Intelliaxis-L capsular marks provided excellent alignment of toric IOLs, with a surgical misalignment of only 0.74° ± 0.58° in 77 eyes. After 3 months, misalignment increased slightly to 3.00° ± 3.99°, around half the errors reported in literature. Capsular marks were more reproducible, sharper, and closer to the IOL plane than corneal marks, improving precision of toric IOL alignment. Capsular marks were still visible in only 21% of eyes after 3 months.
SPOTLIGHT ON THE PREMIUM CHANNEL – AcuFocusHealthegy
Presentation from OIS@ASCRS 2016
Nick Tarantino, OD, Chief Global Clinical & Regulatory Affairs Officer
Video Presentation:
https://www.youtube.com/watch?v=Nc4T9u62rBQ&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=34
Presentation from OIS@ASCRS 2016
Dave Van Meter, President & CEO
Video Presentations:
https://www.youtube.com/watch?v=aisY-FTnTyM&index=26&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNEL - AlconHealthegy
Presentation from OIS@ASCRS 2016
Seba Leoni, VP & Global Head, Surgical Suite
Video Presentation:
https://www.youtube.com/watch?v=hidfQJsrV4o&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=24
Presentation from OIS@ASCRS 2016
Mark Packer, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=CWwqmEDJOhM&index=20&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
John Hendrick, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=c2J1g7HYuek&index=24&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
SPOTLIGHT ON THE PREMIUM CHANNEL - Abbott Medical OpticsHealthegy
Presentation from OIS@ASCRS 2016
Leonard Borrmann, Divisional VP, R&D
Video Presentation:
https://www.youtube.com/watch?v=02VOUB17Xp8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=38
Presentation from OIS@ASCRS 2016
Rajesh K. Rajpal, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=Wbq-D5kwMUk&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=39
SPOTLIGHT ON THE PREMIUM CHANNEL – AcuFocusHealthegy
Presentation from OIS@ASCRS 2016
Nick Tarantino, OD, Chief Global Clinical & Regulatory Affairs Officer
Video Presentation:
https://www.youtube.com/watch?v=Nc4T9u62rBQ&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=34
Presentation from OIS@ASCRS 2016
Dave Van Meter, President & CEO
Video Presentations:
https://www.youtube.com/watch?v=aisY-FTnTyM&index=26&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNEL - AlconHealthegy
Presentation from OIS@ASCRS 2016
Seba Leoni, VP & Global Head, Surgical Suite
Video Presentation:
https://www.youtube.com/watch?v=hidfQJsrV4o&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=24
Presentation from OIS@ASCRS 2016
Mark Packer, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=CWwqmEDJOhM&index=20&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
John Hendrick, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=c2J1g7HYuek&index=24&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
SPOTLIGHT ON THE PREMIUM CHANNEL - Abbott Medical OpticsHealthegy
Presentation from OIS@ASCRS 2016
Leonard Borrmann, Divisional VP, R&D
Video Presentation:
https://www.youtube.com/watch?v=02VOUB17Xp8&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=38
Presentation from OIS@ASCRS 2016
Rajesh K. Rajpal, MD, Chief Medical Officer
Video Presentation:
https://www.youtube.com/watch?v=Wbq-D5kwMUk&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=39
Presentation from OIS@ASCRS 2016
Co-Moderators:
Gilbert H. Kliman, MD, Managing Director – InterWest Partners
Stephen Slade, MD
Company Presentations
Equinox | John Berdahl, MD, Founder & CEO
Presbyopia Therapies | Jim McCollum, Co-Founder
Stroma Medical | Doug Daniels, CEO
Eyenovia | Curt LaBelle, MD, Director
Wicab | Robert Beckman, President & COO
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNEL - Heidelberg EngineeringHealthegy
Presentation from OIS@ASCRS 2016 - Kester Nahen, PhD, Managing Director
Video Presentation:
https://www.youtube.com/watch?v=2MqL1-bz4JE&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=26
Strategies for better toric IOL outcomes (Apr 2018)Han Chieh Yu
Residual astigmatism after cataract surgery makes negative impact on patients’ visual acuity and contrast sensitivity. Posterior corneal astigmatism contributes to total corneal astigmatism, acting as a vector, must be considered in the toric IOL calculation. The decision to advise toric IOL to patients should depend on the estimated post-operative total astigmatism, instead of the power of anterior corneal astigmatism. Getting consistent keratometry values from one of the many instruments is essential for IOL calculation. Toric calculator should also consider the variable ratios between the toricity of the IOL and corneal plane. Intra-operative tips to avoid IOL misalignment and reorientation to correct it are discussed. A small case series utilizing prior methods, with good post-operative refractive cylinder results, will be presented.
Presentation from OIS@ASCRS 2016
Michael Onuscheck, Global Franchise Head, Alcon Surgical
Video Presentation:
https://www.youtube.com/watch?v=RxwelffneOc&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=35
Presentation from OIS@ASCRS 2016
Russ Trenary, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=xMfqxDsyA8M&index=25&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
Ike Ahmed, MD
Video Presentation:
https://www.youtube.com/watch?v=mki-y5vVGDw&index=27&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
Mike Judy, CEO
Video of Presentation:
https://www.youtube.com/watch?v=G5ZfnPKlBSY&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=13
Strategies for better toric IOL outcomes (old version, Nov 2017)Han Chieh Yu
Pre-operative biometry, toric intraocular lens (IOL) implantation techniques, and rotational stability of the IOL are all important for great visual results. Targeting post-operative astigmatism less than 0.5 diopter (D) instead of looking for pre-operative anterior corneal astigmatism that is more than 0.75 D can lead to better refractive results.
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNELHealthegy
Presentation from OIS@ASCRS 2016
Richard Lindstrom, MD
Video Presentation:
https://www.youtube.com/watch?v=HekovU6ekQU&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=27
Presentation from OIS@ASCRS 2016
Joseph Boorady, President & CEO
Video Presentaion:
https://www.youtube.com/watch?v=I_rVlB71VX4&index=32&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Dr. Breyer presents data and subjective patient reports: Patients report a more „crisp“ vision in the Fine Vision TriumF eye when compared to classical trifocal Fine Vision IOL in the other eye.
Presentation by Dr. Detlev Breyer at the World Ophthalmology Congress in Barcelona, 2018: Introduction of a new diffractive trifocal intraocular lens. Comparison with a former diffractive trifocal IOL.
Femtosecond Laser-Assisted Implantation of Toric Multifocal IOL
Based on Automated Corneal Shape Analysis –
Comparison with a Manual Technique, presented at ASCRS 2018 – by Philipp Hagen, D. Breyer, H. Kaymak, K. Klabe, T. Ax, F. Kretz, G. Auffarth
Presentation from OIS@ASCRS 2016
Co-Moderators:
Gilbert H. Kliman, MD, Managing Director – InterWest Partners
Stephen Slade, MD
Company Presentations
Equinox | John Berdahl, MD, Founder & CEO
Presbyopia Therapies | Jim McCollum, Co-Founder
Stroma Medical | Doug Daniels, CEO
Eyenovia | Curt LaBelle, MD, Director
Wicab | Robert Beckman, President & COO
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNEL - Heidelberg EngineeringHealthegy
Presentation from OIS@ASCRS 2016 - Kester Nahen, PhD, Managing Director
Video Presentation:
https://www.youtube.com/watch?v=2MqL1-bz4JE&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=26
Strategies for better toric IOL outcomes (Apr 2018)Han Chieh Yu
Residual astigmatism after cataract surgery makes negative impact on patients’ visual acuity and contrast sensitivity. Posterior corneal astigmatism contributes to total corneal astigmatism, acting as a vector, must be considered in the toric IOL calculation. The decision to advise toric IOL to patients should depend on the estimated post-operative total astigmatism, instead of the power of anterior corneal astigmatism. Getting consistent keratometry values from one of the many instruments is essential for IOL calculation. Toric calculator should also consider the variable ratios between the toricity of the IOL and corneal plane. Intra-operative tips to avoid IOL misalignment and reorientation to correct it are discussed. A small case series utilizing prior methods, with good post-operative refractive cylinder results, will be presented.
Presentation from OIS@ASCRS 2016
Michael Onuscheck, Global Franchise Head, Alcon Surgical
Video Presentation:
https://www.youtube.com/watch?v=RxwelffneOc&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=35
Presentation from OIS@ASCRS 2016
Russ Trenary, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=xMfqxDsyA8M&index=25&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
Ike Ahmed, MD
Video Presentation:
https://www.youtube.com/watch?v=mki-y5vVGDw&index=27&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Presentation from OIS@ASCRS 2016
Mike Judy, CEO
Video of Presentation:
https://www.youtube.com/watch?v=G5ZfnPKlBSY&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=13
Strategies for better toric IOL outcomes (old version, Nov 2017)Han Chieh Yu
Pre-operative biometry, toric intraocular lens (IOL) implantation techniques, and rotational stability of the IOL are all important for great visual results. Targeting post-operative astigmatism less than 0.5 diopter (D) instead of looking for pre-operative anterior corneal astigmatism that is more than 0.75 D can lead to better refractive results.
DIAGNOSTICS-IMPACT ON THE PREMIUM CHANNELHealthegy
Presentation from OIS@ASCRS 2016
Richard Lindstrom, MD
Video Presentation:
https://www.youtube.com/watch?v=HekovU6ekQU&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw&index=27
Presentation from OIS@ASCRS 2016
Joseph Boorady, President & CEO
Video Presentaion:
https://www.youtube.com/watch?v=I_rVlB71VX4&index=32&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
Dr. Breyer presents data and subjective patient reports: Patients report a more „crisp“ vision in the Fine Vision TriumF eye when compared to classical trifocal Fine Vision IOL in the other eye.
Presentation by Dr. Detlev Breyer at the World Ophthalmology Congress in Barcelona, 2018: Introduction of a new diffractive trifocal intraocular lens. Comparison with a former diffractive trifocal IOL.
Femtosecond Laser-Assisted Implantation of Toric Multifocal IOL
Based on Automated Corneal Shape Analysis –
Comparison with a Manual Technique, presented at ASCRS 2018 – by Philipp Hagen, D. Breyer, H. Kaymak, K. Klabe, T. Ax, F. Kretz, G. Auffarth
Presentation of Dr. Philipp Hagen and Dr. Detlev Breyer on the Impact of Biomechanical Indices on Visual Outcome up to Five Years after Refractive Lenticule Extraction (ReLEx) SMILE. ESCRS, Vienna 2018.
Comparison of the two treatments for Keratoconus shows: iCXL is only a treatment for grade I (and II)
Increase irradiation period: from 30 min to 40 min
- more time for oxygen diffusion
- compensates for epithelial UV-absorbance
Purpose: To evaluate the corneal volume (CV) before and after Ferrara intrastromal corneal ring segments (ICRS) implantation and its influence in clinical outcomes in keratoconus patients.
The Conclusion of the analysis was:
No consistent statistically significant dependency between postoperative regression and the considered preoperative parameters could be detected. Stability of postoperative results after ReLEx SMILE is equally good for all included cases.
Total corneal astigmatism in older adults taking into account posterior corne...Álvaro Rodríguez-Ratón
PURPOSE: To study the composition of corneal astigmatism in older adults, evaluating the difference made by the inclusion of posterior corneal astigmatism in a ray tracing calculation of total corneal astigmatism.
SETTING: Ophthalmology clinic.
METHODS: One hundred consecutive patients aged between 60 and 80 years were included in a prospective descriptive study. Their right eye was analysed by an integrated Placido disk and rotating Scheimpflug camera topographer (CSOTM Sirius). Several parameters were measured: anterior corneal astigmatism (ACA) and posterior corneal astigmatism (PCA), total astigmatism based on anterior topographic data (simK) and total corneal astigmatism (TCA) by merging anterior and posterior astigmatism using ray tracing.
RESULTS: Mean ACA was 1.51 diopters (D) and PCA was 0.38D. ACA was aligned 47% with-the-rule and PCA 87% against-the-rule. Cases with against-the-rule ACA showed low magnitude correlation between anterior and posterior surfaces. TCA had a mean deviation of 0.30D @ 3 over SimK in a vector calculation. Eighteen percent (18%) of cases differed by 0.50 D or more between SimK and TCA magnitude, and 53% had 10 or more degrees of axis discrepancy, the difference being higher at lower magnitudes of astigmatism.
CONCLUSIONS: Anterior WTR astigmatism tends to be compensated by posterior ATR astigmatism in older patients. Nevertheless, the high number of cases largely justifies the use of tomographic technology that takes into account the posterior corneal surface for managing individual total corneal astigmatism.
Comparative Study of Visual Outcome between Femtosecond Lasik with Excimer La...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
SOLIX Essential is a technology built upon a proven foundation of high-speed Spectral Domain OCT. The SOLIX Essential offers state-of-the-art imaging from the cornea to the choroid with exclusive technology that will change your approach to disease diagnosis and management.
Presentation about the 3-Years Results of a Femtosecond Laser-assisted Circular Keratotomy-Treatment of Keratoconus, Comparison with (Iontophoresis-Assisted) Corneal Crosslinking – by Dr. Detlev Breyer at the 36 Congress of the European Society of Cataract and Refractive Surgery in Vienna 2018.
The Eyestar 900 features swept-source technology, enabling precise measurement, as well as topographic assessment of the front and back corneal surface and the anterior chamber, including the lens, as well as imaging of all these structures. It also includes cornea-to-retina biometry of the entire eye.
Th e use of premium IOLs requires more specifically than standard monofocal IOLs a thorough clinical and para clinical examination using modern equipments.
We will only mention micro-incision premium IOLs that are used
in our daily practice. All information regarding the characteristics of all available and especially multifocal IOLs are available in the SFO 2012 Report on presbyopia
With regard to safety and predictability ReLEx SMILE is slightly better than Femtosecond LASIK. No overall superiority of any method. More long-term data needed
This presentation compares the 5-year-outcomes after small incision lenticule extraction and femtosecond lasik. According to the patient questionnaire, there are less dry eyes, less pain sensation and better patient comfort in ReLEx SMILE group and
ReLEx SMILE is the treatment of choice.
Das Team um Dr. Hakan Kaymak präsentierte auf der DOC 2019 neue Behandlungsergebnisse von Patienten mit CCS, die in Abhängigkeit von ihrem Befund mit dem Nanolaser behandelt wurden.
Was ist bei der Organisation der IVOM-Therapie zu beachten, um die Compliance der Patienten zu erhöhen? Das Team der Breyer, Kaymak & Klabe Augenchirurgie im MVZ unter der Leitung von Dr. Hakan Kaymak, Düsseldorf, berichtet über die wichtigsten Faktoren und Maßnahmen, die zum Erfolg führen.
Wir stellen verschiedene Tests vor um zu prüfen, ob Premiumlinsen mit Zusatzfunktionen auch für Patienten mit Makulaerkrankungen von Nutzen sind. Präsenter: Kai Neller, Breyer, Kaymak & Klabe Augenchirurgie. Co-Autoren: Svenja Nienhaus (Düsseldorf); Frank Schaeffel (Tübingen); Detlev. R. H. Breyer (Düsseldorf); Karsten Klabe (Düsseldorf); Achim Langenbucher (Homburg); Hakan Kaymak (Düsseldorf)
Kann eine Atropin-Therapie das Fortschreiten von Kurzsichtigkeit verlangsamen? Wir zeigen die 2-Jahresergebnisse der Patienten, die wir in unserer Praxis behandelt haben. Präsenter: Birte Graff, Breyer, Kaymak & Klabe Augenchirurgie, Düsseldorf. Co-Autoren: A. Fricke, Y. Mauritz, D. Breyer*, K. Klabe*, F. Schaeffel, H. Kaymak.
In dem Vortrag gehen wir der Frage nach, ob die blaulichtgetriebene Dopaminfreisetzung die Myopie hemmt und ob die dies über Melanopsin vermittelt wird. Präsenter: S. Funk. Co-Autoren: A.Fricke, D.Breyer, K. Klabe, R. Fulga, F.Schaeffel, H. Kaymak
Vortrag von Dr. Hakan Kaymak und Svenja Nienhaus beim DOC Kongress in Nürnberg 2019, 2. Teil. Von der Nanolaserbehandlung der trockenen AMD über CNV bis zur CCS.
Teil I des Vortrages von Dr. Hakan Kaymak und Svenja Nienhaus beim DOC-Kongress in Nürnberg 2019. In diesem Teil werden die Strukturen einer gesunden Makula erklärt und die Veränderungen, die bei einer hinteren Glasköperabhebung, einer VMTS, einem Makulaforamen und einer Epiretinalen Gliose etc. vorkommen. Besonderheiten der Diagnostik werden ebenso vorgestellt wie einige zur Verfügung stehende Behandlungen.
Vortrag auf der DOC 2019 von K. Neller, Dr. Hakan Kaymak u.a. über die Ursachen der Myopie bei Kindern. Diese können mittels ClouClip erfasst und beeinflusst werden. Der Clouclip wird an der Brille befestigt und misst Leseabstand, Lichtverhältnisse und andere Daten, die für die Erhebung des Myopierisikos relevant sind. Durch sein direktes Feedback bietet er die Möglichkeit, die Risiken durch Verhaltensänderungen zu reduzieren.
Dr. Karsten Klabe berichtet über die Vorteile des Kahook bei der kombinierten Katarakt-Glaukomoperation. Der Vortrag wurde im Rahmen der DOC 2019 gehalten als Beitrag zu einer aktuellen Kontroverse zu dem Thema.
Dr. Karsten Klabe stellt in seiner Präsentation, die er auf der DOC 2019 hielt, die Vorteile des Kahook dual blade bei der Trabekulektomie ab interno dar.
In seinem Vortrag, den Dr. Klabe auf der DOC 2019 hielt, erläutert er Fachärzten die Möglichkeiten moderner Diagnostik des grünen Stars, erklärt die Stadieneinteilung und die Auswirkungen der Krankheit auf die Lebensqualität des Patienten.
Dr. Detlev Breyer erklärt in seinem Vortrag auf der DOC 2019 die Vor- und Nachteile der Monovion im Vergleich zur Implantation verschiedener Multifokallinsen und beschreibt, mit welchen Verfahren eine Monovision erreicht werden kann.
Dr. Detlev Breyer hält im Rahmen der DOC 2019 in Nürnberg diesen Vortrag über seine Erfahrungen mit der Implantierbaren Kontaktlinse IPCL zur Behandlung von Alterssichtigkeit.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Alignment of Toric IOL via automated Femtosecond Laser-Assisted Capsular Marks
1. Breyer, Kaymak & Klabe Eye Surgery and Premium Eyes are Consulting, Study Center & MAB for:
Abott, Alcon, AlimeraSciences, Allergan, AMO, Bayer, Carl Zeiss Meditec, Ellex, Fluoron, Geuder, iOptics, LensAR, Medicem,
Novartis, Oculentis, Oertli, Revision Optics, Santen, Staar Surgical,
Sifi Medtech, Thea, Topcon, Visufarma, Ziemer
Alignment of Toric IOL via automated Femtosecond Laser-
Assisted Capsular Marks
Karsten Klabe, D.R.H. Breyer, H. Kaymak, P. R. Hagen, T. Ax, F.T.A. Kretz, G.U. Auffarth
Breyer, Kaymak & Klabe Eye Surgery and Premium Eyes are Consulting, Study Center & MAB for:
Abott, Alcon, AlimeraSciences, Allergan, Alkahest, AMO, Bayer, Carl Zeiss Meditec, Ellex, Fluoron,
Gesundheitsamt Rhein-Neuss-Kreis, Geuder, Glaukos, Hangzhou Classon Tec, HOYA, iOptics,
KangHong Biotec., LensAR, Medicem, Novartis, Oculentis, Oertli, OMNITM, Optos, PharmaStulln,
PhysIOL, Revision Optics, Santen, Staar Surgical, Sifi Medtech, Teleon Surgical Optics, Thea, Topcon,
Visufarma, Ziemer
2. Background: Since 6 Months LENSAR: Capsular Marks via IntelliAxis-L™
• Cassini LED Videokeratography with
simultaneous Iridography
• Data transferred to the LENSAR
• Cyclotorsion is detected by iris matching
and automatically compensated
• Pair of small opposing tabs on the
capsular rim at implantation axis as part of
laser capsulorhexis
3. Material & Methods: Advantages of Capsulotomy Marks
Corneal Marks
Capsulotomy
Marks
Caspulotomy marks are
more reproducible,
Sharper,
radially closer to IOL-marks, and
closer to IOL-plane
( smaller tilt-effect)
than corneal marks.
Precision in toric
IOL alignment
should be
increased
4. Material & Methods: Disadvantages of Caspulotomy Marks are Very Rare
Capsulotomy marks can be shifted
in case of ovalization of initially
circular capsulotomy
Only impacts axis alignment if
implantation axis is off from
elliptic deformation axes
Rare
(in our data: 1 in 77 eyes)
5. Materials and Methods - Surgeon: Breyer - Reading center: Hagen
Implanted toric IOLs:
• Oculentis: Comfort LS-313 MF15, LS-313
• Zeiss: AT LISA tri 939, AT Torbi 709M
• Alcon: SN6AT2, PanOptix
Patient-& IOL data:
• Eyes = 77
• M : F = 48% : 52%
• Plate haptic : c-loop = 90% : 10%
• Age = (60 ± 11)years
• Preop. corn. cylinder = (-1,6 ± 1,0)D
Compare
• LENSAR protocol data,
• OP microscope foto directly after surgery,
and
• slitlamp foto in mydriasis 3 months after
surgery
in order to determine surgical misalignment and
postoperative IOL rotation.
6. Capsulotomy marks easy to recognize Capsulotomy marks no longer recognizable
Case1 Case 2
??
Results: 3 Months after Surgery
Capsulotomy marks 3 months after surgery
recognizable only in 16 of 77 (21%) eyes
8. Summary: Excellent Alignment of Toric IOL with Intelliaxis-L
First n=77 Eyes:
Comparison with literature
(1 year after surgery):
Alignment errors approx. reduced by half
Alignment error due to surgery:
0.74° ± 0.58°
Misalignment after 3 months:
3.00° ± 3.99°