Prof Mike Trenell presents on the benefits of a physically active lifestyle on ageing and brain health at the 2014 Alzheimer's Research UK meeting in Newcastle, UK.

1. Professor Mike Trenell Newcastle University, UK www.MoveLab.org
@miketrenell

2. Oeppen, J. & Vaupel, J. W. Science 296, 1029–1031 (2002).
Kirkwood TBL. Nature 451, 664-667 (2008)

4. The challenge
Everyday life?
Metabolic
Deregulation?
Cellular defects?
Adapted from: Barabási AL.
N Engl J Med. 2007 26;357(4):404-7.
Muscular
dystrophy Dementia
NAFLD
Type 2
Diabetes
CVD

5. Christakis N Engl J Med 2007; Avery Diab Care 2013

6. Your health decisions Are being made over here
Christakis N Engl J Med 2007; Avery Diab Care 2013

8. Cardiorespiratory Fitness
(max METs)
Men
Women
15
10
5
30 80
Cardiorespiratory Fitness
(% peak)
100
80
60
20 40 50 60 70 90
Jackson, et al. Arch Intern Med 169, 1781–1787 (2009)

9. Women
Cardio fitness
(max METs)
15
10
15
10
Jackson, et al. Arch Intern Med 169, 1781–1787 (2009)
BMI 20; PAI 3
BMI 20; PAI 0
5
20 30 40 50 60 70 80 90
Men
Cardio fitness
(max METs)
5
BMI 30; PAI 3
BMI 30; PAI 0
Age years

10. Cardiovascular fitness and mortality: over 60yrs
1
0.75
0.5
0.25
1 2 3 4 5
Quintiles of maximal exercise capacity
Relative risk of death
Adjusted for age, sex, exam year, smoking status,
ECG response, baseline health conditions
As red but also % body fat
<8.7
>18.4
8.7 – 11.2
11.3 – 13.6
13.7 – 18.3
Sui X, et al. JAMA 298: 2507-2516 (2007)
2603 adults aged 60 years or older

12. examined was one with historically high test scores. Collectively these data indicate that, at the very
least, time spent in physical activity programmes does not hinder academic performance, and it
might indeed improve performance. Given the positive health benefits that are derived from
physical activity, these studies support PE as an important component of children’s health and
wellbeing. Bottom panels adapted from REF. 97 (1996) Appleton & Lange.
examined was one with historically high test scores. Collectively these data indicate that, at the very
least, time spent in physical activity programmes does not hinder academic performance, and it
might indeed improve performance. Given the positive health benefits that are derived from
physical activity, these studies support PE as an important component of children’s health and
wellbeing. Bottom panels adapted from REF. 97 (1996) Appleton & Lange.
Mathematics achievement
Reading achievement
200
200
180
180
160
160
140
140
120
120
y = 150.44 + 0.68906x R2 = 0.232 y = 150.64 + 0.57422x R2 = 0.160
y = 150.44 + 0.68906x R2 = 0.232 y = 150.64 + 0.57422x R2 = 0.160
200
180
160
140
120
0 10 20 30 40 50 60 70 80
0 10 20 30 40 50 60 70 80
Aerobic capacity Aerobic capacity
200
180
160
140
120
100
0 10 20 30 40 50 60 70 80
100
Intraparietal PFC
sulcus
PCC
Mathematics achievement
Reading achievement
Aerobic capacity Aerobic capacity
100
0 10 20 30 40 50 60 70 80
100
Intraparietal PFC
sulcus
PCC
Hillman et al. Nat Rev Neurosci 2008

13. Hillman et al. Nat Rev Neurosci 2008

14. Moore et al. MoveLab, Unpublished Data 2014

15. Larsson et al. Ann Intern Med, 2006

17. Your health decisions Are being made over here
Christakis N Engl J Med 2007; Avery Diab Care 2013

18. Professor Mike Trenell Newcastle University, UK www.MoveLab.org
@miketrenell