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PATIENT CASE
A femalepatients/p a complicated ear surgery yearsago thatlefther with a perforated tympanicmembrane. Patientissufferingfrom
multiple,chronic earinfection with purulent,serousandsometimes sangereous discharge. Shehas been treated over theyears with
multiplecoursesof anti-infectiveagentssuch asCiprodexHC,gentamicin,ofloxacin,compounded CSF powders(Look up to seeso you
knowwhatthis compound is). Hestated thattheCSF powders throughan insufflatorhelped dry up thedischargefor a fewdays beforeshe
runs outof themed and the dischargecomesback full blown.
The ENT doctor is requestingfor compoundingsuggestionsto help thispatient. Heoriginally suggested Ampho Bsteriledrop; however,
patientwas toldduringthevisitthather infection may notbefungal.Sinceher tympanicmembraneiscompletelyperforated, I don'tthink
a drop would bethebestoption for her.
Whatwould you suggestto thedoctor? Whatform? Whataretheorganismsgenerally associated with thistypeof condition?
Perforated Tympanic Membrane and Chronic Ear Infection
Patientcase:
 Perforated tympanicmembranewith multiple,chronicear infectionwith purulent,serous,and sometimessanguineous(presence
of blood) discharge.
 PMH: CiprodexHC,Gentamicin,Ofloxacin,compounded CSF power throughinsufflator (blowingdevice) with positiveeffectbut
dischargecameback full blown after discontinuing CSF
 Duringthelastcheckup,her infection may notbefungal.
Chronicotitismedia:
 Definition =tympanic membraneperforation with chronic inflammation of themiddleear and persistentotorrhea.
 Organism:
o Bacteria:mostcommon areP.aeruginosaandS.aureus.Also H.influenzae,M.catarrhalis
o Fungal:Candida(Thrush)
o Viral:Herpes
 Treatmentdepends upon thestageof disease
 If activeinfection presentin theformof ear drainage,antibiotic eardropsare prescribed.Occasionally,thesemaybe
supplemented with oral antibiotics
 Oncethe activeinfection iscontrolled,surgery isusually recommended (tympanoplasty,mastoidectomy,typanomastoidectomy)
o Goal of medication therapy =control dischargeandinfection
 Treatmentin the absenceof systemicinfection or seriousunderlyingdisease accordingto literatures:
o Topical quinolones antibioticsclearaural dischargebetter than no drugtreatment
o Topical quinolones werebetter than topical antiseptics(Burrow’ssolution,Betadine(povidone-iodine,and boricacid) at
clearingaural discharge
o Topical therapy withnon-quinoloneantibioticsappearsto work butresultisinconsistent.
o Topical quinoloneantibioticscanclearaural dischargebetter atoneor two weeks than systemicquinoloneor systemic
non-quinoloneantibiotics
o WHO recommended topical quinoloneantibioticswithoutadditional oral antibiotics(2004)
 Prophylaxis
o Antimicrobial prophylaxisshould bereserved for control of recurrent acuteotitis media,defined as3+distinctepisodes
per 6 months,or 4+per 12 months
o Amoxicillin20 mg/kgPO QD (children dose)
o Sulfisoxazole50 mg/kgPO QD
o Vaccination
 Pneumococcal vaccinesto reducerecurrencesof acuteotitismediainchildren older than2 year old
 Viral vaccination (flu shot) hasbeen documented to decreasetheincidentof acuteotitis media
RECOMMENDATION
Goal of themedication therapy isto control infection and dischargeuntil stablefor surgical intervention.
Sinceher pastmedical medicationshavebeen working well until thepatientrun out,weshould continuethetherapy withouttheneed of
changingto a differenttherapy.
Literature-supported topical antibiotics =Ciprofloxacin,Ofloxacin
Some availableoptions
 Commercial:
o Ciprofloxacin0.2%solution
o Ciprodex (ciprofloxacin 0.3%and dexamethasone0.1%)
o Cipro HC (ciprofloxacin 0.2%and hydrocortisone1%)
o Ofloxacin0.3%solution
 Compound:
o Ciprofloxacin1%otic drop
o Clotrimazole/gentamicin oticsolution
o Clotrimazole/boricacid otic powder
o Ketoconazole1%otic solution
o Otic insufflation CSF powder (chloramphenicol,sulfanilamidepowder,Amphotericin B,hydrocortisone)
Vaccination prophylaxis:Flu shot, pneumococcal shot
Avoid CortisporinHC (Neomycin,polymycinB) as itisonly forouter ear bacterial infection
Reference
1. WrightD,Safranek S.Treatmentof OtitisMediawith Perforated Tympanic Membrane.2009.AmFamPhysician.79(8):650-654
http://www.aafp.org/afp/2009/0415/p650.html
2. Morden NE, BerkeEM. Topical Fluoroquinoonesfor Eyeand Ear.AmFamPhysician200.62 (8):1870-1876
http://www.aafp.org/afp/2000/1015/p1870.html#sec-3
3. Stritch School of Medicine.OtitisMedia. www.meddean.luc.edu/lumen/meded/mech/cases/case22/ottitis.htm
4. University of Maryland Medical Center.Ear Infection. http://umm.edu/programs/hearing/services/ear-infections
5. University Hospital Southhamptom.EarInfection.
http://www.uhs.nhs.uk/Media/Controlleddocuments/Patientinformation/Earnoseandthroat/Ear-infection-patient-
information.pdf
6. CompoundingDocsPharmacy. https://www.compoundingdocs.com/s_ENT_main.html

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OTITIS MEDIA

  • 1. PATIENT CASE A femalepatients/p a complicated ear surgery yearsago thatlefther with a perforated tympanicmembrane. Patientissufferingfrom multiple,chronic earinfection with purulent,serousandsometimes sangereous discharge. Shehas been treated over theyears with multiplecoursesof anti-infectiveagentssuch asCiprodexHC,gentamicin,ofloxacin,compounded CSF powders(Look up to seeso you knowwhatthis compound is). Hestated thattheCSF powders throughan insufflatorhelped dry up thedischargefor a fewdays beforeshe runs outof themed and the dischargecomesback full blown. The ENT doctor is requestingfor compoundingsuggestionsto help thispatient. Heoriginally suggested Ampho Bsteriledrop; however, patientwas toldduringthevisitthather infection may notbefungal.Sinceher tympanicmembraneiscompletelyperforated, I don'tthink a drop would bethebestoption for her. Whatwould you suggestto thedoctor? Whatform? Whataretheorganismsgenerally associated with thistypeof condition? Perforated Tympanic Membrane and Chronic Ear Infection Patientcase:  Perforated tympanicmembranewith multiple,chronicear infectionwith purulent,serous,and sometimessanguineous(presence of blood) discharge.  PMH: CiprodexHC,Gentamicin,Ofloxacin,compounded CSF power throughinsufflator (blowingdevice) with positiveeffectbut dischargecameback full blown after discontinuing CSF  Duringthelastcheckup,her infection may notbefungal. Chronicotitismedia:  Definition =tympanic membraneperforation with chronic inflammation of themiddleear and persistentotorrhea.  Organism: o Bacteria:mostcommon areP.aeruginosaandS.aureus.Also H.influenzae,M.catarrhalis o Fungal:Candida(Thrush) o Viral:Herpes  Treatmentdepends upon thestageof disease  If activeinfection presentin theformof ear drainage,antibiotic eardropsare prescribed.Occasionally,thesemaybe supplemented with oral antibiotics  Oncethe activeinfection iscontrolled,surgery isusually recommended (tympanoplasty,mastoidectomy,typanomastoidectomy) o Goal of medication therapy =control dischargeandinfection  Treatmentin the absenceof systemicinfection or seriousunderlyingdisease accordingto literatures: o Topical quinolones antibioticsclearaural dischargebetter than no drugtreatment o Topical quinolones werebetter than topical antiseptics(Burrow’ssolution,Betadine(povidone-iodine,and boricacid) at clearingaural discharge o Topical therapy withnon-quinoloneantibioticsappearsto work butresultisinconsistent. o Topical quinoloneantibioticscanclearaural dischargebetter atoneor two weeks than systemicquinoloneor systemic non-quinoloneantibiotics o WHO recommended topical quinoloneantibioticswithoutadditional oral antibiotics(2004)  Prophylaxis o Antimicrobial prophylaxisshould bereserved for control of recurrent acuteotitis media,defined as3+distinctepisodes per 6 months,or 4+per 12 months o Amoxicillin20 mg/kgPO QD (children dose) o Sulfisoxazole50 mg/kgPO QD o Vaccination  Pneumococcal vaccinesto reducerecurrencesof acuteotitismediainchildren older than2 year old  Viral vaccination (flu shot) hasbeen documented to decreasetheincidentof acuteotitis media
  • 2. RECOMMENDATION Goal of themedication therapy isto control infection and dischargeuntil stablefor surgical intervention. Sinceher pastmedical medicationshavebeen working well until thepatientrun out,weshould continuethetherapy withouttheneed of changingto a differenttherapy. Literature-supported topical antibiotics =Ciprofloxacin,Ofloxacin Some availableoptions  Commercial: o Ciprofloxacin0.2%solution o Ciprodex (ciprofloxacin 0.3%and dexamethasone0.1%) o Cipro HC (ciprofloxacin 0.2%and hydrocortisone1%) o Ofloxacin0.3%solution  Compound: o Ciprofloxacin1%otic drop o Clotrimazole/gentamicin oticsolution o Clotrimazole/boricacid otic powder o Ketoconazole1%otic solution o Otic insufflation CSF powder (chloramphenicol,sulfanilamidepowder,Amphotericin B,hydrocortisone) Vaccination prophylaxis:Flu shot, pneumococcal shot Avoid CortisporinHC (Neomycin,polymycinB) as itisonly forouter ear bacterial infection Reference 1. WrightD,Safranek S.Treatmentof OtitisMediawith Perforated Tympanic Membrane.2009.AmFamPhysician.79(8):650-654 http://www.aafp.org/afp/2009/0415/p650.html 2. Morden NE, BerkeEM. Topical Fluoroquinoonesfor Eyeand Ear.AmFamPhysician200.62 (8):1870-1876 http://www.aafp.org/afp/2000/1015/p1870.html#sec-3 3. Stritch School of Medicine.OtitisMedia. www.meddean.luc.edu/lumen/meded/mech/cases/case22/ottitis.htm 4. University of Maryland Medical Center.Ear Infection. http://umm.edu/programs/hearing/services/ear-infections 5. University Hospital Southhamptom.EarInfection. http://www.uhs.nhs.uk/Media/Controlleddocuments/Patientinformation/Earnoseandthroat/Ear-infection-patient- information.pdf 6. CompoundingDocsPharmacy. https://www.compoundingdocs.com/s_ENT_main.html