The document summarizes key studies on the effectiveness of conservative treatment for multidirectional instability (MDI). Three studies found that conservative treatment including strengthening exercises improved some outcomes like muscle activation patterns and kinematics, but did not fully restore shoulders to normal. One study found that after 8 years, only 30% of patients had good results with conservative treatment alone. Overall, the studies suggest that while conservative treatment can provide some benefits for MDI, surgery may be needed for full resolution of symptoms for many patients.
Dr. Richard Chmielewski, DO, FACEP, NMM/OMM gave a lecture on the ins and outs of Osteopathy and Osteopathic Medicine, including various techniques used by the Doctor on a daily basis.
To Compare The Effect Of Proprioceptive Neuromuscular Facilitation Program Ve...IOSR Journals
Abstract: Low back pain has been a matter of concern, affecting up to 90% of population at some point in
their lifetime, up to 50% have more than one episode. People of all age group can be affected by this menace
irrespective to their gender and quality of life. It has become one of the leading causes for the visit to physician
thus also puts a heavy burden on the currency of the country. Physiotherapy is the most widely used form of
treatment adopted for gaining relief from low back pain. The exercises include stretching, strengthening, range
of motion exercises, McKenzie therapy and core stability exercises other techniques like Proprioceptive
neuromuscular facilitation program etc. It has been concluded in various studies core stability exercises and
Proprioceptive neuromuscular facilitation are beneficial in low back pain patients but comparison of their effect
needs to be established to provide early and better relief from the disability. Therefore objective of the study was
to compare the effect of Proprioceptive neuromuscular facilitation program and Core stabilization exercises on
low back pain patients. 40 subjects aged 30 – 50 years with low back pain for more than 4 weeks were made
part of the study based on inclusion and exclusion criteria and were then divided into two groups named A, B.
Group A received Proprioceptive neuromuscular facilitation and group B received Core stabilization exercises
and hot pack given initially for 10-15 minutes to the lower back. The exercise program was given for 4 weeks
with a total of 24 sessions and progression of the activity was made within the tolerance of the patient. Pre and
post treatment readings were taken of pain, Oswestry Disability Questionnaire and Functional Reach Test.
Results were analyzed using paired, unpaired t- test. Results showed that there is significant effect on pain,
Oswestry Disability Questionnaire and Functional Reach Test in the two groups but group A was clinically
more significant than groups B. The study concluded that patients with low back pain are benefitted more by
Proprioceptive neuromuscular facilitation program. So, Proprioceptive neuromuscular facilitation program
should be practiced more.
Keywords: Low Back Pain, Core Stabilization Exercises, Proprioceptive Neuromuscular Facilitation.
Dr. Richard Chmielewski, DO, FACEP, NMM/OMM gave a lecture on the ins and outs of Osteopathy and Osteopathic Medicine, including various techniques used by the Doctor on a daily basis.
To Compare The Effect Of Proprioceptive Neuromuscular Facilitation Program Ve...IOSR Journals
Abstract: Low back pain has been a matter of concern, affecting up to 90% of population at some point in
their lifetime, up to 50% have more than one episode. People of all age group can be affected by this menace
irrespective to their gender and quality of life. It has become one of the leading causes for the visit to physician
thus also puts a heavy burden on the currency of the country. Physiotherapy is the most widely used form of
treatment adopted for gaining relief from low back pain. The exercises include stretching, strengthening, range
of motion exercises, McKenzie therapy and core stability exercises other techniques like Proprioceptive
neuromuscular facilitation program etc. It has been concluded in various studies core stability exercises and
Proprioceptive neuromuscular facilitation are beneficial in low back pain patients but comparison of their effect
needs to be established to provide early and better relief from the disability. Therefore objective of the study was
to compare the effect of Proprioceptive neuromuscular facilitation program and Core stabilization exercises on
low back pain patients. 40 subjects aged 30 – 50 years with low back pain for more than 4 weeks were made
part of the study based on inclusion and exclusion criteria and were then divided into two groups named A, B.
Group A received Proprioceptive neuromuscular facilitation and group B received Core stabilization exercises
and hot pack given initially for 10-15 minutes to the lower back. The exercise program was given for 4 weeks
with a total of 24 sessions and progression of the activity was made within the tolerance of the patient. Pre and
post treatment readings were taken of pain, Oswestry Disability Questionnaire and Functional Reach Test.
Results were analyzed using paired, unpaired t- test. Results showed that there is significant effect on pain,
Oswestry Disability Questionnaire and Functional Reach Test in the two groups but group A was clinically
more significant than groups B. The study concluded that patients with low back pain are benefitted more by
Proprioceptive neuromuscular facilitation program. So, Proprioceptive neuromuscular facilitation program
should be practiced more.
Keywords: Low Back Pain, Core Stabilization Exercises, Proprioceptive Neuromuscular Facilitation.
To Compare The Effect Of Core Stability Exercises And Muscle Energy Technique...IOSR Journals
Abstract: Low back pain is considered one of the commonest condition in the western and industrialized
countries. It is estimated that up to 50% of adults experience low back pain during their life span. People of all
age group can be effected by this menace irrespective to their gender and quality of life. It has become one of
the leading causes for the visit to physician thus also puts a heavy burden on the currency of the country.
Physiotherapy is the most widely used form of treatment adopted for gaining relief from low back pain. The
exercises include stretching, strengthening, range of motion exercises, McKenzie therapy and core stability
exercises other techniques like muscle energy technique etc. It has been concluded in various studies core
stability exercises and muscle energy technique are beneficial in low back pain patients but comparison of their
effect needs to be established to provide early and better relief from the disability. Therefore objective of the
study was to compare the effect of core stability exercises and muscle energy techniques on low back pain
patients. 60 subjects aged 18 – 45 years with low back pain were made part of the study based on inclusion and
exclusion criteria and were then divided into three groups named A, B and C. Group A received core stability
exercise and conventional physiotheraphy and group B received muscle energy techniques and conventional
physiotherapy. The exercise program was given on alternate days with a total of 24 sessions and progression of
the activity was made within the tolerance of the patient. Pre and post treatment readings were taken of pain,
ROM and quality of life scale. Results were analyzed using paired, unpaired t- test and ANOVA. Results showed
that there is significant effect on pain, ROM and quality of life scale in the three groups but group A was
clinically more significant than the other groups. The study concluded that patients with low back pain are
benefitted more by core stability exercises. So, core stability exercises should be practiced more.
Keywords: Low Back Pain, Core Stabilization Exercises, Muscle Energy Technique.
Effectiveness of Strain Counterstrain Technique on Quadratus Lumborum Trigger...IOSR Journals
Abstract: Quadratus lumborum (QL) myofascial trigger points (MTrP) are well documented in low back pain
(LBP) patients. There is a Growing body of evidence suggesting that Strain counterstrain technique (SCS) is an
effective treatment for the pain associated with MTrP. Literature is sparse regarding the effectiveness of SCS on
MTrP in QL in LBP subjects. We studied the immediate effects of SCS on pain intensity & functional outcome
in subjects having LBP with MTrP in QL. 40 subjects were randomly allocated into two groups. The Control
group (CG) received moist heat, & the Experimental group (EG) received moist heat & SCS technique.
Outcome measures were Visual Analogue Scale (VAS) & Patient Specific Functional Scale (PSFS).Pain
scores(VAS) Showed Statistically significant differences within the groups (P<0.0001), while clinically
significant improvement was seen only in EG with mean difference (3.75) , 95% confidence interval (4.17,3.04),
PSFS also showed significant improvement in EG.
Keywords: Quadratus lumborum, Myofascial Trigger Point, Pain, Low Back Pain, Strain Counterstrain
If you have ever treated runners, having them stop or modify activity during rehabilita- tion is nearly impossible. As someone who specializes in the treatment of endurance
athletes, I am always looking for an edge
to return them to activity as soon as possible.
Physical Therapy Practice Guidelines: Thoracic manipulation is both safe and effective in treating mechanical neck pain (neck pain with mobility deficits).
Passive Stretching Exercises vs Mulligan Mobilization with Movement (MWM)Hozefa Mohammed Husain
Passive Stretching Exercises vs Mulligan Mobilization with Movement (MWM) for Pain, ROM and Function in Patients with Adhesive Capsulitis: A Comparative Study
Do We Make Taping More Complicated Than It Needs ToBe?RockTape
Kinesiology tape (K-tape) is gaining popularity with healthcare providers, patients, and athletes. I have used K-tape for more than 10 years, but it wasn’t until the 2008 summer Olympics that my patients started requesting that I use K-tape as a treatment modality. As a sports chiropractor who was also an athletic trainer, I had been using different types of tape already with the main goal of locking down a joint for support.
Recent advances in Manipulative MedicineSoniya Lohana
What new techniques are been used in manipulative medicine and physical therapy that help the patients to recover better and address their condition by various approaches where surgery is not required.
Il Modulo che ti proponiamo oggi intende approfondire le "Tecnologie e l'e-business" come strumento essenziale per coordinare e gestire al meglio le attività dello studio professionale in un contesto di mercato caratterizzato da un continuo cambiamento e dalla necessità sempre più pressante di fornire sistemi di rendicontazione e di reporting.
To Compare The Effect Of Core Stability Exercises And Muscle Energy Technique...IOSR Journals
Abstract: Low back pain is considered one of the commonest condition in the western and industrialized
countries. It is estimated that up to 50% of adults experience low back pain during their life span. People of all
age group can be effected by this menace irrespective to their gender and quality of life. It has become one of
the leading causes for the visit to physician thus also puts a heavy burden on the currency of the country.
Physiotherapy is the most widely used form of treatment adopted for gaining relief from low back pain. The
exercises include stretching, strengthening, range of motion exercises, McKenzie therapy and core stability
exercises other techniques like muscle energy technique etc. It has been concluded in various studies core
stability exercises and muscle energy technique are beneficial in low back pain patients but comparison of their
effect needs to be established to provide early and better relief from the disability. Therefore objective of the
study was to compare the effect of core stability exercises and muscle energy techniques on low back pain
patients. 60 subjects aged 18 – 45 years with low back pain were made part of the study based on inclusion and
exclusion criteria and were then divided into three groups named A, B and C. Group A received core stability
exercise and conventional physiotheraphy and group B received muscle energy techniques and conventional
physiotherapy. The exercise program was given on alternate days with a total of 24 sessions and progression of
the activity was made within the tolerance of the patient. Pre and post treatment readings were taken of pain,
ROM and quality of life scale. Results were analyzed using paired, unpaired t- test and ANOVA. Results showed
that there is significant effect on pain, ROM and quality of life scale in the three groups but group A was
clinically more significant than the other groups. The study concluded that patients with low back pain are
benefitted more by core stability exercises. So, core stability exercises should be practiced more.
Keywords: Low Back Pain, Core Stabilization Exercises, Muscle Energy Technique.
Effectiveness of Strain Counterstrain Technique on Quadratus Lumborum Trigger...IOSR Journals
Abstract: Quadratus lumborum (QL) myofascial trigger points (MTrP) are well documented in low back pain
(LBP) patients. There is a Growing body of evidence suggesting that Strain counterstrain technique (SCS) is an
effective treatment for the pain associated with MTrP. Literature is sparse regarding the effectiveness of SCS on
MTrP in QL in LBP subjects. We studied the immediate effects of SCS on pain intensity & functional outcome
in subjects having LBP with MTrP in QL. 40 subjects were randomly allocated into two groups. The Control
group (CG) received moist heat, & the Experimental group (EG) received moist heat & SCS technique.
Outcome measures were Visual Analogue Scale (VAS) & Patient Specific Functional Scale (PSFS).Pain
scores(VAS) Showed Statistically significant differences within the groups (P<0.0001), while clinically
significant improvement was seen only in EG with mean difference (3.75) , 95% confidence interval (4.17,3.04),
PSFS also showed significant improvement in EG.
Keywords: Quadratus lumborum, Myofascial Trigger Point, Pain, Low Back Pain, Strain Counterstrain
If you have ever treated runners, having them stop or modify activity during rehabilita- tion is nearly impossible. As someone who specializes in the treatment of endurance
athletes, I am always looking for an edge
to return them to activity as soon as possible.
Physical Therapy Practice Guidelines: Thoracic manipulation is both safe and effective in treating mechanical neck pain (neck pain with mobility deficits).
Passive Stretching Exercises vs Mulligan Mobilization with Movement (MWM)Hozefa Mohammed Husain
Passive Stretching Exercises vs Mulligan Mobilization with Movement (MWM) for Pain, ROM and Function in Patients with Adhesive Capsulitis: A Comparative Study
Do We Make Taping More Complicated Than It Needs ToBe?RockTape
Kinesiology tape (K-tape) is gaining popularity with healthcare providers, patients, and athletes. I have used K-tape for more than 10 years, but it wasn’t until the 2008 summer Olympics that my patients started requesting that I use K-tape as a treatment modality. As a sports chiropractor who was also an athletic trainer, I had been using different types of tape already with the main goal of locking down a joint for support.
Recent advances in Manipulative MedicineSoniya Lohana
What new techniques are been used in manipulative medicine and physical therapy that help the patients to recover better and address their condition by various approaches where surgery is not required.
Il Modulo che ti proponiamo oggi intende approfondire le "Tecnologie e l'e-business" come strumento essenziale per coordinare e gestire al meglio le attività dello studio professionale in un contesto di mercato caratterizzato da un continuo cambiamento e dalla necessità sempre più pressante di fornire sistemi di rendicontazione e di reporting.
L'Anteprima del Modulo che ti proponiamo oggi affrontare il tema della "Gestione rischio" e del suo impatto sulla vita dello studio, fornendo un quadro di riferimento generale per individuare e valutare i rischi cui è soggetta l’attività professionale e definendone le possibili strategie di riduzione e contenimento.
Nahdet El Mahrousa’s (NM) flagship program, Incubator of Early-stage Innovative Social Enterprises, has officially opened its 5th Round of incubation and the 2nd this year and we’re very excited for what’s to come!
Social media content trends review. First quarter 2014. Материал рекомендован к просмотру SMM-менеджерам, контент-менеджерам рекламных агентств, менеджерам по digital и pr на стороне заказчика.
Presented an in-service on the evidence behind and the application of thoracic spine manipulation to the Martinsburg VA Medical Center's rehabilitation staff including: 7 PTs, 8 PTAs, 3 OTs, and 4 students.
Running head: NECK PAIN 1
NECK PAIN 2
NECK PAIN
Bamgbola Abitogun
Grand Canyon University
NRS 433V
April 2nd, 2017
Dosage impacts of spinal manipulative treatment for endless neck torment Comment by Denise Foti: APA: The first line of your paper needs to be your paper title not bold-faced
Neck pain is second most common spinal pain to low back torment among musculoskeletal grievances revealed in the all inclusive community and among those exhibiting to manual treatment suppliers. Ceaseless neck torment (i.e. neck torment enduring longer than 90 days) is a typical purpose behind introducing to a chiropractor's office, and such patients frequently get spinal control or activation. Comment by Denise Foti: Indent
Research question: In adults with chronic neck pain, what is the base measurements of control important to create a clinically vital change in neck pain contrasted with directed practice in 2 months Comment by Denise Foti: You need to revise this. Look at the example I provided the first day of class.
(P)-Population: Adults 18 to 60 years old, with a clinical conclusion of endless mechanical neck pain who have not gotten cervical spinal manipulative therapy in the previous year. Patients with non-mechanical neck agony or contraindications to cervical control will be rejected.
(I)-Intervention: Subjects randomized to have control would get standard rotational or sidelong break enhanced method once, twice, or three times each week over a time of 2, 4, or a month and a half. These subjects would likewise get a similar practice regimen given to the control gathering to take out practice as a moment variable influencing results.
(C)-Comparison-An institutionalized administered practice regimen would be utilized as a dynamic control bunch. All subjects, paying little heed to gathering task, would play out an institutionalized practice administration at every session over a time of a month and a half. Utilizing this methodology, we will have the capacity to limit the non-particular impacts because of going to a facility.
(O)-Outcome- Changes in neck pain, measured utilizing the 100mm VAS for agony.
(T)-Time-The result would be measured week by week for two months
Reference
Vernon, H., & Mior, S. (January 01, 1991). The Neck Disability Index: a study of reliability and validity. Journal of Manipulative and Physiological Therapeutics, 14, 7, 409-15.
Injuries to the cervical spine, particularly those including the delicate tissues, speak to a huge wellspring of unending handicap. Techniques for appraisal for such inability, particularly those focused at exercises of day by day living which are most influenced by neck agony, are very few. An alteration of the Oswestry Low Back Pain Index was led ...
Introduction 1 pageConclusion 1 page Fix the format, spelling .docxnormanibarber20063
Introduction 1 page
Conclusion 1 page
Fix the format, spelling and grammatical error
Subjects
Materials and Methods
Subjects were 30 male volunteers recruited from a university population. Subjects were between the ages of 18-35, had no existing cardiorespiratory or musculoskeletal disorders, claimed to be free from consumption of anabolic steroids or any other legal or illegal agents known to increase muscle size currently and for the previous year, and had not performed any regimented resistance training for at least the past year.
Participants were pair-matched according to baseline strength and then randomly assigned to 1 of 2 experimental groups: an internal focus group (INTERNAL) that focused on directly contracting the target muscle during training (n = 15) or an external focus group (EXTERNAL) that focused on the outcome of the lift during training (n = 15). Approval for the study was obtained from the college Institutional Review Board. Informed consent was obtained from all participants prior to beginning the study. Experimental design
The investigation was carried out over a period of 10 weeks, with 8 weeks dedicated to the RT program and 2 weeks allocated for testing. Pre-study testing was carried out in week 1 and post-study testing was carried out in week 10. A supervised progressive RT was performed between weeks 2-9. Resistance Training Procedures
The RT protocol consisted of two exercises: Standing barbell curl and machine leg extension. These exercises were chosen because it is easier to direct focus internally during performance of a single-joint movement. Subjects were instructed to refrain from performing any additional resistance-type or high-intensity anaerobic training for the duration of the study.
Training for both routines consisted of 3 weekly sessions performed on non-consecutive days for 8 weeks. All routines were directly supervised by the research team, which included a National Strength and Conditioning Association certified strength and conditioning specialist and certified personal trainers, to ensure proper performance of the respective routines. Subjects performed 4 sets of 8-12 repetitions per exercise. The supervising research staff member provided relevant cues to subjects on each repetition to reinforce the given focus of attention. For INTERNAL, subjects were cued to “squeeze the muscle!” on each repetition; for EXTERNAL, subjects were cued to “get the weight up!” on each repetition. All sets were carried out to the point of momentary concentric muscular failure, operationally defined as the inability to perform another concentric repetition while maintaining proper form. To maintain ecological validity, cadence of repetitions was carried out in a fashion that allowed subjects to best achieve the given attentional focus. Subjects were afforded 2 minutes rest between sets. The loads were adjusted for each exercise as needed on successive sets to ensure that subjects achieved failure in the tar.
Nikos Malliaropoulos - Rehabilitation of hamstring injuries MuscleTech Network
Nikos Malliaropoulos
Director of the Athletics National Sports Medicine Centre Thessaloniki Greece. Consultant SEM Physician Barts and The London Clinical Senior Lecturer QMUL CSEM.
-
The rehabilitation of Hamstring injuries - Can we be more injury specific?
(6th MuscleTech Network Workshop)
14th October, Barcelona
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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2. Objectives
•Define the current clinical scenario and question
•Identify search methods for the best available evidence
for successful treatment of MDI
•Describe the findings of these key studies
•Address the weaknesses of these key studies
•Summarize the implications for practitioners
3. Multidirectional Instability (MDI)
•Numerous etiologies
oTraumatic
oAtraumatic
oCongenital
oMultifactorial
•Symptomatic global laxity of
glenohumeral joint
•Generally younger, active http://test2.aaos.org/oko/topic_images/SPO041.jpg
o<30
•Men = Women
•Orthopedic Research Institute defines as glenohumeral
instability in >1 direction
•Different from unidirectional instability
4. Clinical Scenario
•Complex pathology, difficult to treat
•Two common intervention
approaches
o Surgery ->
Immobilization -> PT
oConservative PT
management
•Conflicting data to suggest
which is best
•Specific pt populations may
benefit more
from one approach vs. another http://redsports.sg/wp-content/uploads/2008/04/clunking-shoulder.jpg
5. Dynamic and Static Restraints
•Labrum and capsule
•Rotator cuff muscles
•Sup/middle/inf
glenohumeral ligaments
•Orientation and size of
the humeral head and glenoid
•Also the coracoacromial lig,
axillary pouch, and
Scapulothoracic muscles and orientation
6. Clinical Scenario Patient Symptoms
•Loosening of the shoulder in all directions
•This my be pronounced while carrying luggage
or turning over while asleep
•Pain may or may not be present
•Sulcus sign
•Patient may feel shoulder slippage or feeling of insecurity with specific activities
•May have normal observation, AROM, PROM, RROM (in test positions), normal
imaging
7. Special Tests
•Rowe Test for MDI
•Sulcus sign
•Load and shift
•Anterior and posterior
drawer in standing or sitting
•Joint glides in supine
•Push-pull test
8. Grades of Humeral Head Translation
Normal laxity- mild amount of translation up to
25%
Grade 1- A feeling of the humeral head riding up to
the glenoid rim 25-50%
Grade 2- A feeling of the humeral head over riding
the rim, but spontaneously reduces >50%
Grade 3- A feeling of the humeral head over the
rim, but remains dislocated
9. Focused Clinical Question
Is conservative rehabilitation alone an effective intervention
in the treatment of multidirectional shoulder instability?
10. Search Strategy
P- Multidirectional shoulder instability
I- Conservative treatment OR therapeutic exercise OR
non-invasive treatment OR strengthening exercise
C- Invasive treatment OR surgery OR capsular shift
O- Presence of symptoms OR recurrence of
dislocation/subluxation OR return to function
11. Search Strategy Cont'd
•Databases used:
oPubmed
oCINAHL
oSPORTDiscus
oPEDro
•Inclusion criteria:
oStudies investigating effectiveness of conservative
treatment
oEnglish language
oHuman participants
oLast 10 years
oStrengthening regimen
12. Search Strategy Cont'd
•Exclusion criteria:
oStudies investigating unidirectional instability
oPatients with current soft tissue or bone injury
oPatients with history of shoulder surgery
oAnimal models
14. Capsular Shift Surgery
•Capsular shift surgery is the tightening of the capsule,
“shifting” it back into place so that it helps hold the
joint together. It is usually done as an “open” procedure
assisted by an arthroscopy, which is the viewing of the
joint through a magnified scope. The patient is usually
placed into a semi-sitting position on a special bed with
a back that raises up. The patient’s head is stabilized
in a soft, padded head holder.
•Once the capsule is viewed through the arthroscope and the area of
damage located, the open incision is made. The stretched capsule is
brought forward and pulled tighter by folding over itself. It is then sutured
15. Illyés et al (2009)
Study Prospective Cohort
Design
Particip 101 subjects
ants
Control Group: 32 males, 18 females,
average age in mid 20’s
PT Group: 17 males, 15 females, average
age 18
Surgery + PT Group: 7 males, 12 females,
average age in low 30’s
IntervenConservative Group: Education, Mirrors,
tion PNF, biofeedback, strengthening exercises,
closed chain exercises, stamina training
Surgical Group: Open capsular shift,
immobilized in sling for 6 weeks, rehab on
day 1:
aarom elevation to 90, ER to 10 degrees.
After 3 weeks: max ROM without pain.
After 6 weeks: Begin same intervention as
conservative group
Outcom EMG data from pec major, infraspinatus,
e deltoid, upper
Measur trapezius, bicep, tricep, during pull, forward
es punch, elevation, slow/fast overhead throw
Time between first muscle reaching max
activity and last (time broadness)
Normalized maximum amplitudes
Main Only surgical + rehab returned muscles
Finding activity to normal
s
Motion patterns on muscles around joint
with MDI are changed.
Conservative treatment improved time
broadness
to normal, but not for level of muscle
activations (decreased accelerators,
increased
stabilizers).
16. Kiss et al (2010)
Study Non-Randomized Control Trial
Design
Participa 90 subjects
nts
Control Group: 16 males, 9 females,
average age 27
PT Group: 18 males, 16 females, average
age 28
Surgery + PT Group: 12 males, 19 females,
average age 30
Intervent Program consisted of proprioceptive input
ion to improve the sense of joint position, and
on relearning correct movement patterns
with the development of strength and
endurance in the scapulothoracic and
glenohumeral muscles. Mirrors, PNF,
biofeedback were used to retrain patterns of
ST and GH movement. Strength exercises,
closed chain exercises, stamina training
were used to increase stability of muscle
balance and proprioception.
Surgery group had a capsular shift using the
“beach chair” position through an anterior
approach. Surgery was then followed with
postoperative physiotherapy.
Outcom Kinematic characteristics of movement
e measured using the Zebris CMS-HS
Measure movement analysis system.
s
Changes in the electrical potential of the
ant/middle/post parts of the deltoid,
supraspinatus with trapezius, infraspinatus,
biceps brachii, triceps brachii were
recorded.
Maximum muscle contraction was specified
by taking the highest muscle contraction
achieved during various forms of motion.
Bilinear regression line of rhythm was
calculated using 5 parameters of motion
pattern.
Main Patients with MDI had significant
Findings alterations in shoulder kinematics and in
muscle activity compared to controls.
17. Misamore et al (2005)
Study Uncontrolled, Retrospective,
Design Noncomparative Review
Particip 64 patients with atraumatic MDI
ants
21 males, 43 females, average age 18.6
All but 9 participated in sport
IntervenEnrolled in physical therapy program and
tion were placed on home exercise program.
Phase 1 consisted of relative rest from
provocative activities, analgesics, and gentle
ROM exercises. Phase 2 consisted of
rotator cuff and parascapular muscle
strengthening exercises. Slow progressive
strengthening programs were performed
daily at home (15 to 20 min 3x daily).
Phase 3 involved sport specific
exercises if appropriate. Phase 4 involved
returning to sport or work.
Outcom Modified Rowe score (Max of 100 points).
e Includes function, pain, stability, motion.
Measur
es
Main At 2 years surgery had been performed on 20
Finding of the patients to stabilize their shoulder. Of
s the 39 patients not receiving surgery 20 had
good or excellent results regarding pain
relief, 21 had good or excellent results with
stability, 28 reported that the shoulder
condition was better or much better.
At 8 years 1 addition patient received
surgery. Of the 36 non-surgical patients 29
reported no further treatment for their
shoulder instability, none of the patients
were still performing shoulder therapy
exercises. 28 reported persistent problems
with their shoulders, 8 reported no residual
symptoms.
Level 2B
of
Evidenc
e
Conclus At the 8 year follow up 40 of 57 patients
ion (70%) had been treated surgically or had fair
or poor ratings for their shoulders. Only
30% had a good or excellent result based on
18. Ide et al (2003)
Study Prospective Cohort
Design
Particip 46 patients with MDI
ants
12 males, 34 females, average age 20
Interve Prescribed exercise daily for 8 weeks.
ntion Performed exercise in novel shoulder
orthosis to increase scapular inclination and
to stabilize the scapula. Strengthening the
rotator muscles and scapular stabilizers
(serratus anterior, and rhomboids). Isometric
exercises included IR, ER, and isotonic
shoulder strengthening exercises with thera-
band. Wall pushup exercises to strengthen
scapular stabilizers and synchrony training of
the scapulothoracic muscles.
Outco Before and after 8 week program patients
me were evaluated for; shoulder function, pain,
Measur numbness, stability, ROM on a modified
es Rowe grading system. There was then a
follow up at 7 years.
Main Before the rehab program 59 shoulders were
Finding in fair condition and 14 were in poor
s condition. After the rehab program 24
shoulders were in fair condition and 1 was in
poor.
Muscle strength increased by more than 20%
in 22 of 36 shoulders, in 20 of 22 shoulders
good or excellent results were achieved.
Level 2B
of
Eviden
ce
Conclu The aim of rehabilitation should be a gain of
sion 20% in the peak torque of internal and
external rotation and the achievement of
normal muscle balance. Shoulder orthotic
prevents a decrease in scapular inclination;
rather, it increases scapular inclination by
pushing the inferior angle of the scapula and
straightening the thoracic spine. Patients can
achieve stabilization of the glenohumeral
joint and scapula by using the orthosis
correctly. They are permitted to remove the
orthosis after achieving strengthening of the
shoulder muscles upon completion of the
exercise program.
19. Gibson et al (2004)
Study Systematic Review
Design
Particip Adults 16-55 with history of shoulder
ants instability
Excluded stroke, hemiplegia, prior surgery
IntervenNon-operative management including but
tion not limited to immobilization and PT
methods like stretching, strengthening or
stabilization exercises, biofeedback, other
modalities
Outcom Recurrence of instability (redislocation or
e resubluxation)
Measur
es Return to
premorbid function
Alleviation of symptoms
Main Many different intervention protocols, but
Finding mostly based on physiological rationale
s and biological evidence
Paucity of quality trials in this area
Review
limited to qualitative analysis due to poor
reporting in many papers
Current available studies are weak
foundation
Weak but positive trend for conservative
management
Most cohorts found worse outcome with
conservative management, particularly in
those under 30.
Level 1A
of
Evidenc
e
Conclus Weak evidence to support surgery over
ion conservative management.
20. Current Conservative Management
American College of Sports Medicine recommends
strengthening of the scapulothoracic and
glenohumeral muscles
Scapu Mov Muscl Resistance
lothor eme e exercise
acic nt
Fixa Serratu Push up
tion s ant
Fixa Pec Parallel bar
tion minor dip
Fixa Trap Upright row
tion
Fixa Levato Shoulder
tion r shrug
scapul
ae
21. Current Conservative Management
Glenoh Movem Muscle Resista
umeral ent nce
exercis
e
Flexion Ant deltFront
raises
Pec Incline
major bench
(clavicu press
lar
head)
Extensi Latissi Dumbb
on mus ell pull-
dorsi over
Teres Chin-up
major
Pec Bench
major press
22. Current Conservative Management
Glenoh Movem Muscle Resista
umeral ent nce
exercis
e
Abducti Middle Lateral
on delt raises
Suprspi Low
natus pulley
lateral
raises
Adducti Latissi Lat
on mus pull-
dorsi down
Teres Seated
major row
Pec Cable
major crossov
er fly
23. Current Conservative Management
Glenoh Movem Muscle Resista
umeral ent nce
exercis
e
Internal Teres Bent
rotation major row
Subsca One-
pularis arm
dumbbe
ll row
Pec Bench
major press
Ant deltFront
raises
Externa Infraspi Externa
l natus l
rotation rotation
Teres Externa
minor l
rotation
Post Bent-
24. Study findings affecting conservative
management
Study 1 Patients with
MDI have
altered motion
patterns on
muscles around
joint
Study 2 Patients with
MDI had
significant
alterations in
shoulder
kinematics and
in muscle
activation
Study 3 Most patients
who improve
with ther ex
program do so
fairly quickly,
25. Summary and Clinical Implications
•Paucity of good quality studies
oWeak foundation for future research
•Weak evidence to support surgery as a necessity
•Weak evidence to support conservative intervention alone
•Conservative intervention should remain first line
oImprovements should be noticeable early
Absence an indication for surgery
oMost patients will need surgery
• Following surgery
o3-4 weeks immobilization
o12 weeks of Scapular/Glenohumeral strengthening and
stability exercises
o EMG biofeedback can be used in adjunct
26. Gibson, K., A. Growse, L. Korda, E. Wray, and JC MacDermid. "The Effectiveness of Rehabilitation for Nonoperative
Management of Shoulder Instability: a Systematic Review." Journal of Hand Therapy 17.2 (2004): 229-42.
Ide, J., S. Maeda, M. Yamaga, K. Morisawa, and K. Takagi. "Shoulder-strengthening Exercise with an Orthosis for
Multidirectional Shoulder Instability: Quantitative Evaluation of Rotational Shoulder Strength before and after the
Exercise Program." Journal of Shoulder and Elbow Surgery 12.4 (2003): 342-45.
Illyes, A., J. Kiss, and R. Kiss. "Electromyographic Analysis during Pull, Forward Punch, Elevation and Overhead
Throw after Conservative Treatment or Capsular Shift at Patient with Multidirectional Shoulder Joint Instability."
Journal of Electromyography and Kinesiology (2008).
Kiss, Rita M., Árpád Illyés, and Jenő Kiss. "Physiotherapy vs. Capsular Shift and Physiotherapy in Multidirectional
Shoulder Joint Instability." Journal of Electromyography and Kinesiology (2009).
Misamore, G., P. Sallay, and W. Didelot. "A Longitudinal Study of Patients with Multidirectional Instability of the
Shoulder with Seven- to Ten-year Follow-up." Journal of Shoulder and Elbow Surgery 14.5 (2005): 466-70.
American College of Sports Medicine. ACSM’s Resource Manual for Guidelines for Exercise Testing and
Perscription. 6th ed. Wolters Kluwer; 2010: 1-868.
David J. Magee. Orthopedic Physical Assessment. 5th ed. Saunders Elsevier; 2008: 231-360.