This document provides information about MRI and abnormalities seen on MRI related to the spine and discs. It defines common disc abnormalities like bulge, protrusion, extrusion, and sequestration. It describes the appearance of these abnormalities on different MRI sequences. It also discusses signs, symptoms and treatments associated with different types and severity of disc disease.
These slides contains information regarding fractures and dislocations of spine, various classifications of fracture spine, approach to fractures of spine, criteria for surgical or conservative management of patient, various named fractures involving cervical spine and brief description of spine fracture dislocation.
These slides contains information regarding fractures and dislocations of spine, various classifications of fracture spine, approach to fractures of spine, criteria for surgical or conservative management of patient, various named fractures involving cervical spine and brief description of spine fracture dislocation.
Dr.MD.Monsur Rahman,PT
MPT-Musculoskeletal Disorders
Maharishi Markandeshwar Institute Of Physiotherapy And Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana - Ambala,133-207 (Haryana)
Dear all,
This ppt contains the cause, types, clinical and radiological features, treatment and complication of dislocation of the Hip. I hope this is useful to you.
Thank you
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Dr.MD.Monsur Rahman,PT
MPT-Musculoskeletal Disorders
Maharishi Markandeshwar Institute Of Physiotherapy And Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana - Ambala,133-207 (Haryana)
Dear all,
This ppt contains the cause, types, clinical and radiological features, treatment and complication of dislocation of the Hip. I hope this is useful to you.
Thank you
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. • Cranial displacement of disk tissue in
spondylolisthesis
• is a common finding (a, b) that should not
• be mistaken for a true extrusion or protrusion.
3. MRI
MEGNETIC RESONANCE IMAGING
It is a radiological test that make pictures of organs and structures inside the body,
like
X-ray and ct scan
How it is different from:
x-ray AND CT scan
• It uses :
magnetic field and pulses of radio wave energy.
4. What is MRI
• Radiological technique that uses magnetism, radio waves and a computer to
produce images of body structures.
Equipment used for MRI
• Mri machine consist of:
• Mri scaner
• Pts tabel
5.
6. • Mri scanner is a tube surrounded by a giant circular magnet
• Creat a very strong magnetic field.
• The human body is mostly water.
• Water consist of hydrogen and oxygen atoms.
• At the centre of each hydrogen atom is an even smaller particle, called a proton.
Protons are like tiny magnets and are very sensitive to magnetic fields
7.
8.
9. Pt is placed on movable table that is inserted into this magnetic field.
Now the protons in the body line up in the same direction under the effect of
magnetic field in the same way that a magnet can pull the needle.
Short bursts of radio waves are then sent to certain areas of the body, knocking the
protons out of alignment.
10.
11. • When the radio waves are turned off, the protons realign.
• This realignment creat radio signals, which are picked up by receivers.
• Short bursts of radio waves are then sent to certain areas of the body, knocking
the protons out of alignment.
• These signals from the millions of protons in the body are combined through a
computer to create a detailed MRI image
• Because the protons in different types of tissue in the body realign at different
speeds therefore it produce distinct signals.
• Like bones soft tissues muscles etc
12.
13.
14. Strict contraindications
Implanted electric and electronic devices are a strict contraindication to the magnetic
resonance imaging including:
• heart pacemakers
• insulin pumps
• implanted hearing aids
• neurostimulators
• intracranial metal clips
• metallic bodies in the eye
15. Relative contraindications
• Metal hip replacements
• sutures or foreign bodies in other sites are relative contraindications to the MRI
• The first trimester of pregnancy is also a relative contraindication.
16. BASIC SEQUENCES OF MRI
• T1 AND T2
• ADDITIONAL
• FLAIR
• DWI
• ADC
T1 T2
FLUID low high
FAT high high
Air low low
22. Diffuse disc bulge
• Diffusely bulging disc extends symmetrically and circumferentially by more than 2
mm beyond the margins of adjacent vertbera.
• Protrusion:
• Focal assymetrical extension of the disc tissue beyond the verteberal margins .
• Base is broader than any other dimensions.
• Protruded disc does not extend in cranial or caudal direction.
• Bulging of the disk behind a intact annulus fibrosus.
• Displacement occurs within the disk tissue. (Contained disc)
• Often does not cause symptoms.
• Low signal intensity both on T1 and T2 WI.
23.
24. Extrusion:
• Herniation of the disk with perforation of the annulus fibrosis and extrusion of
disk tissue.
• Anteroposterior dimension is greater than base.
• Often symptomatic: radiculopathy.
• Extruded disc can extend in cranial or caudal directions, but maintain continuity
with parent disc.
• Typical appearance is low on all sequences .
• But There may be high signal on T2 and on post contrast images, in or surrounding
the disc because of the significant inflammatory reactions that may occur in
response to extruded disc material.
25.
26.
27.
28. Sciatica due to disk protrusion:
• Gradual onset
• Changing postural abnormality
• Proximal pain is most common
• Well controlled with medication
Sciatica due to disk extrusion
• Abrupt onset
• Constant postural abnormality
• Distal pain, paresthesia ,paresis
• Poorly controlled with medication
• Pain from the extruded disc is usually due to inflammatory changes rather than the
mass effect causing compression of the neural elements.
• There is spantanous regression of disc extrusion and protrusion with time.
• Manage non operatively : 90 % response
29. Sequestrated disc
When the extruded disc material loses its attachment with the parent
disc it is called the sequestrated fragment.
• Sequestrated disc fragment may migrate
• Cranially
• Caudally
• Usually remain within the 5mm of the parent disc.
30. But they may be located:
Between: posterior longitudinal ligament and bony spine.
• Anterior epidural space: Commonly
• Posterior epidural space :occasionally
• Dural sac: rarely
• Paraspinous soft tissues: rarely
Low signal like the parent disc.
Diffuse or peripherally high signal onT2 and post contrast images due to inflammatory
reaction.
31.
32. Quantifying the severity of disc
disease
Mild:
If the anterior epidural fat is not obliterated.
Moderate:
If the epidural fat is obliterated and thecal sac is displaced.
Severe:
If the cord is effaced and nerve roots are displaced.
33. • MR imaging studies to visualize spinal and vertebral structures early in the course
of low back pain with or without sciatica is generally not indicated
• Only if the symptoms fail to improve after a prolonged period—about four to six
weeks then a mri should be performed.
Early MRI or CT studies are indicated, in
the presence of
• Cauda equina syndrome
• Progressive neurological deficits paresis or sensory impairment
• Unbearable pain
• Signs of a tumor or inflammation.
34. • 23 years old lady presents with
complian of low back ache sine
3monts. Pain is not radiating and
relieve with rest and analgesics.
What are mri findings??
35.
36.
37. • This 32-year-old woman
complained of sacral pain
variably radiating into her left
and right legs, of three
months’ duration.
• What is diagnosis on mri???
38.
39. • Central disc protrusion at L5–S1. causing mild dural sac or thecal sac compresion.
• Treatment :????
Conservative therapy
40. • 55-year-old man complained of sciatica in the left S1
distribution, of six weeks’ duration, refractory to
spinal analgesics.
• There was an ipsilatral postural deformity on
forward bending.
41.
42. • Large left paracentral intervertebral disk extrusion at L5–S1 with compression of
the left S1 nerve root.
• Treatment: ??????
43. • This 32-year-old man complained of pain radiating into the right leg in an S1
dermatomal pattern, of several months’ duration. There was no significant
postural deformity.
Central and right para central extrusion causing mild thecal pressure.
Diagnosis on mri ??
44.
45.
46. • 50-year-old woman complained of low back pain radiating into the left leg, of two
months’ duration.
• There were no motor or sensory deficits.
• Treatment???
Conservative therapy
47.
48.
49. • 45 year old female presented with acute pain radiating into her left leg of one
week’s duration. The pain radiated across the buttocks to the posterolateral aspect
of the left high.
• Treatment ????
50.
51. • 37-year-old patient complained of severe pain in the left leg and less severe pain
in the right leg,
• radiating across the posterolateral aspect of the leg to the hee
Mri findings????
56. Focal or broad based disc bulge
• A segment of disc tissue that project s beyond the margin of vertbera but does
not involve the entire circumference of the disc
• This makes it difficult to differentiate
• between disk-level circumscribed protrusions and
• subligamentous extrusions
• peripheral portions of the annulus
• posterior longitudinal ligament
• dura mater.
• Mri cannot distinguish between these three structures
• .
57. • Disk extrusions develop laterally
• Because there is only the anterior epidural membrane.
• While posterior longitudinal ligament itself actually covers only the medial
portion of the posterior aspect of the vertebra.
58. Herniation with a subligamentous
fragment:
Sequestra that migrate beneath the anterior epidural membrane or
beneath portions of the posterior longitudinal ligament are referred to as
subligamentous or submembranous fragments.
Where the annulus fibrosus and anterior epidural membrane or posterior
longitudinal ligament are perforated, the displaced disk tissue will lie in
the epidural space.
• The extruded material may remain connected to the disk,and may migrate
upward or downward .
• or it may detache from parent disc and lie as a sequestrum in the epidural
space.