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Week 3 Assignment (6 points)
Role Playing Exercise- Your supervising manager has shared
the many of the leaders have identified some issues for the each
of their different job roles. Your supervising manager would
like you to email the identified issues to them so each leaders'
issues and solutions can be appropriately reviewed with each of
the interdisciplinary teams.
Targets:
Apply the key concepts, policies, and trends in the US health
care sector in order to identify challenges in the management of
health care organizations.
The assignment must be based upon your selected job role and
the selected course's case study.
Write a professionally-crafted email to address to the
supervising manager (your faculty) with regard to
the predisposing factors affecting the health care services
delivery situation at that time. This submission does not require
citations or references. The goal is to demonstrate your critical
thinking (analysis and application of the general concepts) in
the assessment of a health care sector service delivery.
· Read about critical thinking in your course Syllabus.
· Read about decision making at http://the-happy-
manager.com/tips/7-step-decision-making-process-infographic/
Post your email in your interdisciplinary group discussion area
and submit your organizational announcement into your
assignment dropbox.
1. Identify and Discuss at Least Two Issues Based on Your Job
Role: List a minimum of two issues that contributed to the
situation from the perspective of your job role. For example, if
your role is the supply chain management one of the issues
might be the absence of the sharp disposal containers due to
flood in the warehouse where they are stored off-site.
2. Identify and Discuss Potential
Solution
s for Each Issue: Recommend a realistic solution to each of the
listed issues. For example, recommend using thick plastic water
containers labelled with permanent markers as a temporary
solution. (Do not use the provided example in your
submissions).
3. Identify and Discuss the Workforce and Stakeholders: List
the workforce and stakeholders necessary to achieve the
proposed solutions. For example, the food supplier/manager
needs to be contacted about the empty water containers. The
custodial chief needs to be contacted about the storage locations
and restrictions enforcement.
TIPS:
1. Know the definitions of terms: predisposing factors
2. Make sure the factors and proposed solutions are reasonable
and achievable. Do not make general or common sense
statements. Think about how you would address these issue in
real life and consider the solutions you may propose to address
these issues in your job role.
3. Learn how to write a professionally-written email, crafted to
your supervising manager regarding the issues you have
identified with potential solutions along with the details
regarding the workforce as well as stakeholders. Know the name
of your Supervising Manager.
Morbidity and Mortality Weekly Report
Weekly / Vol. 66 / No. 27 July 14, 2017
INSIDE
718 Mortality from Amyotrophic Lateral Sclerosis and
Parkinson’s Disease Among Different Occupation
Groups — United States, 1985–2011
723 Racial and Geographic Differences in Breastfeeding —
United States, 2011–2015
728 Pneumococcal Vaccination Among Medicare
Beneficiaries Occurring After the Advisory
Committee on Immunization Practices
Recommendation for Routine Use Of 13-Valent
Pneumococcal Conjugate Vaccine and 23-Valent
Pneumococcal Polysaccharide Vaccine for Adults
Aged ≥65 Years
734 High Risk for Invasive Meningococcal Disease
Among Patients Receiving Eculizumab (Soliris)
Despite Receipt of Meningococcal Vaccine
738 Announcement
739 QuickStats
Continuing Education examination available at
https://www.cdc.gov/mmwr/cme/conted_info.html#weekly.
U.S. Department of Health and Human Services
Centers for Disease Control and Prevention
Measles Outbreak — Minnesota April–May 2017
Victoria Hall, DVM1,2; Emily Banerjee, MPH2; Cynthia
Kenyon, MPH2; Anna Strain, PhD2; Jayne Griffith, MPH2;
Kathryn Como-Sabetti, MPH2;
Jennifer Heath, DNP2; Lynn Bahta2; Karen Martin, MPH2;
Melissa McMahon, MPH2; Dave Johnson, MPH3; Margaret
Roddy, MPH2;
Denise Dunn, MPH2; Kristen Ehresmann, MPH2
On April 10, 2017, the Minnesota Department of Health
(MDH) was notified about a suspected measles case. The patient
was a hospitalized child aged 25 months who was evaluated for
fever
and rash, with onset on April 8. The child had no history of
receipt
of measles-mumps-rubella (MMR) vaccine and no travel history
or
known exposure to measles. On April 11, MDH received a
report
of a second hospitalized, unvaccinated child, aged 34 months,
with
an acute febrile rash illness with onset on April 10. The second
patient’s sibling, aged 19 months, who had also not received
MMR
vaccine, had similar symptoms, with rash onset on March 30.
Real-
time reverse transcription–polymerase chain reaction (rRT-
PCR)
testing of nasopharyngeal swab or throat specimens performed
at
MDH confirmed measles in the first two patients on April 11,
and
in the third patient on April 13; subsequent genotyping
identified
genotype B3 virus in all three patients, who attended the same
child
care center. MDH instituted outbreak investigation and response
activities in collaboration with local health departments, health
care facilities, child care facilities, and schools in affected
settings.
Because the outbreak occurred in a community with low MMR
vaccination coverage, measles spread rapidly, resulting in
thousands
of exposures in child care centers, schools, and health care
facilities.
By May 31, 2017, a total of 65 confirmed measles cases had
been
reported to MDH (Figure 1); transmission is ongoing.
Investigation and Results
After receiving notification of the first case on April 10, MDH
and the Hennepin County Human Services and Public Health
Department began an investigation. The Council of State and
Territorial Epidemiologists and CDC case definition* was used
* An acute illness in a Minnesota resident during January 1,
2017–May 12, 2017,
characterized by generalized, maculopapular rash lasting ≥3
days with a temperature
≥101°F (≥38.3°C) and cough, coryza, or conjunctivitis. A
confirmed case is an acute
febrile rash illness with isolation of measles virus from a
clinical specimen; or
detection of measles-virus specific nucleic acid from a clinical
specimen using
polymerase chain reaction; or immunoglobulin G
seroconversion or a significant
rise in measles immunoglobulin G antibody using an evaluated
and validated
method; or a positive serologic test for measles immunoglobulin
M antibody; or
direct epidemiologic linkage to a case confirmed by one of
these methods.
to identify confirmed cases of measles in Minnesota (1). A
health
alert was issued April 12, which notified health care providers
of the two measles cases in Hennepin County and provided
recommendations concerning laboratory testing for measles
and strategies to minimize transmission in health care settings.
Emphasis was placed on recommendations for all children
aged ≥12 months to receive a first dose of MMR. Providers
identified patients with suspected measles based on clinical
findings and reported suspected cases to MDH. Testing with
rRT-PCR was performed at MDH on nasopharyngeal or throat
swabs and urine specimens. Among persons testing positive by
rRT-PCR who had received vaccine ≤21 days before the test,
genotyping was performed to distinguish wild-type measles
virus
https://www.cdc.gov/mmwr/cme/conted_info.html#weekly
Morbidity and Mortality Weekly Report
714 MMWR / July 14, 2017 / Vol. 66 / No. 27 US Department
of Health and Human Services/Centers for Disease Control and
Prevention
The MMWR series of publications is published by the Center
for Surveillance, Epidemiology, and Laboratory Services,
Centers for Disease Control and Prevention (CDC),
U.S. Department of Health and Human Services, Atlanta, GA
30329-4027.
Suggested citation: [Author names; first three, then et al., if
more than six.] [Report title]. MMWR Morb Mortal Wkly Rep
2017;66:[inclusive page numbers].
Centers for Disease Control and Prevention
Brenda Fitzgerald, MD, Director
William R. Mac Kenzie, MD, Acting Associate Director for
Science
Joanne Cono, MD, ScM, Director, Office of Science Quality
Chesley L. Richards, MD, MPH, Deputy Director for Public
Health Scientific Services
Michael F. Iademarco, MD, MPH, Director, Center for
Surveillance, Epidemiology, and Laboratory Services
MMWR Editorial and Production Staff (Weekly)
Sonja A. Rasmussen, MD, MS, Editor-in-Chief
Charlotte K. Kent, PhD, MPH, Executive Editor
Jacqueline Gindler, MD, Editor
Teresa F. Rutledge, Managing Editor
Douglas W. Weatherwax, Lead Technical Writer-Editor
Soumya Dunworth, PhD, Kristy Gerdes, MPH, Teresa M. Hood,
MS,
Technical Writer-Editors
Martha F. Boyd, Lead Visual Information Specialist
Maureen A. Leahy, Julia C. Martinroe,
Stephen R. Spriggs, Tong Yang,
Visual Information Specialists
Quang M. Doan, MBA, Phyllis H. King,
Paul D. Maitland, Terraye M. Starr, Moua Yang,
Information Technology Specialists
MMWR Editorial Board
Timothy F. Jones, MD, Chairman
Matthew L. Boulton, MD, MPH
Virginia A. Caine, MD
Katherine Lyon Daniel, PhD
Jonathan E. Fielding, MD, MPH, MBA
David W. Fleming, MD
William E. Halperin, MD, DrPH, MPH
King K. Holmes, MD, PhD
Robin Ikeda, MD, MPH
Rima F. Khabbaz, MD
Phyllis Meadows, PhD, MSN, RN
Jewel Mullen, MD, MPH, MPA
Jeff Niederdeppe, PhD
Patricia Quinlisk, MD, MPH
Patrick L. Remington, MD, MPH
Carlos Roig, MS, MA
William L. Roper, MD, MPH
William Schaffner, MD
FIGURE 1. Number of measles cases (N = 65) by date of rash
onset — Minnesota, March 30–May 27, 2017
0
1
2
3
4
5
6
N
o.
o
f c
as
es
Date of rash onset
30 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 1 3 5 7 9 11 13 15
17 19 21 23 25 26
Mar Apr May
(genotype B3 virus) from the vaccine virus (genotype A virus).
Patients (or their parents or guardians) with confirmed measles
were interviewed by local public health officials to confirm
symp-
toms, onset date, and exposure history for the 21 days before
rash onset and identify contacts during their infectious period
(4 days before through 4 days after rash onset). Contacts were
defined as persons who had any contact with patients during
their infectious period.
Among the 65 confirmed cases, the median patient age was
21 months (range = 3 months–49 years). Patients were residents
of Hennepin, Ramsey, LeSueur, and Crow Wing counties.
During April 10–May 31, confirmed measles patients were iden-
tified in five schools, 12 child care centers, three health care
facili-
ties, and numerous households; an estimated 8,250 persons were
potentially exposed to measles in these settings. Rash onset
dates
ranged from March 30–May 27, 2017. Sixty-two (95%) cases
were identified in unvaccinated persons, including 50 (77%) in
children aged ≥12 months (i.e., age-eligible for MMR vaccina-
tion). U.S.-born children of Somali descent (Somali children)
accounted for 55 (85%) of the cases. Among the three patients
Morbidity and Mortality Weekly Report
MMWR / July 14, 2017 / Vol. 66 / No. 27 715US Department of
Health and Human Services/Centers for Disease Control and
Prevention
with a history of measles vaccination, all had received 2 MMR
doses before illness onset. As of May 31, 20 (31%) patients had
been hospitalized, primarily for treatment of dehydration or
pneumonia; no deaths had been reported.
Public Health Response
Rosters and attendance records were obtained from child
care centers and schools where persons might have been
exposed to measles, and the vaccination status of each
attendee was verified through the Minnesota Immunization
Information Connection, a system that stores electronic
immunization records (http://www.health.state.mn.us/
miic). Health care facilities similarly identified contacts
who were exposed to measles patients and followed up with
susceptible (i.e., unvaccinated, pregnant, or immunocom-
promised) exposed persons. In accordance with the Advisory
Committee on Immunization Practices 2013 guidelines (2),
postexposure prophylaxis (PEP) with MMR or immune
globulin was recommended for susceptible, exposed persons.
Persons who received PEP with MMR within 72 hours of
exposure or with immune globulin within 6 days of exposure
were placed on a 21-day self-monitoring symptom watch for
development of fever or rash, but could continue attending
child care and school. Susceptible exposed persons who
did not receive PEP according to recommendations were
excluded from child care centers or school, and MDH rec-
ommended that they avoid public gatherings for 21 days,
including having visitors who were susceptible to measles
virus. By May 31, at least 154 persons had received PEP
(26 MMR doses and 128 courses of immune globulin),
and 586 susceptible exposed persons who did not receive
recommended PEP were excluded from child care centers or
school and advised to receive MMR vaccination to protect
against future measles illness.
On April 18, as the outbreak continued, MDH recom-
mended an accelerated MMR schedule; to provide additional
protection, a second dose of MMR vaccine was recommended
for children who had received a first dose >28 days previ-
ously.† These recommendations were initially for all children
living in Hennepin County and for all Minnesota Somali
children regardless of county of residence, because MMR
coverage rates among Somali children in Hennepin County
have declined since 2007. In 2014, coverage with the first
dose of MMR among Somali children in Hennepin County
was 35.6% (Figure 2). In response to the rapid increase in the
† The Advisory Committee on Immunization Practices (ACIP)
recommends
MMR vaccine for prevention of measles, mumps, and rubella
for persons aged
≥12 months. ACIP recommends 2 doses of MMR vaccine
routinely for children,
with the first dose administered at age 12 through 15 months
and the second
dose administered at age 4 through 6 years before school entry.
https://www.
cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm.
number of reported cases, on May 4, 2017, MDH recom-
mended an accelerated vaccination schedule for all children
aged ≥12 months residing in all counties where a measles case
had been reported during the previous 42 days; MDH further
recommended that health care providers throughout the state
consider using an accelerated schedule.
Previously established culturally appropriate community out-
reach approaches (e.g., working with community and spiritual
leaders, interpreters, health care providers, and community
members) (3) were intensified during the outbreak. Using exist-
ing partnerships, state and local public health officials worked
with MDH Somali public health advisors, Somali medical pro-
fessionals, faith leaders, elected officials, and other community
leaders to disseminate educational materials, attend community
events, and create opportunities for open dialogue and educa-
tion about measles and concerns about MMR vaccine. Child
care centers and schools were provided talking points and
informational sheets on measles and MMR vaccine, and posters
with key messages were distributed in mosques and shopping
malls popular with the Somali community. Community out-
reach focused on oral communication, which is preferred by
this community, including radio and television messaging and
telephone call-in lines that permit approximately 500 persons
at a time to listen to a health professional.
Outreach to encourage vaccination was increased during the
out-
break. By the second week of May, the average number of MMR
vaccine doses administered per week in Minnesota had
increased
from 2,700 doses before the outbreak to 9,964, as reported by
the
Minnesota Immunization Information Connection.
Discussion
Minnesota law requires that children aged ≥2 months be
vaccinated against certain diseases or file a medical or consci-
entious exemption to enroll in school, child care, or school-
based early childhood programs. Before 2008, first-dose MMR
vaccination coverage among Minnesota-born Somali children
aged 2 years in Hennepin County exceeded 90%. However,
MMR vaccination coverage rates declined among Minnesota’s
Somali-American community members starting with the 2008
birth-year cohort. The decline in vaccination coverage was in
response to concerns about autism, the perceived increased
rates of autism in the Somali-American community, and the
misunderstanding that autism was related to MMR vaccine
(3,4). Studies have consistently documented that there is not
a relationship between vaccines and autism (5,6). The low
vaccination rate resulted in a community highly susceptible to
measles. Parental concerns were addressed by building trust
with
the community and identifying effective, culturally appropriate
ways to address questions, concerns, and misinformation about
MMR vaccine. In 2011, a smaller measles outbreak began in
http://www.health.state.mn.us/miic
http://www.health.state.mn.us/miic
https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm
https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm
Morbidity and Mortality Weekly Report
716 MMWR / July 14, 2017 / Vol. 66 / No. 27 US Department
of Health and Human Services/Centers for Disease Control and
Prevention
FIGURE 2. Percentage of children receiving measles-mumps-
rubella vaccine at age 24 months among children of Somali and
non-Somali
descent, by birth year — Hennepin County, Minnesota, 2004–
2014
0
10
20
30
40
50
60
70
80
90
100
2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Pe
rc
en
ta
ge
v
ac
ci
na
te
d
Birth year
Somali
Non-Somali
Source: Minnesota Immunization Information Connection,
Minnesota Department of Health.
Summary
What is already known about this topic?
Measles was declared eliminated from the United States in 2000
but continues to circulate in many regions of the world and can
be imported into the United States by travelers. Measles vaccine
is highly effective, with 1 dose being 93% effective and 2 doses
being 97% effective at preventing measles.
What is added by this report?
In a community with previously high vaccination coverage,
concerns about autism, the perceived increased rates of autism
in the Somali-American community, and the misunderstanding
that autism was related to the measles-mumps-rubella (MMR)
vaccine resulted in a decline in MMR vaccination coverage to a
level low enough to sustain widespread measles transmission in
the Somali-American community following introduction of the
virus. Studies have consistently documented that there is not a
relationship between vaccines and autism.
What are the implications for public health practice?
This outbreak demonstrates the challenge of combating
misinformation about MMR vaccine and the importance of
creating long-term, trusted relationships with communities to
disseminate scientific information in a culturally appropriate
and effective manner.
the Somali community in Hennepin County and resulted in 21
cases, including eight cases in persons of Somali descent (4,7).
At that time, the 1-dose MMR vaccination coverage rate among
Somali children aged 2 years in Hennepin County was 54%. The
source of the 2011 outbreak was a Somali child aged 30 months
who acquired measles while visiting Kenya (7). However, the
source of the current outbreak is unknown, which suggests that
additional cases have likely occurred that did not come to the
attention of health care providers or public health departments.
Although indigenous measles transmission has been elimi-
nated in the United States, the virus continues to circulate
widely in many regions of the world, including Africa,
Europe, and parts of Asia, and is often introduced into the
United States by international travelers (8). High measles
vaccination coverage rates across subpopulations within com-
munities are necessary to prevent the spread of measles. The
current Minnesota measles outbreak, with 31% (20 of 65) of
cases requiring hospitalization, demonstrates the importance
of addressing low vaccination coverage rates to ensure that
children are adequately protected from a potentially serious
vaccine-preventable disease (3).
Acknowledgments
Andrew Murray, Carol Hooker, Erica Bagstad, Hennepin County
Human Services and Public Health Department; Ruth Lynfield,
Malini DeSilva, Richard Danila, Danushka Wanduragala, Kirk
Smith, Ben Christianson, Ellen Laine, Hannah Friedlander, Sean
Buuck, Austin Bell, Carmen Bernu, Erica Bye, Corinne
Holtzman,
Katherine Schleiss, Victor Cruz, Megan Sukalski, Dave Boxrud,
Brian Nefzger, Victoria Lappi, Katie Harry, Net Bekele, Jacob
Garfin,
Gongping Liu, Ruth Rutledge, Lisa Levoir, Barbara Miller,
Fatuma
Sharif-Mohamed, Asli Ashkir, Hinda Omar, Minnesota
Department
of Health; Kris Bisgard, Stacy Holzbauer, Raj Mody, Paul
Gastañaduy,
Paul Rota, Rebecca McNall, Adam Wharton, CDC.
Morbidity and Mortality Weekly Report
MMWR / July 14, 2017 / Vol. 66 / No. 27 717US Department of
Health and Human Services/Centers for Disease Control and
Prevention
Conflict of Interest
No conflicts of interest were reported.
1Epidemic Intelligence Service, CDC; 2Minnesota Department
of Health;
3Hennepin County Human Services and Public Health
Department,
Minneapolis, Minnesota.
Corresponding author: Victoria Hall, [email protected], 651-
201-5193.
References
1. Council of State and Territorial Epidemiologists. Public
health reporting
and national notification for measles. Atlanta, GA: Council of
State and
Territorial Epidemiologists; 2012.
http://c.ymcdn.com/sites/www.cste.
org/resource/resmgr/ps/12-id-07final.pdf
2. McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS.
Prevention of measles,
rubella, congenital rubella syndrome, and mumps, 2013:
summary
recommendations of the Advisory Committee on Immunization
Practices
(ACIP). MMWR Recomm Rep 2013;62(No. RR-4).
3. Bahta L, Ashkir A. Addressing MMR vaccine resistance in
Minnesota’s
Somali community. Minn Med 2015;98:33–6.
4. Gahr P, DeVries AS, Wallace G, et al. An outbreak of
measles in an
undervaccinated community. Pediatrics 2014;134:e220–8.
https://doi.
org/10.1542/peds.2013-4260
5. Jain A, Marshall J, Buikema A, Bancroft T, Kelly JP,
Newschaffer CJ.
Autism occurrence by MMR vaccine status among US children
with older
siblings with and without autism. JAMA 2015;313:1534–40.
https://doi.
org/10.1001/jama.2015.3077
6. Madsen KM, Hviid A, Vestergaard M, et al. A population-
based study
of measles, mumps, and rubella vaccination and autism. N Engl
J Med
2002;347:1477–82. https://doi.org/10.1056/NEJMoa021134
7. CDC. Notes from the field: measles outbreak—Hennepin
County,
Minnesota, February–March 2011. MMWR Morb Mortal Wkly
Rep
2011;60:421.
8. Orenstein WA, Papania MJ, Wharton ME. Measles
elimination in
the United States. J Infect Dis 2004;189(Suppl 1):S1–3.
https://doi.
org/10.1086/377693
mailto:[email protected]
http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/12-
id-07final.pdf
http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/12-
id-07final.pdf
https://doi.org/10.1542/peds.2013-4260
https://doi.org/10.1542/peds.2013-4260
https://doi.org/10.1001/jama.2015.3077
https://doi.org/10.1001/jama.2015.3077
https://doi.org/10.1056/NEJMoa021134
https://doi.org/10.1086/377693
https://doi.org/10.1086/377693Measles Outbreak — Minnesota
April–May 2017

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  • 1. Week 3 Assignment (6 points) Role Playing Exercise- Your supervising manager has shared the many of the leaders have identified some issues for the each of their different job roles. Your supervising manager would like you to email the identified issues to them so each leaders' issues and solutions can be appropriately reviewed with each of the interdisciplinary teams. Targets: Apply the key concepts, policies, and trends in the US health care sector in order to identify challenges in the management of health care organizations. The assignment must be based upon your selected job role and the selected course's case study. Write a professionally-crafted email to address to the supervising manager (your faculty) with regard to the predisposing factors affecting the health care services delivery situation at that time. This submission does not require citations or references. The goal is to demonstrate your critical thinking (analysis and application of the general concepts) in the assessment of a health care sector service delivery. · Read about critical thinking in your course Syllabus. · Read about decision making at http://the-happy- manager.com/tips/7-step-decision-making-process-infographic/ Post your email in your interdisciplinary group discussion area and submit your organizational announcement into your assignment dropbox. 1. Identify and Discuss at Least Two Issues Based on Your Job Role: List a minimum of two issues that contributed to the situation from the perspective of your job role. For example, if your role is the supply chain management one of the issues might be the absence of the sharp disposal containers due to flood in the warehouse where they are stored off-site. 2. Identify and Discuss Potential
  • 2. Solution s for Each Issue: Recommend a realistic solution to each of the listed issues. For example, recommend using thick plastic water containers labelled with permanent markers as a temporary solution. (Do not use the provided example in your submissions). 3. Identify and Discuss the Workforce and Stakeholders: List the workforce and stakeholders necessary to achieve the proposed solutions. For example, the food supplier/manager needs to be contacted about the empty water containers. The custodial chief needs to be contacted about the storage locations and restrictions enforcement. TIPS: 1. Know the definitions of terms: predisposing factors 2. Make sure the factors and proposed solutions are reasonable and achievable. Do not make general or common sense statements. Think about how you would address these issue in real life and consider the solutions you may propose to address these issues in your job role. 3. Learn how to write a professionally-written email, crafted to your supervising manager regarding the issues you have identified with potential solutions along with the details
  • 3. regarding the workforce as well as stakeholders. Know the name of your Supervising Manager. Morbidity and Mortality Weekly Report Weekly / Vol. 66 / No. 27 July 14, 2017 INSIDE 718 Mortality from Amyotrophic Lateral Sclerosis and Parkinson’s Disease Among Different Occupation Groups — United States, 1985–2011 723 Racial and Geographic Differences in Breastfeeding — United States, 2011–2015 728 Pneumococcal Vaccination Among Medicare Beneficiaries Occurring After the Advisory Committee on Immunization Practices Recommendation for Routine Use Of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults Aged ≥65 Years
  • 4. 734 High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine 738 Announcement 739 QuickStats Continuing Education examination available at https://www.cdc.gov/mmwr/cme/conted_info.html#weekly. U.S. Department of Health and Human Services Centers for Disease Control and Prevention Measles Outbreak — Minnesota April–May 2017 Victoria Hall, DVM1,2; Emily Banerjee, MPH2; Cynthia Kenyon, MPH2; Anna Strain, PhD2; Jayne Griffith, MPH2; Kathryn Como-Sabetti, MPH2; Jennifer Heath, DNP2; Lynn Bahta2; Karen Martin, MPH2; Melissa McMahon, MPH2; Dave Johnson, MPH3; Margaret Roddy, MPH2; Denise Dunn, MPH2; Kristen Ehresmann, MPH2 On April 10, 2017, the Minnesota Department of Health
  • 5. (MDH) was notified about a suspected measles case. The patient was a hospitalized child aged 25 months who was evaluated for fever and rash, with onset on April 8. The child had no history of receipt of measles-mumps-rubella (MMR) vaccine and no travel history or known exposure to measles. On April 11, MDH received a report of a second hospitalized, unvaccinated child, aged 34 months, with an acute febrile rash illness with onset on April 10. The second patient’s sibling, aged 19 months, who had also not received MMR vaccine, had similar symptoms, with rash onset on March 30. Real- time reverse transcription–polymerase chain reaction (rRT- PCR) testing of nasopharyngeal swab or throat specimens performed at MDH confirmed measles in the first two patients on April 11, and in the third patient on April 13; subsequent genotyping identified genotype B3 virus in all three patients, who attended the same
  • 6. child care center. MDH instituted outbreak investigation and response activities in collaboration with local health departments, health care facilities, child care facilities, and schools in affected settings. Because the outbreak occurred in a community with low MMR vaccination coverage, measles spread rapidly, resulting in thousands of exposures in child care centers, schools, and health care facilities. By May 31, 2017, a total of 65 confirmed measles cases had been reported to MDH (Figure 1); transmission is ongoing. Investigation and Results After receiving notification of the first case on April 10, MDH and the Hennepin County Human Services and Public Health Department began an investigation. The Council of State and Territorial Epidemiologists and CDC case definition* was used * An acute illness in a Minnesota resident during January 1, 2017–May 12, 2017, characterized by generalized, maculopapular rash lasting ≥3 days with a temperature
  • 7. ≥101°F (≥38.3°C) and cough, coryza, or conjunctivitis. A confirmed case is an acute febrile rash illness with isolation of measles virus from a clinical specimen; or detection of measles-virus specific nucleic acid from a clinical specimen using polymerase chain reaction; or immunoglobulin G seroconversion or a significant rise in measles immunoglobulin G antibody using an evaluated and validated method; or a positive serologic test for measles immunoglobulin M antibody; or direct epidemiologic linkage to a case confirmed by one of these methods. to identify confirmed cases of measles in Minnesota (1). A health alert was issued April 12, which notified health care providers of the two measles cases in Hennepin County and provided recommendations concerning laboratory testing for measles and strategies to minimize transmission in health care settings. Emphasis was placed on recommendations for all children aged ≥12 months to receive a first dose of MMR. Providers identified patients with suspected measles based on clinical findings and reported suspected cases to MDH. Testing with
  • 8. rRT-PCR was performed at MDH on nasopharyngeal or throat swabs and urine specimens. Among persons testing positive by rRT-PCR who had received vaccine ≤21 days before the test, genotyping was performed to distinguish wild-type measles virus https://www.cdc.gov/mmwr/cme/conted_info.html#weekly Morbidity and Mortality Weekly Report 714 MMWR / July 14, 2017 / Vol. 66 / No. 27 US Department of Health and Human Services/Centers for Disease Control and Prevention The MMWR series of publications is published by the Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30329-4027. Suggested citation: [Author names; first three, then et al., if more than six.] [Report title]. MMWR Morb Mortal Wkly Rep 2017;66:[inclusive page numbers]. Centers for Disease Control and Prevention
  • 9. Brenda Fitzgerald, MD, Director William R. Mac Kenzie, MD, Acting Associate Director for Science Joanne Cono, MD, ScM, Director, Office of Science Quality Chesley L. Richards, MD, MPH, Deputy Director for Public Health Scientific Services Michael F. Iademarco, MD, MPH, Director, Center for Surveillance, Epidemiology, and Laboratory Services MMWR Editorial and Production Staff (Weekly) Sonja A. Rasmussen, MD, MS, Editor-in-Chief Charlotte K. Kent, PhD, MPH, Executive Editor Jacqueline Gindler, MD, Editor Teresa F. Rutledge, Managing Editor Douglas W. Weatherwax, Lead Technical Writer-Editor Soumya Dunworth, PhD, Kristy Gerdes, MPH, Teresa M. Hood, MS, Technical Writer-Editors Martha F. Boyd, Lead Visual Information Specialist
  • 10. Maureen A. Leahy, Julia C. Martinroe, Stephen R. Spriggs, Tong Yang, Visual Information Specialists Quang M. Doan, MBA, Phyllis H. King, Paul D. Maitland, Terraye M. Starr, Moua Yang, Information Technology Specialists MMWR Editorial Board Timothy F. Jones, MD, Chairman Matthew L. Boulton, MD, MPH Virginia A. Caine, MD Katherine Lyon Daniel, PhD Jonathan E. Fielding, MD, MPH, MBA David W. Fleming, MD William E. Halperin, MD, DrPH, MPH King K. Holmes, MD, PhD Robin Ikeda, MD, MPH Rima F. Khabbaz, MD
  • 11. Phyllis Meadows, PhD, MSN, RN Jewel Mullen, MD, MPH, MPA Jeff Niederdeppe, PhD Patricia Quinlisk, MD, MPH Patrick L. Remington, MD, MPH Carlos Roig, MS, MA William L. Roper, MD, MPH William Schaffner, MD FIGURE 1. Number of measles cases (N = 65) by date of rash onset — Minnesota, March 30–May 27, 2017 0 1 2 3 4
  • 12. 5 6 N o. o f c as es Date of rash onset 30 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 1 3 5 7 9 11 13 15 17 19 21 23 25 26 Mar Apr May (genotype B3 virus) from the vaccine virus (genotype A virus). Patients (or their parents or guardians) with confirmed measles were interviewed by local public health officials to confirm symp- toms, onset date, and exposure history for the 21 days before
  • 13. rash onset and identify contacts during their infectious period (4 days before through 4 days after rash onset). Contacts were defined as persons who had any contact with patients during their infectious period. Among the 65 confirmed cases, the median patient age was 21 months (range = 3 months–49 years). Patients were residents of Hennepin, Ramsey, LeSueur, and Crow Wing counties. During April 10–May 31, confirmed measles patients were iden- tified in five schools, 12 child care centers, three health care facili- ties, and numerous households; an estimated 8,250 persons were potentially exposed to measles in these settings. Rash onset dates ranged from March 30–May 27, 2017. Sixty-two (95%) cases were identified in unvaccinated persons, including 50 (77%) in children aged ≥12 months (i.e., age-eligible for MMR vaccina- tion). U.S.-born children of Somali descent (Somali children) accounted for 55 (85%) of the cases. Among the three patients Morbidity and Mortality Weekly Report
  • 14. MMWR / July 14, 2017 / Vol. 66 / No. 27 715US Department of Health and Human Services/Centers for Disease Control and Prevention with a history of measles vaccination, all had received 2 MMR doses before illness onset. As of May 31, 20 (31%) patients had been hospitalized, primarily for treatment of dehydration or pneumonia; no deaths had been reported. Public Health Response Rosters and attendance records were obtained from child care centers and schools where persons might have been exposed to measles, and the vaccination status of each attendee was verified through the Minnesota Immunization Information Connection, a system that stores electronic immunization records (http://www.health.state.mn.us/ miic). Health care facilities similarly identified contacts who were exposed to measles patients and followed up with susceptible (i.e., unvaccinated, pregnant, or immunocom- promised) exposed persons. In accordance with the Advisory Committee on Immunization Practices 2013 guidelines (2), postexposure prophylaxis (PEP) with MMR or immune globulin was recommended for susceptible, exposed persons. Persons who received PEP with MMR within 72 hours of
  • 15. exposure or with immune globulin within 6 days of exposure were placed on a 21-day self-monitoring symptom watch for development of fever or rash, but could continue attending child care and school. Susceptible exposed persons who did not receive PEP according to recommendations were excluded from child care centers or school, and MDH rec- ommended that they avoid public gatherings for 21 days, including having visitors who were susceptible to measles virus. By May 31, at least 154 persons had received PEP (26 MMR doses and 128 courses of immune globulin), and 586 susceptible exposed persons who did not receive recommended PEP were excluded from child care centers or school and advised to receive MMR vaccination to protect against future measles illness. On April 18, as the outbreak continued, MDH recom- mended an accelerated MMR schedule; to provide additional protection, a second dose of MMR vaccine was recommended for children who had received a first dose >28 days previ- ously.† These recommendations were initially for all children living in Hennepin County and for all Minnesota Somali children regardless of county of residence, because MMR coverage rates among Somali children in Hennepin County have declined since 2007. In 2014, coverage with the first dose of MMR among Somali children in Hennepin County
  • 16. was 35.6% (Figure 2). In response to the rapid increase in the † The Advisory Committee on Immunization Practices (ACIP) recommends MMR vaccine for prevention of measles, mumps, and rubella for persons aged ≥12 months. ACIP recommends 2 doses of MMR vaccine routinely for children, with the first dose administered at age 12 through 15 months and the second dose administered at age 4 through 6 years before school entry. https://www. cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm. number of reported cases, on May 4, 2017, MDH recom- mended an accelerated vaccination schedule for all children aged ≥12 months residing in all counties where a measles case had been reported during the previous 42 days; MDH further recommended that health care providers throughout the state consider using an accelerated schedule. Previously established culturally appropriate community out- reach approaches (e.g., working with community and spiritual leaders, interpreters, health care providers, and community members) (3) were intensified during the outbreak. Using exist-
  • 17. ing partnerships, state and local public health officials worked with MDH Somali public health advisors, Somali medical pro- fessionals, faith leaders, elected officials, and other community leaders to disseminate educational materials, attend community events, and create opportunities for open dialogue and educa- tion about measles and concerns about MMR vaccine. Child care centers and schools were provided talking points and informational sheets on measles and MMR vaccine, and posters with key messages were distributed in mosques and shopping malls popular with the Somali community. Community out- reach focused on oral communication, which is preferred by this community, including radio and television messaging and telephone call-in lines that permit approximately 500 persons at a time to listen to a health professional. Outreach to encourage vaccination was increased during the out- break. By the second week of May, the average number of MMR vaccine doses administered per week in Minnesota had increased from 2,700 doses before the outbreak to 9,964, as reported by the Minnesota Immunization Information Connection. Discussion
  • 18. Minnesota law requires that children aged ≥2 months be vaccinated against certain diseases or file a medical or consci- entious exemption to enroll in school, child care, or school- based early childhood programs. Before 2008, first-dose MMR vaccination coverage among Minnesota-born Somali children aged 2 years in Hennepin County exceeded 90%. However, MMR vaccination coverage rates declined among Minnesota’s Somali-American community members starting with the 2008 birth-year cohort. The decline in vaccination coverage was in response to concerns about autism, the perceived increased rates of autism in the Somali-American community, and the misunderstanding that autism was related to MMR vaccine (3,4). Studies have consistently documented that there is not a relationship between vaccines and autism (5,6). The low vaccination rate resulted in a community highly susceptible to measles. Parental concerns were addressed by building trust with the community and identifying effective, culturally appropriate ways to address questions, concerns, and misinformation about MMR vaccine. In 2011, a smaller measles outbreak began in http://www.health.state.mn.us/miic http://www.health.state.mn.us/miic https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm
  • 19. https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm Morbidity and Mortality Weekly Report 716 MMWR / July 14, 2017 / Vol. 66 / No. 27 US Department of Health and Human Services/Centers for Disease Control and Prevention FIGURE 2. Percentage of children receiving measles-mumps- rubella vaccine at age 24 months among children of Somali and non-Somali descent, by birth year — Hennepin County, Minnesota, 2004– 2014 0 10 20 30 40
  • 20. 50 60 70 80 90 100 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Pe rc en ta ge v ac ci
  • 21. na te d Birth year Somali Non-Somali Source: Minnesota Immunization Information Connection, Minnesota Department of Health. Summary What is already known about this topic? Measles was declared eliminated from the United States in 2000 but continues to circulate in many regions of the world and can be imported into the United States by travelers. Measles vaccine is highly effective, with 1 dose being 93% effective and 2 doses being 97% effective at preventing measles. What is added by this report?
  • 22. In a community with previously high vaccination coverage, concerns about autism, the perceived increased rates of autism in the Somali-American community, and the misunderstanding that autism was related to the measles-mumps-rubella (MMR) vaccine resulted in a decline in MMR vaccination coverage to a level low enough to sustain widespread measles transmission in the Somali-American community following introduction of the virus. Studies have consistently documented that there is not a relationship between vaccines and autism. What are the implications for public health practice? This outbreak demonstrates the challenge of combating misinformation about MMR vaccine and the importance of creating long-term, trusted relationships with communities to disseminate scientific information in a culturally appropriate and effective manner. the Somali community in Hennepin County and resulted in 21 cases, including eight cases in persons of Somali descent (4,7). At that time, the 1-dose MMR vaccination coverage rate among Somali children aged 2 years in Hennepin County was 54%. The source of the 2011 outbreak was a Somali child aged 30 months
  • 23. who acquired measles while visiting Kenya (7). However, the source of the current outbreak is unknown, which suggests that additional cases have likely occurred that did not come to the attention of health care providers or public health departments. Although indigenous measles transmission has been elimi- nated in the United States, the virus continues to circulate widely in many regions of the world, including Africa, Europe, and parts of Asia, and is often introduced into the United States by international travelers (8). High measles vaccination coverage rates across subpopulations within com- munities are necessary to prevent the spread of measles. The current Minnesota measles outbreak, with 31% (20 of 65) of cases requiring hospitalization, demonstrates the importance of addressing low vaccination coverage rates to ensure that children are adequately protected from a potentially serious vaccine-preventable disease (3). Acknowledgments Andrew Murray, Carol Hooker, Erica Bagstad, Hennepin County Human Services and Public Health Department; Ruth Lynfield, Malini DeSilva, Richard Danila, Danushka Wanduragala, Kirk Smith, Ben Christianson, Ellen Laine, Hannah Friedlander, Sean Buuck, Austin Bell, Carmen Bernu, Erica Bye, Corinne
  • 24. Holtzman, Katherine Schleiss, Victor Cruz, Megan Sukalski, Dave Boxrud, Brian Nefzger, Victoria Lappi, Katie Harry, Net Bekele, Jacob Garfin, Gongping Liu, Ruth Rutledge, Lisa Levoir, Barbara Miller, Fatuma Sharif-Mohamed, Asli Ashkir, Hinda Omar, Minnesota Department of Health; Kris Bisgard, Stacy Holzbauer, Raj Mody, Paul Gastañaduy, Paul Rota, Rebecca McNall, Adam Wharton, CDC. Morbidity and Mortality Weekly Report MMWR / July 14, 2017 / Vol. 66 / No. 27 717US Department of Health and Human Services/Centers for Disease Control and Prevention Conflict of Interest No conflicts of interest were reported. 1Epidemic Intelligence Service, CDC; 2Minnesota Department of Health;
  • 25. 3Hennepin County Human Services and Public Health Department, Minneapolis, Minnesota. Corresponding author: Victoria Hall, [email protected], 651- 201-5193. References 1. Council of State and Territorial Epidemiologists. Public health reporting and national notification for measles. Atlanta, GA: Council of State and Territorial Epidemiologists; 2012. http://c.ymcdn.com/sites/www.cste. org/resource/resmgr/ps/12-id-07final.pdf 2. McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2013;62(No. RR-4).
  • 26. 3. Bahta L, Ashkir A. Addressing MMR vaccine resistance in Minnesota’s Somali community. Minn Med 2015;98:33–6. 4. Gahr P, DeVries AS, Wallace G, et al. An outbreak of measles in an undervaccinated community. Pediatrics 2014;134:e220–8. https://doi. org/10.1542/peds.2013-4260 5. Jain A, Marshall J, Buikema A, Bancroft T, Kelly JP, Newschaffer CJ. Autism occurrence by MMR vaccine status among US children with older siblings with and without autism. JAMA 2015;313:1534–40. https://doi. org/10.1001/jama.2015.3077 6. Madsen KM, Hviid A, Vestergaard M, et al. A population- based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002;347:1477–82. https://doi.org/10.1056/NEJMoa021134
  • 27. 7. CDC. Notes from the field: measles outbreak—Hennepin County, Minnesota, February–March 2011. MMWR Morb Mortal Wkly Rep 2011;60:421. 8. Orenstein WA, Papania MJ, Wharton ME. Measles elimination in the United States. J Infect Dis 2004;189(Suppl 1):S1–3. https://doi. org/10.1086/377693 mailto:[email protected] http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/12- id-07final.pdf http://c.ymcdn.com/sites/www.cste.org/resource/resmgr/ps/12- id-07final.pdf https://doi.org/10.1542/peds.2013-4260 https://doi.org/10.1542/peds.2013-4260 https://doi.org/10.1001/jama.2015.3077 https://doi.org/10.1001/jama.2015.3077 https://doi.org/10.1056/NEJMoa021134 https://doi.org/10.1086/377693 https://doi.org/10.1086/377693Measles Outbreak — Minnesota