The document discusses how current scientific research practices are outdated and designed to create friction, preventing optimal sharing and collaboration. It advocates transitioning to more "web-enabled science" by improving open access to content, data, code, materials and tools while rewarding openness. However, changing practices faces challenges like skills gaps. Collective efforts are needed to build capacity through training, educate the next generation, and instill best digital and reproducible practices to help research fully leverage the web.
Given at ISWC 2009 as a part of "Legal and Social Frameworks for Sharing Data on the Web" tutorial with Leigh Dodds and Tom Heath from Talis and Jordan Hatcher from Open Data Commons. 25 Oct 2009. (http://www.opendatacommons.org/events/iswc-2009-legal-social-sharing-data-web/)
Sharing Scientific Data: Legal, Normative and Social IssuesKaitlin Thaney
A look at the legal, normative and social issues surrounding data sharing and the ways we've chosen to address this increasingly complex space.
Presented in Beijing on 25 March 2009.A l
Given at ISWC 2009 as a part of "Legal and Social Frameworks for Sharing Data on the Web" tutorial with Leigh Dodds and Tom Heath from Talis and Jordan Hatcher from Open Data Commons. 25 Oct 2009. (http://www.opendatacommons.org/events/iswc-2009-legal-social-sharing-data-web/)
Sharing Scientific Data: Legal, Normative and Social IssuesKaitlin Thaney
A look at the legal, normative and social issues surrounding data sharing and the ways we've chosen to address this increasingly complex space.
Presented in Beijing on 25 March 2009.A l
Shaping our Future: Digitization Partnerships Across Libraries, Archives and ...UBC Library
Presentation by Ingrid Parent at the National Diet Library in Tokyo, Japan, Dec. 2, 2010.
Shaping our Future: Digitization Partnerships Across Libraries, Archives and Museums
Keynote talk at the Web Science Summer School, Singapore, 8 December 2014. Today we see the rise of Social Machines, like Twitter, Wikipedia and Galaxy Zoo—where communities identify and solve their own problems, harnessing commitment, local knowledge and embedded skills, without having to rely on experts or governments.
The Social Machines paradigm provides a lens onto the interacting sociotechnical systems of our hybrid digital-physical world, citizen-centric and at scale—emphasising empowerment and sociality in a world of pervasive technology adoption and automation.
This talk will present the Social Machines paradigm as an approach to social media analytics and a rethinking of our scholarly practices and knowledge infrastructure.
Short paper presentation at the The 1st International Digital Libraries for Musicology workshop (DLfM 2014) 12TH SEPTEMBER 2014 (FULL DAY), LONDON, UK in conjunction with the ACM/IEEE Digital Libraries conference 2014.
Macroscopes and Distant Reading: Implications for Infrastructures to Support ...Trevor Owens
A talk exploring the implications for digital library infrastructures in the face of developments in how humanities scholars are engaging in computational research of library collections.
Many self-trackers and self-hackers in the Quantified Self community prefers a user-centric and transparent approach (www.noblackbox.co.uk), when aggregating personal data from multiple sources.
QS Mapper is a tool that lets you do just that by supporting the three main features aggregate, explore, and analyse.
See more at www.noblackbox.co.uk
Observing Archives: Web Archiving as Socio-technical PracticeJessica Ogden
This paper presents the preliminary results of an ethnographic study of web archiving, in an effort to explore the ways in which practitioners shape the preservation and maintenance of the archived Web in its various forms. A combination of non/participant observation, documentary sources and interviews were conducted over the course of several weeks in collaboration with web archivists, engineers and managers at the Internet Archive – a private, non-profit digital library that has been archiving the Web since 1996. Whilst several socio- technical components of practice have been identified thus far, this paper focuses on the types of ‘knowledge work’ that informs the selection, collection, repair and maintenance of the archived Web(s). This work draws on Downey (2014) and recent calls within STS (Jackson 2014; Russell & Vinsel 2016) to move beyond a pre- occupation with innovation to consider the repair and maintenance of technologies as potential sites of critical engagement and social discourse. Here the concept of ‘web archival labour’ is proposed to encompass these practices and highlight the ways in which web archivists (as both networked human and non-human agents) shape and maintain the preserved Web through practices that are often embedded in and obscured by the complex technical arrangements of collection and access. As a result, this engagement positions web archives as places of knowledge and cultural production in their own right, revealing new insights into the performative nature of web archiving that have implications for how these new forms of social data are used and understood.
These are the slides of the keynote talk in the science communication session, at the Plant Biology Europe FESPB/EPSO Congress, 24 June 2014 in Dublin (http://europlantbiology.org/).
3 Things Every Sales Team Needs to Be Thinking About in 2017Drift
Thinking about your sales team's goals for 2017? Drift's VP of Sales shares 3 things you can do to improve conversion rates and drive more revenue.
Read the full story on the Drift blog here: http://blog.drift.com/sales-team-tips
Shaping our Future: Digitization Partnerships Across Libraries, Archives and ...UBC Library
Presentation by Ingrid Parent at the National Diet Library in Tokyo, Japan, Dec. 2, 2010.
Shaping our Future: Digitization Partnerships Across Libraries, Archives and Museums
Keynote talk at the Web Science Summer School, Singapore, 8 December 2014. Today we see the rise of Social Machines, like Twitter, Wikipedia and Galaxy Zoo—where communities identify and solve their own problems, harnessing commitment, local knowledge and embedded skills, without having to rely on experts or governments.
The Social Machines paradigm provides a lens onto the interacting sociotechnical systems of our hybrid digital-physical world, citizen-centric and at scale—emphasising empowerment and sociality in a world of pervasive technology adoption and automation.
This talk will present the Social Machines paradigm as an approach to social media analytics and a rethinking of our scholarly practices and knowledge infrastructure.
Short paper presentation at the The 1st International Digital Libraries for Musicology workshop (DLfM 2014) 12TH SEPTEMBER 2014 (FULL DAY), LONDON, UK in conjunction with the ACM/IEEE Digital Libraries conference 2014.
Macroscopes and Distant Reading: Implications for Infrastructures to Support ...Trevor Owens
A talk exploring the implications for digital library infrastructures in the face of developments in how humanities scholars are engaging in computational research of library collections.
Many self-trackers and self-hackers in the Quantified Self community prefers a user-centric and transparent approach (www.noblackbox.co.uk), when aggregating personal data from multiple sources.
QS Mapper is a tool that lets you do just that by supporting the three main features aggregate, explore, and analyse.
See more at www.noblackbox.co.uk
Observing Archives: Web Archiving as Socio-technical PracticeJessica Ogden
This paper presents the preliminary results of an ethnographic study of web archiving, in an effort to explore the ways in which practitioners shape the preservation and maintenance of the archived Web in its various forms. A combination of non/participant observation, documentary sources and interviews were conducted over the course of several weeks in collaboration with web archivists, engineers and managers at the Internet Archive – a private, non-profit digital library that has been archiving the Web since 1996. Whilst several socio- technical components of practice have been identified thus far, this paper focuses on the types of ‘knowledge work’ that informs the selection, collection, repair and maintenance of the archived Web(s). This work draws on Downey (2014) and recent calls within STS (Jackson 2014; Russell & Vinsel 2016) to move beyond a pre- occupation with innovation to consider the repair and maintenance of technologies as potential sites of critical engagement and social discourse. Here the concept of ‘web archival labour’ is proposed to encompass these practices and highlight the ways in which web archivists (as both networked human and non-human agents) shape and maintain the preserved Web through practices that are often embedded in and obscured by the complex technical arrangements of collection and access. As a result, this engagement positions web archives as places of knowledge and cultural production in their own right, revealing new insights into the performative nature of web archiving that have implications for how these new forms of social data are used and understood.
These are the slides of the keynote talk in the science communication session, at the Plant Biology Europe FESPB/EPSO Congress, 24 June 2014 in Dublin (http://europlantbiology.org/).
3 Things Every Sales Team Needs to Be Thinking About in 2017Drift
Thinking about your sales team's goals for 2017? Drift's VP of Sales shares 3 things you can do to improve conversion rates and drive more revenue.
Read the full story on the Drift blog here: http://blog.drift.com/sales-team-tips
تقرير بحثي: مواقف مستخدمي الإنترنت في منطقة الشرق الأوسط حيال السلامة والأمن ...MOTC Qatar
قامت وزارة الاتصالات وتكنولوجيا المعلومات بتدشين النتائج الرئيسية لدراسة جديدة تمت على مستوى منطقة الشرق الأوسط وشمال أفريقيا وتناولت توجهات وسلوكيات مستخدمي الإنترنت
النتائج تم التوصل إليها باستخدام عينة بحثية قوامها 2793 من مستخدمي الإنترنت في المنطقة، تم مقارنة إجاباتهم بتلك البيانات المستخلصة من دراسات قام بها المنتدى الاقتصادي العالمي مستخدماً عينة من 8432 موزعين على 44 دولة من حول العالم
تمت الدراسة بالمشاركة مع "معهد أكسفورد للإنترنت" التابع لجامعة أكسفورد، و "كلية صمويل كيرتس جونسون العليا للإدارة" التابعة لجامعة كورنيل. العمل الميداني تم من خلال اثنين من الشركات العالمية التي تقود دراسات السوق: "كومسكور" و " تولونا
في هذا الاصدار يتم عرض عشر تقنيات خاصة بالعملية التعليمية. من بين تلك التقنيات حلول مبتكرة للطلبة ذوى الإعاقات السمعية الكلية أو الجزئية تعمل على تيسير عملية تعلم الكتابة والقراءة من خلال لغة الإشارة والصور.
كما يتعرض الإصدار لعدد من التقنيات الحديثة التي تنتمي لدول العالم الثالث والتي تستهدف توصيل التعليم إلى الفئات المهمشة والأقل حظاً. ففي الهند هناك مشروع رائد في مجال ربط الهاتف المحمول مع برامج البث الإذاعي لتوصيل التعليم للفئة الأكثر فقراً.
أما أوغتدا فقد برز فيها مؤخراً مشروع للاستفادة من الطاقة الشمسية لبناء فصول متنقلة مزودة بالحواسب الآلية قليلة التكلفة وسهلة الحمل.
نتمني لك قراءة ممتعة.
Discovery and the Age of Insight: Walmart EIM Open House 2013Joe Lamantia
Discovery is the most important business capability in the emerging Age of Insight - it's the missing ingredient that makes Big Data a source of value for businesses and people.
The Language of Discovery is an essential tool for providing discovery capability, whether at the scale of designing a single discovery application, determining the value proposition of a new product or service, or managing a strategic portfolio of technology and business initiatives.
This presentation outlines the Age of Insight, and suggests deep structural and historic precedents visible in the Age of Reason, especially in the central parallels between Natural Philosophy and the emerging discipline of Data Science. We then review the language of discovery, and consider widely visible examples of products and services that demonstrate the language.
We review our own usage of the framework as an analytical and generative toolkit for providing discovery capability, and share best practices for employing this perspective across a variety of levels of need.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
9. our current systems are
designed to create
friction.
despite original intentions.
10.
11. What Des-Cartes did was a good step.
You have added much several ways, &
especially in taking ye colours of thin
plates into philosophical consideration.
If I have seen further it is by standing on
ye shoulders of Giants.
- Isaac Newton, 1676
“
“
13. traditions last not because they are
excellent, but because influential
people are averse to change and
because of the sheer burdens of
transition to a better state ...
“
“
Cass Sunstein
19. “... up to 70% of research from academic labs
cannot be reproduced, representing an enormous
waste of money and effort.”
- Elizabeth Iorns, Science Exchange
28. “One worry I have is that, with reviews like this, scientists will be
even more discouraged from publishing their code [...] We need
to get more code out there, not improve how it looks.”
29. code as a research object
what’s needed
to reuse ?
30. code as a research object
http://xkcd.com/285/