David R. Jones, MD, and Roy S. Herbst, MD, PhD, prepared useful practice aids pertaining to lung cancer for this CME activity titled "Turning Tides in Targeted Therapy for Early-Stage EGFR-Mutated NSCLC: Latest Data and Practical Guidance for Thoracic Surgeons and the Multidisciplinary Team on the Emerging Role of EGFR-Targeted Therapy in Resectable Lung Cancer." For the full presentation, complete CME information, and to apply for credit, please visit us at https://bit.ly/2PSVELG. CME credit will be available until November 9, 2021.
David R. Jones, MD, and Roy S. Herbst, MD, PhD, prepared useful practice aids pertaining to lung cancer for this CME activity titled "Turning Tides in Targeted Therapy for Early-Stage EGFR-Mutated NSCLC: Latest Data and Practical Guidance for Thoracic Surgeons and the Multidisciplinary Team on the Emerging Role of EGFR-Targeted Therapy in Resectable Lung Cancer." For the full presentation, complete CME information, and to apply for credit, please visit us at https://bit.ly/2PSVELG. CME credit will be available until November 9, 2021.
Suresh S. Ramalingam, MD, FACP, FASCO, Alexander Drilon, MD, and John Heymach, MD, PhD, prepared useful Practice Aids pertaining to lung cancer for this CME/MOC activity titled "Everything You Need to Know About Molecular Testing and Targeted Therapies in NSCLC: Essential Guidance for Modern Patient-Centered Precision Lung Cancer Care." For the full presentation, complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/2IIiRzP. CME/MOC credit will be available until November 29, 2021.
Maria Arcila, MD, Zofia Piotrowska, MD, and Joshua Bauml, MD, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/CC activity titled “New Horizons in EGFR-Mutated NSCLC: Broadening the Impact of Precision Testing in the Context of an Expanding Treatment Landscape.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CC information, and to apply for credit, please visit us at https://bit.ly/3kH1ygr. CME/MOC/CC credit will be available until January 25, 2022.
Jessica Donington, MD, Natasha Leighl, MD, MMSc, FRCPC, FASCO, and Brendon Stiles, MD, prepared useful practice aids pertaining to the role of immunotherapy in lung cancer for this CME/MOC/CNE activity titled, "The Expanding Role of Immunotherapy in Locally Advanced and Earlier Stages of Lung Cancer: Rationale, Current Evidence, Key Trials, and Implications for Thoracic Surgeons." For the full presentation, monograph, complete CME/MOC/CNE information, and to apply for credit, please visit us at http://bit.ly/2WibbtU. CME/MOC/CNE credit will be available until June 16, 2020.
Michael Davies, MD, PhD discusses where we go from here in the melanoma field to conclude the 2017 MD Anderson Melanoma Patient Symposium held in Austin, TX on May 6, 2017.
Roy H. Decker, MD, PhD; Kristin Higgins, MD; and Jyoti D. Patel, MD, prepared useful practice aids pertaining to immunotherapies in lung cancer for this CME/MOC activity titled “NSCLC Tumor Board: Navigating the Evolving Role of Immunotherapy in Multimodal Management of Locally Advanced and Early-Stage Lung Cancer.” For the full presentation, monograph, complete CME/MOC information, and to apply for credit, please visit us at http://bit.ly/2mFfEWE. CME/MOC credit will be available until October 22, 2020.
Fase III que utiliza Nab-Paclitaxel + Carboplatino y Pembrolizumab en NSCLC escamoso. El hazard ratio favorece a Nab paclitaxel en el análisis de subgrupos.
Co-Chairs Roy S. Herbst, MD, PhD, and Lecia V. Sequist, MD, MPH, prepared useful Practice Aids pertaining to EGFR-mutated lung cancer for this CME activity titled “New Milestones and Changing Standards of Care in EGFR-Mutated NSCLC: Expanding the Benefits of Genomic Testing and EGFR-Targeted Therapy to Early-Stage Lung Cancer.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at http://bit.ly/36aVo39. CME credit will be available until March 8, 2022.
Suresh S. Ramalingam, MD, FACP, FASCO, Alexander Drilon, MD, and John Heymach, MD, PhD, prepared useful Practice Aids pertaining to lung cancer for this CME/MOC activity titled "Everything You Need to Know About Molecular Testing and Targeted Therapies in NSCLC: Essential Guidance for Modern Patient-Centered Precision Lung Cancer Care." For the full presentation, complete CME/MOC information, and to apply for credit, please visit us at https://bit.ly/2IIiRzP. CME/MOC credit will be available until November 29, 2021.
Maria Arcila, MD, Zofia Piotrowska, MD, and Joshua Bauml, MD, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/CC activity titled “New Horizons in EGFR-Mutated NSCLC: Broadening the Impact of Precision Testing in the Context of an Expanding Treatment Landscape.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CC information, and to apply for credit, please visit us at https://bit.ly/3kH1ygr. CME/MOC/CC credit will be available until January 25, 2022.
Jessica Donington, MD, Natasha Leighl, MD, MMSc, FRCPC, FASCO, and Brendon Stiles, MD, prepared useful practice aids pertaining to the role of immunotherapy in lung cancer for this CME/MOC/CNE activity titled, "The Expanding Role of Immunotherapy in Locally Advanced and Earlier Stages of Lung Cancer: Rationale, Current Evidence, Key Trials, and Implications for Thoracic Surgeons." For the full presentation, monograph, complete CME/MOC/CNE information, and to apply for credit, please visit us at http://bit.ly/2WibbtU. CME/MOC/CNE credit will be available until June 16, 2020.
Michael Davies, MD, PhD discusses where we go from here in the melanoma field to conclude the 2017 MD Anderson Melanoma Patient Symposium held in Austin, TX on May 6, 2017.
Roy H. Decker, MD, PhD; Kristin Higgins, MD; and Jyoti D. Patel, MD, prepared useful practice aids pertaining to immunotherapies in lung cancer for this CME/MOC activity titled “NSCLC Tumor Board: Navigating the Evolving Role of Immunotherapy in Multimodal Management of Locally Advanced and Early-Stage Lung Cancer.” For the full presentation, monograph, complete CME/MOC information, and to apply for credit, please visit us at http://bit.ly/2mFfEWE. CME/MOC credit will be available until October 22, 2020.
Fase III que utiliza Nab-Paclitaxel + Carboplatino y Pembrolizumab en NSCLC escamoso. El hazard ratio favorece a Nab paclitaxel en el análisis de subgrupos.
Co-Chairs Roy S. Herbst, MD, PhD, and Lecia V. Sequist, MD, MPH, prepared useful Practice Aids pertaining to EGFR-mutated lung cancer for this CME activity titled “New Milestones and Changing Standards of Care in EGFR-Mutated NSCLC: Expanding the Benefits of Genomic Testing and EGFR-Targeted Therapy to Early-Stage Lung Cancer.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at http://bit.ly/36aVo39. CME credit will be available until March 8, 2022.
Aula da disciplina de Ciência, Tecnologia e Sociedade, UFABC, março de 2017
Conteúdo:
Atividades sobre Desenvolvimento Sustentável
Sociedade em Rede - Manual Castells
El cambio de paradigma detonador competitividadraquel zambrano
Conocer la importancia de lograr la competitividad, como cambio de paradigmas especialmente en lo concerniente al estilo de liderazgo para dirigir las organizaciones o entes educativos, así como, la premura de que quiénes responsablemente administren los mismo, con un liderazgo transformacional, sin antes tomar en cuenta la causa principal de que la mayoría de las empresas o entes educativos tengan problemas muy serios y no logren el éxito, es la ausencia de liderazgo en todos los niveles y estructuras.
Spring 17 Salesforce Viewing Party : New Delhi Salesforce Developer GroupAtul Gupta(8X)
New Delhi Salesforce Developer Group celebrated the Spring '17 Salesforce Viewing Party, Salesforce's 18th Birthday and FY18 : The Year of Einstein with the Awesome Developers of New Delhi Salesforce Developer Group
Cosa sono le pin bar e strategia opzioni binarieForzaForex
Una guida/tutorial completa per chi vuole sapere con precisione COSA SONO LE PIN BAR. Inoltre ampio spazio è dato all'analisi tecnica delle pin bar con particolare risalto all'ingresso del trade, alla scedenza, al time frame ed a tutti quegli aspetti che interessano il trader di opzioni binarie. Un pdf da scaricare con una strategia da utilizzare ogni qualvolta appare la famosa candela Pin Bar.
Mediante una tabla hemos realizadoun estudio comparativo de 2 libros de textos de la asignatura Cultura y Práctica Digital. Reflexionando sobre los temas mejor y peor abordados, detectando posibles lagunas.(en grupo). Concluyendo con la elección de uno de ellos para nuestra clase.
O DEVER DE FUNDAMENTAÇÃO NO NCPC: Há mesmo o dever de responder todos os argu...Prof. Rogerio Cunha
Texto Publicado no Livro:
DEVER DE FUNDAMENTAÇÃO NO NOVO CPC, O – ANÁLISES EM TORNO DO ARTIGO 489 . Editora LumenJuris, 2015.
Coordenadores: Fernando Andreoni Vasconcellos, Tiago Gagliano Pinto Alberto
Disponível para venda em: https://goo.gl/Gdf8fa
Targovax Next generation immune activators for solid tumorsRoarFredriksen1
Targovax (OSE:TRVX) is a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors. Targovax’s focus is to activate the patient’s immune system to fight cancer, and to bring benefit to cancer patients with few available treatment alternatives. Targovax is developing its product candidates in different cancer indications, including melanoma, mesothelioma, and multiple myeloma, and has demonstrated a favorable safety and tolerability profile.
Targovax’s lead clinical candidate, ONCOS-102, is a genetically modified oncolytic adenovirus, which has been engineered to selectively infect cancer cells and activate the immune system against the tumor. Following very encouraging clinical data in several indications, both as monotherapy and in combinations, ONCOS-102 is progressing into a randomized phase 2 trial in melanoma patients resistant to PD-1 checkpoint inhibitor treatment.
Building on successful clinical studies which have provided deep mechanistic insights into the tumor biology and the human immune systems, Targovax is researching circular RNA (circRNA) as novel cancer medicines. In addition, Targovax has a KRAS immunotherapy program, with lead cancer vaccine candidate, TG01, expected to enter the clinic in an enhanced format in the second half of 2022. Together this provides Targovax with a rich pipeline of innovative future immunotherapy product candidates to follow ONCOS-102.
MUTUAL FUNDS (ICICI Prudential Mutual Fund) BY JAMES RODRIGUESWilliamRodrigues148
Mutual funds are investment vehicles that pool money from multiple investors to purchase a diversified portfolio of stocks, bonds, or other securities. They are managed by professional portfolio managers or investment companies who make investment decisions on behalf of the fund's investors.
2. This presentation of Merck & Co., Inc., Kenilworth, NJ, USA (the “company”) includes “forward-
looking statements” within the meaning of the safe harbor provisions of the United States
Private Securities Litigation Reform Act of 1995. These statements are based upon the current
beliefs and expectations of the company’s management and are subject to significant risks and
uncertainties. There can be no guarantees with respect to pipeline products that the products
will receive the necessary regulatory approvals or that they will prove to be commercially
successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize,
actual results may differ materially from those set forth in the forward-looking statements.
Risks and uncertainties include, but are not limited to, general industry conditions and
competition; general economic factors, including interest rate and currency exchange rate
fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation in the
United States and internationally; global trends toward healthcare cost containment;
technological advances, new products and patents attained by competitors; challenges
inherent in new product development, including obtaining regulatory approval; the company’s
ability to accurately predict future market conditions; manufacturing difficulties or delays;
financial instability of international economies and sovereign risk; dependence on the
effectiveness of the company’s patents and other protections for innovative products; and the
exposure to litigation, including patent litigation, and/or regulatory actions.
The company undertakes no obligation to publicly update any forward-looking statement,
whether as a result of new information, future events or otherwise. Additional factors that could
cause results to differ materially from those described in the forward-looking statements can
be found in the company’s 2015 Annual Report on Form 10-K and the company’s other filings
with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site
(www.sec.gov).
Forward-Looking Statement of
Merck & Co., Inc., Kenilworth, NJ, USA
2
4. Identify patients most likely to benefit from KEYTRUDA
Establish KEYTRUDA as a foundation for the treatment
of cancer in monotherapy and in combinations
Improve long-term disease control and survival
across a wide range of cancers
Merck’s Strategy in Oncology
4
5. KEYTRUDA Program Accomplishments to Date
First anti-PD-1 to market in the U.S.
Approvals in melanoma and 2L PD-L1+ NSCLC
Demonstrated overall survival
- vs. ipilimumab in melanoma
- vs. docetaxel in 2L PD-L1+ NSCLC
Filed in Head and Neck Cancer (U.S.); Priority Review granted
Launching in >50 markets globally
Clinical activity in more than 20 different tumor types
More than 30 registration-enabling studies ongoing
4 FDA Breakthrough Designations
5
In 5 years since entering clinical development
6. ASCO 2016: Continuing to Demonstrate Breadth and
Depth of the Potential for KEYTRUDA
1 Abstract
KEYNOTE-001 Melanoma
ASCO 2013
>80 Abstracts
Data in ~20 tumor types
Overall Survival data in
Melanoma and NSCLC
Long-term follow-up in Head
and Neck Cancer
Early evidence from
~10 combinations
ASCO 2016
6
7. = Lung
= Melanoma
1. Europe: markets depicted on map with dots include France, Germany, Spain, Italy, UK & Switzerland. Additional 24 EU markets shaded green include Slovakia,
Czech, Hungary, Finland, Estonia, Latvia, Lithuania, Poland, Denmark, Sweden, Norway, Austria, Netherlands, Belgium, Luxembourg, Portugal, Slovenia,
Croatia, Malta, Bulgaria, Romania, Greece, Ireland, and Cyprus.
2. Chile & Venezuela: Melanoma approved as Service Product.
Global Opportunity: Launching In More than 50 Markets
7
1
9. -100
0
100
-100
0
100
Keytruda Monotherapy Has Shown Activity in 20 Tumors
9
-100
0
100
-100
0
100
Melanoma1
-100
0
100
NSCLC2
-100
0
100
Gastric6
-100
0
100
-100
0
100
H&N3 TNBC5
-100
0
100
cHL7
-100
0
100
NHL PMBCL8
Urothelial4
ChangeFromBaselineinTumorSize,%
-100
0
100
Mesothelioma9
-100
0
100
Anal14
-100
0
100
-100
0
100
SCLC11
-100
0
100
NPC13
-100
0
100
Biliary Tract15
-100
0
100
Colorectal16
Esophageal12
-100
0
100
Ovarian10
-100
0
100
ER+/HER2– BC17
1. Daud A et al. ASCO 2015; 2. Garon EB et al. ESMO 2014; 3. Seiwert T et al. ASCO 2015; 4. Plimack E et al. ASCO 2015; 5. Nanda R et al. SABCS 2014; 6. Bang YJ et al.
ASCO 2015 ; 7. Moskowitz C et al. ASH 2014; 8. Zinzani PL et al. ASH 2015; 9. Alley EA et al. AACR 2015; 10. Varga A et al. ASCO 2015; 11. Ott PA et al. 2015 ASCO; 12. Doi T
et al. ASCO 2015; 13. Hsu C et al. ECC 2015; 14. Ott PA et al. ECC 2015; 15. Bang Y-J et al. ECC 2015; 16. O’Neil B et al. ECC 2015; 17. Rugo HS et al. SABCS 2015;
18. Frenel JS et al. ASCO 2016; 19. Mehnert JM et al. ASCO 2016; 20. Cohen R et al. ASCO 2016.
Cervical18 Thyroid19 Salivary20
-100
0
100
10. ASCO Monotherapy Data Demonstrate Overall Survival In
Ipilimumab-Naive Melanoma
10
1. Schachter J et al. ASCO 2016
Improve long-term disease control and survival
across a wide range of cancers
Arm Events, n HR (95% CI) P
Pembro Q2W 122 0.68 (0.53-0.87) 0.00085
Pembro Q3W 119 0.68 (0.53-0.86) 0.00083
Ipi 142 — —
Overall Survival
Final analysis data cutoff date: Dec 3, 2015.
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28
0
10
20
30
40
50
60
70
80
90
100
Time, months
OS,%
279 266 249 234 221 215 202 188 176 163 156 96 44 4 0Pembro Q2W
277 266 251 238 215 201 184 179 174 164 156 93 43 1 0Pembro Q3W
278 242 213 189 170 159 145 132 122 113 110 69 28 1 0Ipi
No. at risk
74%
68%
59%
55%
55%
43%
NR (22.1-NR)
NR (23.5-NR)
16.0 (13.5-22.0)
1
11. Improving Efficacy with Selective Combination Therapy
More than 100 combination trials ongoing
11
Standard
Therapies
Targeted
Therapies
Immuno-
modulators
Novel
Vaccines
Combination Strategy
12. Targeted
Therapies
Standard
Therapies
2
4 5
2
6 33
KEYTRUDA-Based Combinations Show Potential for Enhanced
Activity In Many Tumor Types
12
1. Data on file; 2. Papadimitrakopoulou V et al. ASCO 2015; 3. Gangadhar T et al. SITC 2015; 4. San Miguel L et al. ASH 2015.
5. Badros A et al. ASH 2015; 6. Long GV et al. SMR 2015.
Novel
Vaccines
Immuno-
modulators
1
Combination
Strategy
13. ASCO Data Demonstrate Further Progress with Combinations
KEYNOTE-021: 1L NSCLC1
Cohort A
KEYTRUDA +
paclitaxel
N = 25
Cohort B
KEYTRUDA +
paclitaxel +
bevacizumab
N = 25
Cohort C
KEYTRUDA +
pemetrexed
N = 24
All Patients
N = 74
ORR
(confirmed)
PD-L1 ≥ 50%
PD-L1 ≥ 1%
PD-L1 < 1%
12 (48%)
5 (56%)
8 (53%)
4 (44%)
14 (56%)
4 (50%)
10 (50%)
2 (40%)
17 (71%)
6 (75%)
11 (69%)
6 (75%)
43 (58%)
15 (60%)
29 (57%)
12 (54%)
PFS, months,
median
10.3 12.7 10.2 --
Advanced to Phase 3
1. Gadgeel S et al. ASCO 2016; 2. Mateos MV et al. ASCO 2016.
13
Establish KEYTRUDA as a foundation for the treatment of cancer
in monotherapy and in combinations
KEYNOTE-407 KEYNOTE-189 KEYNOTE-185
KEYNOTE-023:
KEYTRUDA + lenalidomide and low-dose
dexamathasone in relapsed/refractory
Multiple Myeloma2
Maximum Change from Baseline in M Protein or
Free Light Chains
Percentchangefrombaseline
35/40 (88%) of patients with a decrease
-100
0
100
14. Internal Pipeline Further Enables Combination Strategy
BET-Bromodomain (MK-8628)
GITR (MK-1248)
IL-10 (MK-1966)
CEACAM1 (MK-6018)
GITR (MK-4166)
PI3K Delta (MK-1822)
IDO
LAG-3 (MK-4280)
Clinical Programs Preclinical Programs
Negative
Immune
Regulators
Epigenetics
Tumor
Microenvironment
Immune Agonists
Program 2
TDO
Multi-specific nanobodies
Program 3
14
Program 1
Program 4
CDK 1,2,5,9 (MK-7965)
15. Biologic Rationale for Predictive Biomarkers
15
Ligand Expression
on Tumor
PD-L1 and PD-L2
Expression
Immunogenic
Microenvironment
Immune-Related Gene
Expression (GEP)
Signature
Increased Antigen
Presentation Due
to High DNA
Mutation Load
DNA Mismatch Repair
Deficiency, DNA
Polymerase Mutation
16. ASCO Data Demonstrate the Potential Importance of Patient
Selection Through PD-L1, MMR-Deficiency, and IFN-γ Markers
Breakthrough Designation in MMR-Deficient CRC
1. Diaz L et al. ASCO 2016; 2. Chow L et al. ASCO 2016.
16
Identify patients most likely to benefit from KEYTRUDA
KEYNOTE-016
Durability of Disease Control in
MMR-Deficient Tumors1
KEYNOTE-012
IFN-γ 6-gene Signature Score significantly associated
with Overall Survival in Head and Neck Cancer2
Overall Survival
0.00
0.25
0.50
0.75
1.00
0 100 200 300 400 500 600 700
Time, days
SurvivalProbability
32 19 10 7 1 0 0 0
118 91 74 56 20 13 12 2IFN-γ Score ≥ Q1
IFN-γ Score < Q1
IFN-γ Score < Q1
IFN-γ Score ≥ Q1
17. Additional internally-owned programs to enter the clinic
Filings in additional tumor types
• Anticipated approval in Head and Neck Cancer (U.S.)
• Anticipated approvals from KEYNOTE-010 filings in 2L PD-L1+ NSCLC
• Results from 1L NSCLC Study, KEYNOTE-024
• Additional novel combination data
What to Expect From Merck Oncology in 2016
17