This document summarizes a study that assessed health risks from occupational exposure to chemicals at a petrochemical industry complex in Iran. The study evaluated risks through a semi-quantitative analysis of 27 chemicals across four units. It also examined spirometry indices in employees. The results found that Raffinate in the Butadiene unit posed the highest risk. Spirometry measures like FVC and FEV1 were negatively correlated with age and work experience, indicating reduced pulmonary function in older and longer-tenured employees. Overall, 48.1% of chemicals posed low risk, 29.6% medium risk, 18.5% high risk, and 3.7% very high risk. The study concluded that variables like age
Safety Pharmacology: Respiratory System Pooja Shimpi
Safety pharmacology are Studies that investigate the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in therapeutic range and above
Safety Pharmacology: Respiratory System Pooja Shimpi
Safety pharmacology are Studies that investigate the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in therapeutic range and above
Safety pharmacology is a branch of pharmacology with its aim to predict the potential clinical risk profile of new chemical entities (NCEs).
It has the ability to predict the potential off-target drug effects on major organ systems which are associated with exposure in the therapeutic range and above.
As an essential part of the spectrum of drug discovery and development, safety pharmacology studies are generally conducted to determine the relative drug effect on main organs, including respiratory system, central nervous system, and cardiovascular system.Safety pharmacology is an essential part of the drug development process that aims to identify and predict adverse effects prior to clinical trials.
SP studies are described in the international conference on harmonization (ICH) S7A and S7B Guidelines.
Importance of guidelines in regulatory toxicity testingChander K Negi
Importance of Guidelines in Regulatory Toxicity studies
Guidelines are the consensus document accepted by a regulatory body
Prevent duplication of clinical trials in humans
Ensure SAFETY, EFFICACY and QUALITY of medicines
Minimize the use of animal testing without compromising safety and effectiveness
Do you want to be a hero? Industrial hygienists do it everyday in the workplace. They protect workers from health hazards that include a variety of dust, mists, fumes, gases, and vapors by testing the atmosphere in which they breath and evaluate the exposure against standards and guidelines. They are interested in examining all of the potential toxins in the air, on building surfaces, those that can be ingested or a combination thereof. It's not an easy task. Industrial hygienist need to talk with many stakeholders in finance, engineering, human resources, public policy, medicine, law, etc. The idea is to identify the potential health hazards that may cause harm to workers, unsuspecting public, and the environment. Many of these hazards involve chemicals, biological and physical agents, radiological exposure, human factors and ergonomics, indoor air quality, toxicology and epidemiology, handling and storage, transportation, research and development, and many other considerations. So if you want to be a hero, contact your local section of the American Industrial Hygiene Association. They can provide the information that you will need for a career pathway from academia to senior business professional.
The final protocol (v5.3). Notable changes include:
1) Confirmation of audit standard (Page 6).
2) Refinement of inclusion and exclusion criteria (Page 7)
3) Confirmation of audit status (Appendix C)
4) Refinement of required data fields (Page 19) including definitions (Pages 20-25)
Regulatory guidelines for conducting toxicity studies by ichAnimatedWorld
ICH is the “International Conference on Harmonization of
Technical Requirements for Registration of Pharmaceuticals for
Human Use”
ICH is a joint initiative involving both regulators and research based industry representatives of the EU, Japan and the US in
scientific and technical discussions of the testing procedures required
to assess and ensure the safety, quality and efficacy of medicines
Preclinical Development, Introduction
Definition, Stages of development of a new drug, Objectives of Preclinical studies, Several steps in preclinical trials, Types of studies in Preclinical trials, Importance of preclinical trials
By
Ms. I. Sai Reddemma.
Department of Pharmacology
Pharmacological Approach to Drug DiscoverySuhas Reddy C
For better understanding of students. This will give you a detailed explanation of Pharmacological approach. Contact me through comment section if you need any assistance in understating
ISO 10993-3: Biological Evaluation of Medical Devices - Tests for Genotoxicit...NAMSA
ISO 10993-3: Biological Evaluation of Medical Devices discusses how to identify when genotoxicity, carcinogenicity or reproductive toxicity testing is necessary for a medical device.
Integration of Risk Assessment and Chemical Characterization (MD&M Minn. 2017)Russell Sloboda
The Toxicological Risk Assessment (TRA) is an important tool in the safety assessment of biomedical devices, providing a chemical-based approach which complements a traditional animal-based testing program. The need for TRA is growing and in some cases, may be considered as a means of circumventing animal testing in the safety evaluation of devices.
Based on results of the chemical characterization, the TRA provides context to the chemistry data and the leachable compounds identified therein, which includes compounds expected to be found and compounds that are unexpected. The objective of the chemical characterization study is to identify and quantify substances that may be released from the test article during clinical use and in practical terms, is comprised of incubations of the test article in various media, e.g., water, ethanol, or hexane, at specific temperatures and durations.
By considering the end use of the characterization data in the TRA during the design of the chemical characterization study it can be assured that the study provides the most useful and informative data. Considering the needs of the TRA can also help in determining appropriate detection limits for the analysis, which in turn can help in determining the amount of test material needed for the study. Further, coordinating with the risk assessment team during the design of characterization study helps ensure that the data are usable and presented in the most suitable manner. By working together, the TRA and chemical characterization study provide an understanding of the impact of potential exposures on the overall safety of a device.
Safety pharmacology is a branch of pharmacology with its aim to predict the potential clinical risk profile of new chemical entities (NCEs).
It has the ability to predict the potential off-target drug effects on major organ systems which are associated with exposure in the therapeutic range and above.
As an essential part of the spectrum of drug discovery and development, safety pharmacology studies are generally conducted to determine the relative drug effect on main organs, including respiratory system, central nervous system, and cardiovascular system.Safety pharmacology is an essential part of the drug development process that aims to identify and predict adverse effects prior to clinical trials.
SP studies are described in the international conference on harmonization (ICH) S7A and S7B Guidelines.
Importance of guidelines in regulatory toxicity testingChander K Negi
Importance of Guidelines in Regulatory Toxicity studies
Guidelines are the consensus document accepted by a regulatory body
Prevent duplication of clinical trials in humans
Ensure SAFETY, EFFICACY and QUALITY of medicines
Minimize the use of animal testing without compromising safety and effectiveness
Do you want to be a hero? Industrial hygienists do it everyday in the workplace. They protect workers from health hazards that include a variety of dust, mists, fumes, gases, and vapors by testing the atmosphere in which they breath and evaluate the exposure against standards and guidelines. They are interested in examining all of the potential toxins in the air, on building surfaces, those that can be ingested or a combination thereof. It's not an easy task. Industrial hygienist need to talk with many stakeholders in finance, engineering, human resources, public policy, medicine, law, etc. The idea is to identify the potential health hazards that may cause harm to workers, unsuspecting public, and the environment. Many of these hazards involve chemicals, biological and physical agents, radiological exposure, human factors and ergonomics, indoor air quality, toxicology and epidemiology, handling and storage, transportation, research and development, and many other considerations. So if you want to be a hero, contact your local section of the American Industrial Hygiene Association. They can provide the information that you will need for a career pathway from academia to senior business professional.
The final protocol (v5.3). Notable changes include:
1) Confirmation of audit standard (Page 6).
2) Refinement of inclusion and exclusion criteria (Page 7)
3) Confirmation of audit status (Appendix C)
4) Refinement of required data fields (Page 19) including definitions (Pages 20-25)
Regulatory guidelines for conducting toxicity studies by ichAnimatedWorld
ICH is the “International Conference on Harmonization of
Technical Requirements for Registration of Pharmaceuticals for
Human Use”
ICH is a joint initiative involving both regulators and research based industry representatives of the EU, Japan and the US in
scientific and technical discussions of the testing procedures required
to assess and ensure the safety, quality and efficacy of medicines
Preclinical Development, Introduction
Definition, Stages of development of a new drug, Objectives of Preclinical studies, Several steps in preclinical trials, Types of studies in Preclinical trials, Importance of preclinical trials
By
Ms. I. Sai Reddemma.
Department of Pharmacology
Pharmacological Approach to Drug DiscoverySuhas Reddy C
For better understanding of students. This will give you a detailed explanation of Pharmacological approach. Contact me through comment section if you need any assistance in understating
ISO 10993-3: Biological Evaluation of Medical Devices - Tests for Genotoxicit...NAMSA
ISO 10993-3: Biological Evaluation of Medical Devices discusses how to identify when genotoxicity, carcinogenicity or reproductive toxicity testing is necessary for a medical device.
Integration of Risk Assessment and Chemical Characterization (MD&M Minn. 2017)Russell Sloboda
The Toxicological Risk Assessment (TRA) is an important tool in the safety assessment of biomedical devices, providing a chemical-based approach which complements a traditional animal-based testing program. The need for TRA is growing and in some cases, may be considered as a means of circumventing animal testing in the safety evaluation of devices.
Based on results of the chemical characterization, the TRA provides context to the chemistry data and the leachable compounds identified therein, which includes compounds expected to be found and compounds that are unexpected. The objective of the chemical characterization study is to identify and quantify substances that may be released from the test article during clinical use and in practical terms, is comprised of incubations of the test article in various media, e.g., water, ethanol, or hexane, at specific temperatures and durations.
By considering the end use of the characterization data in the TRA during the design of the chemical characterization study it can be assured that the study provides the most useful and informative data. Considering the needs of the TRA can also help in determining appropriate detection limits for the analysis, which in turn can help in determining the amount of test material needed for the study. Further, coordinating with the risk assessment team during the design of characterization study helps ensure that the data are usable and presented in the most suitable manner. By working together, the TRA and chemical characterization study provide an understanding of the impact of potential exposures on the overall safety of a device.
Born to a Gujarati OBC family in Vadnagar, Modi helped his father sell tea as a child, and later ran his own stall. He was introduced to the right-wing Hindu nationalist organisation Rashtriya Swayamsevak Sangh at the age of eight, beginning a long association with the organisation. He left home after graduating from school, partly because of an arranged marriage which he rejected. Modi traveled around India for two years, and visited a number of religious centres. He returned to Gujarat and moved to Ahmedabad in 1969 or 1970. In 1971 he became a full-time worker for the RSS. During the state of emergency imposed across the country in 1975, Modi was forced to go into hiding. The RSS assigned him to the BJP in 1985, and he held several positions within the party hierarchy until 2001, rising to the rank of general secretary.
Modi was appointed chief minister of Gujarat in 2001, due to Keshubhai Patel's failing health and poor public image following the earthquake in Bhuj.
Modi led the BJP in the 2014 general election, which gave the party a majority in the Lok Sabha, the first time a single party had achieved this since 1984. Modi himself was elected to parliament from Varanasi. Since taking office, Modi's administration has encouraged foreign direct investment in the Indian economy, increased spending on infrastructure, and reduced spending on health and social welfare programs. Modi has encouraged efficiency in the bureaucracy, and centralized power through the abolition of the planning commission. Modi has begun a high-profile sanitation campaign, and loosened environmental and labor laws. A Hindu nationalist and member of the Rashtriya Swayamsevak Sangh (RSS), Modi remains a controversial figure domestically and internationally.
Evaluation of Haematological, Hepatic and Renal Function of Auto Drivers in T...IOSRJPBS
Background: Episodes of severe air pollution in Asia have been reported in the scientific literature of recent times. The WHO 2005 report Health effects of transport-related air pollution provides the first comprehensive assessment of air pollution related to road transport and of the risks it presents to human health. Environmental pollution has many facets, and the resultant health risks include diseases in almost all organ systems. In this respect, auto rickshaw drivers are at risk, since they are continuously exposed to emissions from vehicles, due to the nature of their job. In view of this, this study is undertaken. Aim And Objectives: The aim of the study is to evaluate the haematological, renal and liver functions of auto drivers in Tirunelveli city and compare it with age and socio demographically matched controls. Materials And Methods: Following inclusion and exclusion criteria, twenty five auto drivers and twenty five controls were investigated for haematological, renal and liver functions. Results: Red blood cell count, haemoglobin level, and Haematocrit level were significantly lower in auto drivers than the control group. Liver enzymes and renal functions showed statistically non significant difference between both groups except for alanine aminotransferase (ALT) which was significantly higher in auto drivers. Conclusion: Work exposure to petroleum products inhalation has health implications as seen by the haematological, and liver function changes. Such group of workers need to be sensitized about the hazards of exposure, appropriate preventive strategies and periodic medical examination.
Selection of optimal air pollution control strategieseSAT Journals
Abstract
Sustainable development needs social, economic, energy and environmental sustainability. We propose a model to minimize the total cost consisting of economic cost of pollution control equipment, health cost because of pollutants emissions. We developed a Mixed Integer Non Linear Programming (MINLP) based model for selection of optimal air pollution control strategy. The model considers multiple pollutants, multiple emission sources and multiple control equipments. Constraints like budget and efficiency of control equipment are included in the model. Affect of emission norms on total cost is discussed. The efficacy of the proposed model is explained by considering simulation case studies of a typical cement plant and a thermal power plant.
Keywords: sustainable development, economic cost, environmental cost, mixed integer non linear programming, optimization.
Quantification of rate of air pollution by means ofIJARBEST JOURNAL
To develop efficient strategies for pollution control, it is essential to assess
both the costs of control and the benefits that may result. These benefits will often include
improvements in public health, including reductions in both morbidity and premature
mortality. Until recently, there has been little guidance about how to calculate the benefits
of air pollution controls and how to use those estimates to assign priorities to different air
pollution control strategies. In this work, a method is described for quantifying the benefits
of reduced ambient concentrations of pollutants (such as ozone and particulate matter)
typically found in urban areas worldwide. The method applies the data on Jakara, Indonesia,
an area characterized by little wind, high population density (8 million people), congested
roads, and ambient air pollution. The magnitude of the benefits of pollution control depends
on the level of air pollution, the expected effects on health of the pollutants (dose-response),
the size of the population affected, and the economic value of these effects. In the case of
Jakarta, the methodology suggests that reducing exposure to lead and nitrogen dioxide
should also be a high priority. An important consequence of ambient lead pollution is a
reduction in learning abilities for children, measured as I.Q. loss. Apart from that, reducing
the proportion of respirable particles can reduce the amount of illness and premature
mortality.
ABSTRACT- Introduction: Pulmonary function tests have added in the early detection of pulmonary dysfunction in patients considered to be normal on the basis of clinical and radiological examination. The present study was designed to evaluate pulmonary functions in car paint sprayers.
Material and Methods: Sixty subjects in the age group 18 to 45 year were divided into two groups (each group having thirty subjects). Group A consisted of healthy controls. Group B consist of healthy, car paint sprayers. Car paint sprayers had employment duration of 5 to 12 years. Anthropometric and respiratory parameters using MEBISOFT were performed. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS‑17).
Results: The results of present study suggested that the values of FVC, FEV1, FEV1/FVC and PEFR were significantly lower in subjects who were in Group B exposed to organic solvents (used for spraying car painting) when compared with Group A subjects.
Conclusion: The present study results strongly recommend for following appropriate safety measure while spraying car painting using organic solvents irrespective of their smoking status and age.
Key-words: Pulmonary function, Car spray painters, SPSS‑17, Anthropometry, BSA, FVC
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Analysis the Effect of Educational Package on Promotion of Protective Behavio...Editor IJCATR
dust phenomenon, especially in the summer, is a serious problem in Khuzestan province and has adverse effects on
health, environment and economic. Behavior change is the base for health associated risks prevention and one of the models for
behavior change in individual level is Health Belief Model. The aim of this study was to analyze the effect of educational
package on promotion of protective behaviors in exposure to dust phenomenon in Ahvaz teachers by SPSS software.
Methods: This was an experimental study in which 200 teachers randomly were divided into two groups, case and control groups
[n=100, in each group]
pha test. Before the educational intervention, questionnaire was
completed by two groups and educational requirements of subjects were detected and an educational package was designed and
implemented for 4 week. The control group received no intervention. After a month the effect of educational package on study
variables was evaluated. Data were analyzed with SPSS statistical software version 17, by descriptive and analytical tests.
Result: Mean age of case and control groups were 39.75±6.95 and 39.78±7.02 years, respectively. There was no significant
association between marriage and behavior, but there was a significant association between employment number of years and
behavior [p=0.03], education and behavior [p=0.03]. Based on the findings of this study there was a significant association
between the knowledge, health belief model components and behavior of the study subjects, before and after the intervention [p<
0.001].
Conclusion: designing and implementation of an educational package based on health belief model can promote the knowledge
and protective behaviors in exposure to dust particles effectively.