This is a research topic carried out in the Emergency Department and the abstract was presented at the International Conference In Emergency Medicine in SanFrancisco April 2008
Association of Hypertension and Pulmonary Functions-Association between cardiac dysfunction and abnormal pulmonary function has remained controversial since long. The objective of this study is to find out the association of hypertension and its severity on pulmonary functions. Study was conducted on 30 hypertensive (study group) and 30 non hypertensive (control group) subjects identified from Medical OPD of SMS Hospital, Jaipur. Pulmonary functions were assessed of both hypertensive (study group) and non hypertensive (control group) subjects by Medspiror). Among pulmonary function tests, difference in means of FVC, FEV1 PEFR, FEF25-75%, MVV and FVC/ FEV1 were found less with significant difference in cases group with predominantly restrictive type of effects are observed. Female’s shows lower values than male hypertensive subjects. Furthermore, FVC, FEV1, PEFR, FEF25-75%, MVV, FVC/ FEV1 were not found to be associated with severity of illness. An inverse relation is found between hypertension and pulmonary functions predominantly restrictive type of pattern. While non significant effects are observed with severity of illness.
New class of therapeutic agents called soluble guanylate cyclase (sGC) stimulators.
Impairment of NO synthesis and signaling through the NO-sGC–cGMP pathway is involved in the pathogenesis of pulmonary hypertension.
Dual mode of action,
Directly stimulating sGC independently of NO, and
Increasing the sensitivity of sGC to NO.
vasorelaxation , antiproliferative and antifibrotic effects
Copeptin as a Novel Biomarker in the Diagnosis of Acute Myocardial Infarction...Premier Publishers
To evaluate the diagnostic value of Copeptin as a novel biomarker in early diagnosis of Acute Myocardial Infarction. 56 patients with acute Myocardial Infarction (STEMI) and 25 healthy controls who were admitted to the Cardiology and Clinical Pathology Departments, national heart institute (NHI) from October 2015 to April 2016. The kit used a double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA) to assay the level of Human Copeptin in samples. As regard copeptin, the median range of copeptin level was 242.5pg/ml in patient group and 75pg/ml in control group. The comparative study between the two groups shows a significant difference (p < 0.05) Conclusion: Copeptin is a reliable diagnostic tool in patients with AMI (STEMI) with sensitivity 85.7%, specificity 86.7%, PPV 96% and NPV 61.9%.
Jonathan Corren, MD, discusses asthma management in this CME activity titled "Targeted Treatment in Severe Asthma: Moving Toward Precision Medicine." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2It37Pk. CME credit will be available until June 3, 2019.
Association of Hypertension and Pulmonary Functions-Association between cardiac dysfunction and abnormal pulmonary function has remained controversial since long. The objective of this study is to find out the association of hypertension and its severity on pulmonary functions. Study was conducted on 30 hypertensive (study group) and 30 non hypertensive (control group) subjects identified from Medical OPD of SMS Hospital, Jaipur. Pulmonary functions were assessed of both hypertensive (study group) and non hypertensive (control group) subjects by Medspiror). Among pulmonary function tests, difference in means of FVC, FEV1 PEFR, FEF25-75%, MVV and FVC/ FEV1 were found less with significant difference in cases group with predominantly restrictive type of effects are observed. Female’s shows lower values than male hypertensive subjects. Furthermore, FVC, FEV1, PEFR, FEF25-75%, MVV, FVC/ FEV1 were not found to be associated with severity of illness. An inverse relation is found between hypertension and pulmonary functions predominantly restrictive type of pattern. While non significant effects are observed with severity of illness.
New class of therapeutic agents called soluble guanylate cyclase (sGC) stimulators.
Impairment of NO synthesis and signaling through the NO-sGC–cGMP pathway is involved in the pathogenesis of pulmonary hypertension.
Dual mode of action,
Directly stimulating sGC independently of NO, and
Increasing the sensitivity of sGC to NO.
vasorelaxation , antiproliferative and antifibrotic effects
Copeptin as a Novel Biomarker in the Diagnosis of Acute Myocardial Infarction...Premier Publishers
To evaluate the diagnostic value of Copeptin as a novel biomarker in early diagnosis of Acute Myocardial Infarction. 56 patients with acute Myocardial Infarction (STEMI) and 25 healthy controls who were admitted to the Cardiology and Clinical Pathology Departments, national heart institute (NHI) from October 2015 to April 2016. The kit used a double-antibody sandwich enzyme-linked immune-sorbent assay (ELISA) to assay the level of Human Copeptin in samples. As regard copeptin, the median range of copeptin level was 242.5pg/ml in patient group and 75pg/ml in control group. The comparative study between the two groups shows a significant difference (p < 0.05) Conclusion: Copeptin is a reliable diagnostic tool in patients with AMI (STEMI) with sensitivity 85.7%, specificity 86.7%, PPV 96% and NPV 61.9%.
Jonathan Corren, MD, discusses asthma management in this CME activity titled "Targeted Treatment in Severe Asthma: Moving Toward Precision Medicine." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2It37Pk. CME credit will be available until June 3, 2019.
Mechanical Ventilation of Patient with COPD ExacerbationDr.Mahmoud Abbas
Mechanical Ventilation of Patient with COPD Exacerbation lecture presented by Dr Andres Esteban at the Egyptian Critical care Summit 2015 held at Cairo, egypt.
The Egyptian Critical Care Summit is the leading medical event and exhibition for Intensive Care Medicine in Egypt.
Background: Chronic Obstructive pulmonary disease (COPD) is an increasing cause of morbidity and mortality world-wide. MMP 9 is an acute phase reactant secreted by the liver in response to infection, inflammation or tissue damage. Methods: This case-control study was conducted on 35 healthy controls and 40 COPD patients at a tertiary care hospital in north India. MMP 9 levels were measured in serum by ELISA Kit. Results: The present study showed that mean MMP 9 levels in serum was significantly higher in COPD group as compared to control group (p<0.0001) and the levels increased with the increasing severity of the disease. Conclusion: Our study confirms that MMP 9 levels were significantly higher in COPD patients as compared to controls and their levels increased with the increasing severity of the disease. Measuring MMP 9 levels in combination with other biochemical markers can be helpful in monitoring disease outcome and management of the disease. Key-words- COPD, MMP 9, Inflammation, Matrix metalloproteinases (MMPs)
Mechanical Ventilation of Patient with COPD ExacerbationDr.Mahmoud Abbas
Mechanical Ventilation of Patient with COPD Exacerbation lecture presented by Dr Andres Esteban at the Egyptian Critical care Summit 2015 held at Cairo, egypt.
The Egyptian Critical Care Summit is the leading medical event and exhibition for Intensive Care Medicine in Egypt.
Background: Chronic Obstructive pulmonary disease (COPD) is an increasing cause of morbidity and mortality world-wide. MMP 9 is an acute phase reactant secreted by the liver in response to infection, inflammation or tissue damage. Methods: This case-control study was conducted on 35 healthy controls and 40 COPD patients at a tertiary care hospital in north India. MMP 9 levels were measured in serum by ELISA Kit. Results: The present study showed that mean MMP 9 levels in serum was significantly higher in COPD group as compared to control group (p<0.0001) and the levels increased with the increasing severity of the disease. Conclusion: Our study confirms that MMP 9 levels were significantly higher in COPD patients as compared to controls and their levels increased with the increasing severity of the disease. Measuring MMP 9 levels in combination with other biochemical markers can be helpful in monitoring disease outcome and management of the disease. Key-words- COPD, MMP 9, Inflammation, Matrix metalloproteinases (MMPs)
Successful management of massive intra-operative pulmonary embolism Apollo Hospitals
Acute Pulmonary Embolism has a high rate of mortality (26%) due to blockade of the pulmonary artery leading to acute increase in right ventricular pressure causing sudden cardiac decompensation. Lack of specific tests for early diagnosis is one of the causes for high rate of mortality but timely diagnosis and active intervention can save the life of the patient.
Presentation of Dr. Lluis Blanch at 10th Pulmonary Medicine Update Course, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
NT-proBNP as a tool to stratify disease severity in pulmonary arterial hypert...Dra. Mônica Lapa
Summary The recent development of treatment modalities for patients with
idiopathic pulmonary arterial hypertension has been based on the evaluation of
many different markers such as functional capacity, addressed by NYHA classification, six-minute walk test (6 MWT) and hemodynamic parameters. The aim of this
study was to evaluate the correlation of N-terminal fragment (NT-proBNP) with other
markers in IPAH and its potential for patient stratification.
We studied 42 IPAH patients consecutively evaluated through right heart
catheterization in the absence of any specific treatment for pulmonary hypertension. Blood samples, clinical evaluation and 6 MWF distance were collected at
baseline.
The levels of NT-proBNP showed a high correlation with hemodynamic
parameters, such as pulmonary vascular resistance (r ¼ 0:80, Po0.001). A significant
difference was found among patients with different functional classes, addressed by
NYHA classification (Po 0.02 for all groups comparison). The discriminant analysis
reinforced the ability of NT-proBNP to stratify patients according to NYHA functional
class. Compared to the other variables studied (hemodynamics and 6 MWT), NTproBNP had the lowest level of overlap in the stratification of IPAH patients.
We conclude that NT-proBNP differs among the different functional classes and
correlates with other measures of disease severity, although its role in predicting
survival still needs to be addressed.
1. A STUDY ON THE USE OF CAPNOMETRY IN ACUTE DYSPNEIC PATIENT IN EMERGENCY DEPARTMENT HOSPITAL UNIVERSITI SAINS MALAYSIA 12TH. INTERNATIONAL CONFERENCE ON EMERGENCY MEDICINE SAN FRANCISCO, USA 3RD - 6TH APRIL 2008 AF Mamat (MD,MMed) 1, R Ahmad 2 (MD, Mmed) Nik HNA Rahman 3 (MBChB, MMed) (Emergency Physicians) 1 Accident & Emergency Department, Hospital Kuala Lumpur 2Lecturer in Emergency Medicine, Hospital Universiti Sains Malaysia 3 Head of Department of Emergency Medicine, Hospital Universiti Sains Malaysia Hospital Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia. Tel: 00609-766 3000, Fax: 00609-765 3370 Email: nhliza@hotmail.com
14. RESULTS 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80-90 Age group (years) Percentage mean age of 54.19 and SD of 17.38 years There were 100 males (66.7%) and 50 females (33.3%) in this study
15. Hypertension Heart disease Asthma/COAD Diabetes mellitus None Types of premorbid condition Percentage Percentage Red Yellow Green (Triage Category) RESULTS
23. REFERENCES Barton C.W & Wang ESJ. (1994). Correlation of End Tidal CO 2 measurements to arterial PaCO2 in non intubated patients. Annals of Emergency Medicine 23, 145 Chan KL, Chan MT & Gin T (2003). Mainstream vs. sidestream capnometry for prediction of arterial carbon dioxide tension during supine craniotomy. Anaesthesia 58, 149-155 Ferrin MS & Tino G (1997). Acute dyspnea. AACN Clin Issues 8, 398-410 G scano & Ambrosian N (2002). Pathophysiology of dyspnea. Lung 180 Ingram RH (1987). Effects of airway versus arterial CO 2 changes on lung mechanics. J Appl Physiol, 603-608 Raemer D Francis D & Philip J (1983). Variation in PCO 2 between arterial blood and peak expired gas during anaesthesia. Anaesth Analg 62, 1065-1069 Sanders AB (1989). Capnometry in emergency medicine. Ann Emerg Med 18, 1287-1290