Introduction, symptoms, economic impact, indigenous vaccine, prevention, control of lumpy skin disease

1. PRACTICE SCHOOL

2. COURSE STRUCTURE AND CONTENTS FOR
•PRACTICE SCHOOL [ BP 706 PS]
•B PHARMACY FINAL YEAR [SEM: 7]
•DOMAIN : 18
•PHARMACOVIGILANCE
•REVIEW ON LUMPY SKIN DISEASE

3. A REVIEW ARTICLE BY :
• SONAR TANUJ DINESH
• FINAL YEAR B. PHARMACY
• [1952811823009]
• GUIDED BY :
• DR. A.G. JADHAV SIR.

4. INDEX
SR NO CONTENTS
1 INTRODUCTION
2 HISTORY
3 CAUSATIVE AGENT
4 SYMPTOMS
5 TREATMENT
6 CONRTOL
7 IMAGES

5. WHAT IS PHARAMACOVIGILANCE?
• IT IS DERIVED FROM TWO WORDS
• PHARMAKON {GREEK}: MEDICINAL SUBSTANCES
• VIGILARE {LATIN}: TO KEEP WATCH
• DEFINITION ACCORDING TO WHO
• PHARMACOVIGILANCE IS THE SCIENCE AND ACTIVITIES
RELATING TO THE DETECTION, ASSESSMENT,
UNDERSTANDING AND PREVENTION OF ADVERSE EFFECTS OR
ANY OTHER MEDICINE/VACCINE RELATED PROBLEM

6. LUMPY SKIN DISEASE
• COW RAISED US
NOW ITS OUR DUTY
TO BE THEIR VOICE
AND SAVE THEM
• SAVE COWS

7. INTRODUCTION OF LUMPY SKIN DISEASE
• LUMPY SKIN DISEASE IS A VIRAL DISEASE THAT
AFFECTS CATTLE. IT IS TRANSMITTED BY BLOOD-
FEEDING INSECTS, SUCH AS CERTAIN SPECIES OF FLIES
AND MOSQUITOES, OR TICKS. IT CAUSES FEVER,
NODULES ON THE SKIN AND CAN ALSO LEAD TO
DEATH, ESPECIALLY IN ANIMALS THAT THAT HAVE NOT
PREVIOUSLY BEEN EXPOSED TO THE VIRUS.

8. HISTORY OF LUMPY SKIN DISEASE
• LUMPY SKIN DISEASE (LSD) IS A VIRAL DISEASE THAT
PREDOMINANTLY AFFECTS CATTLE. FIRST IDENTIFIED
IN AN OUTBREAK IN ZAMBIA IN 1929, THE DISEASE IS
CAUSED BY THE LSD VIRUS (LSDV), A POXVIRUS OF THE
GENUS CAPRIPOXVIRUS. UNTIL THE 1980S. MULTIPLE
OUTBREAKS OF LSD WERE CONFINED TO THE AFRICAN
CONTINENT.

9. WHEN LUMPY SKIN DISEASE DISCOVER IN INDIA?
• IN NOVEMBER 2019 LUMPY SKIN DISEASE IN THE
COUNTRY WAS CONFIRMED IN A LAB. IT WAS MAINLY
RESTRICTED TO SPORADIC CASES IN LOCATIONS SUCH
AS ODISHA. THE ORIGIN OR SOURCE OF THE DISEASE
IN INDIA, AS WELL AS THE OUTBREAK IN 2022
REMAINED UNKNOWN.

10. WORST HIT STATES IN INDIA

11. CAUSATIVE AGENT OF LUMPY SKIN DISEASE
• LUMPY SKIN DISEASE (LSD) IS A VIRAL DISEASE OF
CATTLE CAUSED BY LUMPY SKIN DISEASE VIRUS (LSDV).
THE CAUSATIVE AGENT IS A MEMBER OF THE
CAPRIPOXVIRUS GENUS IN THE POXVIRIDAE FAMILY

12. SYMPTOMS OF LUMPY SKIN VIRUS
• THE SYMPTOMS INCLUDE HIGH FEVER, REDUCED MILK
PRODUCTION, SKIN NODULES, LOSS OF APPETITE,
INCREASED NASAL DISCHARGE AND WATERY EYES,
TOO MUCH OF SALIVATION AND DISCHARGE OF WATER
FROM EYES AND NOSE AND FORMATION OF NODULES
ON THE BODY.

13. DIAGNOSTIC TECHNIQUES OF LUMPY SKIN DISEASE
• DIAGNOSIS OF LSD MAINLY DEPENDS ON THE TYPICAL
CLINICAL SIGNS, DIFFERENTIAL DIAGNOSIS, AND
APPLICATION OF VARIOUS DIAGNOSTIC LABORATORY
TECHNIQUES FOR DETECTION AND CONFIRMATION OF
THE DISEASE, SUCH AS ELECTRON MICROSCOPY
EXAMINATION, VIRUS ISOLATION (VI), SEROLOGICAL
TESTS (SERUM NEUTRALIZATION TEST, AGAR GEL
IMMUNE

14. TRANSMISSION OF LUMPY SKIN DISEASE
• LUMPY SKIN DISEASE IS A VIRAL DISEASE THAT
AFFECTS CATTLE. IT IS TRANSMITTED BY BLOOD-
FEEDING INSECTS, SUCH AS CERTAIN SPECIES OF FLIES
AND MOSQUITOES, OR TICKS. IT CAUSES FEVER,
NODULES ON THE SKIN AND CAN ALSO LEAD TO
DEATH, ESPECIALLY IN ANIMALS THAT THAT HAVE NOT
PREVIOUSLY BEEN EXPOSED TO THE VIRUS.

15. PATHOGENESIS OF LUMPY SKIN DISEASE
• SHEEPPOX, GOATPOX, AND LUMPY SKIN DISEASE ARE
ALL SYSTEMIC DISEASES, WITH CELL-ASSOCIATED
VIREMIA PRECEDING THE APPEARANCE OF LESIONS
AND MARKED LYMPHADENOPATHY. IT IS LIKELY
THAT BLOOD MONOCYTES ARE IMPORTANT IN
SPREADING VIRUS TO SECONDARY SITES OF
INFECTION.

16. ECONOMIC IMPACT OF LUMPY SKIN DISEASE
• SIGNIFICANT LOSSES ARE DUE TO SEVERE EMACIATION,
HIDE DAMAGE, INFERTILITY IN MALES AND FEMALES,
MASTITIS, DROP IN MILK PRODUCTION, AND
ABORTIONS. DUE TO THE REDUCTION IN THE QUALITY
OF THE ANIMALS, THE EFFECT CAN BE SEEN IN THE
OVERALL TRADE OF LIVE ANIMALS AND ANIMAL
PRODUCTS.

17. TREATMENT ON LUMPY SKIN DISEASE
• NO SPECIFIC TREATMENT IS AVAILABLE. CHRONIC
LESIONS ARE HARMLESS. STRONG ANTIBIOTIC
THERAPY PREVENTS SECONDARY INFECTION. VIRUS
SPREADS RAPIDLY; THEREFORE RESTRICTION OF
ANIMAL MOVEMENT AND QUARANTINE
RESTRICTIONS ARE OF LIMITED USE.

18. PREVENTION OF LUMPY SKIN DISEASE
• SEGREGATE SICK ANIMALS
• STOP ALL ANIMALS, ANIMAL PRODUCTS, VEHICLES
AND PERSONS COMING IN OR OUT OF FARM
• AVOID GRAZING IN COMMON PLACE
• BAN ALL VISITORS TO THE FARM
• CALL A VETERNIAN FOR ADVICE, ADOPT
CONTAINMENT VACCINATION

19. CONTROL OF LUMPY SKIN DISEASE
• MOVEMENT CONTROL (QUARANTINE), VACCINATION,
SLAUGHTER CAMPAIGNS AND MANAGEMENT
STRATEGIES. SPECIFIC NATIONAL CONTROL PLANS
VARY BETWEEN COUNTRIES AND SO ADVICE SHOULD
BE SOUGHT FROM THE RELEVANT AUTHORITIES AND
VETERINARIANS.

20. INDIGENOUS VACCINE ON LUMPY SKIN DISEASE
• THE INDIGENOUS VACCINE LUMPI-PROVACIND HAS
BEEN DEVELOPED TO PROTECT LIVESTOCK FROM
LUMPY SKIN DISEASE. THE VACCINE HAS BEEN
DEVELOPED BY THE NATIONAL EQUINE RESEARCH
CENTER, HISAR (HARYANA) IN COLLABORATION WITH
THE INDIAN VETERINARY RESEARCH INSTITUTE,
IZZATNAGAR (BAREILLY).

21. CONCLUSION OF LUMPY SKIN DISEASE
• LUMPY SKIN DISEASE IS ONE OF THE MOST
ECONOMICALLY SIGNIFICANT TRANSBOUNDARY, VIRAL
DISEASES OF DOMESTIC CATTLE. IT IS ECONOMICALLY
SIGNIFICANT IN ANIMALS BECAUSE OF CHRONIC
DEBILITY, DECREASED MILK PRODUCTION AND
WEIGHT, DAMAGED SKINS, ABORTION, AND
MORTALITY

22. SOME IMAGES OF INFECTED CATTLES

23. THANK YOU