B. Antipsychotics Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Fluro buterophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones: Molindone hydrochloride. Benzamides: Sulpieride.

1. Antipsychotics
Mr. Mote Ganesh D
Assistant Professor
Annasaheb Dange College of B.Pharmacy, Ashta
Mr. Mote G.D, ADCBP, Ashta

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13. Classification of Antipsychotic agents
Antipsychotic
agents
Phenothiazeines
Promazine
hydrochloride
Chlorpromazine
hydrochloride
Triflupromazine
Thioridazine
Piperacetazine
Prochlorperazine
Trifluoperazine
Ring
Analogues of
Phenothiazei
nes
Chlorprothixene,
Thiothixene, Loxapine
succinate, Clozapine.
Buterophenone
Haloperidol,
Droperidol,
Risperidone
Beta
amino
ketones
Molindone
hydrochloride
Benzamides
Sulpieride
Mr. Mote G.D, ADCBP, Ashta

14. A. Phenothiazine Class-
1. Aliphatic side chain
S
N
N
CH3
CH3 . HCl
Promazine hydrochloride
S
N
N
CH3
CH3 . HCl
Chlorpromazine hydrochloride
Cl
S
N
N
CH3
CH3
Triflupromazine
C
F
F
F
Mr. Mote G.D, ADCBP, Ashta

15. A. Phenothiazine Class-
2. Piperdine
S
N
Thioridazine Hydrochloride
S
N
H3C
H3C
HCl
.
Mr. Mote G.D, ADCBP, Ashta

16. A. Phenothiazine Class-
3. Piperazine
S
N
Piperacetazine Hydrochloride
C
H3C
.
O N N C
H2
H2
C
OH .HCl
S
N
.
N N CH3
HC
HC COOH
COOH
Prochlorperazine maleate
Cl
S
N
.
N N CH3
Trifluo perazine
C
F
F
F
.HCl
Mr. Mote G.D, ADCBP, Ashta

17. B. Ring analogue of Phenothiazine Class-
S
N
Chlorprothixene
CH3
CH3
Cl
S
thiothixene
S
O
O
N
H3C
H3C
N
N
CH3
H
N
H
N
N
N
CH3
Clozapine
Cl
O
N
N
N
CH3
Loxapine Succinate
Cl
C
O
HO CH2 CH2 C
O
OH
Mr. Mote G.D, ADCBP, Ashta

18. C. Fluro buterophenones
N
OH
Cl
O
F
Haloperidol
O
F
Droperidol
N N NH
O
N O
N
F
N
N
CH3
O Risperidone
Mr. Mote G.D, ADCBP, Ashta

19. D. Beta Amino Ketone
O
N
N
H
H2C CH3
CH3
O
Molindone
E. Benzamide
N
H
N
O
CH3
OCH3
S
O
O
H2N
Sulpiride
Mr. Mote G.D, ADCBP, Ashta

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