A quick review of OCT-A, Technology and abilities

1. OCT-Angiography
By Optovue
A Quick Review
Science and Technology
Abilities
Advances
M. Taherolghalb
Technical and Application Department
Fajr Shahed Co.

2. Financial Disclosure
I have the following financial interests or
relationships to disclose:
Mehdi Taherolghalb has a significant financial
interest in Optovue a company that has a
commercial interest in the market of ophthalmic
devices.

3. About Company
Incorporated in December 2003
Located in Fermont, California, USA
Optovue Founded to develop the next generation ophthalmic
diagnosis instrument based on the Fourier-Domain OCT
technology

4. RTVue XR (Avanti)
Widefield Enface OCT

5. RTVue XR (Avanti)
General Specs
OCT Camera : 70,000 A-SCAN/SECOND
Optical Resolution: (in tissue)
Depth:5.0μm
Beam Spot Size: 22μm
Image Sampling Rate:
Depth: 3.0μm Digital Resolution
Scan Range:
Depth: ~3mm
Transverse: 2mm to 12mm
Scan Beam Wavelength:840±10nm
Exposure Power at pupil: 750μW maximum
Patient Interface:
Working Distance: 22mm
Motorized Focus Range: -15D to +20D

6.  Retina Module:
◦ Line Scans
◦ Retinal Map
◦ 3Dv Retina
◦ Raster (3 Tipes)
◦ Angiovue Retina
◦ Widefield scans w/ MCT
RTVue XR (Avanti)

7.  Glaucoma Module:
◦ ONH Scan
◦ 3D Disk
◦ GCC Scan
◦ Angiovue Disk Scan
RTVue XR (Avanti)

8.  Cornea Module:
◦ Line Scans
◦ 3D Cornea Modeling
◦ Pachymetry w/ Crpw
◦ Angle Measurement
RTVue XR (Avanti)

9. RTVue XR (Avanti)
Innovations
TCP: Total Corneal Power

10. RTVue XR (Avanti)
Innovations
TCP: Total Corneal Power

11. RTVue XR (Avanti)
Innovations
Epithelial Mapping
Keratoconus Management
• Epithelial thickness may be an important parameter
in the early detection of keratoconus diagnosis and
progression2
• ETM™ provides an efficient way to quantify epithelial
thickness and to track change between visits
Refractive Surgery Planning
• An abnormal epithelium may interfere with
Scheimpflug imaging, which could bias refractive
surgery outcomes3
• ETM provides new information on the distribution of
epithelial thickness that may improve visual
outcomes3

12. RTVue XR (Avanti)
Innovations
Epithelial Mapping

13. RTVue XR (Avanti)
Innovations
GCC: Gangelion Cell Complex Analysis

14. RTVue XR (Avanti)
Innovations
GCC: Gangelion Cell Complex Analysis
Measurable GCC Loss

15. RTVue XR (Avanti)
Innovations
GCC: Gangelion Cell Complex Analysis
FLV: Focal Loss Volumes
GLV:Global Loss Volume
FLV and GLV are most reliable parameters for very early
glaucoma detection

16. RTVue XR (Avanti)
New Approach to Micro Vascular Detection
Imaging Individual Layers of the Retina in a Fast and
Non-Invasive Way

17. RTVue XR (Avanti)
What is the technology/science
behind AngioVue
Two key IP protected technologies allow for
OCTA to be used in the daily clinical practice
1) SSADA (Split Spectrum Amplitude
Decorrelation Algorithm) from OHSU (David
Huang, PhD)
2) MCT (Motion Correction Technology) from
MIT (James Fujimoto, PhD)

18. RTVue XR (Avanti)

19. RTVue XR (Avanti)
What Is SADA?
Not for Ophthalmologists 

20. RTVue XR (Avanti)
Role of SSADA
2 repeat OCT frames
Can generate 11
decorrelation sets by
splitting the OCT spectrum
Allowing to build a 304 x 304
Angio-OCT volume in only 3 secs

21. RTVue XR (Avanti)
Role of SSADA
Without split-spectrum, 12 repeat OCT frames
would be required at each B-scan location
and a 400 kHz OCT system would be needed
to generate a 300 x 300 Angio-OCT volume in
3 seconds
Current Swept-Source OCT technology at
100KHz is then not fast enough to achieve
high-quality Angio-OCT imaging without
SSADA.

22. RTVue XR (Avanti)
Role of MCT
MCT corrects the almost inevitable saccade artifact, thereby significantly
improving the image quality and optimizing clinical interpretation.
Fast X Fast Y Merged

23. RTVue XR (Avanti)
Without MCT

24. RTVue XR (Avanti)
What About Numbers?
Maps?
Tables?
Angio Analytics
First Step in Quantified Angiography

25. RTVue XR (Avanti)
Advances
• Non-Perfusion Area Measurement
• Vessels Area Density
• Neovascularization Area Detection &
Measurement

26. RTVue XR (Avanti)
Non-Perfusion Area Measurement

27. RTVue XR (Avanti)
Vessels Area Density

28. RTVue XR (Avanti)
Neovascularization Area Detection &
Measurement
En face outer retina layer

29. RTVue XR (Avanti)
Neovascularization Area Detection &
Measurement
Extracted vessels
Net area = 0.31 mm2

30. RTVue XR (Avanti)
Neovascularization Area Detection &
Measurement
Vessel area density map

31. RTVue XR (Avanti)
Montage

32. Future Advances Are Coming
( Software Upgrade )
3D Microvascular Visualisation
Wider Areas and Lines
RTVue XR (Avanti)

33. Thank you for your attention.