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Liver Transplantation  and Hepatitis C  A Clinical Update Joseph S. Galati, M.D Medical Director St. Luke’s Texas Liver Institute
Liver Transplant Evaluation Goals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Transplant Evaluation RISK BENEFIT
 
Components of the Evaluation Liver Transplant Surgery Medical evaluation Psycho-social Evaluation Financial Evaluation Nutritional Evaluation Radiology Pharmacy
Liver Transplant Evaluation Transplant Nurse Coordinator Medical Evaluation Financial evaluation Psychosocial evaluation
Evaluation for Liver Transplantation ,[object Object],[object Object],[object Object]
Medical Evaluation for Liver Transplantation Severity of Liver Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Medical Evaluation Assessment of Extrahepatic Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Evaluation for Liver Transplantation Surgical Assessment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Psycho-Social Evaluation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Evaluation for Liver Transplantation Assessment of Compliance ,[object Object],[object Object],[object Object],[object Object],[object Object]
Patients with History of Substance Abuse ,[object Object],[object Object],[object Object],[object Object],[object Object]
Psychosocial Assessment ,[object Object],[object Object],[object Object],[object Object],[object Object],I will not drink I will not smoke pot I will take my pills X___________
Survival After Liver Transplantation By Pre-Transplant Length of Abstinence
Evaluation for Liver Transplantation  Financial Assessment ,[object Object],[object Object],[object Object]
Primary Biliary Cirrhosis When to refer to OLT ? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Primary Sclerosing Cholangitis: When to refer to transplant ? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Viral Hepatitis and Liver Transplant ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Transplant Evaluation Acceptable candidate P lace on waiting  list Unacceptable candidate Able to modify negative factors Unable to modify  negative  factors Reject for liver transplant
On the “List” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Deaths on the Waiting List 1990/1995/2000 This accounts for a 25% death rate on the liver list
Cadaveric Donors, Cadaveric Transplants, and Number on Waiting List Source: Donors from OPTN data as of 9/5/00; transplants from Scientific Registry  data as of 9/5/00; snapshot of OPTN waiting list on the last day of each year. Donors Transplants Waiting List at Year’s End
Waiting List Characteristics Liver Registrants in 1999 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Graft Survival Rates by  Waiting List Status at Transplant Note: Waiting list status for 1-year survival reported for codes 1, 2A, 2B, and 3; 5-year  survival reported for codes 1, 2, 3, and 4. Source:  Scientific Registry data as of 9/5/00. 1 Year (1998 Cohort) 5 Years (1992-97 Cohort)
So…when is the proper time to refer for transplant?
Never too early

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O Lt Eval Houston Grand Rounds

  • 1. Liver Transplantation and Hepatitis C A Clinical Update Joseph S. Galati, M.D Medical Director St. Luke’s Texas Liver Institute
  • 2.
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  • 5. Components of the Evaluation Liver Transplant Surgery Medical evaluation Psycho-social Evaluation Financial Evaluation Nutritional Evaluation Radiology Pharmacy
  • 6. Liver Transplant Evaluation Transplant Nurse Coordinator Medical Evaluation Financial evaluation Psychosocial evaluation
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  • 15. Survival After Liver Transplantation By Pre-Transplant Length of Abstinence
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  • 20. Liver Transplant Evaluation Acceptable candidate P lace on waiting list Unacceptable candidate Able to modify negative factors Unable to modify negative factors Reject for liver transplant
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  • 22. Deaths on the Waiting List 1990/1995/2000 This accounts for a 25% death rate on the liver list
  • 23. Cadaveric Donors, Cadaveric Transplants, and Number on Waiting List Source: Donors from OPTN data as of 9/5/00; transplants from Scientific Registry data as of 9/5/00; snapshot of OPTN waiting list on the last day of each year. Donors Transplants Waiting List at Year’s End
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  • 25. Liver Graft Survival Rates by Waiting List Status at Transplant Note: Waiting list status for 1-year survival reported for codes 1, 2A, 2B, and 3; 5-year survival reported for codes 1, 2, 3, and 4. Source: Scientific Registry data as of 9/5/00. 1 Year (1998 Cohort) 5 Years (1992-97 Cohort)
  • 26. So…when is the proper time to refer for transplant?