Overview about evolution of the term Oligometastases,the paradigm and various states of oligometastases,treat options ,clinical trials and relevance in current clinical practice
O. Glehen - HIPEC in colorectal carcinomatosisGlehen
Pr Olivier Glehen presents HIPEC in colorectal carcinomatosis in Slovenia 2013. Présentation de la CHIP dans la carcinose péritonéale d'origine colorectale.
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Overview about evolution of the term Oligometastases,the paradigm and various states of oligometastases,treat options ,clinical trials and relevance in current clinical practice
O. Glehen - HIPEC in colorectal carcinomatosisGlehen
Pr Olivier Glehen presents HIPEC in colorectal carcinomatosis in Slovenia 2013. Présentation de la CHIP dans la carcinose péritonéale d'origine colorectale.
Hypofractionation in early breast cancer is no more a research scholars topic. Multiple studies with robust data have proven its utility. It may hold an important role in many countries with constrained resources. This is a short presentation incorporating important completed and ongoing trials. Feel free to use this.
Running Head Colorectal Cancer Prevention Program-Evaluation Des.docxaryan532920
Running Head: Colorectal Cancer Prevention Program-Evaluation Design 9
Colorectal Cancer Prevention Program Evaluation Design
Kaplan University-PU630-Unit 7
September 20, 2016
Deserie Thomas
Dr. Amy Thompson
COLORECTAL CANCER PREVENTION PROGRAM EVALUATION DESIGN
Engaged Stakeholders What Stakeholders Want to Know
Public Health Department
Document the resources that have been leveraged to support colorectal cancer prevention program efforts.
Local Legislators
Identify the number of people receiving services and the extent to which interventions are yielding intended awareness, behavioral and/or health outcomes for participants.
Intervention participants
Determine the extent to which interventions are yielding intended awareness, behavioral and/or health outcomes for participants.
Community Clinic
Review the quality, contributions, and impact of the Colorectal Cancer Coalition.
Review the quality and implementation progress of the statewide Colorectal Cancer Coalition plan.
Determine to what extent interventions outlined in the Colorectal Cancer Coalition action plan are being executed and yielding intended results.
Local American Cancer Society Partner
Determine whether American Cancer Society products are being incorporated effectively into the efforts of the colorectal cancer prevention program.
Engaging Stakeholders
Health Department
Members of the evaluation advisory committee
Presenters/advocates who share findings with state and community partners
All phases of the evaluation process via regular evaluation advisory committee meetings
Legislators
External reviewers of evaluation plans and methods
Evaluation planning phase
Intervention Participants
Members of the evaluation advisory committee
Data sources (i.e., participants in evaluation interviews and surveys)
Two representatives to participate in all phases of the evaluation process via regular evaluation advisory committee
Community Clinic
External reviewers of evaluation plans and methods
Evaluation implementation phase
Evaluation planning phase
Local American Cancer Society Partner
Data analysts Presenters/advocates who share findings with state and community partners
Evaluation implementation phase Dissemination phase
Evaluation Stakeholder Group Composition
The composition of the evaluation stakeholders will fund and authorized the continuation or expansion of the Colorectal Cancer Prevention Program. The stakeholders are responsible for day to day implementation of the activities that are part of the program, and has a strong influence on the development of thoughtful evaluation questions that will generate evaluation findings that are useful, relevant, and credible (assuming the evaluation applies the appropriate design and data collection and analysis methods). Ideally, the evaluation stakeholders gro ...
About the Ontario Institute for Cancer Researchjosephoicr
The Ontario Institute for Cancer Research’s focus on multi-disciplinary research teams, a collaborative approach and on moving discoveries into the clinic more quickly has advanced both discovery and translation.
How Community Engagement Fits Into The Mission Of The National Center for Adv...SC CTSI at USC and CHLA
Christopher Austin, MD, Director of the National Center for Advancing Translational Sciences (NCATS) shared his thoughts on how community engagement fits into the mission of NCATS at the recent CTSA Community Engagement Key Function Committee (KFC) conference. He proposed a revision of NCATS' mission: "To catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of interventions that tangibly improve human health across a wide range of human diseases and conditions." Learn more about NCATS http://www.ncats.nih.gov/
Presentation at PORTAGE (Paediatric Oncology Roundtable to Transform Access to Global Essentials) Inaugeral Meeting, hosted by Friends of Cancer Patients, Childhood Cancer International and International Society of Paediatric Oncology, 16-18 January 2018, Sharjah, UAE
ndia is one of the developing countries who have national cancer control programme (NCCP). We started way back in 1975 and the plan has been revised three times. The first revision was in 1984, second one in 1991 and third one 2004.
India Cancer Diagnostics Market: Size, Share, and In-Depth Competitive Analys...Kumar Satyam
According to the TechSci Research report, “India Cancer Diagnostics Market –Industry Size, Share, Trends, Competition Forecast & Opportunities, 2028,” the India Cancer Diagnostics Market stood at USD 571.03 billion in 2022 and is anticipated to grow with a CAGR of 7.36% in the forecast period, 2024-2028. Awareness among individuals regarding cancer diagnostics has led to favorable market conditions for the India Cancer Diagnostics market. Several factors contribute to the growth of various cancer diagnostics products, including advancements in technology, government initiatives, and increased healthcare investments.
Market Dynamics
Rising Incidence of Cancer
In 2022, the projected number of new cancer cases in India was 1,461,427, with a crude incidence rate of 100.4 per 100,000 individuals. Approximately one in nine people in India is expected to face a cancer diagnosis during their lifetime. Notably, lung cancer ranked highest among males, while breast cancer held the top spot for females. Within childhood cancers (0-14 years), lymphoid leukemia emerged as the predominant site, accounting for 29.2% in boys and 24.2% in girls. Looking ahead, an estimated 12.8% increase in cancer incidence by 2025 is expected compared to 2020.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Cancer burden in India
New cancer patients
diagnosed every year
2012 10 lakhs
2035(predicted) 17 lakhs
Statistics: GLOBOCAN 2012
3. Cancer deaths in India
Cancer related deaths
per year
2012 6.5 lakhs
2035(predicted) 12 lakhs
Statistics: GLOBOCAN 2012
4. Proportion of Cancer deaths
Cancer deaths /
Incidence
India 6.8
Developed
countries
3.5 to 5.7
Statistics: GLOBOCAN 2012
5. High proportion of cancer
deaths in india is due to
1. Advanced stage at presentation
2. Lack of cancer care facilities
3. Unaffordability of treatment
4. Lack of trained personnel
5. Lack of unified strategy
6. Lack of research - india specific
problems
7. The National Cancer Grid
» NCG is a network of major cancer centers, research
institutes, patient groups and charitable institutions
across India.
» NCG was formed in August 2012.
» Funded by Govt of INDIA
8. The National Cancer Grid
» Its Purpose is to establish
1. Uniform standards of patient care for prevention,
diagnosis, & treatment of cancer.
2. Providing specialized training and education in
oncology.
3. Facilitating collaborative basic, translational and
clinical research in cancer.
9. The National Cancer Grid
» Largest network of cancer hospitals in the world.
» At present has 140 member institutions.
11. Patient Care
» Formulation of evidence-based management
guidelines for common cancers.
» Systematic method of data capture of every patient
being treated at a cancer center.
» Voluntary process of audit & peer review of
institutions.
12. Education and Training
» “National Cancer Library” - free access of high-
quality cancer journals and other educational
resources to the constituent centers.
» Exchange of expertise & mentoring between the
centers.
» Training of cadres of physicians and paramedical
staff
13. Travelling school of pathology
» Workshops conducted in member institutions
about quality surgical pathology reporting.
14. Collaborative research
» Establish research networks (like RTOG &
ESMO), which facilitate high-quality
multicentric cancer research aimed at
addressing India's unique problems.
18. 1. https://tmc.gov.in/ncg/index.php
2. C. S. Pramesh, Rajendra A. Badwe & Ratan Kumar Sinha.
The National Cancer Grid of India. Indian J Med Paediatr
Oncol. 2014 Jul-Sep; 35(3): 226–227.
Refrences