An outbreak of mumps has occurred in northeast Ohio with hundreds of cases reported. Mumps is a contagious viral disease spread through direct contact or respiratory droplets. It causes fever, headache and swelling of the parotid glands. While most cases resolve within 10 days, complications can include meningitis, orchitis and deafness. Public health officials are coordinating a response between local, state and federal agencies to conduct surveillance of cases, track contacts and communicate with the public about risks, especially to vulnerable populations like university students. Ethical considerations around balancing individual rights with public health needs will be important in containment efforts.