblings
• Maternal age less than 20 years
• Births to unmarried mothers
• Medicaid benficiaries (poverty)
• Inadequate prenatal care
Zhou Y, Hallisey E, Freymann G (2006)
International Journal of Health Geographics 5:53
16. Adolescent Risk Factors for Child
Maltreatment
• Area characteristics
• Family
background/structure
• Parent stressors
• Exposure to family
violence
• Parent-child
relationship
• Education
• Peer relationships
• Adolescent stressors
• Antisocial
behaviours
• Precocious
transitions
Thornberry, TP et. al., Child Abuse & Neglect 2013
17. Cumulative Risk
• Long-term damage that occurs through the
compounding of environmental,
socioeconomic and behavioral exposures
across the life-course.
18. Critical Periods
• Note that the peak of
plasticity for each sensitive
period is staggered
throughout development.
• More-complex or
multifaceted brain
functions, especially those
in humans, tend to reflect
cumulative sensitive
periods rather than one
critical period -
19. Connected by 25: Improving the life
chances of the country’s most
vulnerable 14-24 year olds
Disconnected youth: They have not acquired the
skills needed to connect with the labor force and
they have not established social support systems:
1. Those who do not complete high school.
2. Youth deeply involved in the juvenile justice
system.
3. Young, unmarried mothers
4. Adolescents in foster homes
Michael Wald & Tia Martinez 2003
Stanford University
20. Disconnected youth
• Unless something is done they become either
victims of trafficking, commercial sexual
exploitation or incarcerated.
• “These youth need major, major ongoing
support in overcoming the sense of
inadequacy, in acquiring job skills and
education and in staying connected once
change has started to occur.”
Michael Wald & Tia Martinez 2003
Stanford University
21. Child Maltreatment Prevention Readiness in
Low- and Middle-Income Countries
Mikton, Mehra, Butchart, et al (2011)
• Evidence-based interventions alone are not
sufficient to prevent child maltreatment, other
conditions must be met to bridge the
“science-practice” gap.
22. 10 Dimensions of the Readiness Assessment for
Child Maltreatment Prevention
Mikton, Mehra, Butchart, et al (2011)
1. Attitudes toward child maltreatment & its
prevention
2. Knowledge about child maltreatment & its
prevention
3. Existence of scientific data on child
maltreatment & its prevention in the country
4. Existing child maltreatment prevention
programs; CMP components could be
integrated; outcome evaluations
23. 10 Dimensions of the Readiness Assessment for
Child Maltreatment Prevention
Mikton, Mehra, Butchart, et al (2011)
5. Legislation, official mandates of government or
NGOs, and policies relevant to CMP.
6. Will to address the problem
7. Institutional links & resources of institutions
involved in CMP.
8. Material resources –funding, infrastructure,
equipment
24. 10 Dimensions of the Readiness Assessment for
Child Maltreatment Prevention
Mikton, Mehra, Butchart, et al (2011)
9. Human and technical resources
-mental health, social work
10. Informal social resources
25. 9. High Level of
Community Ownership
8. Confirmation /
Expansion
7. Stabilization
6. Initiation
STAGES OF COMMUNITY
5. Preparation
READINESS
4. Preplanning
3. Vague Awareness
2. Denial / Resistance
1. No Awareness
26. Way to Go
• Formation of a coalition of government agencies
and NGO’s that will steer the country’s direction
towards prevention of child maltreatment
• National Prevalence Study on Child Maltreatment
• Invest on a primary prevention program that is
population-based; has been shown to work and
can generate political support: Parenting
Program
39. High income improves evaluation of
life but not emotional well-being
By Daniel Kahneman and Angus Deaton
Center for Health & Well-Being
Princeton University 2010
• When plotted against log income, life evaluation rises
steadily.
• Emotional well-being also rises with log income, but
there is no further progress beyond an annual income of
$75,000.
• Low income exacerbates the emotional pain associated
with misfortunes as divorce, ill health & being alone.
40. Can Money buy happiness?
High income improves evaluation of life but not emotional well-being
Daniel Kahneman and Angus Deaton
Center for Health & Well-Being
Princeton University 2010
• Conclusion: High income buys life satisfaction but
not happiness, and low income is associated with
both low life evaluation and low emotional well-being.