Why should my institution support RRIDs?

•

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Reproducibility woes touch all aspects of the research enterprise. RRIDs are a thoughtful and arguably necessary tool for combating the issue.

Why should my institution
support RRIDs?
RRIDs were created jointly by NIH, Journal Editors, UCSD and other researchers
and function in support of NIH guidelines for Rigor and Transparency
RRIDs are funded and maintained jointly by the following:
U24-DA039832 to The Neuroscience Information Framework, U24-DK097771 to
dkNet, R43-OD024432 to SciCrunch Inc, and Leona M. and Harry B. Helmsley
Charitable Trust

New NIH
Guidelines affect
all grants
(2016/2017)
NIH Rigor and
Transparency Guidelines
describe changes to grant
review guidelines,
including an explicit call to
improve use of:
Antibodies,
Cell Lines,
Organisms,
and Chemicals
What is the annual budget from NIH?

Freeman et al, 2017. Reproducibility2020: Progress and priorities
*

Why these reagents and
not all reagents?

How do you authenticate an antibody?
Nature Methods, 2016: A proposal for validation of antibodies
Mathias Uhlen1, Anita Bandrowski2, Steven Carr3, Aled
Edwards4, Jan Ellenberg5, Emma Lundberg1, David L Rimm6,
Henry Rodriguez7, Tara Hiltke7, Michael Snyder8 & Tadashi
Yamamoto9
These pillars rest on
proper identification

Who authenticates every antibody?
There are 5,700 journals
indexed in PubMed

34 journals say they
require cell line
authentication, others
enforce identification

At the simplest level every study is like a recipe,
resources (ingredients) and a protocol

Papers are still poor at
identifying the simplest
part of the paper, the
materials used, but
when asked the authors
know what they used
so this is culture not
malice!
Vasilevsky 2013

Anatomy of the RRID syntax
NeuroMab Cat# 75-028 Lot#45, RRID:AB_2307331
Company or
Provider
Local
Identifier
Version or
Lot used
Global
Identifier

PubMed ID / DOI
I used this mouse
RRID registered
I made this antibody
I am a UC researcher

1.
RRIDs help researchers demonstrate
they comply with NIH guidelines

2.
RRIDs enable an early warning system
for bad resources

3.
RRIDs enable UC to track resources as
intellectual output of faculty/staff

Useful links for RRIDs
Resource authentication example document:
https://library.ucsd.edu/research-and-collections/data-curation/_files/ExampleAuthenticationKeyBiologicalChemicalResources201609b.pdf
Here are the people pushing RRIDs:
Here are 2 FOAs that mention RRIDs
https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-18-014.html
https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-010.html
Cell Press, eLife etc instructions to authors that we have found so far
https://docs.google.com/spreadsheets/d/1cGtY2oIMfBzg6MKei_S2niCbu0Cici2n17dZNLgBdNw/edit#gid=1245999377
External Resolvers back RRIDs
n2t.net/RRID:AB_90755 (California Digital Library)
identifiers.org/RRID/RRID:AB_90755 (European Bioinformatics institute)
Companies, vendors, random projects etc
Cellosaurus: web.expasy.org/cellosaurus/CVCL_2260
MMRRC: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32045
BioLegend: https://www.biolegend.com/en-us/products/purified-anti-akt1-antibody-12289
NeuroMab: http://neuromab.ucdavis.edu/catalog.cfm
Hypothes.is https://web.hypothes.is/blog/introducing-developer-api-tokens/

Efforts to place the patient at the center of medical research, spurred by the Affordable Care Act’s founding of the Patient Centered Outcomes Research Institute, have begun to change the way clinical research is conceptualized and conducted. Such efforts hold great promise, but also raise potential challenges for ethical oversight. How should oversight bodies approach the presence of patients in potentially unfamiliar research roles, such as investigator? What forms of patient involvement in research, if any, warrant increased scrutiny from oversight bodies? How do we keep the patient voice from being ‘captured’ by special interest groups? This symposium brought together a diverse group of patients and community members, policymakers, bioethicists, and regulatory officials to address these and other issues.

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Abstract dkNET’s Resource Reports (https://dknet.org/rin/rrids) enable researchers to discover research resources that would be useful for their research. The resource report integrated data set and analytics platform combines Research Resource Identifiers (RRIDs), text mining and data aggregation to help you identify key biomedical resources, track these resources, and compare their performance. Resource Reports offer a detailed overview of each resource along with citation metrics from the biomedical literature and even information about what resources have been used together. You'll gain insights about who is using particular resources and how the community views those resources, including usage in published protocols. The dkNET Co-PI, Dr Jeffrey Grethe, will give you live demos during this webinar, including: - How to find and select a research resource such as an antibody or a cell line - How to find Research Resource Identifiers (RRIDs) and proper citation of your resources - How to register resources to obtain RRIDs if the resources do not exist in the system We hope this short webinar will provide an opportunity to use this tool to shape your research activities. Presenter: Jeffrey Grethe, PhD, dkNET Co-Principal Investigator, University of California San Diego Upcoming webinars schedule: https://dknet.org/about/webinar

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Funding agencies, universities, and research institutes all face challenges of reliably identifying their researchers and monitoring outcomes over time. All researchers—and especially early career researchers seeking to establish their careers—need to be reliably connected to their research outputs, without the confusion common, changeable names creates. Graduate students and postdoctoral researchers supported by grants also have specific challenges: if they are not the PI, they are not included in grant information; they may not even know which grant(s) they are supported by; and as a result, the existing challenges of reliably tying publications to grant funding are even more problematic. The use of the unique, persistent ORCID identifier can help support outcomes tracking and evaluation. In 2012, the U.S. National Institutes of Health Biomedical Research Workforce Working Group made recommendations that the NIH should take to support a sustainable biomedical research workforce in the U.S. In the course of its study, working group members were “frustrated and sometimes stymied” by the lack of quality, comprehensive data about biomedical researchers. In response, NIH has recommended the development of a simple, comprehensive tracking system for trainees, implemented a shared, voluntary researcher profile system called the Science Experts Network Curriculum Vitae (SciENcv), and encouraged the adoption of unique, persistent ORCID identifiers for researchers. Additionally, NIH has begun collecting data about individuals in graduate and undergraduate student project roles who are supported by NIH grants. Research universities like Texas A&M are also responding by incorporating the ORCID identifier into their systems, enabling the improved identification, data collection, and career outcome tracking of students and postdoctoral researchers--and educating these early career researchers about the benefits they will receive from a unique, persistent research identifier. They are also beginning to link Electronic Theses and Dissertations (ETDs) to early career researchers' ORCID records. ORCID is an independent, non-profit organization that provides an open registry of unique and persistent identifiers for researchers and scholars. ORCID collaborates with the community to integrate ORCID identifiers into research systems and workflows, improving data management and accuracy across systems. ORCID enables interoperability between research systems worldwide, ensuring that researchers are correctly and automatically linked to their contributions. Since its launch in October 2012, ORCID has seen rapid adoption by more than 670,000 researchers and 130+ member organizations. From Webinar 4/23/14, https://orcid.org/content/identification-early-career-researchers-how-universities-and-funding-organizations-are-using

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Why should my institution support RRIDs?

1. Why should my institution support RRIDs? RRIDs were created jointly by NIH, Journal Editors, UCSD and other researchers and function in support of NIH guidelines for Rigor and Transparency RRIDs are funded and maintained jointly by the following: U24-DA039832 to The Neuroscience Information Framework, U24-DK097771 to dkNet, R43-OD024432 to SciCrunch Inc, and Leona M. and Harry B. Helmsley Charitable Trust

2. Reproducibility woes touch all aspects of the research enterprise

5. New NIH Guidelines affect all grants (2016/2017) NIH Rigor and Transparency Guidelines describe changes to grant review guidelines, including an explicit call to improve use of: Antibodies, Cell Lines, Organisms, and Chemicals What is the annual budget from NIH?

6. Freeman et al, 2017. Reproducibility2020: Progress and priorities *

7. Why these reagents and not all reagents?

8. How do you authenticate an antibody? Nature Methods, 2016: A proposal for validation of antibodies Mathias Uhlen1, Anita Bandrowski2, Steven Carr3, Aled Edwards4, Jan Ellenberg5, Emma Lundberg1, David L Rimm6, Henry Rodriguez7, Tara Hiltke7, Michael Snyder8 & Tadashi Yamamoto9 These pillars rest on proper identification

9. Who authenticates every antibody? There are 5,700 journals indexed in PubMed

10. 34 journals say they require cell line authentication, others enforce identification

11. At the simplest level every study is like a recipe, resources (ingredients) and a protocol

12. • •

13. • • • •

14. The State of The Art in Publishing

15.

16. Papers are still poor at identifying the simplest part of the paper, the materials used, but when asked the authors know what they used so this is culture not malice! Vasilevsky 2013

17.

18. Anatomy of the RRID syntax NeuroMab Cat# 75-028 Lot#45, RRID:AB_2307331 Company or Provider Local Identifier Version or Lot used Global Identifier

19. http://rrid.site

20. PubMed ID / DOI I used this mouse RRID registered I made this antibody I am a UC researcher

21. • • • •

22.

23.

24. -eLife Blog

25.

26. RRIDs in the wild

27.

28.

29.

30. But why should my institution care?

31. 1. RRIDs help researchers demonstrate they comply with NIH guidelines

32. http://doi.org/10.6075/J0RB72JC

33. 2. RRIDs enable an early warning system for bad resources

34.

35. 3. RRIDs enable UC to track resources as intellectual output of faculty/staff

36.

37. To recommend that researchers use RRIDs

38. Useful links for RRIDs Resource authentication example document: https://library.ucsd.edu/research-and-collections/data-curation/_files/ExampleAuthenticationKeyBiologicalChemicalResources201609b.pdf Here are the people pushing RRIDs: Here are 2 FOAs that mention RRIDs https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-18-014.html https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-17-010.html Cell Press, eLife etc instructions to authors that we have found so far https://docs.google.com/spreadsheets/d/1cGtY2oIMfBzg6MKei_S2niCbu0Cici2n17dZNLgBdNw/edit#gid=1245999377 External Resolvers back RRIDs n2t.net/RRID:AB_90755 (California Digital Library) identifiers.org/RRID/RRID:AB_90755 (European Bioinformatics institute) Companies, vendors, random projects etc Cellosaurus: web.expasy.org/cellosaurus/CVCL_2260 MMRRC: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32045 BioLegend: https://www.biolegend.com/en-us/products/purified-anti-akt1-antibody-12289 NeuroMab: http://neuromab.ucdavis.edu/catalog.cfm Hypothes.is https://web.hypothes.is/blog/introducing-developer-api-tokens/

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Why should my institution support RRIDs?