1) Drug-eluting stents use coatings containing drugs to prevent reblockage of arteries. Stents scrape artery walls during placement, causing injury and scar tissue growth that narrows the artery over time.
2) The document describes a phosphatidylcholine polymer coating called PC 1036 that was developed by Biocompatibles Ltd. and used on drug-eluting stents made by Medtronic and Abbott.
3) The coating contains drugs that are slowly released from the polymer to prevent scar tissue growth. The rate of drug release is controlled by the degree of crosslinking in the polymer coating.
MT5007: The coronary stent revolution (A group project for the Management of ...Stefan
This project tracks the development of coronary artery disease interventions, ranging from early method of cardiac bypass to balloon angioplasty to the development of biomedical stents. Analyses of the competitive climate in the biomedical stents industry is discussed. New market and technology strategies are proposed for a regional MNC to leverage domestic industry infrastructure within emerging economies accompanied by a projected 30% growth in CAD due to increased consumption trends and lifestyle factors, e.g. smoking.
MT5007: The coronary stent revolution (A group project for the Management of ...Stefan
This project tracks the development of coronary artery disease interventions, ranging from early method of cardiac bypass to balloon angioplasty to the development of biomedical stents. Analyses of the competitive climate in the biomedical stents industry is discussed. New market and technology strategies are proposed for a regional MNC to leverage domestic industry infrastructure within emerging economies accompanied by a projected 30% growth in CAD due to increased consumption trends and lifestyle factors, e.g. smoking.
Problem associated with drug eluting stentPRAVEEN GUPTA
This ppt will tell us about the problem which a cardiologist has to face after implantation of Drug eluting stent in a patient of coronary artery diseases. Although there are lots of problem but i am going to describe only three major problem.
A presentation regarding a analysis of the marketplace for stents and also how Abbott could enter the market with their new stent technology in order to acquire the most amount of customers.
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
A new polymer-free drug-eluting stent with nanocarriers eluting sirolimus fro...Paul Schoenhagen
Background: Permanent polymers in first generation drug-eluting stent (DES) have been imputed to be a possible cause of persistent inflammation, remodeling, malapposition and late stent thrombosis. We aim to describe the in vivo experimental result of a new polymer-free DES eluting sirolimus from stent-plus-balloon (Focus np stent, Envision Scientific) compared with a bare-metal stent (BMS) (Amazonia CroCo, Minvasys) and with a biolimus A9 eluting stent (Biomatrix, Biosensors).
NEW GENERATIONS OF DRUG-ELUTING
STENTS - A BRIEF REVIEW
*Aleksander Ernst, Joško Bulum
Department of Ischemic Heart Disease, Medical Faculty University of Zagreb,
University Hospital Centre Zagreb, Zagreb, Croatia
*Correspondence to aleksanderernst@gmail.com
Problem associated with drug eluting stentPRAVEEN GUPTA
This ppt will tell us about the problem which a cardiologist has to face after implantation of Drug eluting stent in a patient of coronary artery diseases. Although there are lots of problem but i am going to describe only three major problem.
A presentation regarding a analysis of the marketplace for stents and also how Abbott could enter the market with their new stent technology in order to acquire the most amount of customers.
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
A new polymer-free drug-eluting stent with nanocarriers eluting sirolimus fro...Paul Schoenhagen
Background: Permanent polymers in first generation drug-eluting stent (DES) have been imputed to be a possible cause of persistent inflammation, remodeling, malapposition and late stent thrombosis. We aim to describe the in vivo experimental result of a new polymer-free DES eluting sirolimus from stent-plus-balloon (Focus np stent, Envision Scientific) compared with a bare-metal stent (BMS) (Amazonia CroCo, Minvasys) and with a biolimus A9 eluting stent (Biomatrix, Biosensors).
NEW GENERATIONS OF DRUG-ELUTING
STENTS - A BRIEF REVIEW
*Aleksander Ernst, Joško Bulum
Department of Ischemic Heart Disease, Medical Faculty University of Zagreb,
University Hospital Centre Zagreb, Zagreb, Croatia
*Correspondence to aleksanderernst@gmail.com
Micro-Chemical Analysis for hire / Ending Recalls and Factory Shutdowns / FTIR Microscopy and expert analyses / Medical Device Problem-Solving, Failure Analysis, and Reverse Engineering
Micro-chemical Analysis for hire / Micro-FTIR Spectroscopy and expert analysis / Medical Devices and plastic parts / failure analysis and reverse engineering
Accurate prediction of future performance modeled on accelerated data for shelf life studies of plastic parts deriving and using D&A and Variable Q10 methods
Infrared Microscopy and Microanalyses for hire: Analytical Lab for small comp...John Donohue
Infrared Microscopy and Micro Analyses for hire,
Exact answers and interpretations for lowest prices,
Expert chemical analyses and interpretations,
I don't just tell you what it is, I tell you why it happened.
Industrial Training at Shahjalal Fertilizer Company Limited (SFCL)MdTanvirMahtab2
This presentation is about the working procedure of Shahjalal Fertilizer Company Limited (SFCL). A Govt. owned Company of Bangladesh Chemical Industries Corporation under Ministry of Industries.
About
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Technical Specifications
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
Key Features
Indigenized remote control interface card suitable for MAFI system CCR equipment. Compatible for IDM8000 CCR. Backplane mounted serial and TCP/Ethernet communication module for CCR remote access. IDM 8000 CCR remote control on serial and TCP protocol.
• Remote control: Parallel or serial interface
• Compatible with MAFI CCR system
• Copatiable with IDM8000 CCR
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
Application
• Remote control: Parallel or serial interface.
• Compatible with MAFI CCR system.
• Compatible with IDM8000 CCR.
• Compatible with Backplane mount serial communication.
• Compatible with commercial and Defence aviation CCR system.
• Remote control system for accessing CCR and allied system over serial or TCP.
• Indigenized local Support/presence in India.
• Easy in configuration using DIP switches.
Explore the innovative world of trenchless pipe repair with our comprehensive guide, "The Benefits and Techniques of Trenchless Pipe Repair." This document delves into the modern methods of repairing underground pipes without the need for extensive excavation, highlighting the numerous advantages and the latest techniques used in the industry.
Learn about the cost savings, reduced environmental impact, and minimal disruption associated with trenchless technology. Discover detailed explanations of popular techniques such as pipe bursting, cured-in-place pipe (CIPP) lining, and directional drilling. Understand how these methods can be applied to various types of infrastructure, from residential plumbing to large-scale municipal systems.
Ideal for homeowners, contractors, engineers, and anyone interested in modern plumbing solutions, this guide provides valuable insights into why trenchless pipe repair is becoming the preferred choice for pipe rehabilitation. Stay informed about the latest advancements and best practices in the field.
CFD Simulation of By-pass Flow in a HRSG module by R&R Consult.pptxR&R Consult
CFD analysis is incredibly effective at solving mysteries and improving the performance of complex systems!
Here's a great example: At a large natural gas-fired power plant, where they use waste heat to generate steam and energy, they were puzzled that their boiler wasn't producing as much steam as expected.
R&R and Tetra Engineering Group Inc. were asked to solve the issue with reduced steam production.
An inspection had shown that a significant amount of hot flue gas was bypassing the boiler tubes, where the heat was supposed to be transferred.
R&R Consult conducted a CFD analysis, which revealed that 6.3% of the flue gas was bypassing the boiler tubes without transferring heat. The analysis also showed that the flue gas was instead being directed along the sides of the boiler and between the modules that were supposed to capture the heat. This was the cause of the reduced performance.
Based on our results, Tetra Engineering installed covering plates to reduce the bypass flow. This improved the boiler's performance and increased electricity production.
It is always satisfying when we can help solve complex challenges like this. Do your systems also need a check-up or optimization? Give us a call!
Work done in cooperation with James Malloy and David Moelling from Tetra Engineering.
More examples of our work https://www.r-r-consult.dk/en/cases-en/
Welcome to WIPAC Monthly the magazine brought to you by the LinkedIn Group Water Industry Process Automation & Control.
In this month's edition, along with this month's industry news to celebrate the 13 years since the group was created we have articles including
A case study of the used of Advanced Process Control at the Wastewater Treatment works at Lleida in Spain
A look back on an article on smart wastewater networks in order to see how the industry has measured up in the interim around the adoption of Digital Transformation in the Water Industry.
Cosmetic shop management system project report.pdfKamal Acharya
Buying new cosmetic products is difficult. It can even be scary for those who have sensitive skin and are prone to skin trouble. The information needed to alleviate this problem is on the back of each product, but it's thought to interpret those ingredient lists unless you have a background in chemistry.
Instead of buying and hoping for the best, we can use data science to help us predict which products may be good fits for us. It includes various function programs to do the above mentioned tasks.
Data file handling has been effectively used in the program.
The automated cosmetic shop management system should deal with the automation of general workflow and administration process of the shop. The main processes of the system focus on customer's request where the system is able to search the most appropriate products and deliver it to the customers. It should help the employees to quickly identify the list of cosmetic product that have reached the minimum quantity and also keep a track of expired date for each cosmetic product. It should help the employees to find the rack number in which the product is placed.It is also Faster and more efficient way.
Water scarcity is the lack of fresh water resources to meet the standard water demand. There are two type of water scarcity. One is physical. The other is economic water scarcity.
3. Divergent processes of vascular repair after balloon angioplasty and
stenting of an atherosclerotic vessel. Balloon angioplasty (top) compresses
and fractures the atherosclerotic plaque (light gray) and tunica media
(black), slightly enlarging the artery. After a few days, a thin layer of
platelet-rich thrombus (dark gray) lines the lumen and fills the dissection
plane. The lumen shrinks from combined effects of early elastic recoil and
later formation of a fibrocellular neointima (speckled area). Stent
deployment after angioplasty (bottom) compresses the dissection plane
and enlarges the lumen while stretching the artery with minimal elastic
recoil. Within hours to days after stenting, caps of thrombus infiltrated with
inflammatory cells (dark gray) form over stent struts (black rectangles),
particularly abundant at sites of deep injury. Over ensuing weeks, a
neointima forms (speckled area), thicker where injury is more severe.
Although intimal growth after stenting is greater than after balloon
angioplasty, the residual lumen is also larger, as the scaffolding of the stent
maintains luminal dimensions. Late changes in arterial size are not depicted
because the contribution of remodeling to restenosis after angioplasty or
stenting remains incompletely characterized.
(Figure prepared by James Squire.)
Edelman, E. R. et al. Circulation 1996;94:1199-1202
4. Stents scrape blood vessel walls. This injury causes reblockage.
Edelman and Squire
10. 420μ X 550μ 300μ X 390μ
A Different Manufacturer’s
Drug Eluting Coated Stent
11. IR Spectrum of PC 1036 from Biomaterials 21 (2000) 1847-1859
Phosphatidyl Choline (PC)
coating, invented by
Biocompatibles, Ltd., used
on some Medtronic and
Abbott Drug Eluting
Coronary Stents.
Spectra of coatings obtained
off the actual stent surfaces
show the PC coating and the
anti-restenosis drug it elutes.
All drug was extracted from
the Abbott stent but PC
coating remains.
12. IR Spectra of pure PC, PC 1036, Medtronic Stent Coating, and
Abbott Stent Coating
The Pure PC’s IR shows most of the vibrations present in the PC 1036 coating.
The PC 1036 IR was published back when Biocompatibles, Ltd. was trying to
“drum up” big company interest in their materials. [This particular spectrum is
slightly distorted (an “enlarged” 1090 vibration) because it is a surface spectrum
(obtained via ATR) of a PC polymer in which the hydrophilic PC moieties have
been rotated preferentially to the surface by contact with water. The 1090 is the
C-O-P stretching vibration.]
The Medtronic (Endeavor™) and Abbott (BiodivYsio™) stent coating spectra
were obtained by reflection off the stents’ surfaces.
The stent coatings are excellent matches to the spectrum of PC 1036. Since this
is the coating Biocompatibles, Ltd. developed for the BiodivYsio stent, I believe
it is the PC coating on the Medtronic and Abbott stents. EDAX can be run using
the SEM to see if silicon is detected from the PC 1036 TSMA component. The
literature published by Biocompatibles, Ltd. suggests a TSMA content of 3 to 5%.
At this loading EDAX should detect the silicon.
13. Biocompatibles, Ltd. developed the PC-coated
BiodivYsio™ stent and marketed a number of PC
polymers. One of these polymers, PC1036, appears
to be the PC coating on the BiodivYsio stent,
now a product of Abbott. It also appears to be
the coating Abbott has licensed to Medtronic for
the Endeavor stent.
PC 1036 is made using the four acrylic monomers
shown here.
>2-methacryloyloxyethyl phosphorylcholine (MPC)
>lauryl methacrylate (LMA)
>hydroxypropyl methacrylate (HPMA)
>3-trimethoxysilylpropyl methacrylate (TSMA)
MPC supplies the PC functionality to the polymer.
LMA helps the polymer adhere to metal surfaces.
TSMA makes the polymer crosslinkable, which
improves its adhesion and cohesion and helps control
its rate of drug elution.
HPMA is a co-crosslinker that, used with TSMA at 25%
loading, gave good mechanical properties.
AIBN (azoisobutyronitrile) initiates polymerization.
PC 1036 Biocompatibles, Ltd.
Biocompatibles, Ltd. paper
14. TSMA Hydrolysis initiates the Crosslinking of the Coating
The Drug Elution Rate is determined mainly by the extent of crosslinking.
The hydroxy groups of the HPMA moiety will crosslink with TSMA also.
Biocompatibles, Ltd. paper