This document discusses local and regional innovation systems. It begins by defining key concepts like entrepreneurship, innovation, culture, and entrepreneurial culture. It then discusses why innovation systems are important by noting that innovation involves interactions between many actors. It outlines some key models of innovation systems like national and regional innovation systems. It provides stylized facts about innovation being spatially concentrated and the role of SMEs. It discusses different frameworks for analyzing innovation processes in regions. It then defines regional innovation systems as involving knowledge generation and exploitation subsystems linked to other systems. It notes some basic arguments for why regional innovation systems are important like the role of tacit knowledge and lower costs of interaction at the regional level. Finally, it discusses conditions for assessing