Gregor Mendel conducted experiments with pea plants to establish the basic laws of inheritance. He found that traits from parents separate and recombine in predictable ways when passed to offspring. Mendel determined that traits are determined by discrete factors, now known as genes, which are inherited independently of each other. His work established the fundamental rules of genetics and heredity.
Examples of Codominance. The best example, in this case, is the codominance blood type. ABO group is considered to be a codominant blood group where both father’s and mother’s blood group is expressed. It means that the properties of the blood groups exist in the ABO type.
Codominance is a relationship between two versions of a gene. Individuals receive one version of a gene, called an allele, from each parent. If the alleles are different, the dominant allele usually will be expressed, while the effect of the other allele, called recessive, is masked.
Examples of Codominance. The best example, in this case, is the codominance blood type. ABO group is considered to be a codominant blood group where both father’s and mother’s blood group is expressed. It means that the properties of the blood groups exist in the ABO type.
Codominance is a relationship between two versions of a gene. Individuals receive one version of a gene, called an allele, from each parent. If the alleles are different, the dominant allele usually will be expressed, while the effect of the other allele, called recessive, is masked.
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Law of Dominance - Recessive alleles will always be masked by dominant alleles .
Law of Segregation - At the time of gametes formation the two copies of each hereditary factor segregates so that offspring get one factor from each parent .
Law of Independent Assortment - Genes for one trait are not inherited together with another trait .
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Law of Dominance - Recessive alleles will always be masked by dominant alleles .
Law of Segregation - At the time of gametes formation the two copies of each hereditary factor segregates so that offspring get one factor from each parent .
Law of Independent Assortment - Genes for one trait are not inherited together with another trait .
Introduction to Genetics - Mendelism SMGsajigeorge64
Introduction to Genetics - Mendelism ; Genetics defenition- heridity and variation - heritable and non-heritable variations; Gregor Johann Mendel - rediscovery of Mendelism- Terminology and symbols; Mendel's experiments , laws
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
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Monitor common gases, weather parameters, particulates.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. Starting in the Name Of ALLAH who is most Gracious and Merciful
2. Mendel’s Laws of Hereditary
Presented By: Mr. Abdur Rahman Khan M-Phill UST Bannu KP Pakistan
Presented To: Dr. Shoaib Ahmad
3. Content
• Introduction, What are the Mendel’s Law ?
• Who was Gregor Mendel?
• Mendel's Garden Peas, Pisum sativum
• Dominant and Recessive
• Gene and Allel
• States Two Laws
• Results of his work
• References
4. Introduction; what are the
Mendel´s laws?
•We could define Mendel´s
laws as the basic laws that
talks about the inheritance
of biological features that
every human being has.
•They were created by
Gregor Johann Mendel in
1865. Mendel created two
laws: The law of
Segregation, the law of
Independent Assortment.
5. Who was Gregor Mendel?
• Gregor Johann Mendel was a really famous scientist
that discovered the basic laws of inheritance. They
were called Mendel´s laws. He was born on July
20th of 1822 in Austria and he died on January 6th
1884. He was a Catholic Augustinian.
• An Austrian scientist =research in a Czechoslovakia
monastery.
• Established the basis of modern genetic science.
• Objective = understand how physical traits are
passed from a parent to its offspring.
6. Continue
• He had previously studied science and mathematics
(including Statistics) at the University of Vienna.
Mendel’s knowledge of statistics later proved
valuable in his research on Heredity – the
transmission of characteristics from Parent to
Offspring.
• The theory of inheritance proposed by Mendel can
account for presence of differences among
members of a population generation after
generation.
• Mendel's work was unrecognized until 1990.
7. Mendel's Garden Peas, Pisum sativum
• Mendel did a statistical study (he had a mathematical
background).
• He prepared his experiments carefully and conducted
preliminary studies.
• He chose the garden pea, Pisum sativum, because peas
were easy to cultivate, had a short generation time, and
could be cross-pollinated.
• From many varieties, Mendel chose 22 true-breading
varieties for his experiments.
• True-breeding varieties had all offspring like the
parents and like each other.
8. Mendel's Garden Peas, Pisum sativum
• Mendel studied seven (7) Traits or Characteristics.
Each characteristic occurred in Two Contrasting
Traits:
• Flower Color – purple or white
• Flower Position along Stem – axial or terminal
• Seed or Pea Color – yellow or green
• Seed Texture or Shape – round (smooth) or wrinkled
• Pod Color – green or yellow
• Pod Appearance or Shape – inflated or constricted
• Plant Height – long or short stems
9.
10. Continue
• Mendel traced inheritance of individual traits and
kept careful records of numbers.
• He used his knowledge of Statistics to analyze his
observations of the Seven Characteristics.
11. Continue
• Mendel was able to document the traits of each
generation’s parents by carefully controlling how the
pea plants were Pollinated.
• Pollination occurs when pollen grains produced in the
Male Reproductive parts of a flower, the Anthers, are
transferred to the Female Reproductive part of the
flower, the Stigma.
• Self-Pollination occurs when pollen is transferred from
the Anthers of a flower to the Stigma of either the same
flower or a flower on the same plant.
• Cross-Pollination involves flowers of Two Separate
Plants.
• Pea Plants normally reproduce by Self-Pollination.
12. Concepts about
• Dominant are those characters which shows its self
in first generation or in offspring in expressive from
OR ability to mask the expression of a recessive
allele (Capital)
• Recessive characters are those characters which do
not shows or express its self in first generation or in
offspring at any stage OR masked by a dominant
allele.
• Homozygous- 2 identical alleles (TT, tt)
• Heterozygous- 2 different alleles (Tt)
13. Concepts about
• Genotype- genes of an organism = alleles received
during fertilization.
• Phenotype = the physical appearance of a trait in an
organism . e.g blue eyes, yellow flower.
• Genes – portions of DNA that determine traits.
• Alleles – Genetic factors that controls a trait.
15. Mono Hybride cross
• A monohybrid cross is one that looks at only one
trait (let’s look at plant height – tall or short)
16. Dihybride Cross or 2nd Law
• “Genes for different traits can segregate
independently during the formation of gametes”
• “The Law of Independent Assortment, said that
separate genes for separate traits are passed
independently of one another from parents to
offspring”
19. Mendel's Results and Conclusions
• Whenever Mendel crossed strains, one of P1Traits
failed to appear in the F1 plants. In every case, that
trait reappeared in a ratio of 3:1 in the F2
generation.
• He found that the F1 plants resembled only One of
the parents.
• Characteristic of the other parent reappeared in
about 1/4 of F2 plants; 3/4 of offspring resembled
the F1 plants.
20. As Viewed By Modern Genetics
• Most of Mendel’s findings agree with what now know about
Molecular Genetics - the Study of the Structure and Function
of Chromosomes and Genes.
• A Gene is a segment of DNA on a Chromosome that controls
a particular Hereditary Trait. Because Chromosomes occur in
Pairs, Genes Also occur in Pairs.
• Each of several Alternative forms of a Gene is called an
Allele. Mendel’s Factors are now called alleles.
• Letters are used to represent Alleles:
• Capital Letters refer to a Dominant ( A ) Allele that masks or
hides expression of a recessive allele.
• Lower Case ( a )refer to a Recessive Allele its expression is
masked by a dominant allele.