Ondansetron is a highly potent antiemetic drug that works by blocking serotonin receptors. It is effective in preventing nausea and vomiting from chemotherapy, radiation, gastroenteritis, and post-operatively. Common side effects include headache, diarrhea, and constipation. Ondansetron is metabolized in the liver by cytochrome P450 enzymes and can have drug interactions with inducers or inhibitors of these enzymes. It is generally well-tolerated but rare serious side effects like blindness have been reported. Ondansetron requires careful use with serotonergic drugs due to risk of serotonin syndrome.