1) Healthcare workers are at risk of needle stick injuries and blood/fluid exposure which can potentially transmit infections like HIV, HBV, and HCV. 2) If an exposure occurs, the worker should get first aid, report to authorities, get tested, and may receive post-exposure prophylaxis (PEP) to reduce infection risk depending on the type of exposure and source patient's infection status. 3) Proper management of exposures includes testing involved individuals, assessing risk level, providing recommended PEP treatments like antivirals, and follow up testing and care.