This document discusses various applications of biomedical modeling and simulation including: 1) Using imaging data like CT scans to create 3D geometric models for finite element analysis of things like pulmonary blood flow. 2) Leveraging high-performance computing resources to model complex systems like the cardiovascular system, with simulations of the heart combining different models run across computer clusters. 3) Examples of projects including designing prosthetics, modeling individual organ systems, linking imagery to anatomical ontologies, and visualizing physiological processes like arterial blood flow.