The Strategic PMO plays a critical role in managing organizational transformation from the current to desired state. It establishes a framework including vision, mission, and work streams. The SPMO coordinates initiatives across work streams and provides governance and communications. Its lifecycle includes planning, implementing, and transitioning initiatives. Case studies show how SPMOs guided M&A integration, a shift to global delivery, and driving innovation through Centers of Excellence. Key lessons are communicating change rationale, engaging stakeholders, and establishing metrics to measure success.