This document provides an overview of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It discusses how these diseases are characterized by the progressive loss of neurons in specific areas of the brain. Alzheimer's disease results in cortical atrophy and is defined by neuritic plaques containing amyloid beta and neurofibrillary tangles containing tau protein. Parkinson's disease causes degeneration of dopamine-producing neurons in the substantia nigra and is associated with Lewy bodies containing accumulated alpha-synuclein protein in damaged cells. The document outlines several common mechanisms of neurodegeneration including protein aggregation, mitochondrial dysfunction, and oxidative stress.