This document summarizes Newreka Green Synth Technologies' green chemistry solutions for reducing waste in chemical processes. It provides case studies on recycling neutral and acidic mother liquors from various reduction reactions. These solutions increased yields, reduced costs and effluent, and improved energy efficiency compared to conventional methods. Newreka conducted thousands of experiments recycling mother liquors up to 100 times while maintaining high product purity.

1. Your Answers To Green Chemistry Solutions Newreka Green Synth Technologies Pvt. Ltd., Mumbai, (India)

2. Founders Team of Technocrats from IIT Bombay passionate about Nature Foundation Principles of Green Chemistry, Green Engineering & Enviropreneurship Knowledge Base & Over 40,000 experiments conducted by Experience a dedicated team of 100 Chemists & Chemical Engineers. Service Customized & Sustainable Solutions to reduce & E-FACTOR * Recycle solution. * E-FACTOR = kgs waste generated per kg product About Newreka

5. “ Prevent Waste: Design chemical syntheses to prevent waste, leaving no waste to treat or clean up” 1 st Principle of Green Chemistry

6. Average Composition of Reaction Mass Solvent & Water contribute more than 90% of the Reaction Mass Source Data: ACS GCI Pharmaceutical Roundtable benchmarking exercise 2007 Average composition of Effluents will be similar. Recycle of Water & Solvent can take care of 90% of problem.

7. A Journey through Case Studies of Neutral Mother Liquor Recycle

8. Recycle Solution for Neutral Mother Liquor Product: Pharma Intermediate (Anti-Aids Drug) Unit Process: Reduction Conventional Technology: Catalytic Hydrogenation A Case Study of…

9. Case Study – Neutral Mother Liquor Conventional Technology Unit Process : Reduction

10. Case Study – Neutral Mother Liquor Unit Process : Reduction Newreka Recycle Solution (NRS) TM

11. 1. Water as “Reaction Medium” 2. Atm. Pr., Nominal pH & Temp 3. Neutral ML Recycled 25 times 4. 95% of Theoretical Yield 5. White to Off-White Amine 6. Freedom from Solvents 7. Energy efficient 8. Safe Raw Materials, No Acids or Alkali Case Study – Neutral Mother Liquor 1. Solvent as “Reaction Medium” 2. High Pressure 3. Effluent containing Organics both Solvents & Amine 4. 85% of Theoretical Yield 5. Brown Colored Amine 6. 2 Solvents used 7. Energy Intensive process 8. Hazardous Raw Materials like Raney Ni & Hydrogen Gas A Comparison of Conventional Technology & NRS

13. Product: Pharma Intermediate (Analgesic & Antipyretic Drug) Unit Process: Reduction of P-Nitrophenol to P-Aminophenol Recycle Solution for Neutral Mother Liquor

14. Case Study – Neutral Mother Liquor Unit Process for PAP Conventional Technology

15. Case Study-Neutral mother liquor recycle Unit Process for PAP Newreka Recycle Solution (NRS) TM

16. STAGE : P-AMINOPHENOL

17. STATISTICS : P-AMINOPHENOL Sr. No. No. of experiment Quantity * Number of experiments performed 1520 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Melting range o C Dry product gm Purity % Fresh Off White Crystalline Single spot of product 184 42 99.55 R1 Off White Crystalline Single spot of product 184 43.4 99.65 R2 Off White Crystalline Single spot of product 184 44.8 99.70 R3 Off White Crystalline Single spot of product 184 46.9 99.72 R4 Off White Crystalline Single spot of product 184 47.6 99.75 R5 Off White Crystalline Single spot of product 184 49 99.75

20. 5-Nitro salicylic acid To 5-Amino salicylic acid (Make your chemistry Green)

21. Case Study Unit Process of 5-ASA Conventional Reduction Technology(CRT)

22. 5 ASA PFD

24. STATISTICS:REDUCTION Sr. No. No. of experiment Quantity * Number of experiments performed 131 Product characterization in recycle experiments (5-nitro Salicylic Acid) Recycle No Color Appearance TLC/GC/HPLC Melting range 0 C Dry product gm Purity % Fresh Off white powder Single spot of product 266-270 71 99+ R1 Off white powder Single spot of product 266-270 67.5 99+ R2 Off white powder Single spot of product 266-270 71.2 99+ R3 Off white powder Single spot of product 266-270 70 99+ R4 Off white powder Single spot of product 266-270 70.2 99+ R5 Off white powder Single spot of product 266-270 87 99+

25. Ortho-Nitrophenol To Ortho-Aminophenol (make your chemistry green)

26. Case Study – Neutral Mother Liquor Unit Process for OAP Conventional Technology

27. Case Study-Neutral mother liquor recycle Unit Process for OAP Newreka Recycle Solution (NRS) TM

28. STAGE : O-AMINOPHENOL

30. STATISTICS : O-AMINOPHENOL Sr. No. No. of experiment Quantity * Number of experiments performed 1150 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Melting range o C Dry product gm Purity % Fresh Off White Crystalline Single spot of product 179 28 99.50 R1 Off White Crystalline Single spot of product 179 30.8 99.60 R2 Off White Crystalline Single spot of product 179 33.6 99.62 R3 Off White Crystalline Single spot of product 179 35 99.65 R4 Off White Crystalline Single spot of product 179 36.4 99.70 R5 Off White Crystalline Single spot of product 179 42 99.75

32. Meta Nitro Acetophenone To Meta Amino Acetophenone (make your synthesis green)

33. Case Study – Neutral Mother Liquor Unit Process for MAA Conventional Technology

34. CASE STUDY OF NEUTRAL MOTHER LIQUOR RECYCLE

36. STATISTICS:MAA Sr. No. No. of experiment Quantity * Number of experiments performed 325 Product characterization in recycle experiments ( MAA) Recycle No Color Appearance TLC/GC/HPLC Melting range 0 C Dry product gm Purity % Fresh Yellow Powder Single spot of product 92-96 24.5 99.20 R1 Yellow Powder Single spot of product 92-96 34.0 99.72 R2 yellow Powder Single spot of product 92-96 35.2 99.62 R3 yellow Powder Single spot of product 92-96 35.3 99.72 R4 yellow Powder Single spot of product 92-96 36.3 99.84 R5 yellow Powder Single spot of product 92-96 40. 0 99.52

37. N-ethyl 3- Nitro carbazole To N-ethyl 3- Amino carbazole (Neutral ML Recycle)

38. Case Study Unit Process of REDUCTION Conventional Reduction Technology(CRT)

39. PDILIT PFD NRT CASE STUDY OF NEUTRAL MOTHER LIQUOR RECYCLE

40. STAGE:REDUCTION

42. 1.Recycle of Water Layer 2. No formic acid used. 3. 95% of Theoretical Yield 4. Filtration Time Low 5. Energy efficient 1. High Liquid Effluent . 2. Formic Acid used. 3. 90% of Theoretical Yield 4. Filtration Time High 5. Energy Intensive process A Comparison of Conventional Technology & NRT A Comparison of Conventional Technology & NRS

43. STATISTICS:REDUCTION Sr. No. No. of experiment Quantity - * Number of experiments performed 1203 Product characterization in recycle experiments (N-ethyl 3-nitro carbazole) Recycle No Color Appearance Filtration Time Amine content in ODCB Layer Batch size 55gm Fresh Dark brown Liquid 6 min 34.01 gm R1 Dark brown Liquid 8 min 35.78 gm R2 Dark brown Liquid 4 min 36.68 gm R3 Dark brown Liquid 6 min 37.65 gm R4 Dark brown Liquid 5 min 35.49 gm R5 Dark brown Liquid 4 min 37.69 gm

44. Para Chloro Nitro Benzene To Para Chloro Aniline (Neutral ML Recycle)

45. Case Study Unit Process of PCA Conventional Reduction Technology(CRT)

46. CASE STUDY OF NEUTRAL MOTHER LIQUOR AND SOLVENT RECYCLE

48. STATISTICS:REDUCTION Sr. No. No. of experiment Quantity * Number of experiments performed 202 Product characterization in recycle experiments ( Para Chloro Aniline) Recycle No Color Appearance TLC/GC/HPLC Filtration Time Amine content Fresh Greenish Liquid Single spot of product 10 min 50.81 gm R1 Greenish Liquid Single spot of product 12 min 69.58 gm R2 Greenish Liquid Single spot of produce 22 min 66.05 gm R3 Greenish Liquid Single spot of product 10 min 89.17 gm R4 Greenish Liquid Single spot of product 10 min 50 .48 gm R5 Greenish liquid Single spot of product 10 min 79.79gm

49. Newreka Recycle Solution For Sulphonic Series Compounds (Acidic ML Recycle)

50. Newreka Recycle Solution For 3,5-DNBA To 3,5-DABA (Acidic ML Recycle)

51. Unit Process for 3,5-DNBA Reduction Conventional Technology Case Study – Acidic Mother Liquor ISOLATOR R NO2 Water CIP FILTERATION REDUCTION EXTRACTION Wate r Neutral isolation mass 55% Yield Iron Oxide Spent

52. Case Study-Acidic mother liquor recycle Unit Process for 3,5-DNBA Reduction Newreka Recycle Solution (NRS) TM ISOLATOR NEWREKA REDUCTION CATALYST (NRC ) CATALYST (NGC) NEWREKA GREEN REDUCTION SPENT NRC CENTRIFUGE GREEN AMINE Mother Liquor Storage 1000lit and 1,00,000lit FILTER 65%yield

53. STAGE: 3,5-DNBA Reduction

55. STATISTICS :3,5-DNBA Reduction Sr. No. No. of experiment Quantity * Number of experiments performed 200 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm Purity % Fresh Off white Powder Single spot of product 45.5 98.50 R1 Off white Powder Single spot of product 71 98.34 R2 Off white Powder Single spot of product 59 97.28 R3 Off white Powder Single spot of product 75 98.19 R4 Off white Powder Single spot of product 71.5 98.04 R5 Off white Powder Single spot of product 70 96.97

56. 1.Recycle of ”Reaction Medium” 40times 2.65% of Theoretical Yield. 3.Effluent down by minimum 50%. 4.Mild or neutral pH condition (6 To 7). 5. Energy efficient 1. Highly Acidic Liquid Effluent 2.55% of Theoretical Yield 3.There is no solution of effluent A Comparison of Conventional Technology & NRS for 3,5-DNBA to 3,5-DABA Energy Intensive process 4 . Highly acidic solution(4pH) 5 . A Comparison of Conventional Technology & NRS

57. Newreka recycle solution for 4,4-Di Nitro Stilbene-2,2-di sulphonic acid (DNSDA) To 4,4-Di amino stilbene-2,2-di sulphonic acid (DASDA) (Acidic ML Recycle)

58. Unit Process for Reduction Conventional Technology for DASDA Case Study – Acidic Mother Liquor ISOLATOR Water CIP FILTERATION REDUCTION EXTRACTION Wate r Neutral isolaton mass 78% Yield Spent DNSDA

59. Case Study - Acidic mother liquor recycle Unit Process for Reduction for DASDA Newreka Recycle Solution (NRS) TM ISOLATOR NEWREKA REDUCTION CATALYST (NRC ) CATALYST (NGC) NEWREKA GREEN REDUCTION SPENT NRC CENTRIFUGE GREEN AMINE Mother Liquor Storage 1000lit and 1,00,000lit FILTER 80%yield

60. Comparison of E-factor in Reduction for DASDA

62. STATISTICS :Reduction in DASDA Sr. No. No. of experiment Quantity * Number of experiments performed 200 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm Purity % Fresh Lemon yellow Powder Single spot of product 33 96.45 R1 Lemon yellow Powder Single spot of product 33 95.27 R2 Lemon yellow Powder Single spot of product 34 94.89 R3 Lemon yellow Powder Single spot of product 36 96.02 R4 Lemon yellow Powder Single spot of product 36 95.74 R5 Lemon yellow Powder Single spot of product 37 95.85

63. 1 . Recycle of ”Reaction Medium” 25times. 2. 80% of Theoretical Yield. 3. Effluent down by minimum 50%. 4. Energy efficient. 1. Highly Acidic Liquid Effluent. 2. 78% of Theoretical Yield. 3. There is no solution of effluent. 4. Energy intensive process. A Comparison of Conventional Technology & NRS for DASDA production A Comparison of Conventional Technology & NRS

64. Newreka recycle solution for 4-Nitro Di-phenylene amine-2-Sulphonic acid To 4,4-Di amino Di phenylene-2-Sulphonic acid (FC Acid) (Acidic ML Recycle)

65. Unit Process for Reduction Conventional Technology for FC Acid Case Study – Acidic Mother Liquor ISOLATOR NADPSA Water CIP FILTERATION REDUCTION EXTRACTION Water Neutral isolaton mass Spent Iron Oxide Product yield 84%

66. Case Study - Acidic mother liquor recycle Unit Process for Reduction in FC Acid Newreka Recycle Solution (NRS) TM ISOLATOR NEWREKA REDUCTION CATALYST (NRC ) CATALYST (NGC) NEWREKA GREEN REDUCTION SPENT NRC CENTRIFUGE GREEN AMINE Mother Liquor Storage 1000lit and 1,00,000lit FILTER Yield 88%

67. E-Factor of Reduction process in FC Acid

69. STATISTICS In FC Acid Sr. No. No. of experiment Quantity * Number of experiments performed 200 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm Purity % Fresh violet Amorphous Single spot of product 40 94.4 R1 violet Amorphous Single spot of product 41 93.4 R2 violet Amorphous Single spot of product 41 92.5 R3 violet Amorphous Single spot of product 47 93.6 R4 violet Amorphous Single spot of product 37 93.0 R5 violet Amorphous Single spot of product 44.5 92.0

71. Newreka recycle solution for Meta- phenylene Di-Nitro 4-sulphonic Acid To Meta phenylene Di- Amine 4-sulphonic Acid(MPDSA) (Acidic ML Recycle)

72. Unit Process for Reduction Conventional Technology for MPDSA Case Study – Acidic Mother Liquor ISOLATOR Water CIP FILTERATION REDUCTION EXTRACTION Water Neutral isolaton mass Product yield of 60% Acidic effluent Spent MPDNSA

73. Case Study-Acidic mother liquor recycle Unit Process for Reduction Newreka Recycle Solution (NRS) TM ISOLATOR NEWREKA REDUCTION CATALYST CATALYST NEWREKA GREEN REDUCTION SPENT NRC CENTRIFUGE GREEN AMINE Mother Liquor Storage 1000lit and 1,00,000lit FILTER Yield 65% MPDNSA

74. Comparison of E-Factor in MPDSA

75. STATISTICS : In MPDSA process Sr. No. No. of experiment Quantity * Number of experiments performed 300 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm Purity % Fresh Off white Semi crystal Single spot of product 25 99.45 R1 Off white Semi crystal Single spot of product 28 99.27 R2 Off white Semi crystal Single spot of product 30 99.39 R3 Off white Semi crystal Single spot of product 30 99.16 R4 Off white Semi crystal Single spot of product 30 99.34 R5 Off white Semi crystal Single spot of product 32 99.52

76. 1. Recycle of ”Reaction Medium” 25times. 2. 65% of Theoretical Yield. 3. Off white Colored Product. 4. Energy efficient & safe process. 1. Highly Acidic Liquid Effluent. 2. 60% of Theoretical Yield. 3. Grey Colored Product. 4. Energy Intensive & hazardous process. A Comparison of Conventional Technology & NRS for Reduction process of MPDSA A Comparison of Conventional Technology & NRS

77. DIAZOTIZATION: Meta aminoacetophenone To Meta hydroxyacetophenone (make your synthesis green)

78. Case Study – Acidic Mother Liquor Unit Process : Diazotization Conventional Technology

79. Unit Process : Diazotization Newreka Recycle Solution (NRS) TM Case Study - Acidic mother liquor recycle

80. STAGE:DIAZOTIZATION

81. STATISTICS : DIAZOTIZATION Sr. No. No. of experiment Quantity * Number of experiments performed 283 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Melting range o C Dry product gm Purity % Fresh Off White Amorphous Single spot of product 95 70 99.50 R1 Off White Amorphous Single spot of product 95 72 99.60 R2 Off White Amorphous Single spot of product 95 75 99.59 R3 Off White Amorphous Single spot of product 95 80 99.60 R4 Off White Amorphous Single spot of product 95 83 99.65 R5 Off White Amorphous Single spot of product 95 85 99.68

82. 1 . Recycle of ”Reaction Medium” 75 times. 2. 95% of Theoretical Yield. 3. Yellow Colored Product. 4. Green solvent as Extraction Medium. 5. Energy efficient. 1. Highly Acidic Liquid Effluent. 2. 70% of Theoretical Yield. 3. Brown Colored Product. 4. Class 1 Solvent as Extraction Medium. 5. Energy Intensive process. A Comparison of Conventional Technology & NRS A Comparison of Conventional Technology & NRS

83. Newreka recycle solution for PNCB To Na-PHENOLATE (Alkaline ML Recycle)

84. Unit Process for PNP Conventional Technology Case Study – Alkaline Mother Liquor

85. Case Study -Alkaline mother liquor recycle Unit Process for PNP Newreka Recycle Solution (NRS) TM

86. STATISTICS OF Na-PHENOLATE Sr. No. No. of experiment Quantity * Number of experiments performed 136 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm Fresh Yellow Powder Single spot of product 94 R1 Yellow Powder Single spot of product 95.6 R2 Yellow Powder Single spot of product 96 R3 Yellow Powder Single spot of product 95.2 R4 Yellow Powder Single spot of product 96.3 R5 Yellow Powder Single spot of product 96.8

87. STAGE for PNP

88. 1. Recycle of ”Reaction Medium” 15 times. 2. 25% Savings in Sodium Hydroxide. 3. 99% of Theoretical Yield. 5. Yellow Colored Product. 6. Energy efficient since effluent treatment not needed. Benefits of NRS for Alkaline ML Recycle

89. Newreka recycle solution for Na-PHENEOLATE To PNP (Acidic ML Recycle)

90. Unit Process for PNP Conventional Technology Case Study – Acidic Mother Liquor

91. Case Study-Acidic mother liquor recycle Unit Process for PNP Newreka Recycle Solution (NRS) TM

92. STATISTICS OF PNP Sr. No. No. of experiment Quantity * Number of experiments performed 136 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Melting range o C Dry product gm Purity % Fresh Yellow Crystalline Single spot of product 112-114 142 99.04 R1 Yellow Crystalline Single spot of product 112-114 146 99.18 R2 Yellow Crystalline Single spot of product 112-114 140 98.94 R3 Yellow Crystalline Single spot of product 112-114 144 99.36 R4 Yellow Crystalline Single spot of product 112-114 142 99.27 R5 Yellow Crystalline Single spot of product 112-114 146 99.09

93. STAGE for PNP

94. 1 . Recycle of ”Reaction Medium” 1 5 times 2. 30% Savings in Sulphuric Acid 3. Saleable Na2SO4 by product 4. 95% of Theoretical Yield 5. Yellow Colored Product 6. Useful acidic reaction medium 1. Highly Acidic Liquid Effluent 2. Low yield of product 3. Solid waste mixture of (Na 2 SO 4 + NaCl) 4. 90% of Theoretical Yield 5. Brown Colored Product 6. Waste disposal needed A Comparison of Conventional Technology & NRS A Comparison of Conventional Technology & NRS

95. Case Studies of Green Nitration Technology (Salicylic acid to 5-Nitro salicylic acid)

96. Unit Process for Nitration Conventional Technology for Salicylic acid Case Study – Nitration ISOLATOR FILTERATION NITRATION ICE Acidic effluent solution Reaction mass Gl. Acetic Acid Salicylic acid 5-Nitro Salicylic acid Nitrating Mixture

97. ISOLATOR FILTERATION NITRATION Recycle Acidic ML Reaction mass HNO3 Salicylic acid 5-Nitro Salicylic acid Case Study - Acidic mother liquor recycle Unit Process : Nitration Newreka Recycle Solution (NRS) TM Acidic ML

98. STAGE:NITRATION – SALICYLIC ACID

99. STATISTICS:NITRATION Sr. No. Particulars No. of experiments performed * Number of experiments performed 288 Product characterization in recycle experiments (salicylic acid) Recycle No Color Appearance Melting range 0 C Dry product gm Fresh Yellowish white Amorphous 180 – 190 53 R1 Yellowish white Amorphous 185 – 192 54.7 R5 Yellowish white Amorphous 180 – 192 50 R10 Yellowish white Amorphous 180 – 190 53.2 R15 Yellowish white Amorphous 185 – 190 52.8 R20 Yellowish White Amorphous 180- 192 54 R25 Yellowish white Amorphous 190 – 195 54 R30 Yellowish white Amorphous 190 – 200 54 R35 Yellowish white Amorphous 195- 205 52.7 R40 Yellowish white Amorphous 185 -190 53.2 R45 Yellowish white Amorphous 185 – 190 53.7 R50 Yellowish white Amorphous 185 -190 52.3

101. Case Studies of Green Nitration of Acetophenone (Make Your synthesis Green)

102. Unit Process for Acetophenone Conventional Technology Case Study – Nitration ISOLATOR Mix acid FILTERATION NITRATION ICE acidic solution Reaction mass 98%H2SO4 Acetophenone 71% YIELD WATER

103. Case Study - Nitration of Acetophenone Unit Process for Acetophenone Newreka Nitration Solution ISOLATOR NITRATION GREEN NITRO Yield 82% 98%H2SO4 Mixed acid Acetophenone FILTERATION Ice

104. STAGE: Acetophenone Nitration

105. STATISTICS: NITRATION Sr. No. No. of experiment Quantity * Number of experiments performed 300 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm M.P 0 C Fresh cream Amorphous powder Single spot of product 28.8 76 Fresh cream Amorphous powder Single spot of product 28.2 77 Fresh cream Amorphous powder Single spot of product 27.5 78 Fresh cream Amorphous powder Single spot of product 28.9 79 Fresh cream Amorphous powder Single spot of product 27.9 77 Fresh cream Amorphous powder Single spot of product 28 78

106. 1. Overall addition or maintain time is 12 hrs. 2. 82% of Theoretical Yield 3. 25% Savings in Sulfuric Acid 4. Energy efficient & safe process. 5.Minimise effluent (25%) 6.25% more batch size capacity in same reactor 1. Overall addition or maintain Time is 15 to 16hrs. 2. 71% of Theoretical Yield 3. Sulfuric Acid – 1.5Times 4. Energy Intensive process 5. No effluent minimize 6. No more capacity of batch size. A Comparison of Conventional Technology & NRS A Comparison of Conventional Technology & NRS

107. Case Study of Green Nitration of Benzoic Acid (Make Your Chemistry Green)

108. Unit Process for MNBA Conventional Technology Case Study – Nitration ISOLATOR FILTERATION NITRATION acidic solution Reaction mass Benzoic acid 98% HNO3 90% YIELD COOL WATER 98% H2SO4

109. Case Study-Nitration Unit Process for MNBN Newreka Nitration Solution ISOLATOR NITRATION GREEN NITRO Yield 95% 98%H2SO4 Benzoic acid 98% HNO3 FILTERATION Cool water

110. STAGE: Meta nitro benzoic acid

111. STATISTICS: Meta nitro benzoic acid Sr. No. No. of experiment Quantity * Number of experiments performed 100 Product characterization in recycle experiments Recycle No Color Appearance TLC/GC/HPLC Dry product gm M.P 0 C Fresh OFF WHITE Crystalline powder Single spot of product 120 142 Fresh OFF WHITE Crystalline powder Single spot of product 118.5 139 Fresh OFF WHITE Crystalline powder Single spot of product 124 140 Fresh OFF WHITE Crystalline powder Single spot of product 115 141 Fresh OFF WHITE Crystalline powder Single spot of product 120 141 Fresh OFF WHITE Crystalline powder Single spot of product 119 139

112. 1 . Overall addition or maintain time is 8.5 hrs. 2. 92% of Theoretical Yield 3. 25% Savings in Sulfuric Acid 4. Energy efficient 5.Minimise effluent (25%) 6.25% more batch size capacity in same reactor 1. Overall addition or maintain Time is 12 to 14hrs. 2. 90% of Theoretical Yield 3. Sulfuric Acid – 1.5 Times 4. Energy Intensive process 5. No effluent minimize 6. No more capacity of batch size. A Comparison of Conventional Technology & NRS A Comparison of Conventional Technology & NRS

113. A Case study Of Green Intermediate Synthesis For Anti-AIDS Drug Make Your Molecule Green

114. Unit Process for Diazotization Conventional Technology Case Study – Acidic Mother Liquor

115. Unit Process : Diazotization Newreka Recycle Solution (NRS) TM Case Study-Acidic mother liquor recycle

116. Unit Process : Nitration Conventional Technology Case Study – Neutral Mother Liquor

117. Case Study-Neutral mother liquor recycle Unit Process : Nitration Newreka Recycle Solution (NRS) TM

118. Unit Process for Chlorination Conventional Technology Case Study – Acidic Mother Liquor

119. Case Study-Acidic mother liquor recycle Unit Process for Chlorination Newreka Recycle Solution (NRS) TM

120. Case Study – Neutral Mother Liquor Conventional Technology Unit Process : Reduction

121. Case Study – Neutral Mother Liquor Unit Process : Reduction Newreka Recycle Solution (NRS) TM

122. Case Study: Reducing E-Factor & Improving Yield DRUG : Anti – Retroviral Drug CUSTOMER : A fast growing Indian Pharma Company CONVENTIONAL SYNTHETIC CHEMISTRY PROCESS E-Factor 32 38 28 4 Effluent 1920 TPA 2280 TPA 1680 TPA 240 TPA (for 60TPA plant) GREEN CHEMISTRY SOLUTION BY NEWREKA E-Factor 6 6 1 4 Effluent 360 TPA 360 TPA 60 TPA 240 TPA Stage III Chlorination Stage IV Reduction Stage V Stage II Nitration Stage I Diazo. & Hydrolysis Stage VI Stage II Nitration Stage III Chlorination Stage IV Reduction Stage I Diazo & Hydrolysis Stage VI Stage V

123. Case Study: Reducing E-Factor & Improving Yield

127. 1 . Recycle of ”Reaction Medium” infinite times 2. 95% of Theoretical Yield 3. Ecofriendly solvent as Extraction Medium 4. Energy efficient 1. Acidic Liquid Effluent 2. 85% of Theoretical Yield 3. Harmful Solvent as Extraction Medium 4. Energy Intensive process A Comparison of Conventional Technology & NRS A Comparison of Conventional Technology & NRS

128. A Case study Of Green Intermediate Synthesis For Decongestant Drug Make Your Molecule Green

129. Unit Process for Acetophenone Conventional Technology Case Study – Nitration ISOLATOR Mix acid FILTERATION NITRATION ICE acidic solution Reaction mass 98%H2SO4 Acetophenone 71% YIELD WATER

130. Case Study - Nitration of Acetophenone Unit Process for Acetophenone Newreka Nitration Solution ISOLATOR NITRATION GREEN NITRO Yield 82% 98%H2SO4 Mixed acid Acetophenone FILTERATION Ice

131. Case Study – Neutral Mother Liquor Unit Process for MAA Conventional Technology

132. CASE STUDY OF NEUTRAL MOTHER LIQUOR RECYCLE

133. Case Study – Acidic Mother Liquor Unit Process : Diazotization Conventional Technology

134. Unit Process : Diazotization Newreka Recycle Solution (NRS) TM Case Study - Acidic mother liquor recycle

135. Case Study: Reducing E-Factor & Improving Yield DRUG : Decongestant Drug CUSTOMER : A fast growing Indian Pharma Company CONVENTIONAL SYNTHETIC CHEMISTRY PROCESS GREEN CHEMISTRY SOLUTION BY NEWREKA Stage III Diazotization Stage II Reduction Stage I Nitration Stage II Reduction Stage III Diazotization Stage I Nitration

136. Newreka Recycle Solution For PARATOLUDINE

137. Unit Process for Paratolidine Conventional Technology Case Study – Catalytic Hydrogenation

138. Case Study : Green Reduction Unit Process for Paratoludine Newreka Recycle Solution (NRS) TM Isomer Free

141. Strength of Team Newreka

142. The Deserved Reward by GCNC-2008

143. Thank You & Wish all of You a “ Greener Future” from Team Newreka