The document discusses the paranasal sinuses. There are four pairs of paranasal sinuses located around the nasal cavity that develop from invaginations of the nasal cavity mucosa into the bones. The maxillary sinus is the largest sinus and most clinically relevant as it is close to the teeth. Sinusitis is inflammation of the sinuses which can be acute or chronic and is usually caused by infection, trauma, dental issues or tumors. Anatomical relationships between the sinuses and structures like the orbit and teeth are important for dentists to understand.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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INTRODUCTIONSalivary glands are compound tubuloacinar, exocrine gland and the ducts opens in the oral cavity.
Salivary glands secretes a fluid called saliva that coats the teeth and the mucosa.
Saliva is a complex fluid, produced by the salivary glands, the most important function of which is to maintain the well- being of mouth.
Individuals with a deficiency of salivary secretion experience difficulty in eating, speaking, and swallowing and become prone to mucosal infections and dental caries.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
INTRODUCTIONSalivary glands are compound tubuloacinar, exocrine gland and the ducts opens in the oral cavity.
Salivary glands secretes a fluid called saliva that coats the teeth and the mucosa.
Saliva is a complex fluid, produced by the salivary glands, the most important function of which is to maintain the well- being of mouth.
Individuals with a deficiency of salivary secretion experience difficulty in eating, speaking, and swallowing and become prone to mucosal infections and dental caries.
Has a free tip and attached to forehead by the bridge.
External orifices (nares) bounded laterally by the ala & medially by nasal septum.
Framework above made up of: nasal bones, frontal process of maxilla, nasal part of frontal bone.
Framework below : by plates of hyaline cartilage; upper and lower nasal cartilages, and septal cartilage
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine
Al-Azhar University. There are four pairs of air sinuses making the boundaries of the nasal cavity. Maxillary sinus is the largest air cell. Anatomy and physiology of the maxillary sinus are given. Maxillary sinusitis is an inflammation of the sinus. Odontogenic causes represent nearly 30% of the etiology. Clinical and radiographic examinations are discussed together with treatment plan.
Oro-antral fistula is a rare complication of surgery at the posterior maxillary region. Several techniques for closure are presented. Additionally, information about sinus lift procedure is given.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. CONTENTS
INTRODUCTION
DEVELOPMENT
PARANASAL SINUSES
o FRONTAL SINUS
o MAXILLARY SINUS
o ETHMOIDAL SINUS
o SPHENOIDAL SINUS
CLINICAL ANATOMY
CONCLUSION
REFERENCES
2
3. INTRODUCTION 3
Air filled spaces
Open into the nasal cavity
through its lateral wall
These are- frontal,
maxillary, sphenoidal and
ethmoidal
Function is to make the
skull lighter, warm up and
humidify the inspired air
and also add resonance to
the voice.
5. DEVELOPMENT OF SINUSES 5
At about 25 – 28 weeks of
gestation, three medially directed
projections arise from lateral wall
of nose.
Between these projections small
lateral diverticula invaginate into
primitive choana to eventually form
meati of nose as beginning of the
development of paranasal sinuses.
Sinuses begin developing as small
sacculations of mucosa of nasal
meati and recesses.
As pouches or sacs develop and
grow they will invade the
respective bones to form air sinuses
and cells.
7. ` 7
Sinuses have small orifices
(ostia) which open into recesses
(meati) of the nasal cavities.
• Meati are covered by turbinates
(conchae).
• Turbinates consist of bony
shelves surrounded by erectile
soft tissue.
• There are 3 turbinates and 3
meati in each nasal cavity
(superior, middle, and inferior).
9. FRONTAL SINUS 9
Lies in the frontal bone deep to the superciliary
arch, extends upwards above medial end of
eyebrow, backward into medial part of roof of the
orbit. Opens into middle meatus of nose into ant.
End of hiatus semilunaris through infundibulum
or frontonasal duct.
Rudimentary or absent at birth. Well developed between 7 and 8 years.
Arterial supply- supraorbital artery
Venous drainage- supraorbital and superior ophthalmic veins.
Lymphatic drainage- supra mandibular nodes
Nerve supply-supraorbital nerve
11. MAXILLARY SINUS 11
Largest of the paranasal sinuses, first to
develop.
Pyramidal in shape, base directed
medially towards lateral wall of nose,
apex directed laterally in zygomatic
process of maxilla. Roof is formed by
floor of orbit, floor by alveolar process of
maxilla, Opens into middle meatus of
nose and lower part of hiatus semilunaris.
o Arterial supply- facial, infraorbital and greater palatine
o Venous drainage- facial vein and pterygoid plexus of vein
o Lymphatic drainage- submandibular nodes
o Nerve supply- post. Sup. Alveolar branch of maxillary nerve and middle sup. Alveolar branches from
infraorbital nerve.
13. SPHENOIDAL SINUS
Right and left sphenoidal sinuses lie within the body of sphenoidal bone, separated by
septum.
Related superiorly to optic chiasma and hypophysis cerebri; laterally to internal carotid
artery and cavernous sinus. Opens into sphenoethmoidal recess of corresponding half of
nasal cavity.
13
Arterial supply- post. Ethmoidal and internal carotid
artery.
Venous drainage- pterygoid venous plexus and
cavernous sinus
Lymphatic drainage- retropharyngeal nodes
Nerve supply- post. Ethmoidal nerve and orbital
branches of pterygopalatine ganglion.
14. ETHMOIDAL SINUSES 14
Numerous small inter-communicating
space which lie within the labyrinth of
the ethmoid bone. Divide into anterior,
middle and posterior
Ant. Ethmoidal sinus made up of 1
to 12 air cells, opens in ant part of
hiatus semilunaris of the nose
Middle ethmoidal sinus consist of 7
air cells, opens into middle meatus
of nose.
Post. Ethmoidal sinus – 1 to 7
aircells , opens into superior meatus
of nose.
16. CLINICAL ANATOMY 16
o SINUSITIS- infection of a sinus. It
Causes- headache, persistent thick
purulent discharge from nose
o It is of two types acute and chronic
o Maxillary sinusitis most commonly
involved. since drainage of the sinus is
difficult hence it is drained surgically by
either through antrum puncture or
Caldwell-Luc operation.
17. ACUTE SINUSITIS
It is the acute inflammation of the sinus mucosa with severe
pain in sinus area.
17
18. SUBACUTE MAXILLARY SINUSITIS 18
It is the intermediate stage between
acute and chronic sinusitis. There is
pain only in the form of the local
discomfort.
Patient has persistent discharge.
The voice is nasal, throat is sore with
constant irritating cough. Patient can
not sleep well.
The disease may take a long course
over week or months.
19. CHRONIC SINUSITIS
The term Chronic sinusitis is poorly defined but is best considered as
persistent incompletely resolved acute sinusitis.
19
MMT: Mucous Membrane
Thickening
Ofs: Opacified Frontal Sinus
Oes: Opacified Ethmoid Sinus
Oms: Opacified Maxillary Sinus
M: Mucocoele
20. TREATMENT 20
ACUTE SINUSITIS
1)Drainage is achieved with antibiotics
and nasal decongestants or extraction.
2) Antibiotics
3) Decongestant:Xylometazoline (0.1%)
4) Steam Inhalation : Acts by hydrating
the mucous layer, making it less
viscous and encouraging normal ciliary
clearance of the sinus.
(5) Antral Lavage : Antibiotics and nasal
drops fail, pus must be
removed from the antrum to allow the
sinus mucosa to
recover
CHRONIC SINUSITIS
Dental origin : Affected teeth
must be removed and the socket
closed surgically as there will be
risk of oroantral fistula.
Removal of Nasal Polyp
With presence of Oroantral fistula:
Surgical closure of fistula
Antrostomy: If above all
procedures fails to cure c sinusitis
the inferior meatal Antrostomy
and middle meatal antrostomy can
be done.
21. ODONTOGENIC SINUSITIS 21
Inflammation of the mucosa of any of
the paranasal sinuses
Maxillary sinusitis is usually
odontogenic in origin, because of its
close proximity with the maxillary
teeth.
Cause may be-
o infection- periapical abscess
o Allergy
o Trauma
o Displaced tooth or root
o neoplasm
22. OROANTRAL COMMUNICATION AND FISTULA 22
An oroantral perforation is an unnatural communication between the oral cavity
and maxillary sinus
An oroantral fistula is an epithelialized, pathological, unnatural communication
between these two cavities.
can be mainly due to-
extraction
Periapical lesions
Trauma
Chronic infections of maxillary sinus
During surgery
Infected maxillary implant denture teratomatous
destruction of maxilla
24. 24Treatment - Cases where oroantral
communication is recent and formation of
fistula is not established.
o Immediate surgery repair to achieve primary
closure
o Simultaneous antibiotic prophylaxis to
prevent sinus infection
Cases seen more than 24 hours after accident:- It is
preferable to defer the surgical closure until the gingival
edges of the fistula have healed soundly (approx 3
weeks)
- Supportive measures should be given
- Maxillary sinus should be gently irrigated with warm
normal saline, if there is purulent discharge or signs of
acute or chronic sinusitis is seen.
• Cases of long duration(more than a
month):
- Surgical closure is required
25. ANTROLITHS IN MAXILLARY SINUS 25
Antroliths are calcified
masses found in the maxillary
sinus.
• There is calcification of
masses of stagnant mucus in
site of previous
inflammation, root fragments
or bone chips.
• Asymptomatic but if continue
to grow patient complain of blood
stain nasal discharge or facial
pain.
• Removal if it is symptomatic
26. ODONTOGENIC CYST LESIONS 26
Odontogenic cysts
are the most common
group of extrinsic
lesions that encroach
on the maxillary
sinuses.
• The cyst enlarges ,the
sinus decrease in size
• The result is radioopaque
line between
the cyst and the air
space of the sinus.
28. CARCINOMA 28
Carcinoma of maxillary sinus
arises from mucosal lining ,
symptoms depend on direction of
growth-
o Proptosis or diplopia
o Bulging or ulceration of palate
o Swelling of the face
o Pain
o Nasal obstruction, epixtasis,
epiphora
29. BENIGN TUMOR 29
Benign tumors in the sinus may arise from the
lining as polyps and
papillomas, from bone as osteoma or from
maxillary teeth as
odontomes.
31. DEVELOPMENTALANOMALIES 31
• Crouzon syndrome : Early synostosis (fusion) of
sutures produces hypoplasia of the maxilla and
therefore the maxillary sinus together with the high
arched palate.
• Treacher Collins syndrome : Associated with grossly and
symmetrically underdeveloped maxillary sinuses
and Malar bones.
• Binder syndrome : Hypoplasia of middle third of the face
with smaller maxillary length and maxillary
sinus hypoplasia.
32. CONCLUSION 32
Paranasal Sinuses (PNS) are air containing bony spaces around
the nasal cavity. There are 4 pairs of paranasal
sinuses(bilaterally) but maxillary sinus is considered most
important to dentists due to close proximity of maxillary sinus
to orbit, alveolar ridge, diseases involving these structures may
produce confusing symptoms. Hence a precise information
about the surgical anatomy is essential to dental practitioners.
the close anatomical relationship of the maxillary sinus and the
roots of maxillary molars, premolars and in some instances
canines, can also lead to several endodontic complications.
Clinicians must be particularly cautious when performing
dental procedures involving the maxillary posterior teeth.
33. REFERENCES
Malik N. A. Textbook Of Oral And Maxillofacial Surgery,Jaypee Brothers Medical
Publishers Ltd ;( 4th Edition)2015
Chaurasia B. D. Human Anatomy, CBS publishers and distributers(7th edition)
vol.3,2015
33