This document discusses various neurocutaneous syndromes and diseases that can manifest with both neurological and skin symptoms. It categorizes conditions as autosomal dominant or recessive inheritance patterns or X-linked. Specific diseases mentioned include neurofibromatosis, Von Hippel Lindau disease, Osler-Weber-Rendu syndrome, ataxia telangiectasia, and xeroderma pigmentosa. Several systemic diseases that can involve both the nervous system and skin are also listed, such as systemic lupus erythematosus, antiphospholipid syndrome, Behcet's disease, Sjogren's syndrome, and scleroderma along with their associated symptoms.

1. Differential diagnosis
• Autosomal Dominant
• Autosomal Recessive
• X-Linked
Neurocutaneous
syndromes
• SLE
• APL
• Scleroderma
• Sjogren
• Behcet disease
Neurocutaneous
manifestations of
systemic diseases

2. Neurofibromatosis

3. Von Hippel Lindau disease

4. Osler-Weber-Rendu syndrome

5. Ataxia Telangiectasia

6. Xeroderma Pigmentosa

7. Neurocutaneous manifestations of
systemic diseases
Systemic Lupus
Antiphospholipid Syndrome : Thrombotic events , Levido reticularis
Behcet Disease :Oral-Genital ulcers , Meningio-encephalitis
Sjogren syndrome: Parotid enlargement, PN and Dryness
Scleroderma: Facial pains, Raynouds and dyspepsia