AstraZeneca is developing informatics tools and search solutions to identify new opportunities for drug repositioning. They are using approaches like structure-based predictive modelling, mining existing drug information, and mechanistic repositioning to systematically consider alternative disease indications for compounds. Key initiatives include building an asset repositioning matrix, extending data sources, capturing biological process maps, and launching consortiums to facilitate drug repositioning and combination efforts. The goal is to unlock the potential of existing compounds in new disease areas through both internal efforts and external partnerships.