Monitoring multi-drug resistant organisms (MDROs) in healthcare settings is important to detect new antimicrobial resistance patterns, identify at-risk patient populations, and assess prevention efforts. The document recommends using standardized metrics across five categories: tracking patients, monitoring susceptibility patterns, estimating infection burden, estimating exposure burden, and quantifying healthcare-acquired infections. The metrics can range from basic measures using only clinical culture data to more advanced measures using active surveillance testing and point prevalence surveys. Regular monitoring of a core set of metrics tailored to each facility is needed to effectively measure MDRO burden and prevention strategies.