Marcus Knöll (Bosch): Implementation of Augmented Reality in the Pharmaceutical Process Environment

AUGMENTED
REALITY IN THE
PHARMACEUTICAL
PROCESS
ENVIRONMENT

Augmented Reality in the Pharmaceutical Process Environment
Packaging Technology | PADH/EPS - Dr. Marcus Knöll | 2018-09-27
© Robert Bosch GmbH 2018. All rights reserved, also regarding any disposal, exploitation, reproduction, editing, distribution, as well as in the event of applications for industrial property rights.
2
Content:
•  Why
•  How
•  Solution
•  Next Step
•  Benefits

3
What is augmented reality?
A combination of seeing the reality
overlaid by a virtual scene generated by a
computer that arguments the scene with
additional information

4
Characteristics of AR systems
Augmented
Reality
Glasses
capabilities of computer
generated display,
sound text and effects to
enhance user’s real-
world experience
interactive, reality-based
display environment
creation of a totally
artificial environment
integrates digital
information with the
user’s environment in
real time

5
Low Volume but High Value
Orphan Drugs are largest group of New Drug Submissons
Source: Evaluate Pharma, World Preview 2015

6
What are the main challenges at pharma companies
„ Niche product producers face the following changes due to the high product varieties:
„  High intervals of assembly and disassembly of the machine
„  Adjusting of process parameters after each product change
„  Training of operators to operate various manufacturing concepts (blender, high shear mixer, FBG
and coater)

7
Largest growth from MEA and Asia Pacific
Source: IMS Health “Global Medicines Use in 2020”
Region Populatio
n
millions
Asia 4436
Africa 1216
Europe 738
North
America
579
South
America
422
Oceania 39,8
Source: Wikipedia
Growth of the Generics but Price Sensitive

8
Numbers of SU/person/day will
growth
Source: IMS Health “Global Medicines Use in 2020”
Source: Wikipedia
EU 2015 ~ 2,77 SU/person/day
Growth of the Generics

9
What are the main challenges at pharma companies
„ Generica companies aim to reduce their ownership costs as much as possible in
order to be a strong competitor in the market and get contracts with health
insurances.
„ Costs could be reduced by optimizing the following challenges:
„  Assembly time
„  Costs for training of personal
„  Achieving 100% yield
„  Complex processes and high potential of deviation
„  More Uptime

10
What are the main challenges at Pharma companies
„ Challenges faced by Pharma companies located in Africa & Asia, due to the
following reasons:
„  Limited trained and qualified operators
„  Poor knowledge and experience
Poorly stable processes and high occurrence of deviations,
Which would then lead to high ownership costs & impacting the product quality

11
User requirements of the equipment provider for AR System
„  Device Independent caused by the long life time of the equipment
„  Easy to adapt without programming because the equipment is customized
„  First and foremose Robustness vs Fancy
„  Sustainable Partner
CAP

12
HoloLens eyeglasses as AR tool for the pharmaceutical field
Bosch app has been developed and installed on HoloLens
The following machines have been developed installed on HoloLens eyeglasses:
„  Blender
„  Fluid bed granulator (top-spray and bottom-spray)
„  Pellet coater
„  Tablet coater

13
FBG of Solidlab 1 installed on HoloLens eyeglasses
„ The next slides show the assembly instruction to be followed by the operator to assemble
the fluid bed module bottom-spray of the Solidlab 1
„ The instruction procedure takes into consideration the right order to be followed.

14
FBG of Solidlab 1 installed on HoloLens eyeglasses
„ The next slides show the assembly instruction to be followed by the operator to assemble
the fluid bed module bottom-spray of the Solidlab 1
„ The instruction procedure takes into consideration the right order to be followed.
Detached pi

15
Start point

16
Assembling
the filters

17
Mounting
disk jet into
the vessel

18

19

20

21

22

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HoloLens eyeglasses as AR tool for the pharmaceutical field
„ AR fulfils one of the most important advantages
of Industry 4.0
„ AR technology brings users to experience an
augmented world by overlaying virtual
information in real world.
„ It is the easiest and shortest way represent
relevant information for technicians and
operators at the place where the work is
performed.
„ It is suitable to provide technicians information
and support to asses a problem issue on the
machine
Cyber security
Augmented
reality
Big data
Autonomous
robots
Additive
manufaturi
ng
Simulation
System
integration
Cloud
computing
Internet of
things
INDUSTRY
4.0

24
Why AR should be implemented in Pharma companies
„ Manufacturing in Pharma has high levels of control and standards that are stringent to
meet
„ Use of complex equipment which is difficult to operate and needs specialists to use and
maintain
„ Due to the non-appropriate assembly of the machine, deviations might occur, which would
generate high costs and time loss to the company
„ Having a better understanding of the machine would lead to better control on the process
and thus improving the product quality
„ Providing a remote assistance on the machine, which would shorten down time and save
travel costs
WHY
AR?

25
Benefits of AR on GMP level
„ AR would provide self and individual training to operator
„ The AR would ensure the machine is assembled, maintained and operated correctly, even
by non-sufficient employee experience or by stuff change.
„ Ensure a robust and reproducible process which would minimize deviations occurrence
and deliver high and reproducible product quality
„ Ensure correct identification of spare parts
„ Appropriated information and Standard operating procedures are direct available
ü

26
Main advantages of AR in the pharmaceutical field
Lower total cost of ownership
q  Fast change over
q  Correct Maintenance
q  Right First Time
q  Less training costs
q  Efficient troubleshooting
Less Quality Costs
q  Less Mistakes
q  Better process understanding

Marcus Knöll (Bosch): Implementation of Augmented Reality in the Pharmaceutical Process Environment

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