Diclofenac potassium 50 mg tablets smpc taj pharmaceuticalsTaj Pharma
Diclofenac Potassium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Potassium Dosage & Rx Info | Diclofenac Potassium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Potassium - Drug Information - Taj Pharma, Diclofenac Potassium dose Taj pharmaceuticals Diclofenac Potassium interactions, Taj Pharmaceutical Diclofenac Potassium contraindications, Diclofenac Potassium price, Diclofenac Potassium Taj Pharma Diclofenac Potassium 50 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Potassium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
A 65-year-old man with heart failure and DKA is admitted to hospital with a potassium level of 7.1 mmol/L.
HE was started with
Rx
lisinopril 20 mg daily,
spironolactone 25 mg daily.
Insulin Infusion + 5% Dextrose
Lisinopril Tablets USP 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects Lisinopril: Indications, Side Effects, Warnings, Lisinopril-Drug Information –Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril SmPC- Taj Pharma Stay connected to all updated on Lisinopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Captopril 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Captopril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects -: Indications, Side Effects, Warnings, Captopril - Drug Information - Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril 25 mg Tablets.SMPC- Taj Pharma . Stay connected to all updated on Captopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Diclofenac potassium 50 mg tablets smpc taj pharmaceuticalsTaj Pharma
Diclofenac Potassium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Potassium Dosage & Rx Info | Diclofenac Potassium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Potassium - Drug Information - Taj Pharma, Diclofenac Potassium dose Taj pharmaceuticals Diclofenac Potassium interactions, Taj Pharmaceutical Diclofenac Potassium contraindications, Diclofenac Potassium price, Diclofenac Potassium Taj Pharma Diclofenac Potassium 50 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Potassium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
A 65-year-old man with heart failure and DKA is admitted to hospital with a potassium level of 7.1 mmol/L.
HE was started with
Rx
lisinopril 20 mg daily,
spironolactone 25 mg daily.
Insulin Infusion + 5% Dextrose
Lisinopril Tablets USP 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects Lisinopril: Indications, Side Effects, Warnings, Lisinopril-Drug Information –Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril SmPC- Taj Pharma Stay connected to all updated on Lisinopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Captopril 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Captopril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects -: Indications, Side Effects, Warnings, Captopril - Drug Information - Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril 25 mg Tablets.SMPC- Taj Pharma . Stay connected to all updated on Captopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Literature Survey & Market Survey on Amlodipine and its Recent TrendsTuhin Samanta
Amlodipine is utilized with or without different drugs to treat hypertension. Bringing down hypertension forestalls strokes, respiratory failures, and kidney issues. Amlodipine has a place with a class of medications known as calcium channel blockers. It works by loosening up veins so blood can stream all the more effectively.
Olmesartan 20mg/40mg Tablets USP Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan Dosage & Rx Info | Olmesartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan-Drug Information –Taj Pharma, Olmesartan dose Taj pharmaceuticals Olmesartan interactions, Taj Pharmaceutical Olmesartan contraindications, Olmesartan price, Olmesartan Taj Pharma Olmesartan SmPC-Taj Pharma Stay connected to all updated on Olmesartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
This particular presentation of mine covers salient features of recent drug developed for treatment of dyslipidaemia particularly familial hypercholesterolemia. This presentation also covers recent modifications in treatment guidelines.
Diclofenac sodium 50mg gastro resistant tablets smpc- taj pharmaceuticalsTaj Pharma
Diclofenac Sodium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Sodium Dosage & Rx Info | Diclofenac Sodium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Sodium - Drug Information - Taj Pharma, Diclofenac Sodium dose Taj pharmaceuticals Diclofenac Sodium interactions, Taj Pharmaceutical Diclofenac Sodium contraindications, Diclofenac Sodium price, Diclofenac Sodium Taj Pharma Diclofenac Sodium 50mg Gastro-Resistant Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Sodium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dyslipidemia-latest guidlines-Review of Guidlines by Dr.Jayasoorya p gjpgkmr
Dyslipidemia newer guidelines
2019 ESC/EAS GUIDLINES FOR MANAGEMENT OF DYSLIPIDEMIA
2019 JUNE UPDATED AMERICAN COLLEGE OF CARDIOLOGY GUIDLINES FOR MANAGEMENT OF DYSLIPIDEMIA
INTRODUCTION OF FUROSEMIDE
CLINICAL DATA
CHEMISTRY OF DRUG (INCLUDING DRUG PROPERTIES)
DRUG DATABASES (AVAILABILITY,STORAGE,DOSAGE,ROUTE PREFERENCE)
PHARMACOKINETICS (SITE OF ACTION,TIME/ACTION PROFILE)
MECHANISM OF ACTION
ACTIONS
DESIRED EFFECT
INDICATIONS
THERAPEUTIC USES
CONTRAINDICATIONS
PRECAUTIONS
ADVERSE EFFECTS/SIDE EFFECTS
WARNINGS INCLUDING DOSE ADJUSTMENT IN SPECIAL POPULATION
DRUG INTERACTIONS
TOXICOLOGY & IT’S MANAGEMENT
NURSING CONSIDERATIONS
;RESPONSIBILITIES;ASSESSMENT;POTENTIAL DIAGNOSIS; IMPLEMENTATIONS;EVALUATIONS DURING FUROSIDE ADMINISTRATION
PATIENT/FAMILY TEACHING
SPECIAL CALCULATIONS
CONCLUSION OF FUROSEMIDE
REFERENCES OF FUROSEMIDE
Ibuprofen 400 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Ibuprofen Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ibuprofen Dosage & Rx Info | Ibuprofen Uses, Side Effects -: Indications, Side Effects, Warnings, Ibuprofen - Drug Information - Taj Pharma, Ibuprofen dose Taj pharmaceuticals Ibuprofen interactions, Taj Pharmaceutical Ibuprofen contraindications, Ibuprofen price, Ibuprofen Taj Pharma Ibuprofen 400 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Ibuprofen Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metformin 500mg tablets smpc taj pharmaceuticalsTaj Pharma
Metformin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metformin Dosage & Rx Info | Metformin Uses, Side Effects -: Indications, Side Effects, Warnings, Metformin - Drug Information - Taj Pharma, Metformin dose Taj pharmaceuticals Metformin interactions, Taj Pharmaceutical Metformin contraindications, Metformin price, Metformin Taj Pharma Metformin 500mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Metformin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dexamethasone Sodium Phosphate Injections (Dexona Injections) is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, Cerebral oedema(raised intracranial pressure),auto-immune, endocrine, pulmonary, blood disorders or breathing disorders.
Literature Survey & Market Survey on Amlodipine and its Recent TrendsTuhin Samanta
Amlodipine is utilized with or without different drugs to treat hypertension. Bringing down hypertension forestalls strokes, respiratory failures, and kidney issues. Amlodipine has a place with a class of medications known as calcium channel blockers. It works by loosening up veins so blood can stream all the more effectively.
Olmesartan 20mg/40mg Tablets USP Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan Dosage & Rx Info | Olmesartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan-Drug Information –Taj Pharma, Olmesartan dose Taj pharmaceuticals Olmesartan interactions, Taj Pharmaceutical Olmesartan contraindications, Olmesartan price, Olmesartan Taj Pharma Olmesartan SmPC-Taj Pharma Stay connected to all updated on Olmesartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
This particular presentation of mine covers salient features of recent drug developed for treatment of dyslipidaemia particularly familial hypercholesterolemia. This presentation also covers recent modifications in treatment guidelines.
Diclofenac sodium 50mg gastro resistant tablets smpc- taj pharmaceuticalsTaj Pharma
Diclofenac Sodium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Sodium Dosage & Rx Info | Diclofenac Sodium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Sodium - Drug Information - Taj Pharma, Diclofenac Sodium dose Taj pharmaceuticals Diclofenac Sodium interactions, Taj Pharmaceutical Diclofenac Sodium contraindications, Diclofenac Sodium price, Diclofenac Sodium Taj Pharma Diclofenac Sodium 50mg Gastro-Resistant Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Sodium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dyslipidemia-latest guidlines-Review of Guidlines by Dr.Jayasoorya p gjpgkmr
Dyslipidemia newer guidelines
2019 ESC/EAS GUIDLINES FOR MANAGEMENT OF DYSLIPIDEMIA
2019 JUNE UPDATED AMERICAN COLLEGE OF CARDIOLOGY GUIDLINES FOR MANAGEMENT OF DYSLIPIDEMIA
INTRODUCTION OF FUROSEMIDE
CLINICAL DATA
CHEMISTRY OF DRUG (INCLUDING DRUG PROPERTIES)
DRUG DATABASES (AVAILABILITY,STORAGE,DOSAGE,ROUTE PREFERENCE)
PHARMACOKINETICS (SITE OF ACTION,TIME/ACTION PROFILE)
MECHANISM OF ACTION
ACTIONS
DESIRED EFFECT
INDICATIONS
THERAPEUTIC USES
CONTRAINDICATIONS
PRECAUTIONS
ADVERSE EFFECTS/SIDE EFFECTS
WARNINGS INCLUDING DOSE ADJUSTMENT IN SPECIAL POPULATION
DRUG INTERACTIONS
TOXICOLOGY & IT’S MANAGEMENT
NURSING CONSIDERATIONS
;RESPONSIBILITIES;ASSESSMENT;POTENTIAL DIAGNOSIS; IMPLEMENTATIONS;EVALUATIONS DURING FUROSIDE ADMINISTRATION
PATIENT/FAMILY TEACHING
SPECIAL CALCULATIONS
CONCLUSION OF FUROSEMIDE
REFERENCES OF FUROSEMIDE
Ibuprofen 400 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Ibuprofen Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ibuprofen Dosage & Rx Info | Ibuprofen Uses, Side Effects -: Indications, Side Effects, Warnings, Ibuprofen - Drug Information - Taj Pharma, Ibuprofen dose Taj pharmaceuticals Ibuprofen interactions, Taj Pharmaceutical Ibuprofen contraindications, Ibuprofen price, Ibuprofen Taj Pharma Ibuprofen 400 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Ibuprofen Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metformin 500mg tablets smpc taj pharmaceuticalsTaj Pharma
Metformin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metformin Dosage & Rx Info | Metformin Uses, Side Effects -: Indications, Side Effects, Warnings, Metformin - Drug Information - Taj Pharma, Metformin dose Taj pharmaceuticals Metformin interactions, Taj Pharmaceutical Metformin contraindications, Metformin price, Metformin Taj Pharma Metformin 500mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Metformin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dexamethasone Sodium Phosphate Injections (Dexona Injections) is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, Cerebral oedema(raised intracranial pressure),auto-immune, endocrine, pulmonary, blood disorders or breathing disorders.
Duloxetine 20 mg gastro resistant capsules smpc- taj pharmaceuticalsTaj Pharma
Duloxetine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Duloxetine Dosage & Rx Info | Duloxetine Uses, Side Effects -: Indications, Side Effects, Warnings, Duloxetine - Drug Information - Taj Pharma, Duloxetine dose Taj pharmaceuticals Duloxetine interactions, Taj Pharmaceutical Duloxetine contraindications, Duloxetine price, Duloxetine Taj Pharma Duloxetine 20 mg gastro-resistant capsules SMPC- Taj Pharma . Stay connected to all updated on Duloxetine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telmisartan 40 mg tablets smpc taj pharmaceuticalsTaj Pharma
Telmisartan Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects -: Indications, Side Effects, Warnings, Telmisartan - Drug Information - Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan 40mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Telmisartan Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Valsartan 80mg, 160mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
VALSARTAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, VALSARTAN Dosage & Rx Info | VALSARTAN Uses, Side Effects -: Indications, Side Effects, Warnings, VALSARTAN - Drug Information - Taj Pharma, VALSARTAN dose Taj pharmaceuticals VALSARTAN interactions, Taj Pharmaceutical VALSARTAN contraindications, VALSARTAN price, VALSARTAN Taj Pharma Valsartan 80mg, 160mg Film coated Tablets SMPC- Taj Pharma . Stay connected to all updated on VALSARTAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Irbesartan 150 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
IRBESARTAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IRBESARTAN Dosage & Rx Info | IRBESARTAN Uses, Side Effects -: Indications, Side Effects, Warnings, IRBESARTAN - Drug Information - Taj Pharma, IRBESARTAN dose Taj pharmaceuticals IRBESARTAN interactions, Taj Pharmaceutical IRBESARTAN contraindications, IRBESARTAN price, IRBESARTAN Taj Pharma Irbesartan 150 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on IRBESARTAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Aceclofenac 200mg CR Tablets Taj Pharma SmPCTajPharmaQC
Aceclofenac 200mg CR Tablets Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Aceclofenac Dosage & Rx Info | Aceclofenac Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Aceclofenac-Drug Information –Taj Pharma, Aceclofenac dose Taj pharmaceuticals Aceclofenac interactions, Taj Pharmaceutical Aceclofenac contraindications, Aceclofenac price, Aceclofenac Taj Pharma Aceclofenac SmPC-Taj Pharma Stay connected to all updated on Aceclofenac Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Telmisartan Tablets USP Taj Pharma SmPCTajPharmaQC
Telmisartan Tablets USP 20mg/40mg/80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telmisartan Dosage & Rx Info | Telmisartan Uses, Side Effects Telmisartan: Indications, Side Effects, Warnings, Telmisartan-Drug Information –Taj Pharma, Telmisartan dose Taj pharmaceuticals Telmisartan interactions, Taj Pharmaceutical Telmisartan contraindications, Telmisartan price, Telmisartan Taj Pharma Telmisartan SmPC-Taj Pharma Stay connected to all updated on Telmisartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Allopurinol 300mg tablets smpc taj pharmaceuticalsTaj Pharma
Allopurinol 100mg, 300mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Allopurinol Dosage & Rx Info | Allopurinol Uses, Side Effects -, Allopurinol : Indications, Side Effects, Warnings, Allopurinol - Drug Information - Taj Pharma, Allopurinol dose Taj pharmaceuticals Allopurinol interactions, Taj Pharmaceutical Allopurinol contraindications, Allopurinol price, Allopurinol Taj Pharma Gout Kidney stone Cancer Allopurinol 100mg, 300mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Allopurinol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Azilsartan is an angiotensin II receptor blocker and hypertension medication. Azilsartan has been given the go-ahead to treat hypertension. Moreover, it prevents heart attacks and strokes and is used for heart failure.
Chloroquine phosphate 250 mg tablets smpc taj pharmaceuticalsTaj Pharma
Chloroquine phosphate 250 mg Tablets SMPC: Indications, Side Effects, Warnings, Chloroquinen - Drug Information - Taj Pharma, Chloroquinen dose Taj pharmaceuticals Chloroquinen interactions, Taj Pharmaceutical Chloroquinen contraindications, Chloroquinen price, Chloroquinen , Taj Pharma Chloroquine phosphate 250 mg Tablets SMPC - Taj Pharma . Stay connected to all updated on Chloroquinen Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Lisinopril 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Lisinopril 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Lisinopril Dosage & Rx Info | Lisinopril Uses, Side Effects - Lisinopril: Indications, Side Effects, Warnings, Lisinopril - Drug Information - Taj Pharma, Lisinopril dose Taj pharmaceuticals Lisinopril interactions, Taj Pharmaceutical Lisinopril contraindications, Lisinopril price, Lisinopril Taj Pharma Lisinopril 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Lisinopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Zoledronic acid Solution for Infusion Taj Pharma SmPCTajPharmaQC
Zoledronic acid 4 mg/100 ml Solution for Infusion Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Zoledronic acid Dosage & Rx Info | Zoledronic acid Uses, Side Effects Zoledronic acid: Indications, Side Effects, Warnings, Zoledronic acid -Drug Information –Taj Pharma, Zoledronic acid dose Taj pharmaceuticals Zoledronic acid interactions, Taj Pharmaceutical Zoledronic acid contraindications, Zoledronic acid price, Zoledronic acid Taj Pharma Zoledronic acid SmPC-Taj Pharma Stay connected to all updated on Zoledronic acid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Amoxicillin 250 mg Capsules-Summary of Product CharacteristicsBrown & Burk UK Ltd
Amoxicillin Capsule is used to treat infections in different parts of the body caused by bacteria. It is also used to stop infections when you have a tooth removed or other surgery. Amoxicillin Capsule may also be used in combination with other medicines to treat stomach ulcers.
Amoxicillin 250 mg capsules - summary of product characteristicsBrown & Burk UK Ltd
Amoxicillin Capsule is used to treat infections in different parts of the body caused by bacteria. It is also used to stop infections when you have a tooth removed or other surgery. Amoxicillin Capsule may also be used in combination with other medicines to treat stomach ulcers.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Losartan Tablet 50 mg - Summary of Product Characteristics
1.
2. 1. NAME OF THE MEDICINAL PRODUCT
Losartan Potassium 50 mg film-coated tablets.
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Each Losartan Potassium 50 mg Tablet contains 50 mg of Losartan potassium.
Excipient with known effect: Lactose monohydrate
For a full list of excipients, see section 6.1.
3. 3. PHARMACEUTICAL FORM
Film-coated tablets
Losartan Potassium 50 mg tablet
White to off white, oval shaped biconvex film coated tablets, engraved with “A50” on one side, and a central
break line on opposite side.
The tablet can be divided into equal halves.
4. 4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Treatment of essential hypertension in adults and in children and adolescents 6-18 years of age.
Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥ 0.5
g/day as part of an antihypertensive treatment (see sections 4.3, 4.4, 4.5 and 5.1).
Treatment of chronic heart failure in adult patients, when treatment with Angiotensinconverting enzymes (ACE)
inhibitors is not considered suitable due to incompatibility, especially cough, or contraindication. Patients with heart
failure who have been stabilised with an ACE inhibitor should not be switched to losartan. The patients should have a
left ventricular ejection fraction ≤ 40% and should be clinically stable and on an established treatment regimen for
chronic heart failure.
5. Reduction in the risk of stroke in adult hypertensive patients with left ventricular hypertrophy documented by ECG
(see section 5.1 LIFE study, Race)..
4.2 Posology and method of administration
Posology
Hypertension
The usual starting and maintenance dose is 50 mg once daily for most patients. The maximal antihypertensive effect is
attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose to
100 mg once daily (in the morning).
Losartan may be administered with other antihypertensive agents, especially with diuretics (e.g. hydrochlorothiazide)
(see sections 4.3, 4.4, 4.5 and 5.1).
6. Paediatric population
6 months – less than 6 years
The safety and efficacy of children aged 6 months to less than 6 years has not been established.
Currently available data are described in sections 5.1 and 5.2 but no recommendation on posology can
be made.
6 years to 18 years
For patients who can swallow tablets, the recommended dose is 25 mg once daily in patients >20 to
<50kg. (In exceptional cases the done can be increased to a maximum of 50 mg once daily). Dosage
Should be adjusted according to blood pressure response.
7. In patients >50 kg, the usual dose is 50 mg once daily. In exceptional cases the dose can be adjusted to a
maximum of 100 mg once daily. Doses above 1.4 mg/ kg (or in excess of 100 mg) daily have not been
studied in paediatric patients.
Losartan is not recommended for use in children under 6 years old, as limited data are available in these
patient groups.
It is not recommended in children with glomerular filtration rate < 30 ml/ min / 1.73 m2 , as no data are
available (see also section 4.4).
Losartan is also not recommended in children with hepatic impairment (see also section 4.4).
8. Hypertensive type II diabetic patients with proteinuria ≥ 0.5 g/day
The usual starting dose is 50 mg once daily. The dose may be increased to 100 mg once daily based on
blood pressure response from one month onwards after initiation of therapy. Losartan may be
administered with other antihypertensive agents (e.g. diuretics, calcium channel blockers, alpha- or
beta-blockers, and centrally acting agents) (see sections 4.3, 4.4, 4.5, and 5.1) as well as with insulin and
other commonly used hypoglycemic agents (e.g. sulfonylureas, glitazones and glucosidase inhibitors).
Heart Failure
The usual initial dose of Losartan in patients with heart failure is 12.5 mg once daily. The dose should
generally be titrated at weekly intervals (i.e. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a
maximum dose of 150 mg once daily) as tolerated by the patient.
9. Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by
ECG
The usual starting dose is 50 mg of Losartan once daily. A low dose of hydrochlorothiazide should be
added and/ or the dose of Losartan should be increased to 100 mg once daily based on blood pressure
response.
Special Population
Use in patients with intravascular volume depletion
For patients with intravascular volume-depletion (e.g. those treated with high-dose diuretics), a starting
dose of 25 mg once daily should be considered (see section 4.4).
10. Use in patients with renal impairment and haemodialysis patients
No initial dosage adjustment is necessary in patients with renal impairment and in haemodialysis
patients.
Use in patients with hepatic impairment
A lower dose should be considered for patients with a history of hepatic impairment. There is no
therapeutic experience in patients with severe hepatic impairment. Therefore, losartan is
contraindicated in patients with severe hepatic impairment (see sections 4.3 and 4.4).
Use in Elderly
Although consideration should be given to initiating therapy with 25 mg in patients over 75 years of age,
dosage adjustment is not usually necessary for the elderly.
11. Method of Administration
Losartan tablets should be swallowed whole with a glass of water.
Losartan may be administered with or without food.
4.3 Contraindications
• Hypersensitivity to active substance, or to any of the excipients listed in 6.1.
• 2nd and 3rd trimester of pregnancy (see section 4.4 and 4.6).
• Severe hepatic impairment.
• The concomitant use of Losartan with aliskiren-containing products is contraindicated in patients with diabetes
mellitus or renal impairment (GFR < 60 ml/min/1.73 m2 ) (see sections 4.5 and 5.1).
12. 4.4 Special warnings and precautions for use
Hypersensitivity
Angioedema. Patients with a history of angioedema (swelling of the face, lips, throat, and/ or tongue) should be
closely monitored (See section 4.8).
Hypotension and Electrolyte/Fluid Imbalance
Symptomatic hypotension, especially after the first dose and after increasing of the dose, may occur in patients
who are volume- and/or sodium-depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or
vomiting. These conditions should be corrected prior to administration of Losartan, or a lower starting dose should
be used (see section 4.2). This also applies to children 6 to 18 years of age.
13. Electrolyte imbalances
Electrolyte imbalances are common in patients with renal impairment, with or without diabetes, and should be
addressed. In a clinical study conducted in type 2 diabetic patients with nephropathy, the incidence of
hyperkalemia was higher in the group treated with Losartan as compared to the placebo group (see section 4.8).
Therefore, the plasma concentrations of potassium as well as creatinine clearance values should be closely
monitored, especially patients with heart failure and a Creatinine Clearance between 30-50 ml/ min should be
closely monitored.
The concomitant use of potassium sparing diuretics, potassium supplements and potassium containing salt
substitutes with losartan is not recommended (see section 4.5).
14. Hepatic Impairment
Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in
cirrhotic patients, a lower dose should be considered for patients with a history of hepatic impairment. There is no
therapeutic experience with losartan in patients with severe hepatic impairment. Therefore losartan must not be
administered in patients with severe hepatic impairment (see sections 4.2, 4.3 and 5.2).
Losartan is also not recommended in children with hepatic impairment (see section 4.2).
15. Renal Impairment
As a consequence of inhibiting the renin-angiotensin system, changes in renal function including renal failure have
been reported (in particular, in patients whose renal function is dependent on the rennin angiotensin aldosterone
system such as those with severe cardiac insufficiency or pre-existing renal dysfunction). As with other drugs that
affect the renin-angiotensin-aldosterone system, increases in blood urea and serum creatinine have also been
reported in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney; these changes
in renal function may be reversible upon discontinuation of therapy. Losartan should be used with caution in
patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney
16. Use in paediatric patients with renal function impairment
Losartan is not recommended in children with glomerular filtration rate < 30ml/ min/ 1.73 m2 as no data are
available (see section 4.2).
Renal function should be regularly monitored during treatment with losartan as it may deteriorate.This applies
particularly when losartan is given in the presence of other conditions (fever, dehydration) likely to impair renal
function.
Concomitant use of losartan and ACE-inhibitors has shown to impair renal function. Therefore, concomitant use is
not recommended (see section 4.5).
17. Renal transplantation
There is no experience in patients with recent kidney transplantation.
Primary hyperaldosteronism
Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting
through inhibition of the renin-angiotensin system. Therefore, the use of Losartan tablets is not recommended.
Coronary heart disease and cerebrovascular disease
As with any antihypertensive agents, excessive blood pressure decrease in patients with ischaemic cardiovascular
and cerebrovascular disease could result in a myocardial infarction or stroke.
18. Heart failure
In patients with heart failure, with or without renal impairment, there is - as with other medicinal products acting
on the renin-angiotensin system - a risk of severe arterial hypotension, and (often acute) renal impairment.
There is no sufficient therapeutic experience with losartan in patients with heart failure and concomitant severe
renal impairment, in patients with severe heart failure (NYHA class IV) as well as in patients with heart failure and
symptomatic life threatening cardiac arrhythmias. Therefore, losartan should be used with caution in these patient
groups. The combination of losartan with a beta-blocker should be used with caution (see section 5.1).
19. Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy
As with other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or
obstructive hypertrophic cardiomyopathy.
Galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorbtion (Excipients)
This medicinal product contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp
lactase deficiency or glucose-galactose malabsorption should not take this medicine.
20. Pregnancy
Losartan should not be initiated during pregnancy. Unless continued losartan therapy is considered essential,
patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an
established safety profile for use in pregnancy. When pregnancy is diagnosed, treatment with losartan should be
stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Other warnings and precautions
As observed for angiotensin converting enzyme inhibitors, losartan and the other angiotensin antagonists are
apparently less effective in lowering blood pressure in black people than in non-blacks, possibly because of higher
prevalence of low-renin states in the black hypertensive population.
21. Dual blockade of the renin-angiotensin-aldosterone system (RAAS)
There is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases
the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure). Dual blockade
of RAAS through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is therefore not
recommended (see sections 4.5 and 5.1).
If dual blockade therapy is considered absolutely necessary, this should only occur under specialist supervision and
subject to frequent close monitoring of renal function, electrolytes and blood pressure. ACE-inhibitors and
angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy.
22. 4.5Interaction with other medicinal products and other forms of interaction
Other antihypertensive agents may increase the hypotensive action of Losartan. Concomitant use with other substances
which may induce hypotension as an adverse reaction (like tricyclic antidepressants, antipsychotics, baclofen
andamifostine) may increase the risk of hypotension.
Losartan is predominantly metabolised by cytochrome P450 (CYP) 2C9 to the active carboxy-acid metabolite. In a
clinical trial it was found that fluconazole (inhibitor of CYP2C9) decreases the exposure to the active metabolite by
approximately 50%. It was found that concomitant treatment of losartan with rifampicin (inducer of metabolism
enzymes) gave a 40% reduction in plasma concentration of the active metabolite. The clinical relevance of this effect is
unknown. No difference in exposure was found with concomitant treatment with fluvastatin (weak inhibitor of CYP2C9).
23. As with other medicinal products that block angiotensin II or its effects, concomitant use of other medicinal products
which retain potassium (e.g. potassium-sparing diuretics: amiloride, triamterene, spironolactone) or may increase
potassium levels (e.g. heparin), potassium supplements or salt substitutes containing potassium may lead to increases
in serum potassium. Co-medication is not advisable
Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant
administration of lithium with ACE inhibitors. Very rare cases have also been reported with antiotensin II receptor
antagonists. Co-administration of lithium and losartan should be undertaken with caution. If this combination proves
essential, serum lithium level monitoring is recommended during concomitant use.
24. When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. selective COX-2 inhibitors,
acetylsalicylic acid at anti-inflammatory doses and non-selective NSAIDs), attenuation of the antihypertensive effect
may occur. Concomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of
worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in
patients with poor pre-existing renal function. The combination should be administered with caution, especially in the
elderly. Patients should be adequately hydrated and consideration should be given to monitoring renal function after
initiation of concomitant therapy, and periodically thereafter.
Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone-system (RAAS) through the
combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of
adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure)
compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4 and 5.1).
25. 4.6 Fertility, pregnancy and lactation
Pregnancy
The use of losartan is not recommended during the first trimester of pregnancy (see section 4.4).The use of
losartan is contra-indicated during the 2nd and 3rd trimester of pregnancy (see sections 4.3 and 4.4)
Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the
first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded.
Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Inhibitors (AIIRAs),
similar risks may exist for this class of medicinal products. Unless continued AIIRA therapy is considered
essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which
have an established safety profile for use in pregnancy. When pregnancy is diagnosed, treatment with losartan
should be stopped immediately, and, if appropriate, alternative therapy should be started.
26. Exposure to AIIRA therapy exposure during the second and third trimesters is known to induce human
fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity
(renal failure, hypotension, hyperkalaemia) (see also 5.3). Should exposure to losartan have occurred from the
second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Infants whose mothers have taken losartan should be closely observed for hypotension (see also section 4.3
and 4.4).
Lactation
Because no information is available regarding the use of losartan during breastfeeding, losartan is not
recommended and alternative treatments with better established safety profiles during breast-feeding are
preferable, especially while nursing a newborn or preterm infant.
27. 4.7 Effects on ability to drive and use machines
No studies on the effects on the ability to drive and use machines have been performed. However, when driving
vehicles or operating machinery it must be borne in mind that dizziness or drowsiness may occasionally occur
when taking antihypertensive therapy, in particular during initiation of treatment or when the dose is increased.
4.8 Undesirable effects
Losartan has been evaluated in clinical studies as follows:
• In a controlled clinical trial in > 3,000 adult patients 18 years of age and older for essential hypertension.
• In a controlled clinical trial in 177 hypertensive paediatric patients 6 to 16 years of age.
• In a controlled clinical trial in > 9,000 hypertensive patients 55 to 80 years of age with left ventricular
hypertrophy (see LIFE Study, section 5.1).
28. • In controlled clinical trials in > 7,700 adult patients with chronic heart failure (see ELITE I, ELITE II, and HEAAL
study, 5.1).
In a controlled clinical trial in > 1,500 type 2 diabetic patients 31 years of age and older with proteinuria (see
RENAAL study, section 5.1)
In these clinical trials, the most common adverse event was dizziness.
The frequency of adverse events listed below is defined using the following convention: very common (≥ 1/10);
common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (<
1/10,000), not known (cannot be estimated from the available data).
29. Table 1. The frequency of adverse reactions identified from placebo-controlled clinical studies
and post marketing experience
Adverse reaction Frequency of adverse reaction by indication Other
Hypertension Hypertensive
patients with
left
ventricular
hypertrophy
Chronic
Heart
Failure
Hypertension
and type 2
diabetes with
renal disease
Post-
marketing
experience
30. anaemia common frequency
not known
Blood and lymphatic system disorders
thrombocytopenia common frequency
not known
hypersensitivity
reactions,
anaphylactic
reactions,
angiooedema*,
rare
Immune system disorders
32. Ear and labyrinth disorders
paraesthesia rare
migraine frequency
not known
dysgeusia frequency
not known
vertigo common common
tinnitus frequency
not known
37. Skin and subcutaneous tissue disorders
urticaria uncommon frequency
not known
pruritus uncommon frequency
not known
rash uncommon uncommon frequency
not known
photosensitivity frequency
not known
38. Musculoskeletal and connective tissue disorders
myalgia frequency
not known
arthralgia frequency
not known
rhabdomyolysis frequency
not known
Renal and urinary disorders
renal impairment common
renal failure common
39. erectile
dysfunction /
impotence
frequency
not known
Reproductive system and breast disorders
General disorders and administration site conditions
asthenia uncommon common uncommon common
fatigue uncommon common uncommon common
oedema uncommon
malaise frequency
not known
40. Investigations
hyperkalaemia common uncommon† common‡
increased alanine
aminotransferase
(ALT) §
rare
increase in blood
urea, serum
creatinine, and
serum potassium
common
hyponatraemia frequency
not known
hypoglycaemia common
41. *Including swelling of the larynx, glottis, face, lips, pharynx, and/or tongue (causing airway obstruction); in
some of these patients angiooedema had been reported in the past in connection with the administration of
other medicines, including ACE inhibitors.
** Including Henoch-Schönlein purpura.
II Especially in patients with intravascular depletion, e.g. patients with severe heart failure or under
treatment with high dose Diuretics.
†Common in patients who received 150 mg losartan instead of 50 mg.
‡In a clinical study conducted in type 2 diabetic patients with nephropathy, 9.9% of patients treated with
Losartan tablets developed hyperkalaemia >5.5 mmol/l and 3.4% of patients treated with placebo.
42. §Usually resolved upon discontinuation.
The following additional adverse reactions occurred more frequently in patients who received losartan than
placebo (frequencies not known): back pain, urinary tract infection, and flu-like symptoms.
Renal and urinary disorders
As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function including
renal failure have been reported in patients at risk; these changes in renal function may be reversible upon
discontinuation of therapy (see section 4.4)
43. Investigations
In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely
associated with administration of Losartan tablets.
In a controlled clinical trial on patients with cardiac insufficiency, increase in blood urea, serum creatinine and
serum potassium has been reported.
Paediatric population
The adverse experience profile for pediatric patients appears to be similar to that seen in adult patients. Data
in the pediatric population are limited.
44. Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows
continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are
asked to report any suspected adverse reactions via the Yellow Card Scheme, website
www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store
45. 4.9 Overdose
Symptoms of intoxication
Limited data are available with regard to overdose in humans.. The most likely manifestation of overdose would be
hypotension and tachycardia. Bradycardia could occur from parasympathetic (vagal) stimulation
Treatment of intoxication
If symptomatic hypotension should occur, supportive treatment should be instituted.
Measures are depending on the time of medicinal product intake and kind and severity of symptoms. Stabilisation of
the circulatory system should be given priority. After oral intake, the administration of a sufficient dose of activated
charcoal is indicated. Afterwards, close monitoring of the vital parameters should be performed. Vital parameters
should be corrected if necessary.
Neither Losartan nor the active metabolite can be removed by haemodialysis
46. 5. PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Angiotensin II Receptor Antagonists, ATC code: C09CA01
5.1 Pharmacodynamic properties
Losartan is a synthetic oral angiotensin-II receptor (type AT1) antagonist. Angiotensin II, a potent vasoconstrictor, is the
primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of
hypertension. Angiotensin II binds to the AT1 receptor found in many tissues (e.g. vascular smooth muscle, adrenal
gland, kidneys and the heart) and elicits several important biological actions, including vasoconstriction and the release
of aldosterone. Angiotensin II also stimulates smooth muscle cell proliferation.Sodium cromoglicate has no intrinsic
vasoconstrictor or antihistamine activity
47. Losartan selectively blocks the AT1 receptor. In vitro and in vivo losartan and its pharmacologically active carboxylic acid
metabolite E-3174 block all physiologically relevant actions of angiotensin II, regardless of the source or route of its
synthesis.
Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in
cardiovascular regulation. Furthermore Losartan does not inhibit ACE (kininase II), the enzyme that degrades
bradykinin. Consequently, there is no potentiation of undesirable bradykinin mediated effects.
During administration of Losartan, removal of the angiotensin II negative feedback on renin secretion leads to increased
plasma renin activity (PRA). Increase in the PRA leads to an increase in angiotensin II in plasma. Despite these increases,
antihypertensive activity and suppression of plasma aldosterone concentration are maintained, indicating effective
angiotensin II receptor blockade. After discontinuation of Losartan, PRA and angiotensin II values fell within three days
to the baseline values.
48. Both Losartan and its principal active metabolite have a far greater affinity for the AT1-receptor than for the AT2-
receptor. The active metabolite is 10- to 40- times more active than Losartan on a weight for weight basis.
Hypertension Studies.
In controlled clinical studies, once-daily administration of Losartan to patients with mild to moderate essential
hypertension produced statistically significant reductions in systolic and diastolic blood pressure. Measurements of
blood pressure 24 hours post-dose relative to 5 - 6 hours post-dose demonstrated blood pressure reduction over 24
hours; the natural diurnal rhythm was retained. Blood pressure reduction at the end of the dosing interval was 70 - 80
% of the effect seen 5-6 hours postdose.
Discontinuation of Losartan in hypertensive patients did not result in an abrupt rise in blood pressure (rebound).
Despite the marked decrease in blood pressure, Losartan had no clinically significant effects on heart rate.
49. Losartan is equally effective in males and females, and in younger (below the age of 65 years) and older
hypertensive patients.
LIFE-Study
The Losartan Intervention For Endpoint Reduction in Hypertension [LIFE] study was a randomised, triple-blind,
active-controlled study in 9193 hypertensive patients aged 55 to 80 years with ECG documented left-ventricular
hypertrophy. Patients were randomised to once daily Losartan 50 mg or once daily atenolol 50 mg. If goal blood
pressure (< 140/90 mmHg) was not reached, hydrochlorothiazide (12.5 mg) was added first and, if needed, the
dose of Losartan or atenolol was then increased to 100 mg once daily. Other antihypertensives, with the exception
of ACE-inhibitors, angiotensin II antagonists or beta-blockers were added if necessary to reach the goal blood
pressure
50. The mean length of follow up was 4.8 years.
The primary endpoint was the composite of cardiovascular morbidity and mortality as measured by a reduction in
the combined incidence of cardiovascular death, stroke and myocardial infarction. Blood pressure was significantly
lowered to similar levels in the two groups. Treatment with losartan resulted in a 13.0% risk reduction (p=0.021, 95
% confidence interval 0.77-0.98) compared with atenolol for patients reaching the primary composite endpoint.
This was mainly attributable to a reduction of the incidence of stroke. Treatment with losartan reduced the risk of
stroke by 25% relative to atenolol (p=0.001 95% confidence interval 0.63-0.89). The rates of cardiovascular death
and myocardial infarction were not significantly different between the treatment groups.
51. Race
In the LIFE-Study black patients treated with Losartan had a higher risk of suffering the primary combined
endpoint, i.e. a cardiovascular event (e.g. cardiac infarction, cardiovascular death) and especially stroke, than the
black patients treated with atenolol. Therefore the results observed with losartan in comparison with atenolol in
the LIFE study with regard to cardiovascular morbidity/mortality do not apply for black patients with hypertension
and left ventricular hypertrophy.
RENAAL Study
The Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan RENAAL study was a
controlled clinical study conducted worldwide in 1513 Type 2 diabetic patients with proteinuria, with or without
hypertension. 751 Patients were treated with Losartan.
52. The objective of the study was to demonstrate a nephroprotective effect of Losartan potassium over and above the
benefit of a blood lowering pressure. Patients with proteinuria and a serum creatinine of 1.3 – 3.0 mg/dl were
randomised to receive Losartan 50 mg once a day, titrated if necessary, to achieve blood pressure response, or to
placebo, on a background of conventional antihypertensive therapy excluding ACE-inhibitors and angiotension II
antagonists.
Investigators were instructed to titrate the study medication to 100 mg daily as appropriate; 72 % of patients were
taking the 100 mg daily dose for the majority of the time. Other antihypertensive agents (diuretics, calcium
antagonists, alpha- and beta-receptor blockers and also centrally acting antihypertensives) were permitted as
supplementary treatment depending on the requirement in both groups. Patients were followed up for up to 4.6
years (3.4 years on average).
53. The primary endpoint of the study was a composite endpoint of doubling of the serum creatinine endstage renal
failure (need for dialysis or transplantation) or death.
The results showed that the treatment with Losartan (327 events) as compared with placebo (359 events) resulted
in a 16.1 % risk reduction (p = 0.022) in the number of patients reaching the primary composite endpoint. For the
following individual and combined components of the primary endpoint, the results showed a significant risk
reduction in the group treated with Losartan: 25.3 % risk reduction for doubling of the serum creatinine (p =
0.006); 28.6 % risk reduction for end-stage renal failure (p = 0.002); 19.9 % risk reduction for end-stage renal failure
or death (p = 0.009); 21.0 % risk reduction for doubling of serum creatinine or end-stage renal failure (p = 0.01).
All-cause mortality rate was not significantly different between the two treatment groups. In this study losartan
was generally well tolerated, as shown by a therapy discontinuation rate on account of adverse events that was
comparable to the placebo group.
54. HEAAL Study
The Heart Failure Endpoint Evaluation of Angiotensin II Antagonist Losartan (HEAAL) study was a controlled clinical
study conducted worldwide in 3834 patients aged 18 to 98 years with heart failure (NYHA Class II-IV) who were
intolerant of ACE inhibitor treatment. Patients were randomised to receive losartan 50 mg once a day or losartan
150 mg, on a background of conventional therapy excluding ACE-inhibitors.
Patients were followed for over 4 years (median 4.7 years). The primary endpoint of the study was a composite
endpoint of all cause death or hospitalisation for heart failure.
55. The results showed that treatment with 150 mg losartan (828 events) as compared with 50 mg losartan (889
events) resulted in a 10.1% risk reduction (p=0.027 95% confidence interval 0.82-0.99) in the number of patients
reaching the primary composite endpoint. This was mainly attributable to a reduction of the incidence of
hospitalisation for heart failure. Treatment with 150 mg losartan reduced the risk if hospitalisation for heart failure
by 13.5% relative to 50 mg losartan (p=0.025 95% confidence interval 0.76-0.98). The rate of all cause death was
not significantly different between the treatment groups. Renal impairment, hypotension, and hyperkalaemia were
more common in the 150 mg group than in the 50 mg group, but these adverse events did not lead to significantly
more treatment discontinuations in the 150 mg group.
56. ELITE I and ELITE II Study
In the ELITE Study carried out over 48 weeks in 722 patients with heart failure (NYHA Class II-IV), no difference was
observed between the patients treated with Losartan and those treated with captopril was observed with regard to
the primary endpoint of a long-term change in renal function. The observation of the ELITE I Study, that compared
with captopril, Losartan reduced the mortality risk, was not confirmed in the subsequent ELITE II Study, which is
described in the following.
In the ELITE II Study Losartan 50 mg once daily (starting dose 12.5 mg, increased to 25 mg, then 50 mg once daily)
was compared with captopril 50 mg three times daily (starting dose 12.5 mg, increased to 25 mg and then to 50 mg
three times daily). The primary endpoint of this prospective study was the all-cause mortality
57. In this study 3152 patients with heart failure (NYHA Class II-IV) were followed for almost two years (median: 1.5
years) in order to determine whether Losartan is superior to captopril in reducing all cause mortality. The primary
endpoint did not show any statistically significant difference between Losartan and captopril in reducing all-cause
mortality.
In both comparator-controlled (not placebo-controlled) clinical studies on patients with heart failure the
tolerability of Losartan was superior to that of captopril, measured on the basis of a significantly lower rate of
discontinuations of therapy on account of adverse events and a significantly lower frequency of cough
An increased mortality was observed in ELITE II in the small subgroup (22% of all HF patients) taking beta-blockers
at baseline.
58. Dual Blockade of the renin-angiotensin-aldosterone system (RAAS)
Two large randomised, controlled trials (ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril
Global Endpoint Trial) and VA NEPHRON-D (The Veterans Affairs Nephropathy in Diabetes)) have examined the use
of the combination of an ACE-inhibitor with an angiotensin II receptor blocker.
ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2
diabetes mellitus accompanied by evidence of end-organ damage. VA NEPHROND was a study in patients with type
2 diabetes mellitus and diabetic nephropathy.
59. These studies have shown no significant beneficial effect on renal and/or cardiovascular outcomes and mortality,
while an increased risk of hyperkalaemia, acute kidney injury and/or hypotension as compared to monotherapy
was observed. Given their similar pharmacodynamic properties, these results are also relevant for other ACE-
inhibitors and angiotensin II receptor blockers.
ACE-inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with
diabetic nephropathy.
60. ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study
designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II
receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or
both. The study was terminated early because of an increased risk of adverse outcomes. Cardiovascular death and
stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events
and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently
reported in the aliskiren group than in the placebo group.
61. Paediatric Population
Paediatric Hypertension
The antihypertensive effect of Losartan was established in a clinical study involving 177 hypertensive paediatric
patients 6 to 16 years of age with a body weight > 20 kg and a glomerular filtration rate > 30 ml/ min/ 1.73 m2 .
Patients who weighted >20kg to < 50 kg received either 2.5, 25 or 50 mg of Losartan daily and patients who
weighted > 50 kg received either 5, 50 or 100 mg of losartan daily. At the end of three weeks, losartan
administration once daily lowered trough blood pressure in a dosedependent manner.
62. Overall, there was a dose-response. The dose-response relationship became very obvious in the low dose group
compared to the middle dose group (period I: -6.2 mmHg vs. -11.65 mmHg), but was attenuated when comparing
the middle dose group with the high dose group (period I: -11.65 mmHg vs. -12.21 mmHg). The lowest doses
studied, 2.5 mg and 5 mg, corresponding to an average daily dose of 0.07 mg/ kg, did not appear to offer
consistent antihypertensive efficacy.
These results were confirmed during period II of the study where patients were randomized to continue losartan or
placebo, after three weeks of treatment. The difference in blood pressure increase as compared to placebo was
largest in the middle dose group (6.70 mmHg middle dose vs. 5.38 mmHg high dose). The rise in trough diastolic
blood pressure was the same in patients receiving placebo and in those continuing losartan at the lowest dose in
each group, again suggesting that the lowest dose in each group did not have significant antihypertensive effect.
63. Long-term effects of losartan on growth, puberty and general development have not been studied. The long-term
efficacy of antihypertensive therapy with losartan in childhood to reduce cardiovascular morbidity and mortality
has also not been established.
In hypertensive (N=60) and normotensive (N=246) children with proteinuria, the effect of losartan on proteinuria
was evaluated in a 12-week placebo- and active-controlled (amlodipine) clinical study. Proteinuria was defined as
urinary protein/creatinine ratio of ≥0.3. The hypertensive patients (ages 6 through 18 years) were randomised to
receive either losartan (n=30) or amlodipine (n=30). The normotensive patients (ages 1 through 18 years) were
randomised to receive either losartan (n=122) or placebo (n=124). Losartan was given at doses of 0.7 mg/kg to 1.4
mg/kg (up to maximum dose of 100 mg per day). Amlodipine was given at doses of 0.05 mg/kg to 0.2 mg/kg (up to
a maximum dose of 5 mg per day).
64. Overall, after 12 weeks of treatment, patients receiving losartan experienced a statistically significant reduction
from baseline in proteinuria of 36% versus 1% increase in placebo/amlodipine group (p≤0.001). Hypertensive
patients receiving losartan experienced a reduction from baseline proteinuria of -41.5% (95% CI -29.9;-51.1) versus
+2.4% (95% CI -22.2;14.1) in the amlodipine group. The decline in both systolic blood pressure and diastolic blood
pressure was greater in the losartan group (- 5.5/-3.8 mmHg) versus the amlodipine group (-0.1/+0.8 mm Hg). In
normotensive children a small decrease in blood pressure was observed in the losartan group (-3.7/-3.4 mm Hg)
compared to placebo. No significant correlation between the decline in proteinuria and blood pressure was noted,
however it is possible that the decline in blood pressure was responsible, in part, for the decline in proteinuria in
the losartan treated group.
65. Long-term effects of losartan in children with proteinuria were studied for up to 3 years in the openlabel safety
extension phase of the same study, in which all patients completing the 12-week base study were invited to
participate. A total of 268 patients entered the open-label extension phase and were re-randomized to losartan
(N=134) or enalapril (N=134) and 109 patients had ≥3 years of followup (pre-specified termination point of ≥100
patients completing 3 years of follow-up in the extension period). The dose ranges of losartan and enalapril,
given according to investigator discretion, were 0.30 to 4.42 mg/kg/day and 0.02 to 1.13 mg/kg/day,
respectively. The maximum daily doses of 50 mg for 50 kg were not exceeded for most patients during the
extension phase of the study
66. In summary, the results of the safety extension show that losartan was well-tolerated and led to sustained
decreases in proteinuria with no appreciable change in glomerular filtration rate (GFR) over 3 years. For
normotensive patients (n=205), enalapril had a numerically greater effect compared to losartan on proteinuria
(-33.0% (95%CI -47.2;-15.0) vs -16.6% (95%CI -34.9; 6.8)) and on GFR (9.4(95%CI 0.4; 18.4) vs -4.0(95%CI -13.1;
5.0) ml/min/1.73m2)). For hypertensive patients (n=49), losartan had a numerically greater effect on proteinuria
(-44.5% (95%CI -64.8; -12.4) vs -39.5% (95%CI -62.5; -2.2)) and GFR(18.9(95%CI 5.2; 32.5) vs -13.4(95%CI -27.3;
0.6)) ml/min/1.73m2.
67. An open label, dose-ranging clinical trial was conducted to study the safety and efficacy of losartan in paediatric
patients aged 6 months to 6 years with hypertension. A total of 101 patients were randomized to one of three
different starting doses of open-label losartan: a low dose of 0.1 mg/kg/day (N=33), a medium dose of 0.3
mg/kg/day (N=34), or a high dose of 0.7 mg/kg/day (N=34). Of these, 27 were infants which were defined as
children aged 6 months to 23 months. Study medication was titrated to the next dose level at Weeks 3, 6, and 9
for patients that were not at blood pressure goal and not yet on the maximal dose (1.4 mg/kg/day, not to
exceed 100 mg/day) of losartan
Of the 99 patients treated with study medication, 90 (90.9 %) patients continued to the extension study with
follow up visits every3 months. The mean duration of therapy was 264 days.
68. In summary, the mean blood pressure decrease from baseline was similar across all treatment groups (change
from baseline to Week 3 in SBP was -7.3, -7.6, and -6.7 mmHg for the low-, medium-, and high dose groups,
respectively; the reduction from baseline to Week 3 in DBP was -8.2, -5.1, and 6.7 mmHg for the low-, medium-,
and high-dose groups.); however, there was no statistically significant dose -dependent response effect for SBP
and DBP.
Losartan, at doses as high as 1.4 mg/kg, was generally well tolerated in hypertensive children aged 6 months to
6 years after 12 weeks of treatment. The overall safety profile appeared comparable between treatment groups.
69. 5.2 Pharmacokinetic properties
Absorption
Following oral administration, losartan is well absorbed and undergoes first-pass metabolism, forming an active
carboxylic acid metabolite and other inactive metabolites. The systemic bioavailability of losartan tablets is
approximately 33%. Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4
hours, respectively.
Distribution
Both losartan and its active metabolite are ≥ 99% bound to plasma proteins, primarily albumin. The volume of
distribution of losartan is 34 litres.
70. Biotransformation
About 14% of an intravenously- or orally-administered dose of losartan is converted to its active metabolite. Following
oral and intravenous administration of C-labeled losartan potassium, circulating plasma radioactivity primarily is
attributed to losartan and its active metabolite. Minimal conversion of losartan to its active metabolite was seen in
about one percent of individuals studied.
In addition to the active metabolite, inactive metabolites are formed
14
71. Elimination
Plasma clearance of losartan and its active metabolite is about 600 mL/min and 50 mL/min, respectively. Renal
clearance of losartan and its active metabolite is about 74 mL/min and 26 mL/min, respectively. When losartan is
administered orally, about 4% of the dose is excreted unchanged in the urine, and about 6% of the dose is excreted in
the urine as active metabolite. The pharmacokinetics of losartan and its active metabolite are linear with oral losartan
potassium doses up to 200 mg.
Following oral administration, plasma concentrations of losartan and its active metabolite decline polyexponentially
with a terminal half-life of about 2 hours and 6-9 hours, respectively. During once daily dosing with 100 mg, neither
losartan nor its active metabolite accumulates significantly in plasma.
14
72. Both biliary and urinary excretions contribute to the elimination of losartan and its metabolites. Following an oral
dose/intravenous administration of 14C-labeled losartan in man, about 35% / 43% of radioactivity is recovered in the
urine and 58%/ 50% in the faeces.
Characteristics in Patients
In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially
from those found in young hypertensive patients.
In female hypertensive patients the plasma levels of losartan were up to twice as high as in male hypertensive patients,
while the plasma levels of the active metabolite did not differ between men and women.
14
73. In patients with mild to moderate alcohol-induced hepatic cirrhosis, the plasma levels of losartan and its active
metabolite after oral administration were respectively 5 and 1.7 times higher than in young male volunteers (see
section 4.2 and 4.4).
Plasma concentrations of Losartan are not altered in patients with a creatinine clearance above 10 ml/minute.
Compared to patients with normal renal function, the AUC for Losartan is about 2-times higher in haemodialysis dialysis
patients.
The plasma concentrations of the active metabolite are not altered in patients with renal impairment or in
heamodialysis patients.
Neither Losartan nor the active metabolite can be removed by haemodialysis.
14
74. Pharmacokinetics in paediatric patients
The pharmacokinetics of losartan have been investigated in 50 hypertensive paediatric patients > 1 month to < 16 years
of age following once daily oral administration of approximately 0.54 to 0.77 mg/ kg of losartan (mean doses).
The results showed that the active metabolite is formed from losartan in all age groups. The results showed roughly
similar pharmacokinetic parameters of losartan following oral administration in infants and toddlers, preschool children,
school age children and adolescents. The pharmacokinetic parameters for the metabolite differed to a greater extent
between the age groups. When comparing preschool children with adolescents these differences became statistically
significant. Exposure in infants/ toddlers was comparatively high.
75. 5.3 Preclinical safety data
Preclinical data reveal no special hazard for humans based on conventional studies of general pharmacology,
genotoxicity and carcinogenic potential. In repeated dose toxicity studies, the administration of losartan induced a
decrease in the red blood cell parameters (erythrocytes, haemoglobin, haematocrit), a rise in urea-N in the serum and
occasional rises in serum creatinine, a decrease in heart weight (without a histological correlate) and gastrointestinal
changes (mucous membrane lesions, ulcers, erosions, haemorrhages). Like other substances that directly affect the
renin-angiotensin system, losartan has been shown to induce adverse reactions on late foetal development, resulting in
foetal death and malformations.
76. 6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Lactose monohydrate
Microcrystalline cellulose (E460)
Magnesium stearate (E572)
Pregelatinised maize starch
Hydroxypropylcellulose (E463)
Hydroxypropylmethylcellulose (E464)
Titanium dioxide (E171)
Losartan Potassium 50 mg also contains 4.24 mg (0.108 mmol) of potassium.
78. 6.5 Nature and contents of container
White opaque blisters (aluminium – PVC / PVdC / PE) of 14 tablets. Packs containing 14, 28, 56, 72, 96,
140, and 168 tablets are available.
Polypropylene tablet containers with polypropylene tamper evident closure containing 100 tablets.
Not all pack sizes may be marketed.
79. 6.6 Special precautions for disposal and other handling
No special requirements
7. MARKETING AUTHORISATION HOLDER
Brown & Burk UK Ltd
5 Marryat Close
Hounslow West
TW4 5DQ
United Kingdom
80. 8. MARKETING AUTHORISATION NUMBER(S)
PL 25298/0096
9. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
23/02/2010
10. DATE OF REVISION OF THE TEXT
09/11/2017