Connectors in Mule flows allow communication between Mule and external systems. There are two types of connectors: endpoint-based and operation-based. Endpoint-based connectors follow a request-response pattern and are configured as inbound or outbound endpoints. Operation-based connectors perform a specific operation like query or upsert. Some connectors require global configuration for connection information that can be shared across multiple uses of that connector type in a flow. Common connectors include HTTP, FTP, JMS, and Salesforce.