Mycotoxins are toxic metabolites produced by fungi that can contaminate crops, processed foods, and animal feed in some regions. This document discusses developing strategies to manage mycotoxin contamination in the semi-arid tropics, in order to enhance food safety, protect human and animal health, and prevent interactions between mycotoxins and other pathogens. It proposes an integrated strategy using genetic and natural resource management to improve food quality, safety, and control of mycotoxins in food and feed.