1) The document discusses monitoring lung function and quality of life in patients with Alpha-1 Antitrypsin Deficiency (AATD). 2) AATD is a genetic disorder that causes low levels of alpha-1 antitrypsin protein in the blood and lungs, leading to early onset emphysema and COPD. 3) Several factors are evaluated to monitor lung function and quality of life in AATD patients, including spirometry, imaging tests, exercise tests, and patient-reported outcomes questionnaires. Monitoring these factors is important for managing AATD and evaluating responses to treatments like augmentation therapy.