Oxygen Reversal of Coronary Artery Spasm with Modification of International Standards for the Diagnostic Criteria of Coronary Vasomotor Disorders (Yasser's Modification or Oxygen test)-DR Yasser Mohammed Hassanain.pptx
Abstract Aim of the study: the study aims to clear the initial effect of non-baric oxygen inhalation on the coronary artery spasm. Background: Coronary artery spasm (CAS) is a cardiovascular disorder that plays an important role in the pathogenesis of stable angina, unstable angina, myocardial infarction, and sudden cardiac death. Nitrate, calcium channel blockers, and statins are known established medications in the reversal of coronary artery spasms. Oxygen safety versus adverse effects of nitrate, calcium channel blockers, and statins are comparable. Method of study and patients: My case study was an observational-retrospective seventeen case report series. The study was conducted in Fraskour Central Hospital, Kafr El-Bateekh Central Hospital, and physician outpatient. The author reported the seventeen cases of acute angina with rest chest pain over about 38-months, starting on December 15, 2018, ended on February 7, 2022. Results: The mean age is; 43.2 with the female sex predominance (64.71%). Housewife (29.41%) and students (23.53%) are the most affected occupations. The main complaint is chest pain (64.71%). The most common associated risk factors are female sex (64.71%) and stress (23.53%). Drug-induced (23.53%), hyperventilation syndrome-induced (23.53%), and CO toxicity-induced coronary artery spasm (17.65%) are common diagnoses. The dose of inhaled O2 dose that achieved the reversal of CAS varied from 5 to 12 liter. A maximal dose (12 minutes) was given for CO toxicity. The duration of inhaled O2 dose that achieved the reversal CAS varied from 15 to 80 minutes. Maximal duration (80 minutes) was given in CO toxicity. The complete response had happened in 94.12%. Conclusions: Dramatic clinical reliving and reversal response of electrocardiographic ST-segment depression after oxygen inhalation is an indication for its initial use in coronary artery spasm. Yasser's Modification or Oxygen test for the past "international standards for the diagnostic criteria of coronary vasomotor disorders" improves patient safety and decreases the hazards of nitrate and other medications.
Oxygen Reversal of Coronary Artery Spasm with Modification of International S...YasserMohammedHassan1
Abstract
Aim of the study: the study aims to clear the initial effect of non-baric oxygen inhalation on the coronary artery spasm. Background: Coronary artery spasm (CAS) is a cardiovascular disorder that plays an important role in the pathogenesis of stable angina, unstable angina, myocardial infarction, and sudden cardiac death. Nitrate, calcium channel blockers, and statins are known established medications in the reversal of coronary artery spasms. Oxygen safety versus adverse effects of nitrate, calcium channel blockers, and statins are comparable. Method of study and patients: My case study was an observational-retrospective seventeen case report series. The study was conducted in Fraskour Central Hospital, Kafr El-Bateekh Central Hospital, and physician outpatient. The author reported seventeen cases of acute angina with rest chest pain over about 38 months; starting on December 15, 2018, ended on February 7, 2022. Results: The mean age is 43.2 with the female sex predominance (64.71%). Housewives (29.41%) and students (23.53%) are the most affected occupations. The main complaint is chest pain (64.71%). The most common associated risk factors are female sex (64.71%) and stress (23.53%). Drug-induced (23.53%); hyperventilation syndrome-induced (23.53%); and CO toxicity-induced coronary artery spasm (17.65%) are common diagnoses. The dose of inhaled O2 dose that achieved the reversal of CAS varied from 5 to 12 liter. A maximal dose (12 minutes) was given for CO toxicity. The duration of inhaled O2 dose that achieved the reversal CAS varied from 15 to 80 minutes. Maximal duration (80 minutes) was given in CO toxicity. The complete response had happened in 94.12%. Conclusion: Dramatic clinical reliving and reversal response of electrocardiographic ST-segment depression after oxygen inhalation is an indication of its initial use in coronary artery spasms. Yasser’s Modification or Oxygen test for the past “international standards for the diagnostic criteria of coronary vasomotor disorders” improves patient safety and decreases the hazards of nitrate and other medications.
Use of Capnograph in Breathlessness Patientsnhliza
This is a research topic carried out in the Emergency Department and the abstract was presented at the International Conference In Emergency Medicine in SanFrancisco April 2008
We present the case of a 49-year-old male who was referred from Emergency department with worsening
breathlessness, chest tightness for last 24 hours. He had a background history of Asthma and Hypertension. Initial ECG revealed symmetric T wave inversions in anterior leads and found to have raised
troponin levels. Patient was diagnosed and treated as NSTEMI. While waiting for his coronary angiogram
he underwent echocardiogram whose findings were consistent with right sided impairment. Differential
diagnosis of Pulmonary Embolism has been made and CT Pulmonary Angiogram done that confirmed
diagnosis of Pulmonary Embolism. Early advice from the Respiratory team was sought and patient was
treated with rivaroxaban. After a hospital stay, he made a remarkable recovery.
Rationale: Coronary artery spasm is common ischemic heart disease. It is a serious clinical cardiovascular issue. Nitrates such as nitroglycerine have a pivotal role in the management of coronary artery disease.
Patient concerns: A 45-year-old married, officer, heavy smoker, Egyptian male patient presented with acute excruciating severe chest pain and combined electrocardiographic ST-segment coronary artery spasms.
Diagnosis: Combined ST-segment coronary artery spasms of ST-segment elevations and ST-depressions were the most probable diagnosis.
Interventions: Electrocardiogram, echocardiography, and nitroglycerine intravenous infusion.
Outcomes: Dramatic response of both clinical and electrocardiographic combined ST-segment coronary artery spasms to nitroglycerine.
Lessons: A combined ST-segment coronary artery spasms including ST-segment elevation and ST-depression may be present in the same ECG. The dramatic efficacy of later using nitroglycerine in the management of combined ST-segment coronary artery spasms.
Oxygen Reversal of Coronary Artery Spasm with Modification of International S...YasserMohammedHassan1
Abstract
Aim of the study: the study aims to clear the initial effect of non-baric oxygen inhalation on the coronary artery spasm. Background: Coronary artery spasm (CAS) is a cardiovascular disorder that plays an important role in the pathogenesis of stable angina, unstable angina, myocardial infarction, and sudden cardiac death. Nitrate, calcium channel blockers, and statins are known established medications in the reversal of coronary artery spasms. Oxygen safety versus adverse effects of nitrate, calcium channel blockers, and statins are comparable. Method of study and patients: My case study was an observational-retrospective seventeen case report series. The study was conducted in Fraskour Central Hospital, Kafr El-Bateekh Central Hospital, and physician outpatient. The author reported seventeen cases of acute angina with rest chest pain over about 38 months; starting on December 15, 2018, ended on February 7, 2022. Results: The mean age is 43.2 with the female sex predominance (64.71%). Housewives (29.41%) and students (23.53%) are the most affected occupations. The main complaint is chest pain (64.71%). The most common associated risk factors are female sex (64.71%) and stress (23.53%). Drug-induced (23.53%); hyperventilation syndrome-induced (23.53%); and CO toxicity-induced coronary artery spasm (17.65%) are common diagnoses. The dose of inhaled O2 dose that achieved the reversal of CAS varied from 5 to 12 liter. A maximal dose (12 minutes) was given for CO toxicity. The duration of inhaled O2 dose that achieved the reversal CAS varied from 15 to 80 minutes. Maximal duration (80 minutes) was given in CO toxicity. The complete response had happened in 94.12%. Conclusion: Dramatic clinical reliving and reversal response of electrocardiographic ST-segment depression after oxygen inhalation is an indication of its initial use in coronary artery spasms. Yasser’s Modification or Oxygen test for the past “international standards for the diagnostic criteria of coronary vasomotor disorders” improves patient safety and decreases the hazards of nitrate and other medications.
Use of Capnograph in Breathlessness Patientsnhliza
This is a research topic carried out in the Emergency Department and the abstract was presented at the International Conference In Emergency Medicine in SanFrancisco April 2008
We present the case of a 49-year-old male who was referred from Emergency department with worsening
breathlessness, chest tightness for last 24 hours. He had a background history of Asthma and Hypertension. Initial ECG revealed symmetric T wave inversions in anterior leads and found to have raised
troponin levels. Patient was diagnosed and treated as NSTEMI. While waiting for his coronary angiogram
he underwent echocardiogram whose findings were consistent with right sided impairment. Differential
diagnosis of Pulmonary Embolism has been made and CT Pulmonary Angiogram done that confirmed
diagnosis of Pulmonary Embolism. Early advice from the Respiratory team was sought and patient was
treated with rivaroxaban. After a hospital stay, he made a remarkable recovery.
Rationale: Coronary artery spasm is common ischemic heart disease. It is a serious clinical cardiovascular issue. Nitrates such as nitroglycerine have a pivotal role in the management of coronary artery disease.
Patient concerns: A 45-year-old married, officer, heavy smoker, Egyptian male patient presented with acute excruciating severe chest pain and combined electrocardiographic ST-segment coronary artery spasms.
Diagnosis: Combined ST-segment coronary artery spasms of ST-segment elevations and ST-depressions were the most probable diagnosis.
Interventions: Electrocardiogram, echocardiography, and nitroglycerine intravenous infusion.
Outcomes: Dramatic response of both clinical and electrocardiographic combined ST-segment coronary artery spasms to nitroglycerine.
Lessons: A combined ST-segment coronary artery spasms including ST-segment elevation and ST-depression may be present in the same ECG. The dramatic efficacy of later using nitroglycerine in the management of combined ST-segment coronary artery spasms.
Hemodynamic Stress Response of Carbon-Di-Oxide Pneumoperitoneum during Laparo...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Three and One Method (Yasser’s Method) to Overcome Streptokinase-Induced Hypo...YasserMohammedHassan1
Aim of the study: The study aimed to clarify how to overcome streptokinase-induced hypotension during acute myocardial infarction intravenous infusion? Background: Streptokinase is the cheapest approved thrombolytic agent. Streptokinase is commonly associated with hypotension. The delay in giving a thrombolytic agent for acute myocardial infarction may be hazardous. Method of study and patients: My study was an observational-retrospective twenty-case report series. The study was conducted in Fraskour Central Hospital and Kafr El-Bateekh Central Hospital. The author reported twenty cases of confirmed acute myocardial infarction with indications for thrombolytic over about 34 months, starting on October 5, 2018, ended on July 25, 2021. Testing for the probability of hypotension during infusion of streptokinase was done for all cases. Three and One Method (Yasser’s Method) was only applied in the cases of hypotension during streptokinase intravenous infusion. Results: The mean age in the current study is; 60.6 with male sex predominance (85%). Acute inferior myocardial infarction is the most common (55%) infarction. Pre-testing for the probability of hypotension during infusion of streptokinase was only applied in (50%) with equal positive probability and negative probability test was (50%). Yasser’s Methods was applied in (75%) in response in (100%). Conclusions: Three and One Method (Yasser’s Method) is an innovative clinical and therapeutic method in cardiovascular science. The method is used in cases of acute myocardial infarction. It is indicated in the cases of hypotension during the intravenous infusion of streptokinase. Three and One Method (Yasser’s Method) is effective, safe, and time saving for cases of acute myocardial infarction.
Three and One Method (Yasser’s Method) to Overcome Streptokinase-Induced Hypo...YasserMohammedHassan1
Aim of the study: The study aimed to clarify how to overcome streptokinase-induced hypotension during acute myocardial infarction intravenous infusion? Background: Streptokinase is the cheapest approved thrombolytic agent. Streptokinase is commonly associated with hypotension. The delay in giving a thrombolytic agent for acute myocardial infarction may be hazardous. Method of study and patients: My study was an observational-retrospective twenty-case report series. The study was conducted in Fraskour Central Hospital and Kafr El-Bateekh Central Hospital. The author reported twenty cases of confirmed acute myocardial infarction with indications for thrombolytic over about 34 months, starting on October 5, 2018, ended on July 25, 2021. Testing for the probability of hypotension during infusion of streptokinase was done for all cases. Three and One Method (Yasser’s Method) was only applied in the cases of hypotension during streptokinase intravenous infusion. Results: The mean age in the current study is; 60.6 with male sex predominance (85%). Acute inferior myocardial infarction is the most common (55%) infarction. Pre-testing for the probability of hypotension during infusion of streptokinase was only applied in (50%) with equal positive probability and negative probability test was (50%). Yasser’s Methods was applied in (75%) in response in (100%). Conclusions: Three and One Method (Yasser’s Method) is an innovative clinical and therapeutic method in cardiovascular science. The method is used in cases of acute myocardial infarction. It is indicated in the cases of hypotension during the intravenous infusion of streptokinase. Three and One Method (Yasser’s Method) is effective, safe, and time saving for cases of acute myocardial infarction.
Heart Disease & Chest Pain Treatment At NT Cardiovascular Center Georgiamelvillejackson
http://www.ntcardiovascularcenter.com NT Cardiovascular Center providing latest cutting edge and comprehensive technology for heart disease, chest pain treatments, congestive heart failure, coronary artery disease monitoring, or any critical heart condition.
Electrocardiographic passing phenomenon (flying phenomenon or yasser’s phenom...YasserMohammedHassan1
The new “Passing phenomenon” is a transient electrocardiographic change that spontaneously reversed within a few seconds to a few minutes without any medical interventions and apparent hemodynamic impact. Reassurance is immediate therapy. The electrophysiological study is the future advised investigation
Successful management of massive intra-operative pulmonary embolism Apollo Hospitals
Acute Pulmonary Embolism has a high rate of mortality (26%) due to blockade of the pulmonary artery leading to acute increase in right ventricular pressure causing sudden cardiac decompensation. Lack of specific tests for early diagnosis is one of the causes for high rate of mortality but timely diagnosis and active intervention can save the life of the patient.
- يعتبر تقييم نتائج غازات الدم الشرياني (ABG) مصدر إزعاج للعديد من الطلاب والأطباء المبتدئين حيث يتم تعلمها بشكل سيئ أو يتم تدريسها بشكل سيء.
- تحليل غازات الدم هو أداة تساعد على التشخيص، وليست تشخيصية، وهي شائعة الاستخدام لتقييم الضغوط الجزئية للغاز في الدم ومحتوى القاعدة الحمضية.
- يتيح فهم تحليل غازات الدم واستخدامه لمقدمي الخدمات تفسير اضطرابات الجهاز التنفسي والدورة الدموية والتمثيل الغذائي.
- يمكن إجراء "تحليل غازات الدم" على الدم المأخوذ من أي مكان في الدورة الدموية (الشريان أو الوريد أو الشعيرات الدموية).
- ارتباط تفسير نتائج غازات الدم الشرياني (ABG) مرتبط ارتباطا وثيقا بالحالة الاكلينيكية للمريض ولا يمكن فصلهما بحال.
- اختبار غازات الدم الشرياني (ABG) بشكل صريح للدم المأخوذ من الشريان. يقيم تحليل ABG ضغط المريض الجزئي للأكسجين (PaO2) وثاني أكسيد الكربون (PaCO2). يوفر PaO2 معلومات عن حالة الأوكسجين ، ويقدم PaCO2 معلومات عن حالة التهوية (فشل تنفسي مزمن أو حاد) يتأثر PaCO2 بفرط التنفس (التنفس السريع أو العميق) ، ونقص التهوية (التنفس البطيء أو الضحل)، وحالة القاعدة الحمضية. على الرغم من أنه يمكن تقييم الأكسجين والتهوية بطريقة غير جراحية عن طريق قياس التأكسج النبضي ومراقبة ثاني أكسيد الكربون في نهاية المد ، على التوالي ، فإن تحليل ABG هو المعيار.
- فمن المثير ألا ينزعج الطبيب أو الممرضة اذا وجد صعوبة في تفسير بعض النتائج لغازات الدم.
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Hemodynamic Stress Response of Carbon-Di-Oxide Pneumoperitoneum during Laparo...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Three and One Method (Yasser’s Method) to Overcome Streptokinase-Induced Hypo...YasserMohammedHassan1
Aim of the study: The study aimed to clarify how to overcome streptokinase-induced hypotension during acute myocardial infarction intravenous infusion? Background: Streptokinase is the cheapest approved thrombolytic agent. Streptokinase is commonly associated with hypotension. The delay in giving a thrombolytic agent for acute myocardial infarction may be hazardous. Method of study and patients: My study was an observational-retrospective twenty-case report series. The study was conducted in Fraskour Central Hospital and Kafr El-Bateekh Central Hospital. The author reported twenty cases of confirmed acute myocardial infarction with indications for thrombolytic over about 34 months, starting on October 5, 2018, ended on July 25, 2021. Testing for the probability of hypotension during infusion of streptokinase was done for all cases. Three and One Method (Yasser’s Method) was only applied in the cases of hypotension during streptokinase intravenous infusion. Results: The mean age in the current study is; 60.6 with male sex predominance (85%). Acute inferior myocardial infarction is the most common (55%) infarction. Pre-testing for the probability of hypotension during infusion of streptokinase was only applied in (50%) with equal positive probability and negative probability test was (50%). Yasser’s Methods was applied in (75%) in response in (100%). Conclusions: Three and One Method (Yasser’s Method) is an innovative clinical and therapeutic method in cardiovascular science. The method is used in cases of acute myocardial infarction. It is indicated in the cases of hypotension during the intravenous infusion of streptokinase. Three and One Method (Yasser’s Method) is effective, safe, and time saving for cases of acute myocardial infarction.
Three and One Method (Yasser’s Method) to Overcome Streptokinase-Induced Hypo...YasserMohammedHassan1
Aim of the study: The study aimed to clarify how to overcome streptokinase-induced hypotension during acute myocardial infarction intravenous infusion? Background: Streptokinase is the cheapest approved thrombolytic agent. Streptokinase is commonly associated with hypotension. The delay in giving a thrombolytic agent for acute myocardial infarction may be hazardous. Method of study and patients: My study was an observational-retrospective twenty-case report series. The study was conducted in Fraskour Central Hospital and Kafr El-Bateekh Central Hospital. The author reported twenty cases of confirmed acute myocardial infarction with indications for thrombolytic over about 34 months, starting on October 5, 2018, ended on July 25, 2021. Testing for the probability of hypotension during infusion of streptokinase was done for all cases. Three and One Method (Yasser’s Method) was only applied in the cases of hypotension during streptokinase intravenous infusion. Results: The mean age in the current study is; 60.6 with male sex predominance (85%). Acute inferior myocardial infarction is the most common (55%) infarction. Pre-testing for the probability of hypotension during infusion of streptokinase was only applied in (50%) with equal positive probability and negative probability test was (50%). Yasser’s Methods was applied in (75%) in response in (100%). Conclusions: Three and One Method (Yasser’s Method) is an innovative clinical and therapeutic method in cardiovascular science. The method is used in cases of acute myocardial infarction. It is indicated in the cases of hypotension during the intravenous infusion of streptokinase. Three and One Method (Yasser’s Method) is effective, safe, and time saving for cases of acute myocardial infarction.
Heart Disease & Chest Pain Treatment At NT Cardiovascular Center Georgiamelvillejackson
http://www.ntcardiovascularcenter.com NT Cardiovascular Center providing latest cutting edge and comprehensive technology for heart disease, chest pain treatments, congestive heart failure, coronary artery disease monitoring, or any critical heart condition.
Electrocardiographic passing phenomenon (flying phenomenon or yasser’s phenom...YasserMohammedHassan1
The new “Passing phenomenon” is a transient electrocardiographic change that spontaneously reversed within a few seconds to a few minutes without any medical interventions and apparent hemodynamic impact. Reassurance is immediate therapy. The electrophysiological study is the future advised investigation
Successful management of massive intra-operative pulmonary embolism Apollo Hospitals
Acute Pulmonary Embolism has a high rate of mortality (26%) due to blockade of the pulmonary artery leading to acute increase in right ventricular pressure causing sudden cardiac decompensation. Lack of specific tests for early diagnosis is one of the causes for high rate of mortality but timely diagnosis and active intervention can save the life of the patient.
Similar to Oxygen Reversal of Coronary Artery Spasm with Modification of International Standards for the Diagnostic Criteria of Coronary Vasomotor Disorders (Yasser's Modification or Oxygen test)-DR Yasser Mohammed Hassanain.pptx (20)
- يعتبر تقييم نتائج غازات الدم الشرياني (ABG) مصدر إزعاج للعديد من الطلاب والأطباء المبتدئين حيث يتم تعلمها بشكل سيئ أو يتم تدريسها بشكل سيء.
- تحليل غازات الدم هو أداة تساعد على التشخيص، وليست تشخيصية، وهي شائعة الاستخدام لتقييم الضغوط الجزئية للغاز في الدم ومحتوى القاعدة الحمضية.
- يتيح فهم تحليل غازات الدم واستخدامه لمقدمي الخدمات تفسير اضطرابات الجهاز التنفسي والدورة الدموية والتمثيل الغذائي.
- يمكن إجراء "تحليل غازات الدم" على الدم المأخوذ من أي مكان في الدورة الدموية (الشريان أو الوريد أو الشعيرات الدموية).
- ارتباط تفسير نتائج غازات الدم الشرياني (ABG) مرتبط ارتباطا وثيقا بالحالة الاكلينيكية للمريض ولا يمكن فصلهما بحال.
- اختبار غازات الدم الشرياني (ABG) بشكل صريح للدم المأخوذ من الشريان. يقيم تحليل ABG ضغط المريض الجزئي للأكسجين (PaO2) وثاني أكسيد الكربون (PaCO2). يوفر PaO2 معلومات عن حالة الأوكسجين ، ويقدم PaCO2 معلومات عن حالة التهوية (فشل تنفسي مزمن أو حاد) يتأثر PaCO2 بفرط التنفس (التنفس السريع أو العميق) ، ونقص التهوية (التنفس البطيء أو الضحل)، وحالة القاعدة الحمضية. على الرغم من أنه يمكن تقييم الأكسجين والتهوية بطريقة غير جراحية عن طريق قياس التأكسج النبضي ومراقبة ثاني أكسيد الكربون في نهاية المد ، على التوالي ، فإن تحليل ABG هو المعيار.
- فمن المثير ألا ينزعج الطبيب أو الممرضة اذا وجد صعوبة في تفسير بعض النتائج لغازات الدم.
Mimic HL MI in chest tetany with mirror ECG change, Movable phenomenon (Yasse...YasserMohammedHassan1
The reversal of mirror electrocardiographic change, reversal of ST-segment depression coronary artery spasm, and normalization of Movable phenomenon (Yasser’s phenomenon) after oxygenation. It signifies the role of oxygen in both coronary artery spasm and tetany. Mirror local electrocardiographic change is a novel described expression that may reflect the myocardial polarity in this chest tetany.
COVID-19 Pneumonia with Atrial Fibrillation, Coronary Spasm, and Wavy Triple ...YasserMohammedHassan1
Rationale: A novel COVID-19 with severe acute respiratory syndrome had arisen in Wuhan, China in December 2019 Arrhythmias are commonly recognized sequel in COVID-19 patients. Interestingly, the presentation of COVID-19 infection with a newly coronary artery spasm has a risk impact on both morbidity and mortality of COVID-19 patients. Wavy triple an electrocardiographic sign (Yasser Sign) is a new innovated diagnostic sign in hypocalcemia. Patient concerns: An elderly farmer male COVID-19 patient presented to physician outpatient clinic with bilateral pneumonia, atrial fibrillation, evidence of coronary artery spasm, and Wavy triple an electrocardiographic sign (Yasser Sign). Diagnosis: COVID-19 pneumonia with coronary artery spasm and the Wavy triple an electrocardiographic sign (Yasser Sign). Interventions: Chest CT scan, electrocardiography, oxygenation, and echocardiography. Outcomes: Gradual dramatic clinical, electrocardiographic, and radiological improvement had happened. Lessons: The reversal of electrocardiographic ST-segment depressions in a COVID-19 patient after adding oral nitroglycerine is an indicator for the presence of coronary artery spasm. It signifies the role of the anti-infective drugs, anticoagulants, antiplatelet, and steroids in COVID-19 patients with bilateral pneumonia, AF, coronary artery spasm are effective therapies. The disappearance of AF after initial therapy may a guide for a good prognosis in this case study. The evanescence of Wavy triple ECG sign as a hallmark for the existence of the Movable-weaning phenomenon of hypocalcemia is recommended for further wide-study.
Sgarbossa Criteria in Left Bundle Branch Block in a Hypertensive Emergency, a...YasserMohammedHassan1
Left bundle branch block and hypertensive emergency are very often to occur in the clinical practice. But, developing of Sgarbossa criteria in left bundle branch block throughout the course of hypertensive emergency was an extremely rare. My current case is a hypertensive emergency patient with acute chest pain and left bundle branch block. Sgarbossa criteria were initially very weak but, became highly suggestive for acute ST-segment elevation myocardial infarction with time. With strong collective data for the case, the chance for thrombolytic therapy was strictly indicated. So why was the case developed an acute ST-segment elevation myocardial infarction to received thrombolytic therapy?.
CHARGE syndrome hallmarked with Wolff-Parkinson-White syndrome and patent duc...YasserMohammedHassan1
Abstract
Rationale: CHARGE syndrome or Hall-Hittner syndrome is a pleiotropic disorder, in which the name is derived from the abbreviation epitomizing its six clinical criteria: ocular coloboma, cardiac defects, choanal atresia, growth or developmental retardation, genital hypoplasia, and ear anomalies or deafness. Wolff-Parkinson-White syndrome is the most frequent pattern of ventricular pre-excitation. Patent ductus arteriosus is one of the most frequent congenital heart diseases due to failure of closure of the ductus arteriosus within 72 hours of birth. CHARGE syndrome, Wolff-Parkinson-White syndrome, and patent ductus arteriosus are so difficult to be present in a single entity. Patient concerns: A young female girl patient presented to the physician outpatient clinic with acute confusion status with a past repaired patent ductus arteriosus. Diagnosis: CHARGE syndrome hallmarked with Wolff-Parkinson-White syndrome and patent ductus arteriosus; 20 years post-repairing. Interventions: Plain chest x-ray, electrocardiography, oxygenation, and echocardiography. Outcomes: A dramatic clinical improvement post-oxygenation had happened. Lessons: CHARGE syndrome with Wolff-Parkinson-White syndrome and repaired patent ductus arteriosus is an extreme combination. The existence of infantile electrocardiographic Tee-Pee sign of hypocalcemia and adult low ionized calcium with CHARGE syndrome is highly suggestive of associated DiGeorge phenotype syndrome. An absence of tachycardia post- repairing of patent ductus arteriosus from 11 mo until the 20th-year-old is a good prognostic sign. The presence of an infantile T-wave alternance will strengthen both the risk of serious arrhythmia and the efficacy of patent ductus arteriosus repairing.
Sgarbossa Criteria in Left Bundle Branch Block in a Hypertensive Emergency, a...YasserMohammedHassan1
ABSTRACT
Rationale: Left bundle branch block and hypertensive emergency are very common conditions in clinical cardiovascular and emergency practice. Hypertensive emergency encompasses a spectrum of clinical presentations in which uncontrolled blood pressure leads to progressive end-organ dysfunction. Suspected acute myocardial infarction in the setting of a left bundle branch block presents a unique diagnostic and therapeutic challenge to the clinician. The diagnosis is especially difficult due to electrocardiographic changes caused by altered ventricular depolarization. However, reports on the use of Sgarbossa’s criteria in the management of hypertensive emergencies are rare. Patient concerns: A middle-aged married heavy-smoker Egyptian male worker presented to the emergency department with a hypertensive emergency patient with acute chest pain and left bundle branch block. Sgarbossa’s criteria were initially very weak and, over time, became highly suggestive of acute ST-segment elevation myocardial infarction. Interestingly, chest pain increased as Sgarbossa’s diagnostic criteria were met. Thrombolytic therapy was strongly indicated because of a higher development of Sgarbossa criteria scoring. Intervention; Electrocardiography, oxygenation, streptokinase IVI, and echocardiography Diagnosis: Developing acute ST-segment elevation myocardial infarction in the presence of
left bundle branch block post hypertensive emergency. Outcomes: The dramatic response to developing acute myocardial infarction in the left bundle branch block with hypertensive emergency to streptokinase. Lessons: The higher Sgarbossa criteria scoring in the case was the only indication for thrombolytic. Therefore, how did Sgarbossa's criteria develop during case management to indicate the need for thrombolytic therapy?
Mimic high lateral myocardial infarction in chest tetany with mirror electroc...YasserMohammedHassan1
The reversal of mirror electrocardiographic change, reversal of ST-segment depression coronary artery spasm, and normalization of Movable phenomenon (Yasser’s phenomenon) after oxygenation. It signifies the role of oxygen in both coronary artery spasm and tetany. Mirror local electrocardiographic change is a novel described expression that may reflect the myocardial polarity in this chest tetany.
Zavras-Kounis syndrome simultaneously with reactional myoclonus post-streptok...YasserMohammedHassan1
Rationale: Drug-associated adverse effects are one of the most important entities in clinical medicine. Involuntary movements may have a dynamic serious impact on myocardial muscle. Myoclonus is well as abnormal involuntary movements with a distinct description. Myoclonus is a physical trauma and stress for coronary arteries. Physical and mechanical stress may be causing coronary artery spasm. Drug-inducing allergic angina, allergic coronary artery spasm, and allergic myocardial infarction are renowned as Zavras-Kounis syndrome. Streptokinase is a still-known effective thrombolytic in myocardial infarction. There is a correlation between COVID-19 infection and myocardial infarction. Patient concerns: A 70-year-old married, farmer, smoker, Egyptian male patient was admitted to the critical care unit with acute inferior myocardial infarction and suspected COVID-19 pneumonia. An interlacing generalized myoclonus and allergic coronary artery spasm occurred. Diagnosis: Reactional myoclonus with allergic coronary artery spasm post-streptokinase in COVID-19 inducing myocardial infarction. Interventions: Electrocardiography, oxygenation, streptokinase intravenous infusion, and echocardiography. Outcomes: Reactional generalized myoclonus with coronary artery spasm had happened during-streptokinase infusion but the dramatic response was the result. Lessons: Dramatic clinical and electrocardiographic response after using the traditional anti-allergic signifying its role and suggest the diagnosis of Zavras-Kounis syndrome. The presence of continuing generalized myoclonus movements with the disappearance of coronary artery spasm after stoppage may be directed to the myoclonus cause. Streptokinase causing generalized myoclonus movements previously unknown, so it is a new recording adverse effect finding. The presence of involuntary movements, COVID-19 pneumonia, myocardial infarction, elderly, and cigarette smoking are prognostic factors for the severity of the disease.
Café Au Lait Spot is A Marker for Pheochromocytoma in Hypertensive Crisis Wit...YasserMohammedHassan1
Café au lait Spot is a marker for pheochromocytoma in hypertensive crisis but with a wide-differential diagnosis. Labetalol may be chosen in hypertensive crisis due to pheochromocytoma.
Acute myocardial infarction associated with right bundle branch block and cha...YasserMohammedHassan1
Acute myocardial infarction may be associated right bundle branch block.
Accompanied trifascicular heart block had pre-streptokinase left anterior fascicular block
with left axis deviation and post-streptokinase left posterior fascicular block with right axis
deviation.
Wavy Triple Sign of Hypocalcemia or Yasser’s Sign-in Diabetic Ketoacidosis-Dr...YasserMohammedHassan1
The wavy triple an electrocardiographic sign (Yasser’s sign) and hypocalcemia are commonly seen in diabetic ketoacidosis. Dramatic spontaneous improvement of both wavy triple an electrocardiographic sign (Yasser’s sign) and hypocalcemia simultaneously after the management of diabetic ketoacidosis in most cases.
الأدوية الخطرة بالعناية والطوارئ-Dr. Yasser Mohammed Hassanain Elsayed.pptxYasserMohammedHassan1
• هنالك العديد من الأدوية الخطرة التي طالما نستخدمها بالمستشفيات، خاصة بأقسام الطوارىء أو الرعاية الحرجة.
• البعض منها يكون في أقسام الطوارئ، والبعض الأخر يكون في أقسام الرعاية الحرجة، وأحيانا تكون في الأقسام الداخلية للمستشفيات.
• ربما تتصدر مشكلات كبيرة عن استخدام هذه الأدوية، هذا فضلا عن الصغيرة منها، مثل:
- توقف القلب وربما الموت المفاجيء.
- الزيادة الخطرة بضربات القلب
- حدوث ذبحة صدرية
- أو حدوث جلطة دموية في القلب
- حدوث ألم شديد بالصدر
- حدوث فشل تنفسي أو إثارته.
- حدوث فشل كبدي أو إثارته.
- حدوث ضعف حاد بعضلة القلب أو إثارته.
- الى غير ذلك من صور وأشكال عديدة، من المضاعفات.
ألم الصدر التشخيص- وكيفية التعامل معه-Dr. Yasser Mohammed Hassanain Elsayed.pptxYasserMohammedHassan1
• يعتمد تشخيص وعلاج ألم الصدر على السبب.
فقد تتنوع أسباب ألم الصدر من مشكلات صغيرة، مثل:
- حرقة المعدة
- الضغط النفسي
- حالات الطوارئ الطبية الخطيرة مثل النوبة القلبية
- أو تكوُّن جلطة دموية في الرئتين (الإنصمام الرئوي).
• يأخذ ألم الصدر صورا وأشكالا عديدة، وتتراوح حدته بين الشعور بطعنات حادة وحتى الألم الخفيف. وفي بعض الأحيان، يكون ألم الصدر ساحقًا أو حارقًا. وفي حالات أخرى، ينتقل الألم صعودًا إلى الرقبة وإلى داخل الفك، ثم ينتشر للخلف أو للأسفل لتشعر به في أحد الذراعين أو في الذراعين معًا.
Introduce the Research-Welcome Keys-Dr. Yasser Mohammed Hassanain Elsayed.pptxYasserMohammedHassan1
• The term, research, is much stricter in science than in everyday life.
• It revolves around using the scientific method to generate hypotheses and provide analyzable results.
Hypocalcemia induced camel-hump t-wave, tee-pee sign, and bradycardia in a ca...YasserMohammedHassan1
Rationale: Electrocardiographic is a fundamental tool for a cardiologist, critical care physician, and emergency medicine specialist. The electrolyte imbalance is a very important entity in clinical medicine management. Camel-hump T-wave and the Tee-Pee sign, recently; Wavy triple and Wavy double signs of hypocalcemia (Yasser’s sign) are electrocardiographic findings linked to electrolyte deficiencies. Patient concerns: A middle-aged male car-painter patient presented to the emergency department with atypical severe twisting chest pain, hypocalcemia, hypokalemia, and hypernatremia.
Diagnosis: Hypocalcemia-induced Camel-hump T-wave, Tee Pee sign, Wavy double sign of hypocalcemia (Yasser’s sign), and bradycardia in a car- painter. Interventions: Electrocardiography, arterial blood gases, oxygenation, and echocardiography. Lessons: The dramatic reversal of Camel-hump T-Wave, Tee-Pee sign, Wavy double sign of hypocalcemia (Yasser’s sign) after calcium gluconate injection interpret that these signs were due to hypocalcemia. The twisting chest pain and its limited disappearance immediately after calcium gluconate injection indicate the pain can be named as “chest tetany”. Non-atropine bradycardia response is evidence that the management of the cause of bradycardia sometimes is essential e.g. hypocalcemia in the current case. Outcomes: There was a dramatic response of both clinical and electrocardiography including Camel-hump T-wave, Tee Pee sign, the wavy double sign of hypocalcemia, and bradycardia.
Sgarbossa criteria in left bundle branch block in a hypertensive emergency ya...YasserMohammedHassan1
Rationale: Left bundle branch block and hypertensive emergency are very common conditions in clinical cardiovascular and emergency practice. Hypertensive emergency encompasses a spectrum of clinical presentations in which uncontrolled blood pressure leads to progressive end-organ dysfunction. Suspected acute myocardial infarction in the setting of a left bundle branch block presents a unique diagnostic and therapeutic challenge to the clinician. The diagnosis is especially difficult due to electrocardiographic changes caused by altered ventricular depolarization. However, reports on the use of Sgarbossa’s criteria in the management of hypertensive emergency is rare. Patient concerns: A middle-aged married heavy-smoker Egyptian male worker presented to the emergency department with a hypertensive emergency patient with acute chest pain and left bundle branch block. Sgarbossa’s criteria were initially very weak and, over time, became highly suggestive of acute ST-segment elevation myocardial infarction. Interestingly, chest pain increased as Sgarbossa’s diagnostic criteria were met. Thrombolytic therapy was strongly indicated because of a higher development of Sgarbossa criteria scoring. Intervention; Electrocardiography, oxygenation, streptokinase IVI, and echocardiography Diagnosis: Developing acute ST-segment elevation myocardial infarction in the presence of left bundle branch block post- hypertensive emergency. Outcomes: The dramatic response to developing acute myocardial infarction in left bundle branch block with hypertensive emergency to streptokinase. Lessons: The higher Sgarbossa criteria scoring in the case was the only indication for thrombolytic. Therefore, how did Sgarbossa criteria develop during case management to indicate the need for thrombolytic therapy?
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Surgical Site Infections, pathophysiology, and prevention.pptx
Oxygen Reversal of Coronary Artery Spasm with Modification of International Standards for the Diagnostic Criteria of Coronary Vasomotor Disorders (Yasser's Modification or Oxygen test)-DR Yasser Mohammed Hassanain.pptx
1. Oxygen Reversal of Coronary Artery Spasm with Modification of
International Standards for the Diagnostic Criteria of Coronary
Vasomotor Disorders (Yasser's Modification or Oxygen test)
Retrospective-Observational Study; 17-Case Reports
Dr. Yasser Mohammed Hassanain Elsayed
Researcher and author
Critical Care Medicine and Cardiologist
Egyptian Ministry of Health (MOH)
MB Bch, PGDip Cardiology (Middlesex University, RILA)
International Heart Congress
May 24-25, 2023
Tokyo, Japan
3. Oxygen Reversal of Coronary Artery Spasm
with Modification of International Standards
for the Diagnostic Criteria of Coronary
Vasomotor Disorders (Yasser's Modification
or Oxygen test)
Retrospective-Observational Study; 17-Case Reports
4. Figure 1; The author's diagrammatic presentation for Yasser's Modification or
Oxygen test.
5. Learning objectives
• Abstract
• The study
• Discovery and historical bit
• Principals of Yasser's Modification or Oxygen test
• Types of response
• Target
• Examples
• The study data and statistics
• Discussion
6. Abstract
Aim of the study: the study aims to clear the initial effect of non-baric oxygen inhalation on the coronary artery spasm.
Background: Coronary artery spasm (CAS) is a cardiovascular disorder that plays an important role in the pathogenesis of stable
angina, unstable angina, myocardial infarction, and sudden cardiac death. Nitrate, calcium channel blockers, and statins are known
established medications in the reversal of coronary artery spasms. Oxygen safety versus adverse effects of nitrate, calcium channel
blockers, and statins are comparable. Method of study and patients: My case study was an observational-retrospective seventeen
case report series. The study was conducted in Fraskour Central Hospital, Kafr El-Bateekh Central Hospital, and physician
outpatient. The author reported the seventeen cases of acute angina with rest chest pain over about 38-months, starting on
December 15, 2018, ended on February 7, 2022. Results: The mean age is; 43.2 with the female sex predominance (64.71%).
Housewife (29.41%) and students (23.53%) are the most affected occupations. The main complaint is chest pain (64.71%). The
most common associated risk factors are female sex (64.71%) and stress (23.53%). Drug-induced (23.53%), hyperventilation
syndrome-induced (23.53%), and CO toxicity-induced coronary artery spasm (17.65%) are common diagnoses. The dose of
inhaled O2 dose that achieved the reversal of CAS varied from 5 to 12 liter. A maximal dose (12 minutes) was given for CO
toxicity. The duration of inhaled O2 dose that achieved the reversal CAS varied from 15 to 80 minutes. Maximal duration (80
minutes) was given in CO toxicity. The complete response had happened in 94.12%. Conclusions: Dramatic clinical reliving and
reversal response of electrocardiographic ST-segment depression after oxygen inhalation is an indication for its initial use in
coronary artery spasm. Yasser's Modification or Oxygen test for the past "international standards for the diagnostic criteria of
coronary vasomotor disorders" improves patient safety and decreases the hazards of nitrate and other medications.
7. Table 1- showing remarks of the studymethod and data.
Title Oxygen reversal of coronary artery spasm with modification of
international standards for the diagnostic criteria of coronary
vasomotor disorders (Yasser's Modification or Oxygen test)
Estimated Enrollment 17 participants
Study Type Observational
Observational Model Case report series
Time Retrospective
Study Start Date December 15, 2018
Estimated Study Completion Date February 7, 2022
Analytic method Comparative using percentage %
8. Suggesting hypothesis and research objectives
• Suggesting hypothesis: The effect of non-baric
oxygen inhalation initially can improve the coronary
artery spasm.
• The research objectives are to clear the initial effect
of non-baric oxygen inhalation on the coronary artery
spasm. The dramatic response of coronary artery
spasms to oxygen inhalation will be guided to modify
international standards for the diagnostic criteria of
coronary vasomotor
9. disorders. This document addressed the criteria for
vasospastic angina are included the following (A) nitrate-
responsive angina, (B) transient ischaemic
electrocardiogram changes, and (C) documented coronary
artery spasm. This modification with oxygen will be added
to the above three criteria (Figure 1)
• Eligibility criteria:
• Inclusion criteria: All cases associated with initial ECG
ST-segment depressions.
• Exclusion criteria:
10. Cardiac chest pain with normal ECG.
• Assessment of treatment response was done with the
presence of either:
• Entirely reversal (Complete response) of ECG ST-
segment depressions to oxygen inhalation.
• Incomplete reversal (Partial response) of ECG ST-
segment depressions to oxygen inhalation.
11. Vocabulary or keys for the current
case report
• Chest pain with or without ST-segment
depression
• Oxygen role in the reversal of coronary
artery spasms
12. Discovery
1. History
• Discovery was an accidental
• Precise clinical and electrocardiographic observation.
• I had been observing for important ECG changes
after oxygenation.
13. 2. Principals of
Oxygen Reversal of Coronary Artery
Spasm with Modification of
International Standards for the
Diagnostic Criteria of Coronary
Vasomotor Disorders
(Yasser's Modification or Oxygen test)
14. The analysis for “Yasser's
Modification” or
“Oxygen test”
in
the author's interpretations are
based on the following;
15. 1-There are ECG ST-segment depressions
2-There is a reversal of ST-segment depressions after
oxygenation
3-These ECG ST-segment depressions are transient.
4-The ECG changes were reversed after oxygenation
within a few minutes.
5-There are no initial used medications to help this
reversal.
6-Serial ECG tracings are essential in understanding.
21. Carbon monoxide toxicity-induced CAS
A 14-year-old Egyptian single male adolescent student patient presented to the
ED with a sudden deep loss of consciousness (LOC) in a hot bathroom in a closed
space. The flushed face was noted on examination. His GCS was: 9. The case was
managed urgently and only with high concentration O2 inhalation using the nasal
mask (12 L/m An initial emergency ECG showed sinus tachycardia with the VR;
140 bpm and ST-segment depressions in leads II, III, aVF, I, and V3-6 (Figure 2A).
The second ECG tracing post-oxygenation showed complete normalization of ST-
segment depressions with NSR (Figure 2B). Troponin-T test was negative.
Metabolic acidosis was seen on ABG. Complete recovery had been achieved and
the patient was discharged within 12 hours of ICU admission (Elsayed YMH et al., 2019).
22. Figure 2: A Initial ECG tracing (2A); ECG of the ED presentation showing marked sinus tachycardia of VR; 140 bpm with
ST-segment depressions in leads II, III, aVF (red arrows) and I, V3-6 (blue arrows). The second ECG tracing (2B) was done
within 20 minutes of O2 inhalation showing complete normalization of ST-segment depressions and tachycardia
24. Kounis-Zafras type 1 syndrome
A 36-year-old, an Egyptian, housewife female patient was presented to the POC
with anginal chest pain. The patient gave a recent history of toothache. An oral 100
mg ketoprofen tablet was prescribed for the pain. The patient started to complain of
acute chest pain within 30 minutes of this oral tablet. On examination, the patient
was anxious and irritable. The initial ECG tracing was taken before O2 therapy
showed; NSR with a VR of 96 bpm and straight ST-segment depression in V2-6
leads (Figure 3A). The second ECG tracing showed resolution of ST-segment
depression with decreasing VR to 86 bpm after O2 inhalation 100%, 5 L/m for 20
minutes using a nasal cannula (Figure 3B). Both CPK-MB and troponin levels were
normal. Echocardiography showed an absence of hypokinetic abnormalities with a
normal EF (68%). Dramatic response of clinical chest pain and ECG ST-segment
depression improvement post-oxygenation had happened (Elsayed YMH et al., 2020).
25. Figure 3: Initial ECG tracing (3A); ECG of ED presentation showing NSR of VR; 96 bpm and straight ST-segment
depression in V2-6 ECG leads (lime arrows). The second ECG tracing (3B) was done within 20 minutes of O2 inhalation
showing resolution of ST-segment depression with decreasing the VR to 86 bpm after O2 inhalation 100% (red arrows)
27. Carbon monoxide toxicity-induced CAS
An 11-year-old Egyptian single female student adolescent patient presented to
the ED with sudden acute chest pain, palpitations, and abrupt LOC during the doing
in a closed space hot bathroom. The family gave a history of hypothyroidism on a
single daily100 mcg dose of levothyroxine sodium tab. The flushed face was noted
on examination. Her GCS was: 9. The case was treated urgently only with high
concentration O2 inhalation, 12 L/m, for 30 minutes, using the nasal mask. An
initial emergency ECG showed sinus tachycardia of (VR; 144 bpm) with ST-
segment depressions in II, III, aVF, I, aVL, and V3-6 leads (Figure 4A). Complete
normalization of ST-segment depressions but still showing sinus tachycardia had
happened (Figure 4B). Troponin T test was negative. An initial ABG showed
partially compensated metabolic acidosis. Later echocardiography was completely
normal. Complete clinical recovery and reversal of ECG changes had achieved. The
patient was discharged within 24 hours of ICU admission (Elsayed YMH et al., 2020).
28. Figure 4: Initial ECG tracing (4A); ECG of the ED presentation showing sinus tachycardia (VR; 144) with ST-segment
depressions in II, III, I, aVL, and V3-6 leads (lime arrows). The second ECG tracing (4B) was done post-oxygenation showing
normalization of all the above ST-segment depressions with still showing sinus tachycardia (VR; 116).
30. Carbon monoxide toxicity-induced CAS
An 11-year-old Egyptian single female student adolescent patient presented to
the ED with sudden acute chest pain, palpitations, and a fall in a hot bathroom in a
closed space. The flushed face was noted on examination. Her GCS was: 15. The
case was treated urgently only with a high concentration of O2 inhalation using the
nasal mask (12 L/m) An initial emergency ECG showed sinus tachycardia (VR;
112 bpm) with ST-segment depressions in V4-6 leads (Figure 5A). Complete
normalization of ST-segment depressions had happened within 30 minutes of
oxygenation (Figure 5B). The troponin T-test was negative. Metabolic acidosis
was seen on ABG. Later echocardiography was completely normal. Complete
clinical recovery and reversal of ECG changes had achieved. The patient was
discharged within 24 hours of ICU admission (Elsayed YMH et al., 2020).
31. Figure 5: Initial ECG tracing (5A); ECG of the ED presentation showing sinus tachycardia (VR; 112 bpm) with ST-segment
depressions in V4-6 leads (red arrows) with technical LA/RA lead reversal (orange arrows). The second ECG tracing (5B) was
done within 30 minutes of oxygenation showing complete normalization of all the above abnormalities.
33. Iatrogenic alcohol inhalation inducing CAS and sinus
tachycardia in asthmatic and liver cirrhotic patient
A 67-year-old married, farmer, male, Egyptian patient presented in the POC
with tachypnea, dizziness, and chest pain. Profuse sweating and acute confusion
state were the associated symptoms. The patient relatives gave an old history of BA
and liver cirrhosis. They give a recent asthmatic episode 3 days ago. He was
acutely managed by the other POC. The POC only prescribed humified O2 as
needed. Within 30 minutes of the presentation, the patient gave a recent history of
O2 inhalation mistakenly using alcohol instead of sterile water in the water cup of
the O2 cylinder. Upon examination, the patient appeared tachypneic, pale, sweaty,
and confused. GCS was; 12. There is tachycardia during heart auscultation. The
initial ECG tracing was done on the alcohol toxicity presentation showing sinus
tachycardia with
34. significant ST-segment depressions in both inferior (II, III, and aVF) and
anterior leads (V1-6) with VR; 102 bpm (Figure 6A). Oxygen inhalation
(5 L/min) with an O2 generator was given. The patient had gradually
become calm with clear improvement in the respiratory status. The last
ECG tracing was taken within 80 minutes of O2 inhalation showing
NSR with VR of 60 beats/min and the disappearance of above ST-
segment depressions (Figure 6B). The troponin test was negative. Chest
CT was done within 3 days post-presentation showing no abnormality
detected. Later echocardiography was normal with an EF of 61%.
Abdominal ultrasound showed severe liver cirrhosis. Dramatic response
to the above ST-segment depressions after O2 inhalation had occurred
(Elsayed YMH et al., 2021).
35. Figure 6: Initial ECG tracing (6A); ECG of the ED presentation showing sinus tachycardia with significant ST-segment
depressions in both inferior (lime arrows; II, III, and aVF) and anterior leads (blue arrows; V1-6) with VR; 102 bpm. The
second ECG tracing (6B) was done within 80 minutes of O2 inhalation showing NSR with VR of 60 bpm and the disappearance
of above ST-segment depressions.
37. Over-merriment inducing PVCs and CAS
A 45-year-old married male, a football fan workless patient presented to the
POC with palpitations, severe ischemic chest pain, and dizziness. Symptoms had
happened just after the end of the match and the gain of his team. The patient is a
heavy smoker. Upon examination, the patient appeared anxious, sweaty, and
irritable. An irregular tachycardia was noted on heart auscultation. The initial ECG
tracings showed sinus tachycardia with variable irregular premature ventricular
contractions (PVCs) and ST-segment depressions in anterior leads (V2-6) of VR;
104 bpm (Figure 7A and Figure 7B) The patient was initially managed with O2
inhalation (5 L/min) on an O2 generator using a nasal cannula for about 20 minutes
was given. The ECG tracing was repeated after the set of O2 inhalation that
showed the disappearance of the above abnormalities (Figure 7C).
Echocardiography showed grade-I diastolic dysfunction and mild dilatation in the
left atrium with an EF of 61% (Elsayed YMH et al., 2021).
38. Figure 7: 7A. and 7B. ECG tracings were done upon arrival in the POC showing sinus tachycardia with variable irregular PVCs at
VR; 104 (red, orange, and purple arrows) with ST-segment depressions in anterior leads (V2-6) (lime arrows). 7C. ECG
tracing was done after the set of O2 inhalation that showed the disappearance of the above abnormalities with slight sinus
bradycardia of VR 56 beats/min.
40. Mimic HL-STEMI in chest tetany with mirror ECG change,
Movable phenomenon (Yasser’s phenomenon), and CAS
A 54-year-old married farmer Egyptian heavy smoker male patient presented to
the POC with acute severe chest pain, carpopedal spasm, tachypnea, and
palpitations. Numbness and paraesthesia in both extremities and perioral area were
associated symptoms. He described the chest pain as a twisting agonizing pain. He
gave a recent history of marked psychological stress. Upon general physical
examination; generally, the patient was tachypneic and distressed. The patient was
treated at the POC with was treated with O2 inhalation by O2 cylinder (100%, by
nasal cannula, 5L/min). Ionized calcium was mildly low; 0.65 mmol/L. The
troponin test had become negative. Serial ECG tracings were done. The initial
ECG was done on presentation showing NSR of VR; 96 bpm with ST-segment
elevations, pathological Q, and T-wave inversion in high lateral leads (I and aVL).
41. a wavy triple sign or Yasser’s of hypocalcemia in V1-6 leads. There are
also ST-segment depressions in inferior leads (II, III, and aVF; dark blue
arrows) (Figure 8A). ECG tracing was taken within 40 minutes of the
first ECG tracing and 20 minutes of O2 inhalation showing normalization
of above Wavy triple sign of hypocalcemia and ST-segment depressions.
But there is a reversal of pathological Q, in I and aVL leads to be S-
waves and normalization of ST-segment elevations in the same leads with
NSR of VR 67 (Figure 8B). Within 40 minutes of the above
management, the patient finally showed nearly complete clinical and
ECG improvement. Then, 2 Ca gluconate ampoules (10ml 10%) over IV
over 20 minutes was given (Elsayed YMH et al., 2021).
42. Figure 8: Initial ECG tracing (8A); ECG of POC presentation showing NSR of VR; 96 bpm with ST-segment elevations (red
arrows), pathological Q (lime arrows), and T-wave inversion in high lateral leads (I and aVL). There is a wavy triple sign or
Yasser’s of hypocalcemia in V1-6 leads (red, green, and light blue arrows). There are also ST-segment depressions in inferior
leads (II, III, and aVF; dark blue arrows). The second ECG tracing (8B) was done within 40 minutes of the first ECG tracing
and 20 minutes of O2 inhalation showing normalization of above Wavy triple sign of hypocalcemia and ST-segment depressions.
But there is a reversal of pathological Q in I and aVL leads to be S- waves and normalization of ST-segment elevations in the
same leads with NSR of VR; 67.
44. Fear-inducing CAS in an asthmatic patient with RBBB
A 65-year-old married housewife Egyptian female asthmatic patient presented with her jokey
son to the POC for cardiovascular follow-up. Upon general physical examination; generally, the
patient was good, not distressed. There were no wheezes on chest examination. The initial ECG
tracing was done on the presentation for follow-up showing RBBB with NSR of VR of 70 with
movable artifact (in V1 lead) (Figure 9A). During the ECG procedure, her jokey son told her; that
ECG may be causing electrical shock for her. The mother urgently started to sense severe acute
chest pain. The second ECG tracing was done within one minute of the initial ECG and after
inducible fear, post-above drama showed NSR of VR; 82 with RBBB and ST-segment depression
in both inferior (III and aVF) and anterior (V2-6) leads (Figure 9B). The patient was urgently
managed with O2 inhalation by O2 cylinder (100%, by nasal cannula, 5L/min) and reassurance.
Her son was prevented to be present during doing the third ECG tracing which was done within
15 minutes of O2
45. inhalation and after reliving the chest pain showing NSR of VR; 74,
normalization of the above ST-segment depression, and still the presence
of RBBB (Figure 9C). The troponin test was negative.
Echocardiography was normal with an EF of 67% (Elsayed YMH et al.,
2021).
46. Figure 9; Initial ECG tracing (9A)- ECG of the POC presentation showing NSR of VR; 70 bpm with RBBB (red arrows).
There is a movable artifact in the V1 lead (blue arrows). The second tracing (9B) was done within one minute of the initial
ECG and after inducible fear showing NSR of VR; 82 with RBBB (red arrows), and ST-segment depression in both inferior (III
and aVF; blue arrows ) and anterior (V2-6; lime arrows) leads. The third tracing (9C) was done within 15 minutes of O2
inhalation showing NSR of VR; 74 bpm, normalization of the above ST-segment depression, and still the presence of RBBB (red
arrows).
48. Indomethacin-inducing CAS in an elder osteoarthritic
patient
A 70-year-old widow housewife Egyptian female patient presented to the POC with acute
anginal chest pain after psychological stress. The patient gave a history of osteoarthritis since 15
years ago. She has a recent history of sporadic different doses of indomethacin. Upon general
physical examination; generally, the patient was irritable and distressed. She appeared obese. The
initial ECG tracing was done on the presentation showing NSR of VR; 62 bpm with ST-segment
depression in both inferior (II and aVF) and anterior (V2-6) leads (Figure 10A). The physician
had urgently managed the patient with O2 inhalation by O2 cylinder (100%, by nasal cannula,
5L/min) and reassurance. The second ECG tracing which was done within 20 minutes of O2
inhalation showed NSR of VR; 60 bpm and normalization of the above ST-segment depression
(Figure 10B). The CBC was within normal. RBS was normal (98 mg/dl). The troponin test was
negative. Echocardiography showed an atherosclerotic aortic valve with no significant systolic
gradient, trivial mitral regurgitation, and diastolic dysfunction with reversed E/A ratio, with an EF
of 56%.
49. Figure 10; Initial ECG tracing (10A); ECG of the ED presentation showing NSR of VR; 62 bpm with ST-segment depression
in both inferior (II and aVF; green arrows ) and anterior (V2-6; orange arrows) leads. There is a tremor artifact in limb leads
(brown arrows). The second tracing (10B) was done within 20 minutes of O2 inhalation showing NSR of VR; 60 bpm and
normalization of the above ST-segment depression.
51. Modafinil-inducing CAS in a single student Egyptian girl
patient
A 16-year-old single student Egyptian girl patient presented to the ED with acute
anginal chest pain and palpitations. The patient gave a history of iatrogenic
swallowing modafinil tablet (200mg) for 3 hours. Upon general physical
examination; generally, the patient was agitated and distressed. The initial ECG
tracing was done on the presentation for follow-up showing sinus tachycardia of
VR; 129 bpm with ST-segment depression in high lateral (I and aVL) leads (Figure
11A). The physician had urgently managed the patient with O2 inhalation by O2
(100%, by nasal cannula, 5L/min). The second ECG tracing which was done
within 20 minutes of O2 inhalation showed NSR of VR; 90 bpm and normalization
of the above ST-segment depression with tachycardia (Figure 11B). The troponin
test was negative. Echocardiography showed no abnormality with an EF of 65%.
52. Figure 11; Initial ECG tracing (11A); ECG of the ED presentation showing sinus tachycardia of VR; 129 bpm with ST-segment
depression in high lateral (I and aVL; orange arrows) leads. The second tracing (11B) was done within 20 minutes of O2
inhalation showing NSR of VR; 90 bpm and normalization of the above ST-segment depression.
54. Table 2: Summary of the History, Clinical, and Management Data for the Study Cases.
Case No. Age Sex The main
complaint
BP
mg Hg
Pulse
bpm
Occupation RR O2 Sat.
%
Associated RF Final diagnosis O2 dose (l/m) /
Duration/min
Outcome
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
14
36
11
11
67
45
54
65
70
16
60
50
65
49
47
53
22
M
F
F
F
M
M
M
F
F
F
F
F
M
F
F
M
F
Syncope
Chest pain
Chest pain
Chest pain
Chest pain
Palpiations
Chest pain
Chest pain
Chest pain
Chest pain
Chest pain
Tachypnea
Chest pain
Tachypnea
Tachypnea
Chest pain
Tachypnea
100/70
110/70
100/60
110/80
110/70
150/90
150/90
110/70
140/80
100/80
100/60
100/70
140/80
100/80
100/80
130/70
130/70
140
100
144
120
120
100
104
74
64
130
112
80
120
83
98
83
107
Student
Housewife
Student
Student
Farmer
Workerless
Farmer
Housewife
Housewife
Student
Housewife
Gov. officer
Worker
Housewife
Teacher
Security man
Gov. officer
12
20
44
24
34
18
32
16
19
20
18
26
20
22
23
25
28
89
94
87
90
89
97
96
97
96
98
95
97
99
97
95
97
98
Closed hot bathroom
Ketoprofen
Hypothyroidism
Closed hot bathroom
Asthmatic
Smoking-footballfan
Smoking -Stress
Asthmatic-RBBB
Stress
Stress
Obesity
Stress
Smoking -Stress
Stress- Obesity
Stress
Smoking
Caffeine
CO toxicity
K Z1 syndrome
CO toxicity
CO toxicity
Alcohol toxicity
Enthusiasm CAS
Tetany CAS
Stress CAS
Indomethacin CAS
Modafinil
Salbutamol
HVS CAS
AF CAS
IHVS CAS
IHVS CAS
Stress CAS
IHVS CAS
12 L/m for 20 min
5 L/m for 20 min
12 l/m for 30 min
12 L/m for 30 min
5 L/m for 80 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 15 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 20 min
5 L/m for 15 min
5 L/m for 20 min
5 L/m for 20 min
Responsive (R)
Responsive
Responsive
Responsive
Responsive
Responsive
Responsive
Responsive
Partial R
Responsive
Responsive
Responsive
Responsive
Responsive
Responsive
Responsive
Responsive
AF; Atrial fibrillation, CHB; Closed hot bathroom; F; Female, CAS; Coronary artery spasm, CO; Carbon monoxide, HVS; Hyperventilation syndrome, IHVS; Idiopathic hyperventilation syndrome,
KZ1; Kounis-Zafras type 1 syndrome, M; Male, R; Response, RBBB; Right bundle branch block
55. Age
• Averages age; Range; 11-70 years, mean;
43.2, median; 49, Mode; 11, minimal; 11 years,
maximal; 70 years.
Sex and percentages (%)
• Female sex predominance; 64.71% (11
cases) and male sex; 35.29% (6 cases).
56. Occupation
• Occupations; housewife; 29.41% (5 cases), student; 23.53% (4 cases), farmer;
11.76% (2 cases), gov. officer; 11.76 % (2 cases), worker; 5.88% (1 case), teacher;
5.88% (1 case), security man; 5.88% (1 case), and workerless; 5.88% (1 case)
(Figure 12).
Figure 12 Pie chart presentations showing the percentage of occupation in the study
57. The main complaint
The main complaint; Chest pain; 64.71% (11 cases), tachypnea; 23.53% (4
cases), palpitations; 5.88% (1 case), and syncope; 5.88% (1 case) (Figure
13)
Figure 13; Bar chart presentation showing the main complaint in the study.
58. The associated risk factors (RF)
• The associated risk factors (RF) in the study; Female sex; 64.71% (11 cases), stress; 23.53% (4 cases), CO toxicity; 11.76%
(2 cases), smoking; 5.88% (1 case), obesity; 5.88% (1 case), bronchial asthma; 5.88% (1 case), caffeine; 5.88% (1 case),
ketoprofen; 5.88% (1 case), combined; smoking with stress; 17.65% (3 cases), stress with obesity; 5.88% (1 case), closed hot
bathroom with hyperthyroidism; 5.88% (1 case), and bronchial asthma with RBBB; 5.88% (1 case) (Figure 14)
Figure 14; Bar chart presentation showing the percentage of the associated risk factors in the study.
63. Role of hypoxia in the pathogenesis of CAS
• Role of hypoxia in the pathogenesis of CAS is pivotal and unavoidable. The
imbalance between myocardial O2 supply and demand is the key to the
development of angina pectoris.
• The exact mechanisms for CAS is still idiopathic. CAS is mostly a disease in
middle, elder-aged men, and post-menopausal women.
• Reactive O2 species degrade NO and cause vasoconstriction.
• So, oxidative stress, endothelial dysfunction, and low-grade chronic
inflammation play an important role in the pathogenesis of CAS, leading to
increased coronary SM Ca2+ sensitivity through RhoA/ROCK activation and
resultant hypercontraction.
• A reduced O2 supply to the heart causes coronary vasodilatation (VD).
64. • However, if there are severe and prolonged hypoxia, the VD passes off and
CAS results causing a vicious circle with a further decrease of myocardial
oxygenation.
• Coronary VD is caused by a reduced O2 supply to the heart. If the hypoxia is
severe or prolonged, CAS results due to an over-decreasing of myocardial
oxygenation.
• O2 may stimulate the production of thromboxane A2 (TXA2) and decrease
the syntheses of vasoconstrictor prostaglandins (PGs); the opposite effect is
achieved with smoking due to the release of carboxyhemoglobin (COHb).
• O2 may increase TXA2 production and reduce the formation of
vasoconstrictor PGs, while smoking, due to the formation of COHb, may have
the reverse effect.
65. The dose of inhaled O2 dose that achieved the CAS
• The dose of inhaled O2 dose that achieved the CAS in this study varied from 5
to 12 liter. A maximal dose (12 minutes) was given for CO toxicity.
• The duration of inhaled O2 dose that achieved the CAS in this study varied from
15 to 80 minutes.
• Maximal duration (80 minutes) was given in CO toxicity (Table 2). This is due
to cellular hypoxia in CO toxicity that is induced by the opposition of O2 delivery.
• CO paradoxically binds hemoglobin (Hb) causing proportional practical
anemia. Due to higher binding of CO to Hb with 230-270 times more avidly than
O2. Even with small levels of CO, considerable concentrations of HbCO will exist.
• The CO concentration of 100 ppm yields a HbCO of 16% at enough
equilibration to produce a clinical presentation.
66. • The interaction of CO to Hb will rises the binding of O2
molecules at the 3 other different O2-binding sites causing a
leftward shifting in the oxyhemoglobin dissociation curve.
• The diminishing of the availability of O2 to the hypoxic
tissues will occur. O2 quickens the expulsion of COHb and
mitigates tissue hypoxia if it is comparable with air.
• Using 100 % normobaric O2 inhalation can hurry the
degradation of COHb, with an elimination t 1/2 of about 74
minutes.
67. O2 supply to the heart result in coronary VD
• The decreasing O2 supply to the heart result in coronary VD.
• However, severe or prolonged hypoxia will passes dilatation off and CAS
happen.
• A vicious circle with a moreover decrease in myocardial oxygenation is the
consequence.
• The CAS is associated with increased outflow of prostaglandin (PG)-like
material and can be prevented or reversed by inhibitors of PG synthesis such as
indomethacin or antagonists of PG action such as chloroquine.
• The CAS does not appear to be caused by TXA2 since selective inhibitors of
TXA2 synthesis enhance the hypoxic spasm and by themselves can cause CAS
even in oxygenated hearts.
68. • The mechanism may be related to the loss of negative feedback control of the PG pathway
by TXA2.
• O2 may enhance TXA2 production and reduce the formation of vasoconstrictor PGs.
• The role of CAS in many cardiac events has been reported. The paper presents a quite
different mechanism, overproduction of PGs, as the major factor in producing both the CAS and
disorders of the rhythm which often accompany it.
• Coronary VD is caused by a reduced O2 supply to the heart. If the hypoxia is severe or
prolonged, CAS results, leading to a further reduction of myocardial oxygenation.
Relevant studies
• Unfortunately, there are no available relevant studies for alone use of O2 inhalation in CAS.
70. • The Coronary Vasomotion Disorders International Study Group (COVADIS) represented
the development of international standards for the diagnostic criteria of coronary
vasomotor disorders.
• The first symposium was held on the 4-5 September 2013 and documented the criteria for
coronary artery spasm, which included the following (A) nitrate-responsive angina, (C)
transient ischaemic electrocardiogram changes, and (C) documented coronary artery
spasm.
• But in my study, these criteria will be modified to add the fourth criterion by the oxygen
inhalation in coronary artery spasm as the first initial criterion for the above three one
(Yasser's Modification or Oxygen test) (Figure 15).
71. Safety of O2 inhalation in coronary artery spasms
• Safety of O2 inhalation in coronary artery spasms obligates us to avoid us to use of
hazardous provocation testing in the diagnosis of vasospastic angina.
• This is especially if the provocative stimulus induced chest pain, transient ECG changes, and a
>90 percent constrictor response.
72. Response of coronary artery spasms to oxygen
• The complete response of coronary artery spasms to oxygen inhalation in the
current study had happened in 94.12%.
• Although the diagnosis is based on nitrate-responsive angina with associated
transient ECG changes. And despite nitrates being the mainstay of medical therapy
for CAS.
• But the side effects can’t be tolerated. Headache is the most common side effect
of nitrates. About 10% of cases are intolerant to nitrates due to disabling headaches
or dizziness.
• Nitrate-induced hypotension is common but often asymptomatic.
• Nitrates rarely cause coronary steal and IHD.
73. • Nitrate rebound may happen with experience of nocturnal anginal episodes
during intermittent therapy with nitroglycerin patches.
• Nitrates are contraindicated with concomitant use of PDE-5 inhibitors used
for the treatment of ED, as combination therapy may lead to severe hypotension and
even death.
• Chronic use of nitrates may lead to an increased mortality rate and recurrent
MI.
• However, there are some cases of CAS whose attacks cannot be controlled even
with large doses of CCBs and/or their combination with nitrates.
• A reported case of a 41-year-old man presented with attacks of CAS was
resistant to the combined given of nitrates, CCBs, and a statin. The attacks were
alleviated and disappeared after the withdrawal of nitrates and recurred after re-
administration of the NTG patch. The involvement of nitrate tolerance in the
74. The study limitations
• The study limitations were the absence of coronary catheterization and
provocation testing for the diagnosis of vasospastic angina.
76. • Dramatic clinical reliving and reversal response of ECG ST-segment
depression after O2 inhalation is an indication for its initial use in CAS.
• Yasser's Modification or Oxygen test for the past "international standards for
the diagnostic criteria of coronary vasomotor disorders" improves patient
safety and decreases the hazards of nitrate and other medications.
• Widening the research for use of the oxygen inhalation in the coronary artery
spasm will be recommended