Metolar-XR Capsules (Generic Metoprolol Succinate Capsules)

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Metolar-XR Capsules (Generic Metoprolol Succinate Capsules)

Metolar-XR (Generic Metoprolol Succinate
Capsules) is used to treat high blood pressure,
long term treatment of chest pain due to poor
blood flow to the heart (angina pectoris), and a
number of conditions involving an abnormally
fast heart rate. Metolar-XR capsules are also
used to prevent further heart problems after
myocardial infarction and to prevent headaches in
patients with migraines.

Active Ingredient
The active ingredient present in Metolar-XR capsules is Metoprolol
Succinate. Each extended-release Metolar XR capsule contains
Metoprolol Succinate equivalent to 25 mg, 50 mg or 100 mg of
Metoprolol Tartrate.

Chemical Structure
The structure of Metoprolol Succinate is given below:

Metolar-XR Capsules are manufactured by Cipla Limited,
India in the strengths of 25 mg, 50 mg and 100 mg.
( Website: https://www.cipla.com/ )
URL: https://www.clearskypharmacy.biz/generic-toprol-xl-metolar-xr-by-cipla.html

Generic Metoprolol Succinate Capsules – Brand Names
Generic Metoprolol Succinate Capsules are
available under various drug trade names that
include Lopressor, Toprol XL, Metolar-XR,
Betaloc, Betaone-XL, Embeta, Lopresor,
Metocard-XL, Metolar, Metscore XL, Prolomet-XL,
Met-XL, Sitelol XR, Starpress XL, and Topol-XL
Tab.

Uses of Metolar-XR Capsules
Metolar-XR (Generic Metoprolol Succinate capsules) is used alone or
together with other medicines to treat high blood pressure (hypertension).
High blood pressure adds to the workload of the heart and arteries. If it
continues for a long time, the heart and arteries may not function
properly. This can damage the blood vessels of the brain, heart, and
kidneys, resulting in a stroke, heart failure, or kidney failure. High blood
pressure may also increase the risk of heart attacks or strokes. These
problems may be less likely to occur if blood pressure is controlled.
Metoprolol Succinate capsules are also used to treat severe chest pain
(angina) and lowers the risk of repeated heart attacks. It is given to people
who have already had a heart attack. In addition, Metoprolol is used to
treat patients with heart failure.

Metolar-XR Capsules Dosage
The dosage of Metolar-XR Capsules (Generic Metoprolol Succinate
Capsules) is given below:
Hypertension: The usual initial Adult dosage is 25 mg to 100 mg
once daily in a single dose. The dosage can be increased at weekly
(or longer) intervals until optimum blood pressure reduction is
achieved. Dosages above 400 mg per day have not been studied.
Angina Pectoris: The usual starting adult dosage is 100 mg daily,
given in a single dose. Gradually increase the dosage at weekly
intervals until optimum clinical response has been obtained or
there is a pronounced slowing of the heart rate.

Heart Failure: The dosage must be individualized and closely monitored
during up-titration. Before initiation of Metolar XR, stabilize the dose of
other heart failure medication therapy and ensure that the patient is not
fluid overloaded. The recommended adult starting dose is 25 mg once
daily for two weeks in patients with NYHA class II heart failure and 12.5
mg once daily in patients with more severe heart failure. Double the dose
very two weeks to the highest dosage level tolerated by the patient or up
to 200 mg of Metolar XR.

Migraine Prophylaxis: The dosage is 100 mg to 200 mg once daily
in the morning.
Hyperthyroidism: 95 mg to 190 mg daily, given as a single
dose in the morning. If necessary, the dose may be
increased.

Contraindications
Metolar-XR capsules are contraindicated in patients with a
hypersensitivity to Metoprolol Succinate or any other component
of this medication.
It is also contraindicated in patients with Severe bradycardia,
Second- or third-degree heart block, Cardiogenic shock,
Decompensated cardiac failure, Sick sinus syndrome (unless a
permanent pacemaker is in place), Bronchial asthma or other
obstructive lung disorders and Severe peripheral arterial
circulatory disorder.

Storage Instructions
Metolar-XR capsules (Generic Metoprolol
Succinate capsules) have to be stored at
controlled room temperature i.e. from 20°C to
25°C (68°F to 77°F) with excursions
permitted between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.

Warnings
Intravenous administration of calcium antagonists of the verapamil-type should
not be given to patients treated with beta-blockers.
Metolar-XR (Metoprolol Capsules) may aggravate the symptoms of peripheral
arterial circulatory disorders, mainly due to its blood pressure lowering effect.
Heart Failure: Beta blockers, like Metolar-XR, can cause depression of myocardial
contractility and can precipitate heart failure and cardiogenic shock.
Do not abruptly stop Metoprolol capsules therapy in patients with coronary
artery disease. Severe exacerbation of angina, myocardial infarction, and
ventricular arrhythmias have been observed in patients with coronary artery
disease following the abrupt discontinuation of therapy with beta-blockers.
Use of Metoprolol During Major Surgery: Chronically administered beta-blocking
therapy should not be routinely withdrawn before major surgery; however, the
impaired ability of the heart to respond to reflex adrenergic stimuli may augment
the risks of general anesthesia and surgical procedures.

Warnings
Bradycardia: Bradycardia, including sinus pause, heart block, and cardiac arrest
have occurred with the use of Metoprolol Capsules.
Diabetes and Hypoglycemia: Beta blockers such as Metolar-XR Capsules may
mask tachycardia occurring with hypoglycemia, but other manifestations such as
dizziness and sweating may not be significantly affected.
Pheochromocytoma: If Metolar-XR Capsules are used in the setting of
pheochromocytoma, it should be given in combination with an alpha blocker, and
only after the alpha blocker has been initiated.
Thyrotoxicosis: Lopressor may mask certain clinical signs (e.g., tachycardia) of
hyperthyroidism. Avoid abrupt ithdrawal of beta blockade, which might
precipitate a thyroid storm.
In case you have diabetes, this product may prevent the fast/pounding heartbeat
you would usually feel when your blood sugar level falls too low (hypoglycemia).

Warnings
Risk of Anaphylactic Reactions: While taking beta blockers, patients with a
history of severe anaphylactic reaction to a variety of allergens may be
more reactive to repeated challenge, either accidental, diagnostic, or
therapeutic.
Catecholamine-depleting drugs: Catecholamine-depleting drugs (e.g.,
reserpine) may have an additive effect when given along with beta-
blocking agents or monoamine oxidase (MAO) inhibitors. Observe patients
treated with Metolar-XR plus a catecholamine depletor for evidence of
hypotension or marked bradycardia, which may produce vertigo, syncope,
or postural hypotension.
Digitalis glycosides and beta blockers: Both digitalis glycosides and beta
blockers like Metolar-XR slow atrioventricular conduction and decrease
heart rate. Concomitant use can increase the risk of bradycardia. Monitor
patients heart rate and PR interval.

Warnings
Calcium channel blockers: Concomitant administration of a beta-
adrenergic antagonist with a calcium channel blocker may produce
an additive reduction in myocardial contractility because of negative
chronotropic and inotropic effects.
General Anesthetics: Some inhalation anesthetics may enhance the
cardiodepressant effect of beta blockers.

Side Effects
Side effects of Metoprolol Succinate (Metolar-XR capsules)
can include Drowsiness, dizziness, tiredness, diarrhea, and
slow heartbeat. Decreased sexual ability has been reported
rarely. If any of these effects persist or worsen, tell your
doctor or pharmacist promptly.

Overdose
Signs and symptoms of overdosage of Metolar XR are severe
bradycardia, hypotension and cardiogenic shock. Other symptoms
can also include AV block, heart failure, bronchospasm, hypoxia,
impairment of consciousness / coma, very slow heartbeat, severe
dizziness, severe weakness, fainting, trouble breathing, nausea and
vomiting. There is no specific antidote.
In general, patients with acute or recent myocardial infarction may
be more hemodynamically unstable than other patients and must
be treated accordingly.

Treatment of Overdose
The following general measures should be employed in case of
overdose:
Elimination of the Medication: Gastric lavage should be
performed.Other clinical manifestations of overdose should be
managed symptomatically based on modern methods of intensive care.
Hypotension: Administer a vasopressor, e.g., levarterenol or dopamine.
Bronchospasm: Administer a beta2-stimulating agent and/or a
theophylline derivative.
Cardiac Failure: Administer digitalis glycoside and diuretic. In shock
resulting from inadequate cardiac contractility, consider administration
of dobutamine, isoproterenol, or glucagon.

Metolar-XR Capsules During Pregnancy
Thyronorm (Levothyroxine Sodium tablets) has been classified by
the US FDA as Pregnancy Category C. Metoprolol has been shown
to increase post-implantation loss and decrease neonatal survival in
rats at doses up to 22 times, on a mg/m2 basis, the daily dose of
200 mg in a 60-kg patient. No evidence of impaired fertility or
teratogenicity have been observed during animal studies.
There are no adequate and well-controlled studies in pregnant
women. Since animal reproduction studies are not always
predictive of human response, this medicine should be used during
pregnancy only if clearly needed.

For more details on
Metoprolol-XR Capsules click here
Metolar-XR Capsules (Generic Metoprolol Succinate Capsules) by
Cipla Limited, India.

Metolar-XR Capsules (Generic Metoprolol Succinate Capsules)

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