Maureen Samms-Vaughan, Professor, Department of Obstetrics, Gynecology and Child Health, Faculty of Medical Sciences, The University of the West Indies - The Development and Implementation of a National Parent Support Policy in Jamaica, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Mary Daly, Professor, Department of Social Policy and Intervention, University of Oxford - Presentation of the preliminary findings “Family and Parenting Support: Analytical Framework and Key Orientations in Policy and Provision” at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lena Karlsson, Director, Child Protection Initiative, Save the Children Stockholm, Family and Parenting Support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jenny Pearce, Professor of Young People and Public Policy at the University of Bedfordshire, UK, and John Coleman, Senior Research Fellow in the Department of Education at Oxford University, Parenting teenage victims and perpetrators of violence: lessons rom research on prevention and support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jasmina Byrne and Alice Margaria OoR - Overview analysis of UNICEF supported policy and provision in middle and lower income countries at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ninoslava Pecnik, Professor, Department of Social Work, Faculty of Law, University of Zagreb - Drivers of parenting support, policy and provision in Croatia, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Pat Dolan, Professor and Carmel Devaney, Lecturer and Researcher UNESCO Child and Family Research Centre, School of Political Science and Sociology, Research and Innovation Centre, NUI Galway – Family support for families at risk, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Elana Gaia, Social Policy Specialist, UNICEF CEE/CIS and Denise Stuckenbruck, Child Protection Specialist, UNICEF ESARO – Family support and social protection, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ruti Levtov, Program Officer Promundo-US and Co-Coordinator of the MenCare Campaign, Men and Caregiving, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Mary Daly, Professor, Department of Social Policy and Intervention, University of Oxford - Presentation of the preliminary findings “Family and Parenting Support: Analytical Framework and Key Orientations in Policy and Provision” at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lena Karlsson, Director, Child Protection Initiative, Save the Children Stockholm, Family and Parenting Support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jenny Pearce, Professor of Young People and Public Policy at the University of Bedfordshire, UK, and John Coleman, Senior Research Fellow in the Department of Education at Oxford University, Parenting teenage victims and perpetrators of violence: lessons rom research on prevention and support, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Jasmina Byrne and Alice Margaria OoR - Overview analysis of UNICEF supported policy and provision in middle and lower income countries at the Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ninoslava Pecnik, Professor, Department of Social Work, Faculty of Law, University of Zagreb - Drivers of parenting support, policy and provision in Croatia, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Pat Dolan, Professor and Carmel Devaney, Lecturer and Researcher UNESCO Child and Family Research Centre, School of Political Science and Sociology, Research and Innovation Centre, NUI Galway – Family support for families at risk, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Elana Gaia, Social Policy Specialist, UNICEF CEE/CIS and Denise Stuckenbruck, Child Protection Specialist, UNICEF ESARO – Family support and social protection, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Ruti Levtov, Program Officer Promundo-US and Co-Coordinator of the MenCare Campaign, Men and Caregiving, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Bernadette Madrid, University of the Philippines, Director of the Child Protection Unit, Philippines - Parenting support in the context of violence prevention, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lorraine Sherr, Professor, University College London– Parenting support in the context of HIV, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Florence Martin, Senior Coordinator at Better Care Network during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Presentation by Emebet Mulugeta (Ph.D.), Associate Professor at Addis Ababa University, Ethiopia, and Director at Nia Center for Children and Family Development, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Putting Children First: Session 2.4.B Mike Wessells - Strengthening community...The Impact Initiative
Putting Children First: Identifying solutions and taking action to tackle poverty and inequality in Africa.
Addis Ababa, Ethiopia, 23-25 October 2017
This three-day international conference aimed to engage policy makers, practitioners and researchers in identifying solutions for fighting child poverty and inequality in Africa, and in inspiring action towards change. The conference offered a platform for bridging divides across sectors, disciplines and policy, practice and research.
A presentation from 27 June 2019 at the IAFFE Conference in Glasgow, Scotland by Elena Camilletti and Sarah Cook
Related: https://www.unicef-irc.org/journal-articles/63
International Association for Feminist Economists #IAFFE2019
Gender Based Violence in Schools: Problems, Challenges and MeasuresGarima Singh
Gender based violence is violence against any person on the basis of gender, including acts that inflict physical, mental or sexual harm or threats of such acts.
The information contained in these slides was shared during NAEYC's 2016 Institute for Professional Development conference held in Baltimore, Maryland June 5-8, 2016. These slides consolidate much of the early intervention information shared by SFL's Director of Early Childhood Education Initiatives, Kamna Seth, and Senior Manager, Gauri Shirali-Deo. The topic presented, Understanding Early Intervention: Reflecting on the Scope, Need for Early Diagnosis, and Implementation of Early Intervention, underscores the importance of identifying developmental delays and developing educational strategies to address the needs of diverse learners.
Presentation by Maureen Samms-Vaughan, Department of Obstetrics, Gynecology and Child Health, Faculty of Medical Sciences, The University of West Indies, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Advocacy Action Plan Exploring Language and Literacy Developm.docxstandfordabbot
Advocacy Action Plan
“Exploring Language and Literacy Development in Early Childhood Education “
Angel Winslow
EDSD 7085: Inspired Leadership, Informed Advocacy, and Improved Policy
Module 4 Assignment 2
Date Due: November 9, 2022
Exploring Language and Literacy Development in Early Childhood Education
The advocacy program entails putting forward early literacy development in children as a critical area for advancing education. It is essential that children acquire language skills right from the young age so as to prepare them for lifelong learning and achievements. The advocacy requires participation of stakeholders of early literacy development that include families, parents, caregivers, educators, and policy makers in the area of early childhood education. Organization such as NAEYC ensure that teachers are properly trained to spearhead the acquisition of literacy and language skills in children. Center for Early Literacy Learning recommends that teachers and educators should use evidence-based practices to promote literacy skills in young learners.
2
Advocating for language and literacy development in early childhood learners
Supporting literacy development for learners in early education setting
Working with stakeholders that include caregivers, family members, parents, educators and caregivers in literacy development
Advance the reading writing skills of young learners
NAEYC ensures that teachers and educators are well trained to guide young learners in meeting literacy needs
Center for Early Literacy Learning recommends use of evidence-based practices
Regulations and Policies associated with the topic
The common core state standards ensure uniformity in learning expectations in all the states in the United States of America. Common core standards for English and literacy the standards and expectations that language learners are expected to achieve. This standard apply to the advocacy issue because language learning starts at an early age. The third-grade reading law is a regulation that was adopted by many states across the country to ensure that young learners are able to read before they can be promoted to fourth grade. The third-grade reading law apply to the advocacy topic since reading is one of the essentials elements necessary for literacy development. No Child Left Behind of 2002 is a law that seeks to promote literacy by providing guidelines for administering literacy tests. Race to the Top is one of the laws that provided the groundwork for the establishment of common core standards. Every Student Succeeds Act of 2015 is a law that guided the adoption of Common Core Standards as a policy area in literacy and learning development. The law led to the adoption of the policy called Literacy Education for All, Results for the Nation (LEARN) which promotes literacy education in the country (Castillo, 2020).
3
The third-grade reading legislation
No Child Left Behind of (2002)
Race to the Top (20.
Bernadette Madrid, University of the Philippines, Director of the Child Protection Unit, Philippines - Parenting support in the context of violence prevention, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Lorraine Sherr, Professor, University College London– Parenting support in the context of HIV, Expert Consultation on Family and Parenting Support, UNICEF Office of Research – Innocenti Florence 26-27 May 2014
Presentation by Florence Martin, Senior Coordinator at Better Care Network during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Presentation by Emebet Mulugeta (Ph.D.), Associate Professor at Addis Ababa University, Ethiopia, and Director at Nia Center for Children and Family Development, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Putting Children First: Session 2.4.B Mike Wessells - Strengthening community...The Impact Initiative
Putting Children First: Identifying solutions and taking action to tackle poverty and inequality in Africa.
Addis Ababa, Ethiopia, 23-25 October 2017
This three-day international conference aimed to engage policy makers, practitioners and researchers in identifying solutions for fighting child poverty and inequality in Africa, and in inspiring action towards change. The conference offered a platform for bridging divides across sectors, disciplines and policy, practice and research.
A presentation from 27 June 2019 at the IAFFE Conference in Glasgow, Scotland by Elena Camilletti and Sarah Cook
Related: https://www.unicef-irc.org/journal-articles/63
International Association for Feminist Economists #IAFFE2019
Gender Based Violence in Schools: Problems, Challenges and MeasuresGarima Singh
Gender based violence is violence against any person on the basis of gender, including acts that inflict physical, mental or sexual harm or threats of such acts.
The information contained in these slides was shared during NAEYC's 2016 Institute for Professional Development conference held in Baltimore, Maryland June 5-8, 2016. These slides consolidate much of the early intervention information shared by SFL's Director of Early Childhood Education Initiatives, Kamna Seth, and Senior Manager, Gauri Shirali-Deo. The topic presented, Understanding Early Intervention: Reflecting on the Scope, Need for Early Diagnosis, and Implementation of Early Intervention, underscores the importance of identifying developmental delays and developing educational strategies to address the needs of diverse learners.
Presentation by Maureen Samms-Vaughan, Department of Obstetrics, Gynecology and Child Health, Faculty of Medical Sciences, The University of West Indies, during the "Expert Consultation on Family and Parenting Support," Florence, Italy 26-27 May 2014.
Advocacy Action Plan Exploring Language and Literacy Developm.docxstandfordabbot
Advocacy Action Plan
“Exploring Language and Literacy Development in Early Childhood Education “
Angel Winslow
EDSD 7085: Inspired Leadership, Informed Advocacy, and Improved Policy
Module 4 Assignment 2
Date Due: November 9, 2022
Exploring Language and Literacy Development in Early Childhood Education
The advocacy program entails putting forward early literacy development in children as a critical area for advancing education. It is essential that children acquire language skills right from the young age so as to prepare them for lifelong learning and achievements. The advocacy requires participation of stakeholders of early literacy development that include families, parents, caregivers, educators, and policy makers in the area of early childhood education. Organization such as NAEYC ensure that teachers are properly trained to spearhead the acquisition of literacy and language skills in children. Center for Early Literacy Learning recommends that teachers and educators should use evidence-based practices to promote literacy skills in young learners.
2
Advocating for language and literacy development in early childhood learners
Supporting literacy development for learners in early education setting
Working with stakeholders that include caregivers, family members, parents, educators and caregivers in literacy development
Advance the reading writing skills of young learners
NAEYC ensures that teachers and educators are well trained to guide young learners in meeting literacy needs
Center for Early Literacy Learning recommends use of evidence-based practices
Regulations and Policies associated with the topic
The common core state standards ensure uniformity in learning expectations in all the states in the United States of America. Common core standards for English and literacy the standards and expectations that language learners are expected to achieve. This standard apply to the advocacy issue because language learning starts at an early age. The third-grade reading law is a regulation that was adopted by many states across the country to ensure that young learners are able to read before they can be promoted to fourth grade. The third-grade reading law apply to the advocacy topic since reading is one of the essentials elements necessary for literacy development. No Child Left Behind of 2002 is a law that seeks to promote literacy by providing guidelines for administering literacy tests. Race to the Top is one of the laws that provided the groundwork for the establishment of common core standards. Every Student Succeeds Act of 2015 is a law that guided the adoption of Common Core Standards as a policy area in literacy and learning development. The law led to the adoption of the policy called Literacy Education for All, Results for the Nation (LEARN) which promotes literacy education in the country (Castillo, 2020).
3
The third-grade reading legislation
No Child Left Behind of (2002)
Race to the Top (20.
Presentation from international meeting on children's work and child labour hosted by the Africa Child Policy Forum, Organisation for Social Science Research in Eastern and Southern Africa, and Young Lives in Addis Ababa, 20-21 March 2014
Between March 2004 and March 2011, the Family and Parenting Institute managed the Parenting Fund on behalf of successive UK governments. The parenting fund was the largest and most successful scheme ever to support UK parenting.
The Parenting Fund provided support to a web of grassroots organisations across the country which, in turn, supported the most vulnerable families in their communities. The families who were helped were experiencing problems including intergenerational unemployment, relationships marked by conflict, drink and drug abuse, and frequent contact with the police.
This report examines the success of the fund and the Family and Parenting Institute’s role in administering funding
On Nov. 12, the Annie E. Casey Foundation released "Creating Opportunity for Families: A Two-Generation Approach," a KIDS COUNT policy report. In addition, the Foundation held a webinar to highlight data and recommendations from the report. Learn more at http://www.aecf.org/resources/creating-opportunity-for-families/.
A presentation given by Prof. Phil Robinson at The Journey, CHA Conference 2012, in the 'Innovations in Mental Health Care for Children and Young People' stream.
There is growing global recognition that violence against women and violence against children, and in particular intimate partner violence against women and violence against children by parents or caregivers, intersect in different ways. As global evidence of and interest in these intersections continue to grow, strategies are needed to enhance collaborations across these fields and thus ensure the best outcomes for both women and children. In response, the Sexual Violence Research Initiative (SVRI), the UNICEF Innocenti – Global Office of Research and Foresight, and the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction hosted by WHO’s Department of Sexual and Reproductive Health, partnered to coordinate a global participatory process to identify research priorities that relate to the intersections between violence against children and violence against women.
While priorities are important, the way in which these priorities are determined is also crucial, especially for ownership, contextualization and use. Inclusive, participatory research-setting, such as used in this work, serves to promote a diversity of voices – especially from low- and middle-income countries which have historically lacked representation – and minimize the risk of bias when establishing research priorities.
This report describes the process used to determine the priorities for research on the intersections between violence against children and violence against women, and the top 10 research questions identified.
A partnership with the UNFPA-UNICEF Global Programme to End Child Marriage, UNFPA-UNICEF Joint Programme on the Elimination of Female Genital Mutilation and the UNICEF Office of Research - Innocenti, the STAR Initiative (Strategic Technical Assistance for Research) to end harmful practices aims to strengthen evidence generation and learning. The initiative has three areas of focus: evidence generation, evidence synthesis and research dissemination and uptake.
African countries are facing the world’s worst teacher shortage. To shore up the deficit and achieve universal primary education by 2030, 6.1 million primary school teachers need to be hired in Africa alone.
As COVID-19 exacerbates pressures placed on education budgets, it is crucial that the deployment of quality teachers in Africa is driven by a quest for equity, effectiveness, and efficiency, since no child should be deprived of learning opportunities because of the school they attend or their area of residence.
UNICEF Innocenti is seeking to expand the evidence base on teacher deployment in Africa in order to identify how the deployment of qualified teachers can be optimized to improve equity in learning outcomes. While the equity of primary school teacher deployment is the intended focus of this research, pre-primary teacher deployment will also be analyzed.
African countries are facing the world’s worst teacher shortage. To shore up the deficit and achieve universal primary education by 2030, 6.1 million primary school teachers need to be hired in Africa alone.
As COVID-19 exacerbates pressures placed on education budgets, it is crucial that the allocation of quality teachers in Africa is driven by a quest for equity, effectiveness, and efficiency, since no child should be deprived of learning opportunities because of the school they attend or their area of residence.
UNICEF Innocenti is seeking to expand the evidence base on teacher allocation in Africa in order to identify how the allocation of qualified teachers can be optimized to improve equity in learning outcomes. While the equity of primary school teacher allocation is the intended focus of this research, pre-primary teacher allocation will also be analyzed.
Evidence suggests that developing specific core capacities from childhood can support performance in school, work, and life.
These nine “core capacities” are cornerstones of life skills. We often overlook these capacities as innate basic skills, so they are underutilized in efforts to promote child well-being and development.
But by nurturing, expanding, and modelling these capacities, children can better understand and interact with the world around them, and realise their unique potential.
Visit our research report launched 9 December 2021: unicef-irc.org/what-makes-me
On 19 October 2021, over 500 researchers, practitioners, policymakers and activists from around the world gathered to take stock of what we know about the intersections between
violence against children and violence against women, identify existing knowledge gaps and discuss opportunities to increase coordination across efforts to prevent and respond to both
forms of violence.
This summary presents key takeaways from the event organized by UNICEF Innocenti, in collaboration with the Global Partnership to End Violence, the World Health Organization,
the Sexual Violence Research Initiative and the UK FCDO.
The Office of Research – Innocenti is UNICEF’s dedicated research centre. Our core mandate is to undertake cutting-edge, policy-relevant research that equips the organization and the wider global community to deliver results for children. This project brief summarizes our research on the Data Must Speak project.
Effective solutions to end violence against children will require researchers, practitioners, and leaders to come together to take stock of what we know, bridge gaps across the field, and influence change through the use and generation of VAC evidence.
This webinar aimed to share evidence and foster discussion on intersections between violence against women and violence against children, highlighting opportunities for greater collaboration, to build knowledge, and to translate it into policy and programmes.
Opening remarks: Alessandra Guedes, Gender and Development Research Manager, UNICEF Innocenti
Presenting evidence:
- Clara Alemann, Director of Programs, Promundo, The Hague
- Manuela Colombini, Assistant Professor in Health Systems and Policy and Gender-based Violence, and Loraine Bacchus, Associate Professor of Social Science, LSHTM
- Chandré Gould, Senior Research Fellow, and Matodzi Amisi, Senior Research Consultant, Institute for Security Studies, South Africa
- Isabelle Pearson, Research Fellow for the Gender Violence & Health Centre at LSHTM and Heidi Stöckl, Professor of Public Health Evaluation, Ludwig-Maximilians-Universität München
Panel discussion:
- Paul Bukuluki, Associate Professor of Social Work and Medical Anthropology, Makerere University, Uganda
- Lina Digolo, Senior Associate, The Prevention Collaborative, Kenya
- Lori Heise, Professor of Gender, Violence and Health at the Johns Hopkins Bloomberg School of Public Health, United States
- Santi Kusumaningrum, Co-founder and Director, PUSKAPA - Center on Child Protection and Wellbeing at Universitas Indonesia
- Tarisai Mchuchu-MacMillan, Executive Director, MOSAIC, South Africa
Closing remarks: Emily Esplen, Head of Ending Violence Team, FCDO, United Kingdom
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on digital learning.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our work on research uptake and impact.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on violence against children and women.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on gender-responsive age-sensitive social protection.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on child labour.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Global Kids Online project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on disrupting harm.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Time to Teach project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on the Let Us Learn project.
As the UNICEF Office of Research-Innocenti, we conduct research to inform policymaking and implementation. This project brief summarizes our research on children, migration, and displacement.
More from UNICEF Office of Research - Innocenti (20)
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The Development and Implementation of a National Parent Support Policy in Jamaica
1.
2. Background to Policy Development
› Research
› State Initiatives
› Existing Laws and Policies
National Approach to Parenting
- National Parenting Support Policy
- National Parenting Strategy
- National Parent Support Commission
Lessons Learnt
3.
4. Pre-Independent Jamaica
Arose from concerns about children and
families of lower socio-economic status
Illegitimacy and Concubinage considered
a problem
“My Mother who Fathered Me” by Edith
Clarke
5. Independent Jamaica
Young University
Focussed on early childhood group and lower
SES
Health Concerns: Malnutrition
Education: Early Childhood Movement
Social : Ethnographic Studies on families
6. Limited parent-child interaction
Limited father involvement
Inadequate resources to provide
stimulation in the home
Gender differences in expectations for
boys and girls.
7. Large sample size
Quantitative analysis
Comprehensive in scope: Multiple factors investigated e.g.
family structure, family function, parenting stress
Outcome measures included: Parenting able to be linked to
child academic and behaviour outcomes
Population based methodology led to inclusion of parents of
all socio-economic groups
Longitudinal methodology allowed for tracking of parenting
across time and in children of different ages
11. 2004: First National Survey on Parenting. Special module in the
annual household survey, the Jamaica Survey of Living Conditions
Quantitative analysis
Comprehensive in scope: Multiple factors investigated e.g. family
structure, family function, parenting stress
Population based methodology led to inclusion of parents of all
socio-economic groups
Included children of all ages
No capacity for inclusion of outcome measures
No capacity for Longitudinal methodology
12.
13. Arose from the Ministry of Education in 1991
Attempt to strengthen the MoE’s efforts to
improve parenting through PTAs
Coalition for Better Parenting, an umbrella
group of NGOs supporting parenting formed
Initially supported by UNICEF and MoE
Sustainability challenges
14. Early Childhood Commission (ECC)
established by the Government of Jamaica
in 2003 to advance ECD
Governed by a multi-sectoral, multi-disciplinary
board. Policies and
programmes implemented by operational
arm
15. Acknowledged the importance of parenting in
young children’s development
Recommended the following:
› Professional representing parenting interests be
appointed to ECC Board (2004)
› Development of a National Parenting Support Policy
› Parenting and Community Intervention Sub-
Committee of the ECC Board established (2005)
› Parenting added to Community Intervention Co-ordinator
title (2005)
16. ECC National Strategic Plan for ECD used ife cyce
approach
Included parenting as first key strategic objective
Also included identification and support for families at risk
as Strategic Objective 3
Objective: To provide parents with accessible and high
quality parent education and support allowing for optimal
development of children
17. EARLY CHILDHOOD DEVELOPMENT SECTOR
NSP STRATEGY MAP – OCTOBER 2007
STRATEGIC PLAN 2008-13
National impact
Customer
satisfaction
Key processes Working environment
I1. Critical thinking,
socially
competent,
healthy children
ready for life
I2. Parents are
informed, educated,
Fathers, mothers, guardians
are involved and satisfied
with services provided to
their children
involved and
supported in meeting
early childhood
development needs
Our children’s
special needs are
taken care of
IP1:
Effective
parenting
education
and
support
IP2:
Effective
preventive
health
care
IP3:
Effective
screening,
diagnosis
and
intervention
for “at risk”
IP4: Safe
learner
centred
well-maintained
EC facilities
LG1: The sector and sector
agencies are achieveing
targets and are governed by
frameworks that promote
achieving results in a
consultative environment
LG2:
IP5: Effective
curriculum
delivery by
trained early
childhood
practitioners
Timely clear and current
information to support evidence
based decision making
18.
19. Development of National Parent Support
Policy (2005)
NPSP would not be punitive. Focus on
“support” and education (existing Child
Care and Protection Act)
Policy should include children of all ages
20. Assess what existed
› Review of existing parenting materials
› Review of existing parenting
Conduct Research to Fill Gaps
› Parental request for help
› Limited accessibility
› Variable quality
Develop Strategy to meet Objectives
› Mapping of Parenting Support Programmes
› Development of Parenting Strategy
› Development of Parenting Standards
21.
22. Child Care and Protection Act (2004)
Office of Children’s Advocate (2006)
› Commission of Parliament mandated to enforce and
protect child rights
Conditional Cash Transfer Programme (2002) (Ministry
of Labour and Social Security)
› Children: from birth to completion of secondary
education
› Elderly: 60 years or over, and not in receipt of a
pension
› Persons with Disabilities
› Pregnant and Lactating Women
› Poor Adults 18-59 years
23.
24. National Parent Support Policy
National Parent Support Commission
National Parenting Strategy
National Parenting Standards
25. First attempt by GOJ to codify a broad national
understanding of parenting issues, and at stating its
commitment to strengthen and improve parent
support services
Provides an enabling environment to support
parents in execution of their responsibilities
Defines the institutional framework required to
support national programming
Identifies and defines the role of stakeholders : GOJ,
NGOs, FBOs, academia, media, IDP etc
26. All parents in Jamaica, -whether by virtue of
having given birth, adopting or serving as
guardians- recognise and accept their duty
to ensure that the rights of children are
always upheld, the best interests of children
are always promoted and their children are
always loved and provided with
opportunities and resources to achieve their
full potential and ultimate fulfilment within
safe, caring and nurturing environments
27. All Jamaicans make wise choices about
becoming parents and make parenting a
priority
All Jamaican children are loved, nurtured
and protected instinctively and
unconditionally by their parents
Each parent understands and utilises /
applies positive practices in effective
parenting
28. An enabling institutional framework exists
to support parenting
Ensuring that the principles and implications
of effective parenting are communicated to
the public in user friendly ways that enable
comprehension of the material
Policy includes Parent Charter outlining
parental responsibilities
29. Effected through the National Parent
Support Commission Act (2012)
Established to implement National Parent
Support Policy
Structure similar to that of ECC
30. Advise the Minister on policy matters
relating to parenting and family matters
in Jamaica, including initiatives to
achieve the goals of the NPP and to
strengthen the partnerships between
home and school
Act as a co-ordinating agency to
streamline GOJ activities relating to
parent support
31. Monitor and evaluate the implementation of the NPP
Make recommendations to the Minister with respect
to plans and programming concerning parenting
support and home –school relationships
Convene consultations with relevant stakeholders
Analyse resource needs and make
recommendations for budgetary allocations for
parenting support programmes
Identify alternative sources of financing through
negotiations with donor and non-donor agencies
32. Identify, collect and disseminate information
and best practices on relevant to parenting
practices and outcome in Jamaica
Develop a national standards and
accreditation system for the delivery of
parenting support services
Collaborate with NGOs programmes to ensure
effective co-ordination of activities, utilisation
of resourcesand implementation of the NPSP
and plans and programmes relating thereto.
33. Management Board of 16-21 members
Reports directly to Minister of Education
through the Chairman
Cross Sectoral
Representatives of GOJ MDA as well as
individuals
Operational Arm, managed by ED
34. Children’s Advocate
ED of CDA
ED of ECC
PS in Ministries responsible for social security
PS in Ministry responsible for health
PS in Ministry responsible for youth
PS in Ministry responsible for education
Opposition Representative
Attorney at Law appointed by the AG’s office
A person between 15 and 24 years of age
A representative of a teachers’ association
At least 4 persons from civil society, with knowledge in child
psychology, social work or parenting matters
Other persons from academia or the private sector with
knowledge as above
ED of NPSC (ex-officio
35. Developed by the ECC through
consultation with stakeholders
36. A national network of branded community-based
parenting support centres (“one-stop-shops”),
with parenting information and
courses, and a potential range of other
recreational and social services available
A concept more than a building: attached or
allied to variety of public and private services,
e.g. health clinic, basic or primary school,
NGO, FBO, library
Staffed through agency/community initiatives:
existing or new paid staff or volunteers
37. Level I: Provides a place where information
is available to parents
Level II: Parenting Support Training
Programmes provided in addition
Level III: Specialist Services also available
38.
39.
40. Standard 1: Physical Environment
Standard 2: Programme Design
Standard 3: Programme Administration
Standard 4: Human Resources
Standard 5: Programme Materials
Standard 6: Programme Monitoring and
Evaluation
41.
42. Existence of local research important to address needs
Lower SES groups and EC was the driver for both research
and policy development, but policy included all groups
Stakeholder partnerships: CBP, Consultations,
Representation on GOJ Commissions
Existence of an enabling agency (institutional anchor) for
policy development
Policy development drove establishment of government
agency to co-ordinate parenting
This agency was important for policy implementation
43. Parents Places being established
primarily in primary schools (NPSC) and
early childhood centres (ECC) where
GOJ staff exists
Limited establishment by communities;
limited human resources as parent
facilitators