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Nutrition In The
   Fast Lane
Use healthy eating habits and
 exercise to combat cancer,
 diabetes and heart disease.
Objectives
  • Discuss possible causes for cancer, diabetes and heart
    disease.

  • Identify the role of nutrition and exercise as interventions in
    preventing cancer, diabetes and heart disease.
Definition of Cancer

                              What is Cancer?

                              • Cancer is not just one disease –
                                there are hundreds of different
                                types of cancers.

                              • Cancers are mutations within
                                the genetic makeup or DNA.
   Cancer cell under attack     Once this occurs, they begin to
                                crowd out the “good cells”.
    by the immune system
Definition of Cancer
• Mutations or changes within our
  body’s cells can also occur when the
  DNA is damaged by “free radicals”
  (which can damage cells, DNA and
  proteins).

• Cancer has two major categories;
  solid tumors and hematologic
  cancers.

    Solid tumors are initially confined
     to a specific tissue on organ.
     They can shed and travel through
     the blood system.

    Hematologic tumors involve the
     blood and lymphatic system –
     enabling disease to travel fast.
Risk Factors of Cancer
                     • Heredity – genetic predisposition
                       for cancer
                     • Chemical and environmental
                       carcinogens – soot, coal tar,
                       cigarette smoke, asbestos, amyl
                       chloride arsenic, sweeteners
                       (saccharin and cyclamates),
                       smoked foods and nitrates (used
                       to smoked foods)
                     • Radiation – ultraviolet rays from
                       the sun, x-rays and radioactive
                       chemicals
                     • Growing older
                     • Poor diet
                     • Alcohol
                     • Lack of exercise and obesity
Cancer – SEER Incidence
  From 2003 – 2008, the median age of diagnosis for cancer of all sites was 66 years of age.
  Approximately 1.1% were diagnosed under age 20; 2.7% between 20 and 34; 5.6% between
  35 and 44; 14.1% between 45 and 54; 22.7% between 55 and 64; 24.7% between 65 and 74;
  21.4% between 75 and 84; and 7.8% 85+ years of age.

  The age-adjusted incidence rate was 464.4 per 100,000 men and women per year. These
  rates are based on cases diagnosed in 2004-2008 from 17 SEER geographic areas.


                                                       Incidence Rates by Race
           Race/Ethnicity                                              Male                Female
           All Races                                      541.0 per 100,000 men   411.6 per 100,000 women
           White                                          543.6 per 100,000 men   423.0 per 100,000 women
           Black                                          626.1 per 100,000 men   400.9 per 100,000 women
           Asian/Pacific Islander                         347.7 per 100,000 men   297.0 per 100,000 women
           American Indian/Alaskan Native                 338.0 per 100,000 men   309.0 per 100,000 women
           Hispanic                                       360.2 per 100,000 men   287.5 per 100,000 women
Source: SEER.Cancer.Gov/StatFacts (Surveillance Epidemiology and End Results)
Cancer – U.S. Mortality
  From 2003 – 2007, the median age at death for cancer of all sites was 73 years of age.
  Approximately 0.4% died under age 20; 0.8% between 20 and 34; 2.6% between 35 and 44;
  9.0% between 45 and 54; 17.8% between 55 and 64; 24.9% between 65 and 74; 29.7%
  between 75 and 84; and 14.9% 85+ years of age.

  The age-adjusted death rate was 183.8 per 100,000 men and women per year. These rates
  are based on patients who died in 2003-2007 in the U.S.


                                                         Death Rates by Race
           Race/Ethnicity                                              Male                Female
           All Races                                      225.4per 100,000 men    155.4 per 100,000 women
           White                                          222.5 per 100,000 men   155.0 per 100,000 women
           Black                                          296.5 per 100,000 men   180.6 per 100,000 women
           Asian/Pacific Islander                         134.2 per 100,000 men   94.1 per 100,000 women
           American Indian/Alaskan Native                 183.7 per 100,000 men   138.0 per 100,000 women
           Hispanic                                       150.5 per 100,000 men   102.3 per 100,000 women
Source: SEER.Cancer.Gov/StatFacts (Surveillance Epidemiology and End Results)
Foods That Combat Cancer
• Tomato products with “olive oil” (contain
  lycopene)

• Fish (i.e., cod, herring, mackerel, sardines
  (contain selenium)

• “Veggies” (i.e., broccoli, brussel sprouts,
  cabbage and cauliflower (7 or more “handfuls”
  per week can reduce cancer by 50%)

• Berries, green vegetables (vitamin C), citrus
  fruits (antioxidants – fight free radicals that
  damage DNA)

• Wheat germ, nuts (vitamin E – fights certain
  cancers)
What is Diabetes?
• People with diabetes have high blood sugar because of either:

   • Type I – They do not make enough insulin or

   • Type II – The body cells are not able to use the insulin and
     prevent glucose (sugar) from been delivered inside the cell.
Risk Factors of Diabetes




        Age (over 45 years)          History of diabetes during pregnancy




 Low physical activity   Family history of diabetes   High blood pressure
Symptoms of Diabetes




Being more tired than usual        Frequent urination           Being very hungry




 Losing weight       Being very thirsty       Being irritable      Blurred vision
Diabetes – Incidence
 • Among U.S. residents aged 65 years and older, 10.9 million, or 26.9%, had
   diabetes in 2010.
 • About 215,000 people younger than 20 years had diabetes (type 1 or type 2) in
   the United States in 2010.
 • About 1.9 million people aged 20 years or older were newly diagnosed with
   diabetes in 2010 in the United States.
 • In 2005–2008, based on fasting glucose or hemoglobin A1c levels, 35% of U.S.
   adults aged 20 years or older had pre-diabetes (50% of adults aged 65 years or
   older). Applying this percentage to the entire U.S. population in 2010 yields an
   estimated 79 million American adults aged 20 years or older with pre-diabetes.
 • Diabetes is the leading cause of kidney failure, non-traumatic lower- limb
   amputations, and new cases of blindness among adults in the United States.
 • Diabetes is a major cause of heart disease and stroke.
 • Diabetes is the seventh leading cause of death in the United States


Source: National Diabetes Facts Sheet, 2011
Diabetes – Incidence
  From 2003 – 2007, the median age at death for cancer of all sites was 73 years of age.
  Approximately 0.4% died under age 20; 0.8% between 20 and 34; 2.6% between 35 and 44;
  9.0% between 45 and 54; 17.8% between 55 and 64; 24.9% between 65 and 74; 29.7%
  between 75 and 84; and 14.9% 85+ years of age.

  The age-adjusted death rate was 183.8 per 100,000 men and women per year. These rates
  are based on patients who died in 2003-2007 in the U.S.




              Sufficient data are not available to estimate the total prevalence of diabetes (diagnosed and undiagnosed) for other U.S.
              racial/ethnic minority populations
Source: National Diabetes Facts Sheet, 2011
New Cases of Diagnosed Diabetes




Source: National Diabetes Facts Sheet, 2011
Diagnosed and Undiagnosed Diabetes




Source: National Diabetes Facts Sheet, 2011
Nutrition guidelines for those at risk for diabetes

• Carbohydrates are one of the (3) key nutrients our bodies need to
  be strong and healthy. Carbohydrates, however, directly raise
  blood sugar (glucose). They need to be limited, if you are at risk
  of diabetes.
Nutrition guidelines for those at risk for diabetes


   • Foods containing “carbs” breads, cereals, grains, starchy
     vegetables, crackers, snacks, dried beans, peas and lentils,
     fruits, milk and yogurt, desserts, sweets, regular soda

   • Limit “carb” intake to 3-4 carbs per meal

                         1 carb choice = 15 grams (g) of carbs
              Most WOMEN need                       Most MEN need

Each Meal     3 to 4 car choices = 45 to 60 carbs   4 to 5 carb choices = 60 to 75 g of carbs


Snacks        1 carb choice = 15 g of carbs         1 to 2 carb choices = 15 to 30 g of carbs
(if needed)
Nutrition Facts                                            Read Food Labels
Serving Size 8 Crackers (28g)                                    Check the serving size:
Amount per serving                                               8 crackers. Is that how
                                                                 much you plan to eat?
Calories     120         Fat Calories       30

                             % Daily Value
                                                      This number – 28g – is the weight
Total Fat 3.5g                              5%        of the crackers, not the amount of
                                                      carbs in the serving
      Saturated Fat 1g                      5%

      Trans Fat 0g

      Polyunsaturated Fat 1.5g

      Monounsaturated Fat 0.5g

Cholesterol 0mg                             0%

Sodium 140mg                                6%

Total Carbohydrate 22g                      7%
                                                                      Count total carbs.
      Dietary Fiber 1g

      Sugars 7g                                              You do not need to count
                                                             sugars separately because
Protein 2g                                                   the are already counted as
Vitamin A         0%            Vitamin C        0%          part of the total carbs.

Calcium           10%           Iron             4%
What is Heart Disease?

                         • Heart Disease or
                           cardiopathy is an
                           umbrella term for a
                           variety of diseases
                           affecting the heart.

                         • Coronary artery disease
                           is the leading cause of
                           death in every country.
                           Every American has a
                           40% chance of dying
                           from heart disease.
Effects of Heart Disease?


                                                    Damaged arteries slow
                                                    down your memory and
                                                    the ability of your
                                                    organs to function.




High blood pressure or the effects of cigarette smoke can damage the inside of
your arteries. Your body tries to repair the “tears” with cholesterol. But if the
repair is with “LDL,” inflammation will occur. A plaque _______ becomes
“irritated” and ruptures. This encourages a blood clot to form. The result
could be a heart attack, stroke, impotence and/or memory loss.
Risk Factors of Heart Disease?


                               Tobacco smoke               Physical Inactivity
                                    Stress                       Stress
Major Risk Factors you
CANNOT control               High Blood Pressure          High Blood Pressure
                            High Blood Cholesterol       High Blood Cholesterol
Increasing Age                                           Obesity & Overweight
Male Sex (Gender)
Heredity (Including Race)

Major Risk Factors you                            Alcohol
CAN control
                                                   Stress
Tobacco Smoke                               High Blood Pressure
High Blood Cholesterol                     High Blood Cholesterol
 - (LDL Bad Cholesterol)                     Diabetes Mellitus
High Blood Pressure
Physical Inactivity                               Obesity
Obesity and Overweight
Diabetes Mellitus
Foods good for your heart
                                                             Antioxidants
                                                          (anti-inflammatory
     Nuts               Olive Oil         Fish               substances):




All nuts (i.e.,       Helps to raise   3 portions/per      Nuts, any tea,
walnuts, peanuts) –   your HDL good    week – Salmon,      red wine,
1 handful a day       cholesterol.     white fish (cod     grapes,
decreases the                          or bass) a must     cranberries,
incidence of heart                     which reduces       onions and
disease between 20                     triglycerides in    tomatoes.
- 60 percent. The                      your blood and
best nuts are those                    lowers plaque
high in omega-3                        build up.
fatty acids.
Foods to avoid for your heart


  Saturated fats LIMIT    to 20 grams a day
   – luncheon meats, full fat diary products, baked goods,
    fried fast foods, palm and coconut oils, maple syrup.
Exercise your way to good health

             Exercise and good nutrition:
             adults need at least 30
             minutes of moderate to
             vigorous physical exercise
             at least 5 days a week

             Children and adolescents:
             60 minutes a day per week.

             Examples of exercise:
             Gardening, bicycling, yard
             work, dancing, stair
             climbing, moderate-heavy
             house cleaning, swimming,
             brisk walking and working
             out.
Now, to make sense of this!
Fruits and Vegetables
                        Any vegetable or
Any fruit or 100%       100% vegetable
fruit juice counts      juice counts as a
as part of the Fruit    member of the
Group.                  Vegetable Group.

                        Vegetable may be
Fruits may be           raw or cooked;
fresh, canned           fresh, frozen,
frozen, or dried,       canned, or
and may be              dried/dehydrated,
whole, cut-up, or       and may be whole,
pureed.                 cut-up, or massed.
Protein Foods
    All foods made from meat, poultry, seafood, beans and
   peas, eggs, processed soy products, nuts, and seeds are
   considered part of the Protein Foods Group. Beans and
           peas are also part of the Vegetable Group.
Nutrition In The Fast Lane
  • Use healthy eating habits and exercise to combat cancer,
    diabetes and heart disease. Combining both regularly and in
    enough quantity will give you an overall push in the right the
    direction to a better and healthy quality of life.
Bibliography

 • American Cancer Society, Cancer facts and figures 2009, Atlanta:
   American Cancer Society, 2009.

 • Park Y, Hunter DJ, Spiegelman D, et al. Dietary fiber intake and
   risk of colorectal cancer: a pooled analysis of prospective cohort
   studies. JAMA 2005:294;2849-2857.

 • P.A. Futrea, L. Coin, M. Marshall, T. Dowen, T. Hubbard, r.
   Wooster, et. al., A census of human cancer genes, Nat. Rev.
   Cancer 4 (2004) 177-183.

 • Y.J. Surh, Cancer Chemoprevention with dietary phytochemicals,
   Nat. Rev. Cancer 3 (2003) 768-780.

 • The Diabetes Control and Complication Trial research group. The
   effect of intensive treatment of diabetes on the development of
   long-term complications in insulin dependent diabetes mellitus. N
   Engl J Med 1993;329;997-86.

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Nutrition In The Fast Lane

  • 1. Nutrition In The Fast Lane Use healthy eating habits and exercise to combat cancer, diabetes and heart disease.
  • 2. Objectives • Discuss possible causes for cancer, diabetes and heart disease. • Identify the role of nutrition and exercise as interventions in preventing cancer, diabetes and heart disease.
  • 3. Definition of Cancer What is Cancer? • Cancer is not just one disease – there are hundreds of different types of cancers. • Cancers are mutations within the genetic makeup or DNA. Cancer cell under attack Once this occurs, they begin to crowd out the “good cells”. by the immune system
  • 4. Definition of Cancer • Mutations or changes within our body’s cells can also occur when the DNA is damaged by “free radicals” (which can damage cells, DNA and proteins). • Cancer has two major categories; solid tumors and hematologic cancers.  Solid tumors are initially confined to a specific tissue on organ. They can shed and travel through the blood system.  Hematologic tumors involve the blood and lymphatic system – enabling disease to travel fast.
  • 5. Risk Factors of Cancer • Heredity – genetic predisposition for cancer • Chemical and environmental carcinogens – soot, coal tar, cigarette smoke, asbestos, amyl chloride arsenic, sweeteners (saccharin and cyclamates), smoked foods and nitrates (used to smoked foods) • Radiation – ultraviolet rays from the sun, x-rays and radioactive chemicals • Growing older • Poor diet • Alcohol • Lack of exercise and obesity
  • 6. Cancer – SEER Incidence From 2003 – 2008, the median age of diagnosis for cancer of all sites was 66 years of age. Approximately 1.1% were diagnosed under age 20; 2.7% between 20 and 34; 5.6% between 35 and 44; 14.1% between 45 and 54; 22.7% between 55 and 64; 24.7% between 65 and 74; 21.4% between 75 and 84; and 7.8% 85+ years of age. The age-adjusted incidence rate was 464.4 per 100,000 men and women per year. These rates are based on cases diagnosed in 2004-2008 from 17 SEER geographic areas. Incidence Rates by Race Race/Ethnicity Male Female All Races 541.0 per 100,000 men 411.6 per 100,000 women White 543.6 per 100,000 men 423.0 per 100,000 women Black 626.1 per 100,000 men 400.9 per 100,000 women Asian/Pacific Islander 347.7 per 100,000 men 297.0 per 100,000 women American Indian/Alaskan Native 338.0 per 100,000 men 309.0 per 100,000 women Hispanic 360.2 per 100,000 men 287.5 per 100,000 women Source: SEER.Cancer.Gov/StatFacts (Surveillance Epidemiology and End Results)
  • 7. Cancer – U.S. Mortality From 2003 – 2007, the median age at death for cancer of all sites was 73 years of age. Approximately 0.4% died under age 20; 0.8% between 20 and 34; 2.6% between 35 and 44; 9.0% between 45 and 54; 17.8% between 55 and 64; 24.9% between 65 and 74; 29.7% between 75 and 84; and 14.9% 85+ years of age. The age-adjusted death rate was 183.8 per 100,000 men and women per year. These rates are based on patients who died in 2003-2007 in the U.S. Death Rates by Race Race/Ethnicity Male Female All Races 225.4per 100,000 men 155.4 per 100,000 women White 222.5 per 100,000 men 155.0 per 100,000 women Black 296.5 per 100,000 men 180.6 per 100,000 women Asian/Pacific Islander 134.2 per 100,000 men 94.1 per 100,000 women American Indian/Alaskan Native 183.7 per 100,000 men 138.0 per 100,000 women Hispanic 150.5 per 100,000 men 102.3 per 100,000 women Source: SEER.Cancer.Gov/StatFacts (Surveillance Epidemiology and End Results)
  • 8. Foods That Combat Cancer • Tomato products with “olive oil” (contain lycopene) • Fish (i.e., cod, herring, mackerel, sardines (contain selenium) • “Veggies” (i.e., broccoli, brussel sprouts, cabbage and cauliflower (7 or more “handfuls” per week can reduce cancer by 50%) • Berries, green vegetables (vitamin C), citrus fruits (antioxidants – fight free radicals that damage DNA) • Wheat germ, nuts (vitamin E – fights certain cancers)
  • 9. What is Diabetes? • People with diabetes have high blood sugar because of either: • Type I – They do not make enough insulin or • Type II – The body cells are not able to use the insulin and prevent glucose (sugar) from been delivered inside the cell.
  • 10. Risk Factors of Diabetes Age (over 45 years) History of diabetes during pregnancy Low physical activity Family history of diabetes High blood pressure
  • 11. Symptoms of Diabetes Being more tired than usual Frequent urination Being very hungry Losing weight Being very thirsty Being irritable Blurred vision
  • 12. Diabetes – Incidence • Among U.S. residents aged 65 years and older, 10.9 million, or 26.9%, had diabetes in 2010. • About 215,000 people younger than 20 years had diabetes (type 1 or type 2) in the United States in 2010. • About 1.9 million people aged 20 years or older were newly diagnosed with diabetes in 2010 in the United States. • In 2005–2008, based on fasting glucose or hemoglobin A1c levels, 35% of U.S. adults aged 20 years or older had pre-diabetes (50% of adults aged 65 years or older). Applying this percentage to the entire U.S. population in 2010 yields an estimated 79 million American adults aged 20 years or older with pre-diabetes. • Diabetes is the leading cause of kidney failure, non-traumatic lower- limb amputations, and new cases of blindness among adults in the United States. • Diabetes is a major cause of heart disease and stroke. • Diabetes is the seventh leading cause of death in the United States Source: National Diabetes Facts Sheet, 2011
  • 13. Diabetes – Incidence From 2003 – 2007, the median age at death for cancer of all sites was 73 years of age. Approximately 0.4% died under age 20; 0.8% between 20 and 34; 2.6% between 35 and 44; 9.0% between 45 and 54; 17.8% between 55 and 64; 24.9% between 65 and 74; 29.7% between 75 and 84; and 14.9% 85+ years of age. The age-adjusted death rate was 183.8 per 100,000 men and women per year. These rates are based on patients who died in 2003-2007 in the U.S. Sufficient data are not available to estimate the total prevalence of diabetes (diagnosed and undiagnosed) for other U.S. racial/ethnic minority populations Source: National Diabetes Facts Sheet, 2011
  • 14. New Cases of Diagnosed Diabetes Source: National Diabetes Facts Sheet, 2011
  • 15. Diagnosed and Undiagnosed Diabetes Source: National Diabetes Facts Sheet, 2011
  • 16. Nutrition guidelines for those at risk for diabetes • Carbohydrates are one of the (3) key nutrients our bodies need to be strong and healthy. Carbohydrates, however, directly raise blood sugar (glucose). They need to be limited, if you are at risk of diabetes.
  • 17. Nutrition guidelines for those at risk for diabetes • Foods containing “carbs” breads, cereals, grains, starchy vegetables, crackers, snacks, dried beans, peas and lentils, fruits, milk and yogurt, desserts, sweets, regular soda • Limit “carb” intake to 3-4 carbs per meal 1 carb choice = 15 grams (g) of carbs Most WOMEN need Most MEN need Each Meal 3 to 4 car choices = 45 to 60 carbs 4 to 5 carb choices = 60 to 75 g of carbs Snacks 1 carb choice = 15 g of carbs 1 to 2 carb choices = 15 to 30 g of carbs (if needed)
  • 18. Nutrition Facts Read Food Labels Serving Size 8 Crackers (28g) Check the serving size: Amount per serving 8 crackers. Is that how much you plan to eat? Calories 120 Fat Calories 30 % Daily Value This number – 28g – is the weight Total Fat 3.5g 5% of the crackers, not the amount of carbs in the serving Saturated Fat 1g 5% Trans Fat 0g Polyunsaturated Fat 1.5g Monounsaturated Fat 0.5g Cholesterol 0mg 0% Sodium 140mg 6% Total Carbohydrate 22g 7% Count total carbs. Dietary Fiber 1g Sugars 7g You do not need to count sugars separately because Protein 2g the are already counted as Vitamin A 0% Vitamin C 0% part of the total carbs. Calcium 10% Iron 4%
  • 19. What is Heart Disease? • Heart Disease or cardiopathy is an umbrella term for a variety of diseases affecting the heart. • Coronary artery disease is the leading cause of death in every country. Every American has a 40% chance of dying from heart disease.
  • 20. Effects of Heart Disease? Damaged arteries slow down your memory and the ability of your organs to function. High blood pressure or the effects of cigarette smoke can damage the inside of your arteries. Your body tries to repair the “tears” with cholesterol. But if the repair is with “LDL,” inflammation will occur. A plaque _______ becomes “irritated” and ruptures. This encourages a blood clot to form. The result could be a heart attack, stroke, impotence and/or memory loss.
  • 21. Risk Factors of Heart Disease? Tobacco smoke Physical Inactivity Stress Stress Major Risk Factors you CANNOT control High Blood Pressure High Blood Pressure High Blood Cholesterol High Blood Cholesterol Increasing Age Obesity & Overweight Male Sex (Gender) Heredity (Including Race) Major Risk Factors you Alcohol CAN control Stress Tobacco Smoke High Blood Pressure High Blood Cholesterol High Blood Cholesterol - (LDL Bad Cholesterol) Diabetes Mellitus High Blood Pressure Physical Inactivity Obesity Obesity and Overweight Diabetes Mellitus
  • 22. Foods good for your heart Antioxidants (anti-inflammatory Nuts Olive Oil Fish substances): All nuts (i.e., Helps to raise 3 portions/per Nuts, any tea, walnuts, peanuts) – your HDL good week – Salmon, red wine, 1 handful a day cholesterol. white fish (cod grapes, decreases the or bass) a must cranberries, incidence of heart which reduces onions and disease between 20 triglycerides in tomatoes. - 60 percent. The your blood and best nuts are those lowers plaque high in omega-3 build up. fatty acids.
  • 23. Foods to avoid for your heart Saturated fats LIMIT to 20 grams a day – luncheon meats, full fat diary products, baked goods, fried fast foods, palm and coconut oils, maple syrup.
  • 24. Exercise your way to good health Exercise and good nutrition: adults need at least 30 minutes of moderate to vigorous physical exercise at least 5 days a week Children and adolescents: 60 minutes a day per week. Examples of exercise: Gardening, bicycling, yard work, dancing, stair climbing, moderate-heavy house cleaning, swimming, brisk walking and working out.
  • 25. Now, to make sense of this!
  • 26. Fruits and Vegetables Any vegetable or Any fruit or 100% 100% vegetable fruit juice counts juice counts as a as part of the Fruit member of the Group. Vegetable Group. Vegetable may be Fruits may be raw or cooked; fresh, canned fresh, frozen, frozen, or dried, canned, or and may be dried/dehydrated, whole, cut-up, or and may be whole, pureed. cut-up, or massed.
  • 27. Protein Foods All foods made from meat, poultry, seafood, beans and peas, eggs, processed soy products, nuts, and seeds are considered part of the Protein Foods Group. Beans and peas are also part of the Vegetable Group.
  • 28. Nutrition In The Fast Lane • Use healthy eating habits and exercise to combat cancer, diabetes and heart disease. Combining both regularly and in enough quantity will give you an overall push in the right the direction to a better and healthy quality of life.
  • 29. Bibliography • American Cancer Society, Cancer facts and figures 2009, Atlanta: American Cancer Society, 2009. • Park Y, Hunter DJ, Spiegelman D, et al. Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA 2005:294;2849-2857. • P.A. Futrea, L. Coin, M. Marshall, T. Dowen, T. Hubbard, r. Wooster, et. al., A census of human cancer genes, Nat. Rev. Cancer 4 (2004) 177-183. • Y.J. Surh, Cancer Chemoprevention with dietary phytochemicals, Nat. Rev. Cancer 3 (2003) 768-780. • The Diabetes Control and Complication Trial research group. The effect of intensive treatment of diabetes on the development of long-term complications in insulin dependent diabetes mellitus. N Engl J Med 1993;329;997-86.